A short P-wave duration is associated with incident heart failure in the elderly: a 15 years follow-up cohort study

作     者：Bozena Ostrowska Lars Lind Elena Sciaraffia Carina Blomström-Lundqvist Bozena Ostrowska;Lars Lind;Elena Sciaraffia;Carina Blomstr?m-Lundqvist

作者机构：Department of Medical SciencesUppsala UniversityUppsalaSweden School of Medical ScienceFaculty of Medi-cine and HealthÖrebro UniversityÖrebroSweden 

出 版 物：《Journal of Geriatric Cardiology》 (老年心脏病学杂志（英文版）)

年 卷 期：2022年第19卷第9期

页      面：643-650页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：funded by Uppsala University Hospital (Sweden) 

主　　题：prevention incident wave 

摘      要：BACKGROUND Early identification of patients at risk of congestive heart failure(HF)may alter their poor *** aim was therefore to test whether simple electrocardiographic variables,the P-wave and PR-interval,could predict incident *** The PIVUS(Prospective Investigation of the Vasculature in Uppsala Seniors)study(1016 individuals all aged 70 years,50%women)was used to identify predictors of *** with prevalent HF,QRS duration≥130 ms,atrial tachyar-rhythmias,implanted pacemaker/defibrillator,second-and third-degree atrioventricular block or delta waves at baseline were *** proportional hazard analysis was used to relate the PR interval,P-wave duration(Pdur)and amplitude(Pamp),measured in lead V1,to incident *** was performed for gender,RR-interval,beta-blocking agents,systolic blood pressure,body mass index and *** Out of 836 subjects at risk,107 subjects were diagnosed with HF during a follow-up of 15 *** the multivariate analysis,there was a strong U-shaped correlation between Pdur in lead V1 and incident HF(P=0.0001)which was significant for a Pdur60 ms[HR=2.75;95%CI:1.87-4.06,at Pdur 40 ms]but not for prolonged *** was no significant relationship between incident HF and the PR-interval or the Pamp.A Pdur60 ms improved discrimination by 3.7%when added to the tradi-tional risk factors including sex,RR-interval,beta-blocking agents,systolic blood pressure,BMI and smoking(P=0.048).CONCLUSIONS A short Pdur,an easily measured parameter on the ECG,may potentially be a useful marker of future HF,enabling its early detection and prevention,thus improving outcomes.