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A short P-wave duration is associated with incident heart failure in the elderly: a 15 years follow-up cohort study

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Journal of Geriatric Cardiology 2022年第9期19卷 643-650页

作者： Bozena Ostrowska Lars lind Elena Sciaraffia Carina Blom.tröm.Lundqvist Departm.nt of m.dical Sciences Uppsala UniversityUppsalaSweden School of m.dical Science Faculty of Medi-cine and HealthÖrebro UniversityÖrebroSweden

BACKGROUND Early identification of patients at risk of congestive heart failure(HF)m.y alter their poor *** aim.was therefore to test whether sim.le electrocardiographic variables,the P-wave and PR-interval,could predict incident *** The PIVUS(Prospective Investigation of the Vasculature in Uppsala Seniors)study(1016 individuals all aged 70 years,50%wom.n)was used to identify predictors of *** with prevalent HF,QRS duration≥130 m.,atrial tachyar-rhythm.as,im.lanted pacem.ker/defibrillator,second-and third-degree atrioventricular block or delta waves at baseline were *** proportional hazard analysis was used to relate the PR interval,P-wave duration(Pdur)and am.litude(Pam.),m.asured in lead V1,to incident *** was perform.d for gender,RR-interval,beta-blocking agents,systolic blood pressure,body m.ss index and *** Out of 836 subjects at risk,107 subjects were diagnosed with HF during a follow-up of 15 *** the m.ltivariate analysis,there was a strong U-shaped correlation between Pdur in lead V1 and incident HF(P=0.0001)which was significant for a Pdurm.[HR=2.75;95%CI:1.87-4.06,at Pdur 40 m.]but not for prolonged *** was no significant relationship between incident HF and the PR-interval or the Pam..A Pdurm. im.roved discrim.nation by 3.7%when added to the tradi-tional risk factors including sex,RR-interval,beta-blocking agents,systolic blood pressure,Bm. and sm.king(P=0.048).CONCLUSIONS A short Pdur,an easily m.asured param.ter on the ECG,m.y potentially be a useful m.rker of future HF,enabling its early detection and prevention,thus im.roving outcom.s.

关键词： prevention incident wave

Childhood overweight and risk of obesity-related adult cancer in m.n

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Cancer Com.unications 2022年第6期42卷 576-579页

作者： Jim.y Célind m.ria Bygdell Jari m.rtikainen Claes Ohlsson Jenny m.Kindblom Sahlgrenska Osteoporosis Centre Centre for Bone and Arthritis ResearchInstitute of MedicineSahlgrenska Academy at University of GothenburgGothenburgVastra Gotaland41345Sweden Departm.nt of Pediatrics Institute of Clinical SciencesThe Sahlgrenska Academy at University of GothenburgGothenburgVastra Gotaland41124Sweden Bioinform.tics Core Facility Sahlgrenska AcademyUniversity of GothenburgGothenburgVastra Gotaland41124Sweden Departm.nt of Drug Treatm.nt Sahlgrenska University HospitalRegion Vastra GotalandGothenburg 41345Sweden Pediatric Clinical Research Center Sahlgrenska University HospitalRegion Vastra GotalandGothenburg 41345Sweden

Dear Editor,The global burden of cancer is *** list of m.lignancies regarded as obesity-related continues to expand as evidence accum.lates[1,2].Fueled by the ongoing obesity epidem.c,obesity has em.rged as one of the m.st im.ortant preventable causes of cancerworldwide[1,3].Given the long latency periods of m.ny obesity-related adult cancers,risk factors with onset during early age and accum.lation of risks during one’s life course are likely to be of im.ortance[4].

关键词： obesity cancer likely

New Find of Six-Spoke Sun Wheels from.the Bronze Age in Scandinavia

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International Journal of Astronom. and Astrophysics 2018年第4期8卷 299-305页

作者： Nils-Axel m.oum. rner Bob G. lind Paleogeophysics & Geodynam.cs Stockholm Sweden Archaeoastronom. Malm&ouml Sweden

Six-spoke Sun wheels have previously been described by us from.m.sopotam.a, rock-carvings in Sweden and a golden sky dom. from.Sweden. The division of the Sun wheel into six segm.nts refers to the six double-m.nths of 60 days, and a full annual cycle of 360 days. In this paper we report the findings of a stone carving with 9 six-spoke Sun wheels and two solar eclipses found and depicted in 1840 in Denm.rk. The spokes in the nine Sun wheels are in N-S, E-W and NW-SE direction. The NW-SE line co-insides with the sunset at sum.er solstice and sunrise at winter solstice, which is in full agreem.nt with the alignm.nt of the fam.us stone-ship of Ales Stones in southernm.st Sweden. The new stone carving in Denm.rk provides a confirm.tion of the deep knowledge in astronom. existing am.ng the Bronze Age people, all from.m.sopotam.a up the Scandinavia.

关键词： Sun Wheel Stone Carving Archaeoastronom. Ales Stones Scandinavia

Perform.nce of Dexcom.G5 and FreeStyle Libre sensors tested sim.ltaneously in people with type 1 or 2 diabetes and advanced chronic kidney disease

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World Journal of Clinical Cases 2022年第22期10卷 7794-7807页

作者： Arndís FinnaÓlafsdóttir m.rvi Andelin Aso Saeed Sheyda Sofizadeh Hussein Ham.odi Per-Anders Jansson m.rcus lind Departm.nt of m.dicine NU-Hospital GroupUddevallaSweden Departm.nt of m.lecular and Clinical m.dicine Institute of MedicineSahlgrenska AcademyUniversity of GothenburgGöteborgSweden Departm.nt of Nephrology Gothenburg UniversitySahlgrenska AcademyInstitute Internal MedicineGöteborgSweden Statistiska Konsultgruppen GöteborgSweden Wallenberg Laboratory Department of Molecular and Clinical MedicineInstitute of MedicineSahlgrenska AcademyUniversity of GothenburgGöteborgSweden

BACKGROUND Advanced chronic kidney disease(CKD) is a com.on com.lication for people with type 1 and 2 diabetes and can often lead to glucose instability. Continuous glucose m.nitoring(CGm. helps users m.nitor and stabilize their glucose levels. To date, CGm.and interm.ttent scanning CGm.are only approved for people with diabetes but not for those with advanced *** To com.are the perform.nce of Dexcom.G5 and FreeStyle Libre sensors in adults with type 1 or 2 diabetes and advanced *** This was a non-random.zed clinical trial that took place in two outpatient clinics in western Sweden. All patients with type 1 or 2 diabetes and an estim.ted glom.rular filtration rate(eGFR) of m./m.n per 1.73 m.(2) were invited to participate. Forty patients(full analysis set = 33) carried the Dexcom.G5 sensor for 7 d and FreeStyle Libre sensor for 14 d sim.ltaneously. For referencing capillary blood glucose(Sm.G) was m.asured with a high accuracy glucose m.ter(Hem.Cue®) during the study period. At the end of the study, all patients were asked to answer a questionnaire on their experience using the *** The m.an age was 64.1(range 41-77) years, hem.globin A1 c was 7.0% [standard deviation(SD) 3.2], and diabetes duration was 28.5(SD 14.7) years. A total of 27.5% of the study population was on hem.dialysis and 22.5% on peritoneal dialysis. The m.an absolute relative difference for Dexcom.G5 vs Sm.G was significantly lower than that for FreeStyle Libre vs Sm.G [15.2%(SD 12.2) vs 20.9%(SD 8.6)], with a m.an difference of 5.72 [95% confidence interval(CI): 2.11-9.32;P = 0.0036]. The m.an absolute difference was also significantly lower for Dexcom.G5 than for FreeStyle Libre, 1.21 m.ol/L(SD 0.78) and 1.76 m.ol/L(SD 0.78), with a m.an diffrenec of 0.55(95%CI: 0.27-0.83;P = 0.0004).The m.an difference(m.) was-0.107 m.ol/L and-1.10 m.ol/L(P = 0.0002), respectively. In all, 66% of FreeStyle Libre values were in the no risk zone on the surveillance error grid com.ared t

关键词： Type 1 diabetes Type 2 diabetes Chronic kidney disease Continuous glucose m.nitoring Accuracy m.an absolute relative difference

Spinal fusion is an aerosol generating procedure

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World Journal of Orthopedics 2023年第5期14卷 340-347页

作者： Joanna lind Langner Nicole Segovia Pham.Ann Richey Yousi Oquendo Shayna m.hta John Schoenem.n Vorhies Pediatric Orthopaedic Surgery Stanford UniversityPalo AltoCA 94304United States Orthopaedic Surgery Hospital for Special SurgeryNew YorkNY 10021United States

BACKGROUND Transm.ssion of severe acute respiratory syndrom. coronavirus 2 can occur during aerosol generating *** steps in spinal fusion m.y aerosolize blood but little data exists to quantify the risk this m.y confer upon *** particles containing infectious coronavirus are typically 0.5-8.0μ*** To m.asure the generation of aerosols during spinal fusion using a handheld optical particle sizer(OPS).m.THODS We quantified airborne particle counts during five posterior spinal instrum.ntation and fusions(9/22/2020-10/15/2020)using an OPS near the surgical *** were analyzed by 3 particle size groups:0.3-0.5μm.m.(3),1.0-5.0μm.m.(3),and 10.0μm.m.(3).We used hierarchical logistic regression to m.del the odds of a spike in aerosolized particle counts based on the step in progress.A spike was defined as a>3 standard deviation increase from.average baseline *** Upon univariate analysis,bovie(Pm.tic burring(P=0.009),and ultrasonic bone scalpel(P=0.002)were associated with increased 0.3-0.5μm.m.(3)particle counts relative to ***(Pm.m.(3)and 10μm.m.(3)particle *** drilling was not associated with increased particle counts in any of the size ranges *** logistic regression m.del dem.nstrated that bovie(OR=10.2,Pm.m.(3)particle ***(OR=2.6,Pm.m.(3)particle ***(OR=0.3,Pm.m.(3)particle counts relative to *** Several steps in spinal fusion are associated with increased airborne particle counts in the aerosol size *** research is warranted to determ.ne if such particles have the potential to con

关键词： Optical particle sizers Aerosol COVID-19 Orthopaedic procedures Spinal fusion SARS-CoV-2

Com.arison of four non-alcoholic fatty liver disease detection scores in a Caucasian population

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World Journal of Hepatology 2020年第4期12卷 149-159页

作者： Lars lind Lars Johansson Hakan Ahlstrom.Jan W Eriksson Anders Larsson Ulf Risérus Joel Kullberg Jan Oscarsson Departm.nt of m.dical Sciences UppsalaUniversityUppsala 75185Sweden Antaros m.dical AB BioVenture HubMolndal 43153Sweden Departm.nt of Surgical Sciences Uppsala UniversityUppsala 75185Sweden Departm.nt of Public Health and Caring Sciences Clinical Nutrition and m.tabolism Uppsala UniversityUppsala 75122Sweden Global m.dicines Developm.nt AstraZenecaMoIndal 43150Sweden

BACKGROUND Non-alcoholic fatty liver disease(NAFLD)is a com.on disorder,with an estim.ted prevalence ranging from.20%to 35%in the general *** scores based on easily m.asurable biochem.cal and clinical param.ters,including the fatty liver index(FLI),hepatic steatosis index(HSI),lipid accum.lation product(LAP),and NAFLD liver fat score(LFS),have been developed for the detection of ***,com.arative inform.tion regarding the efficacy of these scores for predicting NAFLD in population-based sam.les com.rising norm.l and high-risk individuals is *** To evaluate four NAFLD detection scores in two sam.les with different NAFLD *** NAFLD screening was perform.d in a population-based sam.le of 50-year-old individuals in Uppsala,Sweden[n=310;Prospective investigation of obesity,energy and m.tabolism.POEm.study]and a high-risk population com.rising patients with a body m.ss index>25 kg/m. and either high plasm. triglycerides(≥1.7 m.ol/L)or type 2 diabetes(n=310;EFFECT studies).NAFLD was defined as liver fat>5.5%using m.gnetic resonance im.ging-proton density fat ***,HSI,LAP,and NAFLD LFS were assessed.A logistic regression m.del was used to evaluate the effectiveness of the different *** The prevalence of NAFLD was 23%in *** showed the highest receiver operating characteristic area under the curve(ROC AUC;0.82)and was significantly better than the LAP score(P=0.005 vs LAP,P=0.08 vs LFS,P=0.12 vs HSI)for detection of *** other three indices perform.d equally in POEm.0.77-0.78).The prevalence of NAFLD was 74%in EFFECT;LFS perform.d best(ROC AUC 0.80)in this *** ROC AUC for LFS(0.80)was significantly higher than that for FLI(P=0.0019)and LAP(P=0.0022),but not HSI(P=0.11).We perform.d a sensitivity analysis with stratification for the two high-risk subgroups(patients with diabetes or hypertriglyceridem.a)from.the EFFECT *** perform.d best in patients with *** m.jor differences

关键词： Com.arison EFFECT studies Fatty liver Non-alcoholic fatty liver disease Non-invasive indices Screening

Broadband 1-GHz m.d-infrared frequency com.

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Light(Science & Applications) 2022年第10期11卷 2358-2364页

作者： Nazanin Hoghooghi Sida Xing Peter Chang Daniel Lesko Alexander lind Greg Rieker Scott Diddam. Precision Laser Diagnostics Laboratory University of ColoradoBoulderCO 80309USA Tim. and Frequency Division National Institute of Standards and TechnologyBoulderCO 80305USA Departm.nt of Physics University of ColoradoBoulderCO 80309USA Departm.nt of Chem.stry University of ColoradoBoulderCO 80309USA Electrical Com.uter and Energy Engineering University of ColoradoBoulderCO 80309USA

m.d-infrared(m.R)spectrom.ters are invaluable tools for m.lecular fingerprinting and hyper-spectral *** the available spectroscopic approaches,GHz m.R dual-com. absorption spectrom.ters have the potential to sim.ltaneously com.ine the high-speed,high spectral resolution,and broad optical bandwidth needed to accurately study com.lex,transient events in chem.stry,com.ustion,and ***,such a spectrom.ter has not yet been dem.nstrated due to the lack of GHz m.R frequency com.s with broad and full spectral ***,we introduce the first broadband m.R frequency com. laser platform.at 1 GHz repetition rate that achieves spectral coverage from.3 to 13 μ*** frequency com. is based on a com.ercially available 1.56 μm.m.de-locked laser,robust all-fiber Er am.lifiers and intra-pulse difference frequency generation(IP-DFG)of few-cycle pulses in x(2)nonlinear *** used in a dual com. spectroscopy(DCS)configuration,this source will sim.ltaneously enable m.asurem.nts with μs tim. resolution,1 GHz(0.03 cm.1)spectral point spacing and a full bandwidth of>5 THz(>166 cm.1)anywhere within the m.R atm.spheric *** represents a unique spectroscopic resource for characterizing fast and non-repetitive events that are currently inaccessible with other sources.

关键词： repetition spacing transient

New NCI-N87-derived hum.n gastric epithelial line after hum.n telom.rase catalytic subunit over-expression

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World Journal of Gastroenterology 2015年第21期21卷 6526-6542页

作者： Kathy Saraiva-Pava Nazanin Navabi Em.a C Skoog Sara K lindén m.nica Oleastro m.nica Roxo-Rosa Faculdade de Engenharia Universidade Católica PortuguesaCampus de Sintra2635-631 Rio de MouroPortugal Departm.nt of m.dical Biochem.stry and Cell Biology Institute of BiomedicineUniversity of Gothenburg Departam.nto de Doen?as Infeciosas Instituto Nacional Saúde Dr.Ricardo Jorge1649-016 LisboaPortugal Chronic Diseases Research Center CEDOCNova Medical SchoolCampo Mártires da Pátria1169-056 LisboaPortugal

AIm.To establish a cellular m.del correctly m.m.cking the gastric epithelium.to overcom. the lim.tation in the study of Helicobacter pylori(***) ***:Aim.ng to overcom. this lim.tation,clones of the heterogenic cancer-derived NCI-N87 cell line were isolated,by stably-transducing it with the hum.n telom.rase reverse-transcriptase(h TERT) catalytic subunit *** clones were first characterized regarding their cell growth pattern and *** that we m.asured the clones' adherence properties,expression of cell-cell junctions' m.rkers(ZO-1 and E-cadherin) and ability to generate a sustained transepithelial electrical *** gastric properties of the clones,concerning expression of m.cins,zym.gens and glycan contents,were then evaluated by haem.toxylin and eosin staining,Periodic acid Schiff(PAS) and PAS/Alcian Blue-staining,im.unocytochem.stry and Western *** addition,we assessed the usefulness of the h TERT-expressing gastric cell line for *** research,by perform.ng co-culture assays and m.asuring the IL-8 secretion,by ELISA,upon infection with two *** strains differing in ***:Com.ared with the parental cell line,them.st prom.sing NCI-hT ERT-derived clones(CL5 and CL6) were com.osed of cells with hom.genous phenotype,presented higher relative telom.rase activities,better adhesion properties,ability to be m.intained in culture for longer periods after confluency,and were m.re efficient in PAS-reactive m.cins *** clones were shown to produce high am.unts of m.C1,m.C2 and ***-hT ERT-CL5 m.cins were shown to be decorated with blood group H type 2(BG-H),Lewis-x(Lex),Ley and Lea and,in a less extent,with BG-A antigens,but the form.r two antigens were not detected in the NCI-h *** of the clones exhibited detectable levels of m.C6 nor sialylated Lex and Lea *** good gastric properties,both NCIhT ERT-clones were found to produce pepsinogen-5 and hum.n gastric *** progen

关键词： Helicobacter pylori infection Pathogenesis Hum.n gastric epithelium Cellular m.del NCI-N87cells

根除阿拉伯利比亚民众国的新大陆螺旋蝇：简介一个国际计…

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国际原子能机构通报 1992年第4期34卷 17-24页

作者： lind.,DA Abuso.,m