Multi-compartmental transdermal patch for simultaneous delivery of multiple drugs:formulation and evaluation of newly developed novel dosage form

作     者：Vijayan Venugopal Jayaraja Kumar Selvadurai Muralidharan P.Vasanth Raj 

作者机构：Unit of Pharmaceutical TechnologyFaculty of PharmacyAIMST UniversityBedong-08100Malaysia 

出 版 物：《Journal of Coastal Life Medicine》 (海岸生命医学杂志（英文版）)

年 卷 期：2015年第7期

页      面：534-538页

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

主　　题：Multi-compartmental Transdermal patch Aceclofenac Serratiopeptidase 

摘      要：Objective:To evaluate the formulation of multi-compartmental transdermal patches for simultaneous delivery of multiple drugs:aceclofenac and ***:The patch was prepared by simple solvent casting method using hydroxy propyl methyl celluloseK100Mas matrix forming agent and dimethyl sulphoxide as permeation *** prepared transdermal patch was evaluated by physiochemical parameters andin-vitro diffusion ***:The multi-compartmental transdermal patch showed sustained drug release over the period of 12 ***:Multicompartmental transdermal patches shows better bioavailability,therapeutic efficacy and very economic as compared with other dosage forms.