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Neural Regeneration Research 2025年第5期20卷 1403-1404页

作者： Oliver Kann Lennart Soder Babak Khodaie Institute of Physiology and Pathophysiology Heidelberg UniversityHeidelbergGermany Interdisciplinary Center for Neurosciences(IZN) Heidelberg UniversityHeidelbergGermany

The metabolite lactate (L-lactate) can be generated and released by diverse brain cells,including neurons,astrocytes,and oligodendrocytes (Kann,2023;Rae et al.,2024).Lactate production usually requires the degradation of glucose (D-glucose)-and glycogen in astrocytes-to pyruvate by glycolysis and subsequent conversion of pyruvate to lactate by the enzyme lactate dehydrogenase(Figure 1A;Dienel,2019;Rae et al.,2024).

关键词： consequences Figure restoration

Long-term bone and lung consequences associated with hospital-acquired severe acute respiratory syndrome:a 15-year follow-up from a prospective cohort study

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Bone Research 2020年第1期8卷 107-114页

作者： Peixun Zhang Jia Li Huixin Liu Na Han Jiabao Ju Yuhui Kou Lei Chen Mengxi Jiang Feng Pan Yali Zheng Zhancheng Gao Baoguo Jiang Department of Orthopedics and Trauma Peking University People’s HospitalBeijingChina Department of Respiratory Medicine Peking University People’s HospitalBeijingChina Department of Clinical Epidemiology and Biostatistics Peking University People’s HospitalBeijingChina Department of Central Laboratory Peking University People’s HospitalBeijingChina Department of Education Peking University People’s HospitalBeijingChina Department of Radiology Peking University People’s HospitalBeijingChina

The most severe sequelae after rehabilitation from SARS are femoral head necrosis and pulmonary fibrosis. We performed a 15-year follow-up on the lung and bone conditions of SARS patients. We evaluated the recovery from lung damage and femoral head necrosis in an observational cohort study of SARS patients using pulmonary CT scans, hip joint MRI examinations, pulmonary function tests and hip joint function questionnaires. Eighty medical staff contracted SARS in 2003. Two patients died of SARS, and78 were enrolled in this study from August 2003 to March 2018. Seventy-one patients completed the 15-year follow-up. The percentage of pulmonary lesions on CT scans diminished from 2003(9.40 ± 7.83)% to 2004(3.20 ± 4.78)%(P < 0.001) and remained stable thereafter until 2018(4.60 ± 6.37)%. Between 2006 and 2018, the proportion of patients with interstitial changes who had improved pulmonary function was lower than that of patients without lesions, as demonstrated by the one-second ratio(FEV1/FVC%, t = 2.21, P = 0.04) and mid-flow of maximum expiration(FEF25%–75%, t = 2.76, P = 0.01). The volume of femoral head necrosis decreased significantly from 2003(38.83 ± 21.01)% to 2005(30.38 ± 20.23)%(P = 0.000 2), then declined slowly from 2005 to 2013(28.99 ± 20.59)% and plateaued until 2018(25.52 ± 15.51)%. Pulmonary interstitial damage and functional decline caused by SARS mostly recovered, with a greater extent of recovery within 2 years after rehabilitation. Femoral head necrosis induced by large doses of steroid pulse therapy in SARS patients was not progressive and was partially reversible.

关键词： doses consequences slowly

Childhood sleep:physical,cognitive,and behavioral consequences and implications

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World Journal of Pediatrics 2024年第2期20卷 122-132页

作者： Jianghong Liu Xiaopeng Ji Susannah Pitt Guanghai Wang Elizabeth Rovit Terri Lipman Fan Jiang School of Nursing University of Pennsylvania418 Curie Blvd.Room 424Claire M.Fagin HallPhiladelphiaPA 19104USA College of Health Sciences University of DelawareNewarkDE 19716USA Geisinger Commonwealth School of Medicine ScrantonPA 18510USA Pediatric Translational Medicine Institute Department of Developmental and Behavioral PediatricsSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina

Background Sleep problems in children have been increasingly recognized as a major public health *** research has extensively studied and presented many risk factors and potential mechanisms for children’s sleep *** this paper,we aimed to identify and summarize the consequences and implications of child sleep *** sources A comprehensive search for relevant English language full-text,peer-reviewed publications was performed focusing on pediatric sleep studies from prenatal to childhood and adolescence in a variety of indexes in PubMed,SCOPUS,and Psych Info published in the past two *** relevant data-based articles and systematic reviews are *** Many adverse consequences are associated with child sleep deficiency and other sleep problems,including physical outcomes(e.g.,obesity),neurocognitive outcomes(e.g.,memory and attention,intelligence,academic performance),and emotional and behavioral outcomes(e.g.,internalizing/externalizing behaviors,behavioral disorders).Current prevention and intervention approaches to address childhood sleep problems include nutrition,exercise,cognitive–behavioral therapy for insomnia,aromatherapy,acupressure,and *** interventions may be particularly important in the context of coronavirus disease *** research and policy strategies can target the risk factors of child sleep as well as the efficacy and accessibility of *** Given the increasing prevalence of child sleep problems,which have been shown to affect children’s physical and neurobehavioral wellbeing,understanding the multi-aspect consequences and intervention programs for childhood sleep is important to inform future research direction as well as a public health practice for sleep screening and intervention,thus improving sleep-related child development and health.

关键词： Behavior Child sleep consequences Implications Neurocognitive Physical Prevention/intervention

The role of degenerative pathways in the development of irreversible consequences after brain ischemia

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Neural Regeneration Research 2019年第6期14卷 982-983页

作者： Ryszard Pluta Marzena U?amek-Kozio? Laboratory of Ischemic and Neurodegenerative Brain Research Mossakowski Medical Research CentrePolish Academy of Sciences First Department of Neurology Institute of Psychiatry and Neurology

Ischemic stroke and irreversible consequences:Ischemic stroke in humans is the second most common cause of death in the world(Mozaffarian et al.,2016).The outcomes after a stroke are often dependent on complications,including motor disorders,depression and dementia(Pluta et al.,2018a),which causes a high risk of re-hospitalization and/or palliative *** is also the main reason for long-term disability in people after stroke,with up to half of those who survived the stroke will not regain their independence until the end of their lives(Mozaffarian et al.,2016).According to epidemiological forecasts,human ischemic stroke will soon become the dominant cause of death worldwide(Bejot et al.,2016)as well as dementia with the phenotype of Alzheimer’s disease(AD;Kim and Lee 2018).It is suggested that human ischemic stroke and experimental brain ischemia in animals are associated with the possible development of AD neuropathology(Pluta et al.,2018a).

关键词： degenerative pathways irreversible consequences brain ischemia

Biochemical consequences of glucocerebrosidase 1 mutations in Parkinson’s disease

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Neural Regeneration Research 2024年第4期19卷 725-727页

作者： Jeong Hyun Yoon Chiao-Yin Lee Anthony HV Schapira Department of Clinical and Movement Neurosciences University College London Institute of Neurology Faculty of Medicine Imperial College London Aligning Science Across Parkinson's(ASAP)Collaborative Research Network

Parkinson’s disease(PD,OMIM#168600)is a common neurodegenerative disorder with a global prevalence of approximately 8.5 *** is characterized by four cardinal motor symptoms:bradykinesia,rigidity,resting tremor,and subsequently by postural *** usually involves non-motor symptoms such as rapid eye movement sleep disorder,dementia,anosmia,and autonomic *** gene glucocerebrosidase 1(GBA1),which encodes the lysosomal enzyme glucocerebrosidase(GCase)(IUBMB:EC 3.***.1.45),shows strong linkage with PD;variants of GBA1 are the commonest genetic association with PD(Sidransky et al.,2009).Several mechanisms may underlie the relationship between GBA1 mutations/variants and the molecular pathology of PD(Figure 1A and B).

关键词： cerebro consequences

The Biological consequences of Global Change

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Integrative Zoology 2010年第2期5卷 85-86页

作者： Nils Chr.STENSETH Centre for Ecological and Evolutionary Synthesis(CEES) Department of BiologyUniversity of OsloOsloNorway

ChangeClimate is currently *** changes will havea variety of effects on biological systems,at various lev-els spanning from the physiological to the ecosystem ***,among others,need to address the questionof how climate changes(and variation)affect biologicalprocess at these different levels of organization,and theyneed to do so in an integrated *** this view inmind,Integrative Zoology is pleased to present this spe-cial issue on“the biological consequences of globalchange.”This special issue is linked to a larger initiativeof the International Society of Zoological Sciences,namely,its flagship research program with the same title:the“Bio-logical consequences of Global Change”(BCGC).Thisspecial issue is the first in a series of such issues:duringthe period 2010 to 2012 Integrative Zoology plan to pub-lish one such special issue per year.

关键词： sequences consequences Global

Genomic consequences of apple improvement

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Horticulture Research 2021年第1期8卷 97-109页

作者： Zoe Migicovsky Kyle M.Gardner Christopher Richards C.Thomas Chao Heidi R.Schwaninger Gennaro Fazio Gan-Yuan Zhong Sean Myles Department of Plant Foodand Environmental SciencesFaculty of AgricultureDalhousie UniversityTruroNSCanada USDA-ARS Plant Germplasm Preservation Research UnitFort CollinsCOUSA USDA-ARS Grape Genetics Research UnitGen evaNYUSA Present address:Agriculture and Agri-Food Canada Fredericton Research and Development CentreFrederictonNBCanada

The apple(Malus domestica)is one of the world's most commercially important perennial crops and its improvement has been the focus of human effort for thousands of ***,we genetically characterise over 1000 apple accessions from the United States Department of Agriculture(USDA)germplasm collection using over 30,000 singlenucleotide polymorphisms(SNPs).We con fi rm the close genetic relationship between modern apple cultivars and their primary progenitor species,Malus sieversii from Central Asia,and fi nd that cider apples derive more of their ancestry from the European crabapple,Malus sylvestris,than do dessert *** determine that most of the USDA collection is a large complex pedigree:over half of the collection is interconnected by a series of fi rst-degree *** addition,15%of the accessions have a fi rst-degree relationship with one of the top 8 cultivars produced in the *** the exception of‘Honeycrisp',the top 8 cultivars are interconnected to each other via pedigree *** cultivars‘Golden Delicious'and‘Red Delicious'were found to have over 60 fi rst-degree relatives,consistent with their repeated use by apple *** detected a signature of intense selection for red skin and provide evidence that breeders also selected for increased fi *** results suggest that Americans are eating apples largely from a single family tree and that the apple's future improvement will bene fi t from increased exploitation of its tremendous natural genetic diversity.

关键词： cultivar crops consequences

The August 2011 Flood in Ibadan, Nigeria: Anthropogenic Causes and consequences

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International Journal of Disaster Risk Science 2012年第4期3卷 207-217页

作者： Babatunde S.Agbola Owolabi Ajayi Olalekan J.Taiwo Bolanle W.Wahab Department of Urban and Regional Planning University of IbadanIbadanOYO 200284Nigeria Department of Geology Obafemi Awolowo UniversityIle-Ife220005Nigeria Department of Geography University of IbadanIbadanOYO 200284Nigeria

Determining when and where flood strikes can be a daunting task. Apart from heavy and prolonged rainfalls and river overflows, there are anthropogenic causal factors of flooding. These anthropogenic factors are significantly variable and exacerbate floods, but may be difficult to measure. This study aims to unravel some of the anthropogenic factors, particularly with respect to their contributions to the flood in Ibadan City on 26 August 2011. Data were collected through structured questionnaire and key informant interviews. The August 2011 Ibadan flood was perhaps the worst in the history of this ancient city. Twelve anthropogenic factors are broadly identified as having contributed to the flood and the flood had five major consequences. Some policy implications that can help prevent future flood occurrence are outlined.

关键词： flood floods consequences

Immunological consequences of arsenic trioxide-induced necrosis

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Cellular & Molecular Immunology 2023年第3期20卷 308-309页

作者： Shubhangi Gavali Wulf Tonnus Andreas Linkermann Division of Nephrology Department of Internal Medicine 3University Hospital Carl Gustav Carus at the Technische Universitat DresdenDresdenGermany Division of Nephrology Department of MedicineAlbert Einstein College of MedicineBronxNYUSA

The exact mechanism of arsenic trioxide (ATO, As_(2)O_(3)) poisoning has been a mystery for centuries. While rumors even suggest that it might have killed Napoleon, more recent work suggests ATO as a potential treatment option for acute promyelocytic leukemia [1]. While the potency of ATO in cell killing has been recognized, hardly anyone has considered the immunological consequences of cell death in tumors or tissues following ATO treatment. In this issue of Cellular and Molecular Immunology, Chen et al. address this question, adding yet another chapter to the complex relation between cell death and the immune response .

关键词： consequences death acute

Frugivory and seed dispersal:integrating patterns, mechanisms and consequences of a key animal-plant interaction

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Integrative Zoology 2011年第3期6卷 165-167页

作者： Tomás A.CARLO Ahimsa CAMPOS-ARCEIZ Michael A.STEELE Wenhua XIONG Department of Biology The Pennsylvania State UniversityUSA School of Geography The University of Nottingham Malaysia CampusMalaysia Department of Biology Wilkes UniversityUSA Institute of Zoology Chinese Academy of SciencesChina

The study of frugivory and seed dispersal is both excit-ing and challenging because it integrates research from multiple biological disciplines,including zoology,botany,physiology,behavioral ecology,evolution,conservation,and population and community *** the center of these investigations is one of the most important mutual-istic relationships hypothesized to organize and maintain diversity in terrestrial ecosystems:the movement of plant seeds by fruit and seed-eating animals(Bascompte&Jordano 2007).Although recent studies on the seed dis-persal process have advanced the breadth and depth of our understanding of this keystone interaction,many ques-tions are still unanswered.A clear synthesis and theoreti-cal framework for integrating what we do know also re-mains ***,the imperative to better under-stand the movement of organisms in the face of human-induced global changes has sparked an additional need for seed dispersal studies(Wang&Smith 2002;Bullock&Nathan 2008;Nathan et al.2008).

关键词： integrating interaction consequences