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Shuyu pills inhibit immune escape and enhance chemosensitization in hepatocellular carcinoma

World Journal of Gastrointestinal Oncology 2021年第11期13卷 1725-1740页

作者： Zhe Deng Yong-jie Teng Qing Zhou Zhao-guang Ouyang Yu-xing hu Hong-Ping Long Mei-jie hu Si Mei Feng-Xia Lin xin-Jun Dai Bo-Yu Zhang Ting Feng Xue-Fei Tian College of Integrated Chinese and Western Medicine Hunan Key Laboratory of Translational Research in Formulas and Zheng of Traditional Chinese MedicineHunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina The First Hospital of hunan University of Chinese Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Department of Preventive Dentistry Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative MedicineGuangzhou Medical UniversityGuangzhou 510132Guangdong ProvinceChina Experiment Center of Medical Innovation The First Hospital of Hunan University of Chinese MedicineHunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Department of Physiology Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Department of Cardiology Shenzhen Bao'an Traditional Chinese Medicine Hospital GroupThe Affiliated Hospital of Guangzhou University of Chinese MedicineShenzhen 518133Guangdong ProvinceChina College of Acupuncture and Massage Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina

BACKGROUND hepatocellular carcinoma(HCC)is characterized by dysregulation of the immune microenvironment and the development of ***,expression of the programmed cell death protein 1(PD-1)/programmed cell death 1 ligand 1(PD-L1)axis,an immune checkpoint,may lead to tumour immune escape,resulting in disease *** latest research shows that tumour immune escape may be caused by the upregulation of PD-L1 mediated by hypoxia-inducible factor-1 alpha(HIF-1α),and simultaneous inhibition of HIF-1αand PD-L1 has the potential to enhance the host’s antitumour ***,inhibition of the PD-1/PD-L1 axis may mitigate tumour *** pills(SYPs)contain immunity-enhancing and antitumour components,making them a potential HCC *** To investigate the efficacy of SYPs for HCC treatment via simultaneous HIF-1α and PD-L1 inhibition and the mechanism *** A subcutaneous xenograft tumour model was first established in BALB/c nude mice by the subcutaneous injection of 1×107 SMMC-7721 *** mice(male,5 weeks old;n=24)were then randomly divided into the following four groups(n=6):Control(0.9%normal saline),SYP(200 mg/kg),SYP+cisplatin(DDP)(200 mg/kg+5 mg/kg DDP weekly via intraperitoneal injection),and DDP(5 mg/kg cisplatin weekly via intraperitoneal injection).The dose of saline or SYPs for the indicated mouse groups was 0.2 mL/d via intragastric *** tumour volumes and body weights of the mice were measured every 2 *** mice were euthanized by cervical dislocation after 14 d of continuous treatment,and the xenograft tissues were excised and *** blot assays were used to measure the protein expression of HIF-1α,PD1,PD-L1,CD4+T cells,and CD8+T cells in HCC tumours from *** reverse transcription polymerase chain reaction was used for real-time quantitative detection of PD-1,PD-L1,and HIF-1α mRNA *** immunofluorescence assay was conducted to examine the expressio

关键词： Shuyu pills hepatocellular carcinoma Tumour microenvironment Immune escape Chemoresistance

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Liposuction of the zygomatic arch area facilitates correction of temporal depression

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Chinese Medical Journal 2020年第14期133卷 1757-1758页

作者： Chun-hu Wang Zi-Rong Li xin Li jie Li meng Wang Xue-Bing Liang Xiao-Ning Yang Ke-ming Wang Ji-guang Ma Fa-Cheng Li 17th Department of Plastic Surgery Plastic Surgery HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100041China Department of Plastic Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China 18th Department of Plastic Surgery Plastic Surgery HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100041China

To the Editor:Temporal depression is characterized by height difference between temporal concavity and lateral projection of the zygomatic *** aim of correction of temporal depression is to decrease the height difference between the concavity and lateral *** this study,we investigated whether decreasing the projection of the zygomatic arch by liposuction would benefit for correction of temporal depression.

关键词： correction cavity projection

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The wide-field photometric system of the Nanshan One-meter Telescope

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Research in Astronomy and Astrophysics 2020年第12期20卷 373-382页

作者： Chun-Hai Bai Guo-jie Feng Xuan Zhang hu-Biao Niu Abdusamatjan Eskandar guang-xin Pu Shu-Guo Ma Jin-Zhong Liu Xiao-Jun Jiang Lu Ma Ali Esamdin Na Wang xinjiang Astronomical Observatories Chinese Academy of SciencesUrumqi 830011China Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China

The Nanshan One-meter Wide-field Telescope is a prime focus system that is located at Nanshan Station of xinjiang Astronomical *** field of view was designed to 1.5°× 1.5°,and the Johnson-Cousins UBVRI system was chosen as the main filter *** telescope has been providing observation services for astronomers since September *** source searching and time-domain surveys are the main scientific *** system’s test results are reported including linearity,dark current,bias,readout noise and gain of the CCD *** accurate instrumental calibration coefficients in UBVRI bands were driven with Landolt standard stars during photometric ***,the limiting magnitudes are given with signal-to-noise ratios and various exposure times for observers.

关键词： telescope filter CCD photometry

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Development of a MWDC prototype of the CSR external-target experiment

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Nuclear Science and Techniques 2024年第10期35卷 121-134页

作者： Zhou-Bo he Zhi Qin Peng Ma he-Run Yang Xiang-Lun Wei Chen-Gui Lu Xiang-jie Wen Xiu-Ling Zhang Tao Chen Zhi-jie Li Yuan-Sheng Yang Mei-Qiang Zhan Can-Wen Liu meng Li Tian-Li Qiu Yi-Wei Gong xin-jie huang Xiao-Hao Yin Zhi-Xuan he Jun-Wei Zhang Hai-Chuan Zou Sheng-Wei Fu Dong Guo Jun-Wei Yan Zhe Cao Zhi Deng jie Kong Zhi-Gang Xiao Rong-Jiang hu Li-Min Duan Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China Department of Physics Tsinghua UniversityBeijing 100084China University of Science and Technology of China Hefei 230026China Key Laboratory of Radiation Physics and Technology of the Ministry of Education Institute of Nuclear Science and TechnologySichuan UniversityChengdu 610064China School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China North China University of Water Resources and Electric Power Zhengzhou 450000China

The cooling storage ring(CSR)external-target experiment(CEE)is a spectrometer used in construction to study the properties of nuclear matter in high-baryon density regions at the heavy-Ion Research Facility in Lanzhou(HIRFL).This study presents the design,simulation,manufacturing,and testing of a half-size prototype of a multi-wire drift chamber(MWDC)for the ***,the performance of the MWDC connected to homemade electronics was *** results demonstrated that an energy resolution of 18.5% for 5.9-keV X-rays and a position resolution of 194μm for protons can be achieved by the current *** the size of the largest MWDC reached 176 cm×314 cm,a set of 98 cm×98 cm prototypes was built using the new *** positioning accuracy of the anode wires in this prototype is better than 20μ*** optimization,using commercially available electronics,the prototype can achieved an energy resolution of 19.7%for a^(55)Fe X-ray *** CEE-MWDC detector and electronics were simultaneously *** energy resolution of 22%was achieved for the^(55)Fe source;the track residuals were approximately 330μm for the cosmic *** results demonstrate that the current design and techniques meet the requirements of the CEE-MWDC array.

关键词： CEE MWDC Garfield++ ^(55)Fe source Position resolution

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New experimental measurement of^(nat)Se(n,γ)cross section between 1 eV to 1 keV at the CSNS Back-n facility

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Chinese Physics B 2022年第8期31卷 117-124页

作者： xin-Rong hu Long-Xiang Liu Wei Jiang jie ren Gong-Tao Fan Hong-Wei Wang Xi-guang Cao Long-Long Song Ying-Du Liu Yue Zhang xin-Xiang Li Zi-Rui Hao Pan Kuang Xiao-he Wang Ji-Feng hu Bing Jiang De-xin Wang Suyalatu Zhang Zhen-Dong An Yu-Ting Wang Chun-Wang Ma Jian-Jun he Jun Su Li-Yong Zhang Yu-Xuan Yang Sheng Jin Kai-jie Chen Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Spallation Neutron Source Science Center Dongguan 523803China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China Xiangtan University Xiangtan 411105China Institute of Nuclear Physics Inner Mongolia University for the NationalitiesTongliao 028000China Sun Yat-sen University Zhuhai 510275China henan Normal University Xinxiang 453007China Beijing Normal University Beijing 100875China School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450052China ShanghaiTech University Shanghai 200120China

The^(74)Se is one of 35 p-nuclei,and^(82)Se is a r-process only nucleus,and their(n,γ)cross sections are vital input parameters for nuclear astrophysics reaction network *** neutron capture cross section in the resonance range of isotopes and even natural selenium samples has not been ***γ-rays originating from neutron-induced capture events were detected by four C_(6)D_(6) liquid scintillator detectors at the Back-n facility of China Spallation Neutron Source(CSNS).The pulse height weighting technique(PHWT)was used to analyze the data in the 1 e V to 100 ke V *** deduced neutron capture cross section was compared with ENDF/B-VIII.0,JEFF-3.2,and JENDL-4.0,and some differences were *** parameters were extracted by the R-matrix code SAMMY in the 1 e V-1 ke V *** the cross sections ofnatSe and resonance parameters are given in the *** datasets are openly available at http://***/10.11922/sciencedb.j00113.00019.

关键词： ^(nat)Se(n γ)cross section CSNS Back-n facility C_6D_6 detectors resolved resonance region Rmatrix

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Simulation and test of the SLEGS TOF spectrometer at SSRF

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Nuclear Science and Techniques 2023年第3期34卷 171-184页

作者： Kai-jie Chen Long-Xiang Liu Zi-Rui Hao Yu-Gang Ma Hong-Wei Wang Gong-Tao Fan Xi-guang Cao Hang-hua Xu Yi-Fei Niu xin-Xiang Li xin-Rong hu Yu-Xuan Yang Sheng Jin Pan Kuang School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China University of Chinese Academy of Science Beijing 100080China Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China School of Nuclear Science and Technology University of South ChinaHengyang 421001China School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450052China

The Shanghai laser electron gamma source(SLEGS)is a powerful tool for exploring photonuclear physics,such as giant dipole resonance(GDR)and pygmy dipole resonance,which are the main mechanisms of collective nuclear *** goal of the SLEGS neutron time-of-flight(TOF)spectrometer is to measure GDR and specific nuclear structures in the energy region above the neutron *** SLEGS TOF spectrometer was designed to hold 20 sets of EJ301 and LaBr3 ***4 was used to simulate the efficiency of each detector and the entire spectrometer,which provides a reference for the selection of detectors and layout of the SLEGS TOF *** the events of 208Pb,implementations of coincidence and time-of-flight technology for complex experiments are available;thus,and neutron decay events can be *** performance of SLEGS TOF spectrometer was systematically evaluated using offline experiments,in which the time resolution reached approximately 0.9 ns.

关键词： SLEGS Time-of-flight Photoneutron nuclear reaction

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Comparison of acute pneumonia caused by SARS-CoV-2 and other respiratory viruses in children:a retrospective multi-center cohort study during COVID-19 outbreak

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Military Medical Research 2021年第4期8卷 468-480页

作者： guang-Li ren Xian-Feng Wang Jun Xu Jun Li Qiong meng Guo-Qiang Xie Bo huang Wei-Chun Zhu Jing Lin Cheng-he Tang Sheng Ye Zhuo Li jie Zhu Zhen Tang ming-xin Ma Cong Xie Ying-Wen Wu Chen-Xi Liu Fang Yang Yu-Zong Zhou Ying Zheng Shu-Ling Lan Jian-Feng Chen Feng Ye Yu he BenQing Wu Long Chen Si-Mao Fu Cheng-Zhong Zheng Yuan Shi Department of Pediatrics General Hospital of Southern Theater Command of PLA111 Liuhua RoadYuexiu DistrictGuangzhou 510010GuangdongChina. Department of Pediatrics the Third People’s Hospital of ShenzhenShenzhen 518100GuangdongChina. Pediatric Intensive Care Unit Wuhan Children’s HospitalTongji Medical CollegeHuazhong University of Science&TechnologyWuhan 430010China. Pediatric Intensive Care Unit Maternal and Child Health Hospital of HuangshiHuangshi 435000HubeiChina. Department of Pediatrics the Second People’s Hospital of Guangdong ProvinceGuangzhou 510317China. Department of Pediatrics the Third Affiliated Hospital of Zunyi Medical University(the First People’s Hospital of Zunyi)Guizhou 563000China. Department of Pediatrics the Eighth People’s Hospital of GuangzhouGuangzhou 510440China. Department of Pediatrics the First Affiliated Hospital of Xinxiang Medical UniversityXinxiang 453100HenanChina. Pediatric Intensive Care Unit the Children’s Hospital Zhejiang University School of MedicineHangzhou 310000China. Department of Emergency/Critical Medicine Children’s Hospital of Nanjing Medical UniversityNanjing 210008China. Department of Pediatrics the Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510260China. Department of Medical information date room General Hospital of Southern Theater Command of PLAGuangzhou 510010China. Department of Pediatrics the First Affiliated Hospital of Jinan UniversityGuangzhou 510632China. Department of Pediatrics Maternal and Child Health Hospital of YangjiangYangjiang 529500GuangdongChina. Department of Pediatrics Shenzhen Hospital Affiliated to the University of Chinese Academy of SciencesShenzhen 518107GuangdongChina. Department of Pediatrics Nanfang Hospital of Southern Medical UniversityGuangzhou 510515China. Department of Pediatrics Zhujiang Hospital of Southern Medical UniversityGuangzhou 510280China. Department of Pediatrics Military Hospital of 74 Group of PLAGuangzhou 510318China. Department of Neonatology

Background:Until January 18,2021,coronavirus disease-2019(COVID-19)has infected more than 93 million individuals and has caused a certain degree of *** pneumonia caused by common viruses such as respiratory syncytial virus,rhinovirus,human metapneumovirus,human bocavirus,and parainfluenza viruses have been more common in ***,the incidence of COVID-19 in children was significantly lower than that in *** purpose of this study was to describe the clinical manifestations,treatment and outcomes of COVID-19 in children compared with those of other sources of viral pneumonia diagnosed during the COVID-19 ***:Children with COVID-19 and viral pneumonia admitted to 20 hospitals were enrolled in this retrospective multi-center cohort study.A total of 64 children with COVID-19 were defined as the COVID-19 cohort,of which 40 children who developed pneumonia were defined as the COVID-19 pneumonia *** 284 children with pneumonia caused by other viruses were defined as the viral pneumonia *** epidemiologic,clinical,and laboratory findings were compared by Kolmogorov-Smirnov test,t-test,Mann-Whitney U test and Contingency table *** usage,immunotherapy,blood transfusion,and need for oxygen support were collected as the treatment ***,intensive care needs and symptomatic duration were collected as the outcome ***:Compared with the viral pneumonia cohort,children in the COVID-19 cohort were mostly exposed to family members confirmed to have COVID-19(53/64 vs.23/284),were of older median age(6.3 years vs.3.2 years),and had a higher proportion of ground-glass opacity(GGO)on computed tomography(18/40 vs.0/38,Pren in the COVID-19 pneumonia cohort had a lower proportion of severe cases(1/40 vs.38/284,P=0.048),and lower cases with high fever(3/40 vs.167/284,Phe propor

关键词： Children Severe acute respiratory syndrome Coronavirus disease-2019 Viral pneumonia

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Efficacy and safety of modified tetracycline dosing in a quadruple therapy for helicobacter pylori:A retrospective single center study

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World Journal of Gastroenterology 2023年第22期29卷 3508-3518页

作者： Ying-Chao Sun meng-Jia Zhu Xue-Qin Chen Lei Yue Yi-Ru Zhao xin-jie Wang John J Kim Qin Du Wei-Ling hu Department of Gastroenterology Sir Run Run Shaw HospitalMedical SchoolZhejiang UniversityHangzhou 310016Zhejiang ProvinceChina Division of Gastroenterology Loma Linda University HealthLoma LindaCA 92354United States Department of Gastroenterology Zhejiang University School of Medicine Second Affiliated HospitalHangzhou 310009Zhejiang ProvinceChina Institute of Gastroenterology Zhejiang UniversityHangzhou 310016Zhejiang ProvinceChina

BACKGROUND Although highly effective as a component of helicobacter pylori(***)treatment regimen,tetracycline is associated with a high incidence of medicationrelated adverse *** dosing of tetracycline as part of quadruple therapy may improve safety while providing comparable eradication *** To evaluate the efficacy and safety of modified dosing of tetracycline in patients receiving tetracycline and furazolidone-containing quadruple therapy in patients with *** *** Consecutive patients(10/2020-12/2021)who received tetracycline and furazolidone quadruple therapy for *** infection at Sir Run Run Shaw Hospital were *** patients received tetracycline,furazolidone,proton pump inhibitor,and bismuth for 14 d as primary or rescue *** tetracycline dose group received tetracycline 500 mg twice daily while standard group received 750 mg twice daily or 500 mg three times *** Three hundred and ninety-four patients[mean age=46.3±13.9,male=137(34.8%),and 309(78.4%)primary therapy]completed tetracycline and furazolidone quadruple therapy for *** infection including those who received modified tetracycline dose in 157 and standard doses in 118(750 mg twice daily)and 119(500 mg three times daily).Eradication rates in the modified tetracycline dose group were 92.40%and in the standard groups,eradication rates were 93.20%for 750 mg twice daily group and 92.43%for 500 mg three times daily group,respectively,without statistical difference(P=0.959).The incidence of adverse events was lower in the modified tetracycline dose(15.3%vs 32.3%and 29.4%;P=0.002)compared to the standard dose *** In a real-world experience,modified tetracycline dosing as part of tetracycline and furazolidone quadruple therapy for 14 d demonstrated high efficacy,comparable to standard tetracycline dose regimens,with a favorable safety profile.

关键词： helicobacter pylori Tetracycline Furazolidone Eradication Penicillin allergy Bismuth quadruple therapy

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Reversion effects of curcumin on multidrug resistance of MNNG/HOS human osteosarcoma cells in vitro and in vivo through regulation of P-glycoprotein

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Chinese Medical Journal 2013年第21期126卷 4116-4123页

作者： Si meng Zhao jie Li xin Tian Ji-guang Li Yong-gang Li Jian-min Shandong Univ Qilu Hosp Dept Orthoped Jinan 250012 Shandong Peoples R China Shandong Univ Prov Hosp Dept Ophthalmol Jinan 250021 Shandong Peoples R China

Background P-glycoprotein （P-gp） encoded by ATP-binding cassette sub-family B member 1 （ABCB1） gene is a kind of ATP-dependent drug transporter, which plays important roles in multidrug resistance （MDR） of human cancers, such as osteosarcoma. Curcumin is a natural phenolic coloring compound originating from the rhizomes of Curcuma Ionga, which is proved to possess antitumor biological activities including reversion of MDR. However, the effect and molecular mechanisms of curcumin to osteosarcoma MDR remain unclear.

关键词： curcumin P-glycoprotein multidrug resistance osteosarcoma MNNG/HOS cell

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Transcriptional regulation of secondary metabolism and autophagy genes in response to DNA replication stress in Setosphaeria turcica

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Journal of Integrative Agriculture 2023年第4期22卷 1068-1081页

作者： meng Ya-nan ZHANG xin-jie ZENG Fan-li ZHAI Wei-bo LI Pan hu Jing-jing XIAO Sheng-lin HAO Zhi-min CAO Zhi-yan CheN Chuan DONG Jin-gao State Key Laboratory of North China Crop Improvement and Regulation Hebei Agricultural UniversityBaoding 071001P.R.China College of Life Sciences Hebei Agricultural UniversityBaoding 071001P.R.China Key Laboratory of Microbial Diversity Research and Application of hebei Province School of Life SciencesHebei UniversityBaoding 071001P.R.China Key Laboratory of hebei Province for Plant Physiology and Molecular Pathology Hebei Agricultural UniversityBaoding 071001P.R.China College of Plant Protection Hebei Agricultural UniversityBaoding 071001P.R.China

The fungal pathogen Setosphaeria turcica causes northern corn leaf blight(NCLB),which leads to considerable crop *** turcica elaborates a specialized infection structures called appressorium for maize ***,we demonstrated that the *** triggers an S-phase checkpoint and ATR(Ataxia Telangiectasia and Rad3 related)-dependent self-protective response to DNA genotoxic insults during maize ***,how the regulatory mechanism works was still largely ***,we report a genome wide transcriptional profile analysis during appressorium formation in the present of DNA replication *** performed RNA-Seq analysis to identify *** genes responsive to DNA replication *** the current work,we found that appressorium-mediated maize infection by *** is significantly blocked by S-phase checkpoint.A large serial of secondary metabolite and melanin biosynthesis genes were blocked in appressorium formation of *** during the replication *** secondary metabolite biosynthesis genes including alcohol dehydrogenase GroES-like domain,multicopper oxidase,ABCtransporter families,cytochrome P450 and FAD-containing monooxygenase were related to plant pathogen *** addition,we demonstrated that autophagy in *** is up-regulated by ATR as a defense response to *** identified StATG3,StATG4,StATG5,StATG7 and StATG16 genes for autophagy were induced by ATR-mediated S-phase *** therefore propose that in response to genotoxic stress,*** utilizes ATR-dependent pathway to turn off transcription of genes governing appressorium-mediated infection,and meanwhile inducing transcription of autophagy genes likely as a mechanism of self-protection,aside from the more conservative responses in eukaryotes.

关键词： Setosphaeria turcica appressorium secondary metabolite autophagy DNA replication stress

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