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Genes & Diseases 2024年第3期11卷 34-38页

作者： mj mahesh kumar Shailendra Arindkar Masum Saini Perumal Nagarajan National Institute of Immunology New Delhi 100067India Center for Cellular and Molecular Biology Hyderabad 500007India Regional Center for Biotechnology Faridabad 121001India

Non-alcoholic fatty liver disease(NAFLD)and type 2 diabetes mellitus(T2DM)are two disease conditions for which obesity is a risk factor.^(1)Due to the close relationship between the three pathologies,researchers frequently use the same mouse models to identify the underlying processes of obesity,NAFLD,and *** instance,leptin(Lep)-null(ob/ob)and leptin receptor(Lepr)-deficient(db/db)mice spontaneously develop NAFLD and show different phenotypes of extreme obesity and diabetes,respectively.

关键词： obesity NAFLD Lep

Techno-Economic Optimization of Novel Stand-Alone Renewable Based Electric Vehicle Charging Station near Bahria Town Karachi,Sindh Pakistan

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Energy Engineering 2024年第6期121卷 1439-1457页

作者： Aneel kumar mahesh kumar Amir Mahmood Soomro Laveet kumar Department of Electrical Engineering Mehran University of Engineering and TechnologyJamshoroPakistan Department of Mechanical Engineering Mehran University of Engineering and TechnologyJamshoroPakistan

Electric vehicles (EVs) are the most interesting and innovative technology in the 21st century because of theirenormous advantages, both technically and economically. Their emissions rate compared to fuel-based vehicles isnegligible as they do not consume fuel and hence do not emit any harmful gases. However, their bulk production,adoption and lack of charging stations increase the stress of power stations due to modern-day lifestyles. If Electricvehicles demand increases drastically then conventional power stations will not bear their demand and if theygenerate electricity by conventional means it will be very costly and may further add greenhouse gases. Therefore,this research provides the techno-economic assessment of a stand-alone renewable-dependent electric vehiclecharging station, excluding any burden on electrical utility. The proposed study is carried out in Bahria Town,Karachi, a city in Pakistan. In this study, HOMER Pro software was utilized for techno-economic assessment. Ahybrid system comprising solar Photovoltaic/Wind Turbine/Fuel cells and battery storage is included in the *** and wind resources were taken from NASA’s website, where charging stations will be integrated. The overallresults show promising in terms of total Net Present Cost and the Cost of Energy which are 2.72M $ and 0.237 $,respectively. The total system generation is 3,598 Megawatt hours per year, and the total energy consumption is 885Megawatt hours per year.

关键词： Electrical vehicle techno economic analysis solar energy wind energy hydrogen energy

Emergence of taurine as a therapeutic agent for neurological disorders

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Neural Regeneration Research 2024年第1期19卷 62-68页

作者： Ashok Jangra Priyanka Gola Jiten Singh Pooja Gond Swarnabha Ghosh mahesh Rachamalla Abhijit Dey Danish Iqbal Mehnaz Kamal Punya Sachdeva Saurabh kumar Jha Shreesh Ojha Dinesh kumar Niraj kumar Jha Hitesh Chopra Shing Cheng Tan Department of Pharmaceutical Sciences Central University of HaryanaMahendergarhHaryanaIndia Department of Biology University of SaskatchewanSaskatoonSKCanada Department of Life Sciences Presidency UniversityKolkataWest BengalIndia Department of Health Information Management College of Applied Medical SciencesBuraydah Private CollegesBuraydahSaudi Arabia Department of Pharmaceutical Chemistry College of PharmacyPrince Sattam Bin Abdulaziz UniversityAl-KharjSaudi Arabia GloNeuro Vishwakarma RoadNoidaIndia Department of Biotechnology School of Engineering&Technology(SET)Sharda UniversityGreater NoidaUttar PradeshIndia Department of Pharmacology and Therapeutics College of Medicine and Health SciencesUnited Arab Emirates UniversityAl AinUnited Arab Emirates School of Bioengineering&Biosciences Lovely Professional UniversityPhagwaraIndia Department of Biotechnology School of Applied&Life Sciences(SALS)Uttaranchal UniversityDehradunIndia Chitkara College of Pharmacy Chitkara UniversityPunjabIndia UKM Medical Molecular Biology Institute Universiti Kebangsaan MalaysiaKuala LumpurMalaysia

Taurine is a sulfur-containing,semi-essential amino acid that occurs naturally in the *** alternates between inflammation and oxidative stress-mediated injury in various disease *** part of its limiting functions,taurine also modulates endoplasmic reticulum stress,Ca^(2+)homeostasis,and neuronal activity at the molecular *** effectively protects against a number of neurological disorders,including stro ke,epilepsy,cerebral ischemia,memory dysfunction,and spinal cord *** various therapies are available,effective management of these disorders remains a global *** 30 million people are affected *** design of taurine fo rmation co uld lead to potential drugs/supplements for the health maintenance and treatment of central nervous system *** general neuroprotective effects of taurine and the various possible underlying mechanisms are discussed in this *** article is a good resource for understanding the general effects of taurine on various *** the strong evidence for the neuropharmacological efficacy of taurine in various experimental paradigms,it is concluded that this molecule should be considered and further investigated as a potential candidate for neurotherapeutics,with emphasis on mechanism and clinical studies to determine efficacy.

关键词： antioxidant epilepsy γ-amino butyric acid neurodegenerative disorders neuroprotection oxidative stress spinal cord injury taurine

Investigation of 58Ni(n, p)58Co reaction cross-section with covariance analysis

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Chinese Physics C 2024年第2期48卷 78-90页

作者： Akash Hingu S.Mukherjee Siddharth Parashari Arora Sangeeta A.Gandhi Mahima Upadhyay mahesh Choudhary Sumit Bamal Namrata Singh G.Mishra Sukanya De Saurav Sood Sajin Prasad G.Saxena Ajay kumar R.G.Thomas B.K.Agrawal K.Katovsky A.kumar Department of Physics Faculty of ScienceThe M.S.University of BarodaVadodara 390002India Faculty of Electrical Engineering and Communication Brno University of TechnologyBrnoCzech Republic Department of Physics Faculty of ScienceUniversity of ZagrebBijenička c.32Zagreb 10000Croatia Department of Physics University Institute of SciencesChandigarh UniversityGharuanMohali 140413PunjabIndia Department of Physics Banaras Hindu UniversityVaranasi 221005India Horia Hulubei National Institute for Physics and Nuclear Engineering Măgurele 077125Romania Nuclear Physics Division Bhabha Atomic Research CentreMumbai 400085India Health Physics Division Bhabha Atomic Research CentreMumbai 400085India Department of Physics(H&S) Government Women Engineering CollegeAjmer 305002India Saha Institute of Nuclear Physics Kolkata 700064India Homi Bhabha National Institute Anushakti NagarMumbai 400094India

The excitation function of the 58Ni(n,p)58Co reaction was measured using the well-established neutron activation technique andγ-ray *** in the energy range of 1.7 to 2.7 MeV were generated using the 7Li(p,n)*** neutron flux was measured using the standard 115In(n,n’)115mIn monitor *** results of the neutron spectrum averaged cross-section of 58Ni(n,p)58Co reactions were compared with existing cross-section data available in the EXFOR data library as well as with various evaluated data libraries such as ENDF/B-VIII.0,JEFF-3.3,JENDL-4.0,and *** calculations were performed using the nuclear reaction code *** nuclear level density(NLD)models were tested,and their results were compared with the present *** NLDs were also obtained through the spectral distribution method(SDM).The cross-section results,along with the absolute errors,were obtained by investigating the uncertainty propagation and using the covariance *** forγ-ray true coincidence summing,low-energy background neutrons,andγ-ray self attenuation were *** experimental cross-section obtained in the present study is consistent with previously published experimental data,evaluated libraries,and theoretical calculations carried out using the TALYS code.

关键词： nuclear reactions (n,p)reaction cross-section measurement covariance analysis nuclear level density

Optimal integration of battery energy-storage system with high penetration of renewable energy in radial distribution network

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Clean Energy 2022年第3期6卷 404-411页

作者： Hafsa Imra Sheikh mahesh kumar Rathi Amir Mahmood Soomro Department of Electrical Engineering Mehran University of Engineering and TechnologyJamshoroPakistan

Considering the intermittent nature of renewable energy,a storage system to reserve power in off-peak hours and then to supply it during peak hours is ***,if these storage devices in a network are not placed in an appropriate manner,the advantages can never be *** this study,the allocation and sizing strategies of a battery energy-storage system(BESS)in an optimal way are proposed to improve the performance of the radial distribution *** test network adopted is a standard IEEE 33 bus network that is integrated with solar *** are carried out in DIgSILENT PowerFactory for the distribution network model and the process of optimization is done through MATLAB®.The optimization algorithm adopted is the genetic *** system is studied for 24 hours with a step size of 15 minutes,employing a time-sweep analysis of dynamic *** is studied under three different scenarios and the results are *** results illustrate a considerable reduction in power losses in the case of the optimized *** total losses before the optimization process are 16365.57 *** total losses after the employment of the proposed solution are 10246.5 kW,which means that the losses are reduced by≤62%.

关键词： energy and environment energy storage solar

Two-level supply chain models with imperfect quality items when demand influences price and marketing promotion

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Journal of Management Analytics 2022年第4期9卷 480-495页

作者： Rita Yadav Sarla Pareek Mandeep Mittal mahesh kumar Jayaswal Department of Mathematics and Statistics Banasthali VidyapithBanasthaliIndia Department of Mathematics Amity Institute of Applied SciencesAmity University Uttar PradeshNoidaIndia

The present paper studies a supply chain model with items that are of imperfect quality and with the assumption that end demand is responsive to price and promotion *** seller delivers items to the buyer in a *** an inspection process,it is observed that few articles produced are not of perfect *** defects might be the result of common operations or static *** defective items are then collected and are sold at a lower/discounted *** this paper,supply chain models are developed to approve the interaction among the players,in the supply chain *** interaction between the players is demonstrated by non-cooperative and cooperative game theoretical *** non-cooperative approach,optimal solutions are attained by game theoretic approaches named as Seller–Stackelberg and Buyer–*** the cooperative approach,a Pareto efficient solution is *** the last,numerical illustrations with sensitivity scrutiny are presented to support the theory of the present paper.

关键词： game theory imperfect quality items supply chain co-operative game non-cooperative games

Recent advances on pathogenesis,diagnosis,prevention,immunological aspects,and vectors of dengue:A review

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Asian Pacific Journal of Tropical Biomedicine 2023年第8期13卷 325-338页

作者： mahesh Chandra Sahu Rakesh kumar Samantaray Aditi Pal Sanghamitra Pati Division of Medical Entomology ICMR-Regional Medical Research CentreChandrasekharpurBhubaneswar-751023OdishaIndia ICMR-Regional Medical Research Centre ChandrasekharpurBhubaneswar-751023OdishaIndia

Dengue is a vector-borne disease caused by the dengue virus(DENV)of family *** fever is common in both developed and developing ***,approximately 400 million cases of dengue fever are reported annually,resulting in approximately 22000 *** cases in India have progressively increased in the last *** recent years,substantial progress has been made in understanding various aspects of dengue,including its pathogenesis,diagnosis,prevention strategies,immunological responses,and the role of vectors in its *** transmission of a positive RNA virus occurs through Aedes mosquitoes,specifically Aedes aegypti and Aedes *** virus is associated with a wide spectrum of symptoms,ranging from mild undifferentiated fever to severe hemorrhagic fever and shock,posing a potential threat to human *** are 4 types of antigenically distinct dengue serotypes(DENV-1 to DENV-4)and among them,DENV-2 is more lethal and extremely *** overcome the severity of dengue,Dengvaxia is administered to children 9 to 16 years old with evidence of previous dengue *** diagnosis of dengue is carried out by ELISA-based non-structural protein(NS1)and immunoglobulin ***,there are no specific biomarkers to identify severe disease *** factors and temperature play an important role in complex interaction among host,vector,and virus to manifest the severity of *** is a need for the refinement of climate-based disease forecasting models in India to effectively control the spread of *** mosquito repellent should be used periodically to kill or repel the Aedes mosquito to prevent the spread of dengue in humans.

关键词： Dengue Aedes mosquitoes Insecticide NS1 Immunoglobulin

Sm^(3+)induced structural phase transition,spectral,morphological,magnetic,dielectric and impedance properties of Ni_(0.1)Cu_(0.9)Sm_(x)Fe_(2-x)O_(4) nanoferrites

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Journal of Rare Earths 2023年第11期41卷 1736-1745,I0003页

作者： K.Rajashekhar G.Vinod K.mahesh kumar G.Harikishan Laxman Naik J Department of Physics University College of ScienceOsmania UniversityHyderabad500007TelanganaIndia Department of Physics Kamala Institute of Technology and ScienceHuzurabad505468TelanganaIndia Department of Physics CMR College of Engineering&TechnologyHyderabad501401TelanganaIndia

In the present study,rare earth samarium(Sm^(3+))substituted Ni-Cu spinel ferrites with the composition of Ni_(0.1)Cu_(0.9)Sm_(x)Fe_(2-x)O_(4)(0≤x≤0.05 in steps of 0.01)were synthesized by using the citrate induced sol-gel auto combustion *** ferrites'structural,optical,magnetic,and dielectric studies were carried out using X-ray diffraction(XRD),Fourier transform infrared spectroscopy(FTIR),field emission scanning electron microscopy(FESEM),ultraviolet-visible(UV-vis),a vibrational sample magnetometer(VSM),and an LCR *** pure Ni-Cu ferrite exhibits a tetragonal structure owing to the presence of the John Tellar ion(Cu^(2+)).XRD patterns confirm that the tetragonal structure gradually transforms into the cubic spinel structure with samarium *** nano-scale structures of these ferrites were confirmed by the average crystallite size(10.11-20.99 nm)derived from the X-ray diffraction patterns,and grain size(42.60-83.36 nm)assessed from FESEM *** existence of elements according to their chemical composition was verified by using energy dispersive X-ray(EDX)*** absorption bands(v_(1) and v_(2))detected in FTIR transmission spectra below the wavenumber of 600 cm^(-1)reveal the stretching vibrations of M-O bonds in the spinel structure at tetrahedral and octahedral *** band gap ene rgy obtained from UV absorption reveals the semiconducting nature of the *** high saturation magnetization(M_(s))is noticed at 15 K temperature for x=0.02 composition as 32.98 emu/g,while at 300 K for x=0.01composition as 27.61 emu/*** suggested cation distribution is in good agreement with observed and predicted magnetic moment values at 300 *** expected behavior of ferrites reveals the observed dielectric constant,loss tangent,and ac-conductivity values in the frequency range of 20 Hz-20 ***-Cole plots confirm that the impedance contribution is attributed to grain boundaries.

关键词： Nanoferrites XRD Magnetic properties Dielectric properties Cole-cole plots Rare earths

Single-atom catalysts boosted ultrathin film sensors

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Rare Metals 2020年第10期39卷 1110-1112页

作者： Rahul kumar mahesh kumar Department of Electrical Engineering Indian Institute of Technology JodhpurJodhpur 342037India

Nowadays,demand for fast and accurate detection of toxic and flammable gases is increasing for human health safety,industrial process and environmental ***,gas sensor technology has become a requisite in our daily *** nanoscience and nanotechnology propel fabrication of a gas sensor at the miniaturization level for burgeoning Internet of things applications.

关键词： film nanotechnology gases

Effective and Efficient Video Compression by the Deep Learning Techniques

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Computer Systems Science & Engineering 2023年第5期45卷 1047-1061页

作者： Karthick Panneerselvam K.mahesh V.L.Helen Josephine A.Ranjith kumar Department of Computer Applications Alagappa UniversityKaraikudiIndia Department of Computer Science and Engineering lovely professional UniversityPhagwaraPunjabIndia School of Business and Management Christ UniversityBengaluruKarnatakaIndia

Deep learning has reached many successes in Video *** has become a growing important part of our daily digital *** advancement of better resolution content and the large volume offers serious challenges to the goal of receiving,distributing,compressing and revealing highquality video *** this paper we propose a novel Effective and Efficient video compression by the Deep Learning framework based on the flask,which creatively combines the Deep Learning Techniques on Convolutional Neural Networks(CNN)and Generative Adversarial Networks(GAN).The video compression method involves the layers are divided into different groups for data processing,using CNN to remove the duplicate frames,repeating the single image instead of the duplicate images by recognizing and detecting minute changes using GAN and recorded with Long Short-Term Memory(LSTM).Instead of the complete image,the small changes generated using GAN are substituted,which helps with frame-level *** wise comparison is performed using K-nearest Neighbours(KNN)over the frame,clustered with K-means and Singular Value Decomposition(SVD)is applied for every frame in the video for all three colour channels[Red,Green,Blue]to decrease the dimension of the utility matrix[R,G,B]by extracting its latent *** frames are packed with parameters with the aid of a codec and converted to video format and the results are compared with the original *** experiments on several videos with different sizes,duration,Frames per second(FPS),and quality results demonstrated a significant resampling *** normal,the outcome delivered had around a 10%deviation in quality and over half in size when contrasted,and the original video.

关键词： Convolutional neural networks(CNN) generative adversarial network(GAN) singular value decomposition(SVD) K-nearest neighbours(KNN) stochastic gradient descent(SGD) long short-term memory(LSTM)