Pancreatic neuroendocrine tumor liver metastasisin a patient with previously diagnosed pancreatic adenocarcinoma: an unexpected diagnosis

作     者：Mario Fontes-Sousa Helena Magalhaes Bianca Machado Olga Sousa Manuela Machado 

作者机构：Department of Medical OncologyPortuguese Oncology Institute-PortoPorto 4200-072Portugal Pathology DepartmentPortuguese Oncology Institute-PortoPorto 4200-072Portugal Radioncology DepartmentPortuguese Oncology Institute-PortoPorto 4200-072Portugal 

出 版 物：《Journal of Cancer Metastasis and Treatment》 (癌症转移与治疗（英文版）)

年 卷 期：2018年第4卷第1期

页      面：69-74页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Neoplasm metastasis pancreatic cancer neuroendocrine tumors biomarkers survivorship chemoradiotherapy 

摘      要：Locally advanced pancreatic carcinoma has an usually poor prognosis despite multimodal approaches and sequential *** authors present a case of a long-term survivor with stage III pancreatic adenocarcinoma achieving partial response after a multimodal approach including local and systemic ***,three years after diagnosis and amidst several episodes of cholangitis,hepatic metastasis were *** pancreatic adenocarcinoma being the obvious culprit for metastization,a hepatic biopsy was considered at that time given a stable primary disease and presenting three years since the initial *** this point,a biopsy could have specific diagnostic,prognostic and therapeutic implications and after it was performed,an unexpected diagnosis of pancreatic neuroendocrine tumor was ***,we urge clinicians to consider hepatic biopsy in similar cases-generally when it may change prognosis and treatment strategies-and perform histological confirmation of metastatic disease whenever feasible,even if the answer may seem obvious at first impression.