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Morphological and microcirculatory evaluation of the rat testis after detorsion with or without a capsular release with a tunica vaginalis flap

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Asian Journal of Andrology 2016年第3期18卷 462-466,I0010,I0011页

作者： Tamas Jozsat Zoltan Klarik Ferenc Kiss Eniko Toth Anita Mester Zoltan Hargitai Yi-Che Changchien magdalena Fossum Norbert Nemeth Department of Women's and Children's Health Karolinska Institutet Stockholm Sweden Department of Pediatric Surgery Division of Urology Astrid Lindgren Children's Hospital. Karolinska University Hospital Stockholm Sweden Department of Operative Techniques and Surgical Research Institute of Surgery Faculty ot MedicineUniversity of Debrecen Hungary Department of Pathology Kenezy Gyula Hospital Uebrecen Hungary

Testicular torsion may lead to serious ischemia, and the viability depends on the duration of torsion and the effect of ischemia-reperfusion. Testicular decompression and tunica vaginalis flap application technique were introduced in 2008 by Kutikov et al. We aimed to examine the impact of this method on the testicular microcirculation and hemorheological parameters in a rat model. Six adult rats underwent bilateral scrotal exploration. Intravaginal torsion of the testis was created by 720° rotation on both sides for 2 h. After detorsion, the right testes underwent tunica albuginea incision and tunica vaginalis flap application. Testicular microcirculation was monitored and hematological parameters, erythrocyte deformability, and aggregation were determined. Measurements were performed before and after torsion, directly after detorsion, on the 1^st-2^nd and 8^th postoperative day. After the last sampling, testicles were removed to determine their volume for histological examinations. The microcirculatory parameters demonstrated slight differences between testicles. Apical zone of the left （nondecompressed） testicles had elevated compared to the middle zone （P 〈 0.05）. On the 2^nd and 8^th day, the microcirculation of the testes normalized but not equally. The erythrocyte aggregation and deformability decreased by the 8^th day. Both testicles underwent atrophy and epithelial necrosis, but the volume of the decompressed ones was lower （1.07±0.08 vs 1.25 ± 0.31）. Histologically, there was no significant difference in epithelial damage score between decompressed and nondecompressed testes. In conclusion, 2-h ischemia led to alteration in testicular microcirculation, reduction in volume, changes in hemorheological parameters and serious epithelial necrosis both in decompressed and nondecompressed testicles without remarkable differences.

关键词： ischemia rat model reperfusion spermatic cord torsion surgical flaps testicular compartment syndrome testis

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Accuracy of non-invasive liver stiffness measurement and steatosis quantification in patients with severe and morbid obesity

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Hepatobiliary Surgery and Nutrition 2021年第5期10卷 610-622,I0004-I0007页

作者： magdalena Eilenberg Petra Munda Judith Stift Felix BLanger Gerhard Prager Michael Trauner Katharina Staufer Division of General Surgery Department of SurgeryMedical University of ViennaViennaAustria Department of Visceral Surgery and Medicine InselspitalUniversity Hospital BernBernSwitzerland Division of Gastroenterology&Hepatology Department of Internal Medicine IIIMedical University of ViennaViennaAustria Clinical Institute of Pathology Medical University of ViennaViennaAustria Division of Transplantation Department of SurgeryMedical University of ViennaViennaAustria

Background:Vibration controlled transient elastography(VCTE)and controlled attenuation parameter(CAP™)have shown reliable performance predicting fibrosis and steatosis in normal-to overweight patients but have not been validated in severe to morbid *** study aimed at determining the accuracy of VCTE,CAP™and the composite score FibroScan-AST(FAST)in patients with a body mass index(BMI)of≥35 kg/m^(2).Methods:Patients scheduled for bariatric-metabolic surgery underwent preoperative VCTE/CAP™measurement,and intraoperative liver *** feasibility and accuracy of VCTE,CAP™and the composite score FAST were retrospectively analysed to evaluate fibrosis,steatosis and active fibrotic non-alcoholic steatohepatitis[NASH+non-alcoholic fatty liver disease(NAFLD)activity score≥4+fibrosis grade≥2]using per protocol(PP)and intent to diagnose(ITD)***:In total,170 patients(median BMI 44.4 kg/m²)were included in the *** biopsy showed NASH,simple steatosis,and normal livers in 60.6%(n=103),28.8%(n=49),and 10.6%(n=18),*** and CAP™delivered reliable results in 90.6%(n=154/170)and 90.5%(n=134/148).The AUC(PP)of VCTE,CAP™,and FAST were 0.687(≥F2),0.786(≥F3),0.703(≥S2),0.738(S3),and 0.780(active fibrotic NASH).The AUC increased to 0.742(≥F2),0.842(≥F3),0.712(≥S2),0.780(S3),and 0.836(active fibrotic NASH)in patients below the median BMI of 44.4 kg/m².Conclusions:VCTE,CAP™and FAST show acceptable accuracy for the detection of fibrosis,steatosis and NASH in a real-life cohort of patients with *** improves in patients with a BMI<44.4 kg/m^(2).

关键词： Transient elastography controlled attenuation parameter(CAP™) FibroScan-AST score(FAST score) obesity non-alcoholic fatty liver disease(NAFLD)

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Complications in growth-friendly spinal surgeries for early-onset scoliosis: Literature review

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World Journal of Orthopedics 2021年第8期12卷 584-603页

作者： Michał Latalski Marek Fatyga Ireneusz Sowa magdalena Wojciak Grzegorz Starobrat Anna Danielewicz Children Orthopaedic Department Medical University of LublinLublin 20-093Poland Children Orthopaedic Department University Hospital for ChildrenLublin 20-093Poland Department of Analytical Chemistry Medical University of LublinLublin 20-093Poland

BACKGROUND The treatments for early-onset scoliosis(EOS),defined as curvature of the spine with onset before 10 years of age,continue to pose a great challenge for pediatric *** treatment goals for EOS include minimizing spinal deformity while maximizing thoracic volume and pulmonary *** surgical techniques have different advantages and drawbacks;however,the two major concerns in the management of EOS are repeated surgeries and *** To review the current literature to assess the safety of EOS surgical treatment in terms of the rate of complications and unplanned *** In January 2021 two independent reviewers systematically searched three electronic medical databases(PubMed,the Cochrane Library,and Embase)for relevant *** step of the review was done according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses *** to the heterogeneity of articles and topics after data analysis,a descriptive(synthetic)analysis was *** A total of 2136 articles were *** articles were included in this systematic review,after applying our inclusion and exclusion *** surgery has a varying but high rate of *** most frequent complications were categorized as implant(54%),general(17%),wound(15%)and alignment(12%).The rate of complications might have been even higher than reported,as some authors do not report all types of *** 54%of patients required unplanned surgeries due to complications,which comprised 15%of all *** The literature concerning the definitions,collection,and interpretation of data regarding EOS surgery complications is often difficult to *** creates problems in the comparison,analysis,and improvement of spine surgery ***,this observation indicates that data on the incidence of complications can be underestimated,and should be interpreted with *** of the high rate of

关键词： Scoliosis Spine Growth-friendly implant Surgery Complications Treatment

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Microheterogeneity of acute phase proteins in patients with uIterative colitis

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World Journal of Gastroenterology 2006年第32期12卷 5191-5195页

作者： Marian Grzymis■awski Katarzyna Derc magdalena Sobieska Krzysztof Wiktorowicz Department of Gastroenterology and Human Nutrition University of Medical Sciences Pozna■Poland Biology and Environmental Studies University of Medical Sciences Pozna■Poland

AIM： TO estimate the serum α1-antichymotrypsin （ACT）, α1-acid glycoprotein （AGP） and transferrin （Tf） concentrations and to evaluate the microheterogeneity of these acute phase proteins in patients with ulcerative colitis. METHODS： Twenty-seven patients with ulcerative colitis （UC） and 17 healthy control subjects were studied. The patients were categorised as severe （n = 9）, moderate （n = 10） and mild groups （n = 8） using Truelove and Witts＇ classification of ulcerative colitis. Microheterogeneity of ACT, AGP and Tf was analysed by crossed immunoaffinity electrophoresis （CIAE） with concanavalin A. In all serum samples standard electrophoresis of serum proteins was performed, iron （Fe） concentration, total iron binding capacity （TIBC） and C-reactive protein （CRP） were also measured. RESULTS： Our patients suffering from ulcerative colitis had significantly higher serum ACT and AGP concentrations and lower serum transferrin concentration in comparison to healthy subjects. Changes in concentrations of acute phase proteins were dependent on the activity of the inflammatory process. The glycosylation patterns of transferrin were related to the inflammation status. We also observed the correlation between ACT and AGP concentrations, patterns of transferrin glycosylation and changes in standard protein electrophoresis or blood cell count. CONCLUSION： The glycosylation patterns of transferrin obtained from patients suffering from ulcerative colitis are highly branched and sialylated compared with those obtained from healthy subjects. In contrast, the glycosylation patterns of transferrin do not differ according to the activity index of ulcerative colitis. The microheterogeneity patterns of AGP and ACT are similar in ulcerative colitis patients and healthy subjects.

关键词： Glycoproteins Acute phase response Ulcerative colitis

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磺化水热碳催化乙酰丙酸酯化生成戊酮酸乙酯(英文)

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催化学报 2014年第6期35卷 929-936页

作者： Filoklis D.Pileidis Maham Tabassum Sam Coutts Maria-magdalena Ttitirici Queen Mary University of London School of Engineering and Materials Science Mile End Road E1 4NS London United Kingdom Queen Mary University of London School of Engineering and Materials ScienceMile End Road E1 4NS London United Kingdom

The synthesis of carbon-based, heterogeneous sulphonic catalysts for the production of levulinate esters. Hydrothermal treatment at moderated temperatures was employed to generate highly functional carbonaceous materials, referred to as hydrothermal carbons (HTCs), from both glucose, cellulose and rye straw. The products were sulfonated to generate solid acid-catalysts. Characterisation of the as-synthesised materials as well as catalyst activity tests were performed. SEM images indicate the micrometre-sized particles present in both HTCs were largely unaffected by sulfonation, although cellulose-derived HTC displayed signs of inadequate hydrolysis. FT-IR spectroscopy and elemental analysis confirmed successful incorporation of sulphonic groups. 13C solid state NMR, in addition to TGA, elucidated the carbons’ structural composition and supported the common-ly-proposed hydrothermal carbonisation mechanism. Finally, the catalysts were tested via levulinic acid-ethanol esterification and gave high conversion and ester-selectivities (> 90%).

关键词：固体酸催化剂乙酰丙酸碳材料酯化甲酸乙酯 FT-IR光谱酸水水热处理

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