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Increased long-distance and homo-trans interactions related to H3K27me3 in Arabidopsis hybrids

Journal of Integrative Plant Biology 2024年第2期66卷 208-227页

作者： Zhaoxu Gao Yanning Su Le Chang Guanzhong Jiao Yang Ou Mei Yang Chao Xu Pengtao Liu Zejia Wang Zewen Qi Wenwen Liu Linhua Sun Guangming He Xing Wang Deng Hang He School of Advanced Agriculture Sciences and School of Life Sciences State Key Laboratory of Protein and Plant Gene ResearchPeking UniversityBeijing 100871China College of Grassland Science Beijing Forestry UniversityBeijing 100083China Peking University Institute of Advanced Agricultural Sciences Shandong Laboratory of Advanced Agricultural Sciences in WeifangWeifang 261325China

In plants,the genome structure of hybrids changes compared with their parents,but the effects of these changes in hybrids remain elusive.Comparing reciprocal crosses between Col×C24 and C24×Col in Arabidopsis using high-throughput chromosome conformation capture assay(Hi-C)analysis,we found that hybrid three-dimensional(3D)chromatin organization had more long-distance interactions relative to parents,and this was mainly located in promoter regions and enriched in genes with heterosis-related pathways.The interactions between euchromatin and heterochromatin were increased,and the compartment strength decreased in hybrids.In compartment domain(CD)boundaries,the distal interactions were more in hybrids than their parents.In the hybrids of CURLY LEAF(clf)mutants clfCol×clfC24and clfC24×clfCol,the heterosis phenotype was damaged,and the long-distance interactions in hybrids were fewer than in their parents with lower H3K27me3.ChIP-seq data revealed higher levels of H3K27me3 in the region adjacent to the CD boundary and the same interactional homo-trans sites in the wild-type(WT)hybrids,which may have led to more long-distance interactions.In addition,the differentially expressed genes(DEGs)located in the boundaries of CDs and loop regions changed obviously in WT,and the functional enrichment for DEGs was different between WT and clf in the longdistance interactions and loop regions.Our findings may therefore propose a new epigenetic explanation of heterosis in the Arabidopsis hybrids and provide new insights into crop breeding and yield increase.

关键词： 3D chromatin organization H3K27me3 homo-trans hybrids long-distanceinteractions

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Combining metal-organic frameworks(MOFs)and covalentorganic frameworks(COFs):Emerging opportunities for new materials and applications

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Nano Research 2022年第4期15卷 3514-3532页

作者： Zhixi Li Jun Guo Yue Wan Yutian Qin Meiting Zhao Tianjin Key Laboratory of Molecular Optoelectronic Sciences Department of ChemistryInstitute of Molecular Aggregation ScienceTianjin UniversityTianjin 300072China School of Chemistry Tiangong UniversityTianjin 300387China

In the past decades,metal-organic frameworks(MOFs)and covalent organic frameworks(COFs)basically enjoy the coordination chemistry and covalent chemistry,respectively,and such uniqueness has become the major obstacle hampering their further scope diversity and application multi-functionalization.Inspired from the principle of organic retrosynthesis,combining coordination bond and covalent bond together offers additional opportunities for constructing novel MOFs,COFs and MOF@COF hybrids as well as confer on them superior performances in versatile application fields.In this review,we firstly classify and summarize the recently reported synthesis strategies based on the integration of metal-ligand coordination and dynamic covalent bonds.Then,the application performances of as-constructed MOFs,COFs as well as MOF@COF hybrids are discussed and highlighted in the fields of adsorption,separation,catalysis,biosensing,energy storage and so on.Last,our personal insights of the remaining challenges and further prospects are also provided,in order to trigger much more inspirations and endeavors for this hot research field.

关键词： metal-organic frameworks(MOFs) covalent organic frameworks(COFs) hybrids coordination chemistry covalent chemistry applications

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Tailoring V_(2)CT_(x) to form a derivative hybrid by partial oxidation for enhanced lithiation behavior

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Particuology 2023年第3期74卷 1-8页

作者： Ming Lu Yaopeng Zhang Qinhua Gu Wenjuan Han Yujie Qi Xia Zhang Bingsen Zhang Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang110016China Department of Chemistry College of ScienceNortheastern UniversityShenyang110819China The Joint Laboratory of MXene Materials Key Laboratory of Functional Materials Physics and Chemistry of the Ministry of EducationJilin Normal UniversityChangchun130103China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang110016China

Utilizing MXene to form the multifunctional derivative is a route to construct high-performance electrode materials.To address this issue,V_(2)CT_(x) MXene was employed to realize a derivative of VOx/V_(2)CT_(x) MXene via a partial oxidation process.Relying on the annealing in the air atmosphere,the controlled oxidation behavior transformed V_(2)CT_(x) MXene partially to V_(2)O_(5) and formed a derivative hybrid of V_(2)O_(5)/V_(2)CT_(x) MXene.As a result,a package of capacity,rate performance,and cyclability can be enhanced.This work explores the derived behavior of MXenes and provides a route for constructing the hybrid with less interface contact.Furthermore,these findings can be extended to other MXene materials.

关键词： V_(2)CT_(x)MXenes Oxidation Lithiation hybrids

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Current advances of transition metal dichalcogenides in electromagnetic wave absorption:A brief review

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International Journal of Minerals,Metallurgy and Materials 2023年第3期30卷 428-445页

作者： Shijie Zhang Jiying Li Xiaotian Jin Guanglei Wu School of Material Science and Engineering Henan Province Engineering Research Center of New Cermet Matrix CompositesHenan University of TechnologyZhengzhou 450001China Institute of Materials for Energy and Environment State Key Laboratory of Bio-fibers and Eco-textilesCollege of Materials Science and EngineeringQingdao UniversityQingdao 266071China

Transition metal dichalcogenides(TMDs)show great advantages in electromagnetic wave(EMW)absorption due to their unique structure and electrical properties.Tremendous research works on TMD-based EMW absorbers have been conducted in the last three years,and the comprehensive and systematical summary is still a rarity.Therefore,it is of great significance to elaborate on the interaction among the morphologies,structures,phases,components,and EMW absorption performances of TMD-based absorbers.This review is devoted to analyzing TMD-based absorbers from the following perspectives:the EMW absorption regulation strategies of TMDs and the latest progress of TMD-based hybrids as EMW absorbers.The absorption mechanisms and component-performance dependency of these achievements are also summarized.Finally,a straightforward insight into industrial revolution upgrading in this promising field is proposed.

关键词： transition metal dichalcogenides phase manipulation hybrids hierarchical structure absorption mechanism

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Cytotoxic and antibacterial polyketide-indole hybrids synthesized from indole-3-carbinol by Daldinia eschscholzii

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Acta Pharmaceutica Sinica B 2019年第2期9卷 369-380页

作者： Liping Lin Nan Jiang Huimin Wu Yaning Mei Jie Yang Renxiang Tan State Key Laboratory Cultivation Base for TCM Quality and Efficacy Nanjing University of Chinese Medicine State Key Laboratory of Pharmaceutical Biotechnology Nanjing University School of Pharmacy Nanjing Medical University Department of Clinical Laboratory the First Affiliated Hospital of Nanjing Medical University Jiangsu Province Academy of Traditional Chinese Medicine

Two skeletally undescribed polyketide-indole hybrids(PIHs), named indolchromins A and B,were generated from indole-3-carbinol(I3 C) in the fungal culture(Daldinia eschscholzii). The indolchromin structures were elucidated mainly by their 1 D and 2 D NMR spectra with the former confirmed by the single-crystal X-ray crystallographic analysis. Each indolchromin alkaloid was chirally separated into four isomers, whose absolute configurations were assigned by comparing the recorded circular dichroism(CD) spectra with the electronic CD(ECD) curves computed for all optional stereoisomers. Furthermore, the indolchromin construction pathways in fungal culture were clarified through enzyme inhibition, precursor feeding experiment, and energy calculation. The cascade reactions,including decarboxylative Claisen condensation catalyzed by 8-amino-7-oxononanoate synthase(AONS),C(sp3)-H activation, double bond migration, and Michael addition, all undergone compatibly during the fungal cultivation. In an MIC range of 1.3–8.6 μmol/L,(2 S,4 R)-and(2 R,4 S)-indolchromin A and(2 R,4 S)-indolchromin B are inhibitory against Clostridium perfringens, Clostridium difficile, Veillonella sp.,Bacteroides fragilis, and Streptococcus pyogenes.(2 R,4 S)-Indolchromin A and(2 S,4 S)-indolchromin B were cytotoxic against the human breast cancer cell line MDA-MB-231 with IC50 values of 27.9 and131.2 nmol/L, respectively, with the former additionally active against another human breast cancer cell line MCF-7(IC_(50)94.4 nmol/L).

关键词： Polyketide-indole hybrids Indole-3-carbinol Daldinia eschscholzii 8-Amino-7-oxononanoate synthase Decarboxylative Claisen condensation Antibacterial Anticancer

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Expression Analysis of miRNAs and Highly-expressed Small RNAs in Two Rice Subspecies and their Reciprocal hybrids

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Journal of Integrative Plant Biology 2010年第11期52卷 971-980页

作者： Fangfang Chen Guangming He Hang He Wei Chen Xiaopeng Zhu Manzhong Liang Liangbi Chen Xing Wang Deng Graduate Program in Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730China National Institute of Biological Sciences Zhongguancun Life Science ParkBeijing 102206China Department of Molecular Cellular and Developmental BiologyYale UniversityNew HavenConnecticut 06520USA Peking-Yale Joint Center of Plant Molecular Genetics and Agrobiotechnology College of Life SciencesPeking UniversityBeijing 100871China Institute of Biophysics the Chinese Academy of SciencesBeijing 100101China Department of Botany College of Life SciencesHunan Normal UniversityChangsha 410081China

Heterosis,or hybrid vigor,is the phenomenon whereby progeny of two inbred lines exhibit superior agronomic performance compared with either parent.We analyzed the expression of miRNAs and highly expressed small RNAs （defined according to Solexa sequencing results） in two rice （Oryza sativa） subspecies （japonica cv.Nipponbare and indica cv.93-11） and their reciprocal hybrids using microarrays.We found that of all the 1141 small RNAs tested,140 （12%,140 of 1141） and 157 （13%,157 of 1141） were identified being significantly differentially expressed in two reciprocal hybrids,respectively.All possible modes of action,including additive,high-and low-parent,above high-and below low-parent modes were exhibited.Both F1 hybrids showed non-additive expression patterns,with downregulation predominating.Interestingly,15 miRNAs displayed stark opposite expression trends relative to midparent in reciprocal hybrids.Computational prediction of targets of differentially expressed miRNAs showed that they participated in multifaceted developmental pathways,and were not distinguishable from the targets of non-differentially expressed miRNAs.Together,our findings reveal that small RNAs play roles in heterosis and add a new layer in the understanding and exploitation of molecular mechanisms of heterosis.

关键词： Heterosis hybrids Exhibitions Parents RNA Additives

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Design, synthesis, and biological evaluation of ligustrazine/resveratrol hybrids as potential anti-ischemic stroke agents

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Chinese Journal of Natural Medicines 2020年第8期18卷 633-640页

作者： ZHANG Yin-Qiu WU Jian-Bing YIN Wei ZHANG Yi-Hua HUANG Zhang-Jian State Key Laboratory of Natural Medicines Jiangsu Key Laboratory of Drug Discovery for Metabolic DiseasesCenter of Drug DiscoveryChina Pharmaceutical UniversityNanjing 210009China

To search for potent anti-ischemic stroke agents,a series of tetramethylpyrazine(TMP)/resveratrol(RES)hybrids 6 a-t were designed and synthesized.These hybrids inhibited adenosine diphosphate(ADP)-or arachidonic acid(AA)-induced platelet aggregation,among them,6 d,6 g-i,6 o and 6 q were more active than TMP.The most active compound 6 h exhibited more potent antiplatelet aggregation activity than TMP,RES,as well as positive control ticlopidine(Ticlid)and aspirin(ASP).Furthermore,6 h exerted strong antioxidative activity in a dose-dependent manner in rat pheochromocytoma PC12 cells which were treated with hydrogen peroxide(H2 O2)or hydroxyl radical(·OH).Importantly,6 h significantly protected primary neuronal cells suffered from oxygen-glucose deprivation/reoxygenation(OGD/R)injury,comparable to an anti-ischemic drug edaravone(Eda).Together,our findings suggest that 6 h may be a promising candidate warranting further investigation for the intervention of ischemic stroke.

关键词： Ligustrazine Resveratrol hybrids Anti-platelet aggregation Antioxidant Ischemic stroke

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R-loop-derived cytoplasmic RNA-DNA hybrids activate an immune response

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四川生理科学杂志 2022年第12期44卷 2163-2163页

作者： Magdalena P Crossley Department of Chemical and Systems Biology Stanford University Stanford CA USA Department of Chemical Engineering Stanford University Stanford CA USA Department of Genetics Stanford University Stanford CA USA The Institute for Chemistry Engineering & Medicine for Human Health (ChEM-H) Stanford University Stanford CA USA Department of Molecular Genetics Erasmus University Medical Center Rotterdam The Netherlands

R-loops are RNA-DNA-hybrid-containing nucleic acids with important cellular roles.Deregulation of R-loop dynamics can lead to DNA damage and genome instability1,which has been linked to the action of endonucleases suc... 详细信息

关键词： DNA hybrids consequences

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Enzyme@silica nanoflower@metal-organic framework hybrids： A novel type of integrated nanobiocatalysts with improved stability

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Nano Research 2018年第8期11卷 4380-4389页

作者： Yingjie Du Jing Gao Huajiao Liu Liya Zhou Ying He Zhihong Huang Yanjun Jiang School of Chemical Engineering and Technology Hebei University of Technology 8 Guangrong Road Hongqiao District Tianjin300130 China Hebei Provincial Key Lab of Green Chemical Technology and High Efficient Energy Saving Hebei University of Technology 8Guangrong Road Hongqiao District Tianjin 300130 China

A novel integrated nanobiocatalyst system based on an enzyme@silica nanoflower@metal-organic framework （enzyme@SNF@ZIF-8） structure with improved stability is fabricated for the first time. The versatility of this system is validated using penicillin G acylase （PGA） and catalase （CAT） as model enzymes. The microporous ZIF-8 layer can be controlled by varying the number of ZIF-8 coating cycles, which produces PGA@SNF@ZIF-8 nanobiocatalysts with different ZIF-8 layer thicknesses. After the second ZIF-8 coating cycle, a PGA@SNF@ZIF-8（2） structure with a homogeneous and well-intergrown ZIF-8 layer is formed, which possesses excellent mechanical and chemical stability. Moreover, PGA@SNF@ZIF-8（2） shows improved thermal/storage stability and reusability compared with free PGA and PGA immobilized on silica nanoflowers （PGA@SNF）. The obtained CAT-based nanobiocatalysts （CAT@SNF@ZIF-8（2）） also show excellent catalytic performance.

关键词： silica nanoflower metal-organic framework hybrids nanobiocatalyst immobilization

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Fitness of F1 hybrids between stacked transgenic rice T1c-19 with cry1C*/bar genes and weedy rice

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Journal of Integrative Agriculture 2019年第12期18卷 2793-2805页

作者： HUANG Yao WANG Yuan-yuan QIANG Sheng SONG Xiao-ling DAI Wei-min Weed Research Laboratory College of Life Sciences Nanjing Agricultural University

Compared to single-trait transgenic crops, stacked transgenic plants may be more prone to become weedy, and transgene flow from stacked transgenic plants to weedy relatives may pose a potential environmental risk because these hybrids could be more advantageous under specific environmental conditions. Evaluation of the potential environmental risk caused by stacked transgenes is essential for assessing the environmental consequences caused by crop-weed transgene flow. The agronomic performance of fitness-related traits was assessed in F1+(transgene positive) hybrids(using the transgenic line T1 c-19 as the paternal parent) in monoculture and mixed planting under presence or absence glufosinate pressure in the presence or absence of natural insect pressure and then compared with the performance of F1–(transgene negative) hybrids(using the non-transgenic line Minghui 63(MH63) as the paternal parent) and their weedy rice counterparts. The results demonstrated that compared with the F1– hybrids and weedy rice counterparts, the F1+ hybrid presented higher performance(P0.05) under natural insect pressure, respectively, lower performance(P0.05) in the absence of insect pressure in monoculture planting, respectively. And compared to weedy rice counterparts, the F1+ hybrid presented higher performance(P0.05) in the presence or absence of insect pressure in mixed planting, respectively. The F1+ hybrids presented nonsignificant changes(P>0.05) under the presence or absence glufosinate pressure under insect or non-insect pressure in monoculture planting. The all F1+ hybrids and two of three F1– hybrids had significantly lower(Phybrids in the majority of cases.

关键词： weedy rice hybrids stacked transgenes safety assessment fitness

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