R-loop-derived cytoplasmic RNA-DNA hybrids activate an immune response

作     者：Magdalena P Crossley 

作者机构：Department of Chemical and Systems Biology Stanford University Stanford CA USA Department of Chemical Engineering Stanford University Stanford CA USA Department of Genetics Stanford University Stanford CA USA The Institute for Chemistry Engineering & Medicine for Human Health (ChEM-H) Stanford University Stanford CA USA Department of Molecular Genetics Erasmus University Medical Center Rotterdam The Netherlands 

出 版 物：《四川生理科学杂志》 (Sichuan Journal of Physiological Sciences)

年 卷 期：2022年第44卷第12期

页      面：2163-2163页

核心收录：

学科分类：071011[理学-生物物理学] 0710[理学-生物学] 07[理学] 

基　　金：NCI-designated Comprehensive Cancer Center National Science Foundation, NSF National Institutes of Health, NIH, (DP2-CA271386, GM119334, S10OD018220, T32-CA09302, T32-HG000044) National Institutes of Health, NIH Jane Coffin Childs Memorial Fund for Medical Research, JCC, (61-1755) Jane Coffin Childs Memorial Fund for Medical Research, JCC V Foundation for Cancer Research, VFCR, (D2018-017) V Foundation for Cancer Research, VFCR Leukemia and Lymphoma Society, LLS, (5455-17) Leukemia and Lymphoma Society, LLS Stanford Cancer Institute, SCI National Organization for Women, NOW Nederlandse Organisatie voor Wetenschappelijk Onderzoek, NWO Ministry of Science, ICT and Future Planning, MSIP, (NRF-2020R1A2C1101575) Ministry of Science, ICT and Future Planning, MSIP Korea Research Institute of Standards and Science, KRISS, (KRISS-GP2021-0003-10) Korea Research Institute of Standards and Science, KRISS National Research Foundation of Korea, NRF KWF Kankerbestrijding, DCS Oncode Institute 

主　　题：DNA hybrids consequences 

摘      要：R-loops are RNA-DNA-hybrid-containing nucleic acids with important cellular *** of R-loop dynamics can lead to DNA damage and genome instability1,which has been linked to the action of endonucleases such as ***,the mechanisms and cellular consequences of such processing have remained unclear.