Efficacy and safety of modified tetracycline dosing in a quadruple therapy for Helicobacter pylori:A retrospective single center study
作者机构：Department of GastroenterologySir Run Run Shaw HospitalMedical SchoolZhejiang UniversityHangzhou 310016Zhejiang ProvinceChina Division of GastroenterologyLoma Linda University HealthLoma LindaCA 92354United States Department of GastroenterologyZhejiang University School of Medicine Second Affiliated HospitalHangzhou 310009Zhejiang ProvinceChina Institute of GastroenterologyZhejiang UniversityHangzhou 310016Zhejiang ProvinceChina
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2023年第29卷第22期
页 面：3508-3518页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：Supported by the Zhejiang Provincial Natural Science Foundation,No.LY23H160016 Zhejiang Medical Association,No.2019ZYC-A88
主 题：Helicobacter pylori Tetracycline Furazolidone Eradication Penicillin allergy Bismuth quadruple therapy
摘 要：BACKGROUND Although highly effective as a component of Helicobacter pylori(***)treatment regimen,tetracycline is associated with a high incidence of medicationrelated adverse *** dosing of tetracycline as part of quadruple therapy may improve safety while providing comparable eradication *** To evaluate the efficacy and safety of modified dosing of tetracycline in patients receiving tetracycline and furazolidone-containing quadruple therapy in patients with *** *** Consecutive patients(10/2020-12/2021)who received tetracycline and furazolidone quadruple therapy for *** infection at Sir Run Run Shaw Hospital were *** patients received tetracycline,furazolidone,proton pump inhibitor,and bismuth for 14 d as primary or rescue *** tetracycline dose group received tetracycline 500 mg twice daily while standard group received 750 mg twice daily or 500 mg three times *** Three hundred and ninety-four patients[mean age=46.3±13.9,male=137(34.8%),and 309(78.4%)primary therapy]completed tetracycline and furazolidone quadruple therapy for *** infection including those who received modified tetracycline dose in 157 and standard doses in 118(750 mg twice daily)and 119(500 mg three times daily).Eradication rates in the modified tetracycline dose group were 92.40%and in the standard groups,eradication rates were 93.20%for 750 mg twice daily group and 92.43%for 500 mg three times daily group,respectively,without statistical difference(P=0.959).The incidence of adverse events was lower in the modified tetracycline dose(15.3%vs 32.3%and 29.4%;P=0.002)compared to the standard dose *** In a real-world experience,modified tetracycline dosing as part of tetracycline and furazolidone quadruple therapy for 14 d demonstrated high efficacy,comparable to standard tetracycline dose regimens,with a favorable safety profile.
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