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Assessment of the bioaccessibility and bioavailability prediction of omega 3 and conjugated fatty acids by in vitro standardized digestion model (INFOGEST) and cell model

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FOOD BIOSCIENCE 2023年第3期53卷 1678-1691页

作者： Salsinha, Ana Sofia Cunha, Sara A. machado, manuela Rodriguez-Alcala, Luis Miguel Relvas, Joao B. Pintado, manuela Univ Catolica Portuguesa CBQF Ctr Biotecnol & Quim Fina Escola Super Biotecnol Lab Associado Rua Diogo Botelho 1327 P-4169005 Porto Portugal Univ Porto Inst Invest & Inovacao Saude Rua Alfredo Allen 208 P-4200135 Porto Portugal Univ Porto Inst Biol Mol & Celular IBMC Rua Alfredo Allen 208 P-4200135 Porto Portugal Fac Med Univ Porto FMUP Dept Biomed P-4200319 Porto Portugal

Omega 3 EPA and DHA are polyunsaturated fatty acids with relevant health benefits. Conjugated linoleic and linolenic acids are known for their anti-carcinogenic effect, anti-inflammatory properties and body weight reduction. To achieve therapeutical doses, high amounts of these fatty acids' food sources must be consumed. Thus, the intake of enriched oils with a high concentration of these fatty acids is often used. But several factors influence their bioavailability. Here, by using the INFOGEST static in vitro protocol of gastrointestinal tract digestion it was studied the bioaccessibility of these fatty acids in different matrixes: Pomegranate and Fish oil and omega 3, CLA and CLNA soft-gel enriched capsules. After digestion, the Recovery Index for the major bioactive PUFAs are very low: Pomegranate oil is 2%, Fish oil 11-13%, CLNA 17%, CLA 6% and Omega 3 capsules 3%. Higher initial concentrations of these PUFAs seem to be related to higher degrees of oxidation. In Pomegranate oil, CLNA and Omega 3 capsules, the digestion process negatively influenced the antioxidant potential. The opposite was verified for the Fish oil and CLA capsules. Importantly, bioaccessibility studies of similar matrixes are very scarce and intestinal permeability is absent in most of the studies. Intestinal permeability studies were performed using a Caco-2/HT29-MTX co-culture: there is significative incorporation of the bioactive fatty acids into the intestinal cells, which may affect their permeability performance. Interestingly, most fatty acids remain in the non-bioaccessible fraction which may be relevant when designing oral routes of administration and in gut microbiota modulation.

关键词： Fish oil Pomegranate oil INFOGEST digestion Method Bioaccessibility Intestinal permeability Bioactive fatty acids

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Novel avocado oil-functionalized yogurt with anti-obesity potential:Technological and nutraceutical perspectives

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Food Bioscience 2022年第6期50卷 161-170页

作者： manuela machado Sérgio Sousa Pilar Morais Arménio Miranda Luís M.Rodriguez-Alcalá Ana Maria Gomes manuela Pintado Universidade Católica Portuguesa CBQF Centro de Biotecnologia e Química Fina-Laboratório AssociadoEscola Superior de BiotecnologiaRua Diogo Botelho 13274169-005PortoPortugal Frulact S.ARua do Outeiro589Gemunde4475-150MaiaPortugal

Studies on bioactive lipids have been increasing in the last years due to their proven health *** purpose of this research work was to develop a yogurt with bioactive lipids with anti-obesity *** this purpose,yogurts were produced with avocado oil in free form or encapsulated as a *** presence of avocado oil enhanced the nutritional quality of yogurts through a reduction(more than 75%)of their atherogenic and thrombogenic *** high nutritional value was particularly evident in samples with bigel,as these yogurts presented eight-fold higher levels of total fatty acids than the yogurts with avocado oil in free *** addition,yogurts with avocado bigel presented better stability throughout the gastrointestinal tract-results showed a higher recovery percentage of oleic acid(47.2%)when compared to 24%in the yogurts with avocado in free *** results from the in vitro studies demonstrated that these functional yogurts can increase the lipolytic rate in adipocytes,translated by an increase of ca.20%in glycerol release in yogurts with ***,the hepatic lipid accumulation in cells subjected to steatosis induced by chloroquine was reduced by 35%in cells treated with yogurt digested *** results showed the potential of these functional yogurts to modulate obesity-related metabolism.

关键词： Lipid metabolism Obesity Dairy products Functional foods

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Impact of simulated in vitro gastrointestinal digestion on bioactive compounds,bioactivity and cytotoxicity of melon (Cucumis melo L. inodorus) peel juice powder

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Food Bioscience 2022年第3期47卷 1358-1367页

作者： Ricardo Gómez-García Ana A.Vilas-Boas manuela machado Débora A.Campos Cristóbal N.Aguilar Ana R.Madureira manuela Pintado Universidade Católica Portuguesa CBQF-Centro de Biotecnologia e Química Fina – Laboratório AssociadoEscola Superior de BiotecnologiaRua Diogo Botelho 13274169-005PortoPortugal BBG-DIA.Bioprocesses and Bioproducts Group.Food Research Department School of ChemistryAutonomous University of CoahuilaSaltilloCoahuilaMexico

The objectives of this research work were to evaluate the effect of in vitro gastrointestinal digestion (GIT) on melon peel juice (MPJ) powder from fruit processing industry by-products,considering (i) the recovery and accessibility indexes,(ii) the changes on antioxidant activity,and (iii) the prebiotic *** exposition to GIT conditions a decrease on the total phenolic content (TPC = 65.31%) and antioxidant activity by ABTS = 39.77% and DPPH = 45.91% were ***,these both parameters exhibited stable accessibility,accounting with 81.89%,76.55%,and 54.07% for TPC,ABTS and DPPH,*** gastrointestinal digestion,the non-absorbed fraction exhibited a positive impact on the growth of Bifidobacterium and Lactobacillus strains,possibly associated with the high content of simple sugar (glucose and fructose).This fraction also showed to be safe on Caco-2 intestinal *** findings suggest that MPJ might be used as a potential food functional ingredient.

关键词： Melon by-products Functional ingredients Phenolic antioxidants Simulated digestion Prebiotic effect

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Treatment of Chronic Oxaliplatin-Induced Peripheral Neuropathy: A Systematic Review

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Journal of Cancer Therapy 2020年第9期11卷 519-534页

作者： Alda Tavares Ana Agrelo manuela machado Department of Medical Oncology Hospital Pedro Hispano Matosinhos Local Health Unit Matosinhos Portugal Department of Anesthesiology Portuguese Institute of Oncology of Porto Porto Portugal Department of Medical Oncology Portuguese Institute of Oncology of Porto Porto Portugal

Introduction: Oxaliplatin is a platinum-derivative chemotherapeutic agent used in digestive tumours, in the adjuvant and metastatic setting. Oxaliplatin can cause a chronic peripheral sensory neuropathy which impacts the quality of life and is dose limiting. To date, no therapeutic strategies have proved effective in the treatment of oxaliplatin-induced peripheral neuropathy (OIPN). Methods: A computerized search of the literature on PubMed database was performed. Publisher original articles were included if they focused on treatment of peripheral neuropathy among patients submitted to oxaliplatin. Eleven out of 242 reviewed papers met our inclusion criteria and were subjected to a 19-item quality checklist. Results: The included studies differed with respect to study design, patient population and sample size, neuropathic symptoms assessment and efficacy measure. Most studies had an adequate quality. Ten trials tested one drug, and one pilot study tested a non-pharmacological treatment—the neurofeedback. Of these, 3 trials included only patients submitted to oxaliplatin-based chemotherapy. Duloxetine showed moderate efficacy in 3 trials. Topical treatment with capsaicin or 10% amitriptyline was promisors in 2 single-arm trials with a few samples.

关键词： Peripheral Neuropathy Oxaliplatin Chemotherapy-Induced Peripheral Neuropathy Pain Neurotoxicity Supportive Care

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Multiple Synchronous Tumours:A Peculiar Clinical Case

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Journal of Cancer Therapy 2019年第7期10卷 602-608页

作者： Maria Leitao Tiago Alpoim manuela machado Medical Oncology Department IPOPortoPortugal

Background: Due to improvements in diagnosis, the better outcomes of oncological patients and the increase in the average age, the incidence of synchronous tumours is likely to increase. Aim: To reflect on the challenges of a case with multiple integrated diagnostic and therapeutic approaches and to bring to consideration the increasing prevalence of similar situations. Case Presentation: In this clinical case, the authors describe the evolution of an asymptomatic patient with several synchronous tumours (a GEJ primary adenocarcinoma, a low grade urothelial carcinoma in situ, a localized squamous cell lung carcinoma and 2 IPMNs). Conclusion: The challenge of this case lies in the difficult diagnostic approach, the assembly of a multidisciplinary and time-sensitive treatment plan and the individualized follow-up, due to lack of guidelines. More research is needed in this area.

关键词： Gastric Cancer Multiple Primary Neoplasms Synchronous

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Case Report: A Long Survivor Patient with Stage IV Gastric Adenocarcinoma

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Journal of Cancer Therapy 2020年第6期11卷 357-364页

作者： Marta Pina Maria Leitão manuela machado Medical Oncology Department Portuguese Institute of Oncology of Porto Porto Portugal

Gastric cancer (GC) is the fifth most common malignancy of the world and third leading cause of cancer death. At diagnosis, 35% of GC patients have distant metastases and in these cases the survival rate is very poor with a median overall survival (OS) inferior to 1 year. We report a case of a 67-year-old woman with gastric carcinoma initially deemed limited stage on diagnosis (cT2N0M0), treated surgically with radical subtotal gastrectomy with Billroth II reconstruction. In the staging CT scan, the patient presented a liver image that was considered benign. Three months later, due to abdominal pain, the patient performed another CT scan and the diagnostic of a large single liver metastasis was made;retrospectively it was observed that the lesion was present at diagnosis and that it had increased. A biopsy was performed which confirmed the metastatic origin. In a multidisciplinary team, the lesion was considered unresectable. She was proposed for first line (1st L) palliative chemotherapy (ChT) with FOLFIRI, with partial response as best response. After 30 cycles of FOLFIRI, bone metastases were diagnosed. The patient was submitted to a cementoplasty of D11-12 and L1-2. Afterwards, she started 2nd L ChT with mFOLFOX6 and at the same time she started zoledronic acid every 28 days. The best response to mFOLFOX6 was stable disease. Since November 2018, the patient has been treated with zoledronic acid every 28 days alone and maintains stable disease without ChT.

关键词： Gastric Cancer Metastatic Gastric Cancer Palliative Surgery Palliative Chemotherapy Survival

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Pancreatic neuroendocrine tumor liver metastasisin a patient with previously diagnosed pancreatic adenocarcinoma: an unexpected diagnosis

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Journal of Cancer Metastasis and Treatment 2018年第1期4卷 69-74页

作者： Mario Fontes-Sousa Helena Magalhaes Bianca machado Olga Sousa manuela machado Department of Medical Oncology Portuguese Oncology Institute-PortoPorto 4200-072Portugal Pathology Department Portuguese Oncology Institute-PortoPorto 4200-072Portugal Radioncology Department Portuguese Oncology Institute-PortoPorto 4200-072Portugal

Locally advanced pancreatic carcinoma has an usually poor prognosis despite multimodal approaches and sequential *** authors present a case of a long-term survivor with stage III pancreatic adenocarcinoma achieving partial response after a multimodal approach including local and systemic ***,three years after diagnosis and amidst several episodes of cholangitis,hepatic metastasis were *** pancreatic adenocarcinoma being the obvious culprit for metastization,a hepatic biopsy was considered at that time given a stable primary disease and presenting three years since the initial *** this point,a biopsy could have specific diagnostic,prognostic and therapeutic implications and after it was performed,an unexpected diagnosis of pancreatic neuroendocrine tumor was ***,we urge clinicians to consider hepatic biopsy in similar cases-generally when it may change prognosis and treatment strategies-and perform histological confirmation of metastatic disease whenever feasible,even if the answer may seem obvious at first impression.

关键词： Neoplasm metastasis pancreatic cancer neuroendocrine tumors biomarkers survivorship chemoradiotherapy

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Is the determination of ctDNA a scientific “spy” that foresees cancer?

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World Journal of Respirology 2017年第2期7卷 35-38页

作者： Joana Espiga de Macedo manuela machado Department of Medical Oncology Centro Hospitalar de Entre Douro e Vouga Department of Medical Oncology Portuguese Institute of Oncology

Since 1948, circulating tumour DNA(ctDNA) was first identified in human blood. ctDNA is in fact DNA shed by tumour cells from all metastatic tumour locations throughout the whole body, and is thrown into the bloodstream and can then be isolated by a standard blood draw. Using this technique scientists can obtain a wide view of tumour heterogeneity, identify different mechanisms of drug resistance, what is its predominance and the clinical rational of precision cancer medicine become a part of our daily practice. Secondly, early detection of cancer may also contribute to global decrease in cancer mortality.

关键词： Tumour biopsies Liquid biopsies Circulating tumour DNA Precision cancer medicine

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A Sustained Complete Response in an Elderly Patient with Metastatic Colorectal Adenocarcinoma—A Clinical Case

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Journal of Cancer Therapy 2020年第6期11卷 351-356页

作者： Maria Leitão Isabel Vilas-Boas manuela machado Medical Oncology Department Portuguese Institute of Oncology of Porto Porto Portugal

Background: The increasing life expectancy of people worldwide will signify that oncologists everywhere will be faced with many difficult decisions regarding treatment options in the elderly population with cancer. These patients carry specific challenges that should be discussed. Aim: To report the clinical case of an elderly patient with a metastatic colorectal cancer with a sustained complete response and reflect on the particularities on this special population. Clinical case: In 2009, an 80-year-old man presents with colorectal cancer, undergoes surgery and intraoperatively a peritoneal implant is resected. He is deemed fit for chemotherapy and is treated with 8 cycles of capecitabine. After a 10-year follow-up, he remains with no evidence of disease. Conclusion: Chronological age is insufficient to establish a treatment plan;oncologists must evaluate the patient multidimensionally and develop personalized options for the therapy and follow-up of older individuals.

关键词： Elderly Chemotherapy Cancer Colorectal

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A Single Case of Two Synchronous Metastatic Tumours

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Journal of Cancer Therapy 2019年第8期10卷 671-676页

作者： Filipa Pereira Tiago Alpoim Maria Leitao manuela machado Medical Oncology Department IPO PortoPortoPortugal

The incidence of multiple primary tumours increases with age and due to multiple other factors as environmental and genetic predisposition. The authors describe a case of a 77-year-old female patient with diagnosis in September 2009 of colon mucinous adenocarcinoma. She was submitted to surgery, considered R1 and adjuvant chemotherapy. Six months after treatment she had abdominal recurrence on a nodular lesion in peritoneal fat. The patient was submitted to surgery and did multiple courses of systemic treatment. She underwent cytoreductive surgery with hyperthermic chemotherapy, too. In December 2014 she presented a nodular lesion on the bladder and after excision, the histology confirmed a high-grade transitional cell carcinoma and she maintains treatment with endovesical BCG instillations. After that, she had no evidence of peritoneal disease progression. Besides the bad prognosis associated to peritoneal disease, our case report describes a long survival (5 years with no disease progression) in a patient with high risk at diagnosis to peritoneal recurrence. This case shows the importance of multimodal approach and the impact of locoregional treatment in localized metastatic disease.

关键词： Colon Cancer Bladder Cancer Multiple Primary Neoplasms Synchronous

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