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Exercised blood plasm. prom.tes hippocam.al n.urogen.sis in.the Alzheim.r's disease rat brain

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Journ.l of Sport an. Health Scien.e 2024年第2期13卷 245-255页

作者： Cecilie Skarstad n.revik Aleksi m.Huuha Ragn.ild n.RФsbjФrgen.Lin.a Hildegard Bergersen.Kam.lla Jacobsen.Rodrigo m.guel-dos-San.os Liv Ryan.Belm. Sken.er Jose Bian.o n.m.reira Asgeir Kobro-Flatm.en.m.n.o P.Witter n.than.Scrim.eour Atefe R.Tari Cardiac Exercise Research Group(CERG) Department of Circulation and Medical ImagingNorwegian University of Science and Technology7491TrondheimNorway Departm.n. of n.urology an. Clin.cal n.urophysiology St.Olavs University Hospital7030TrondheimNorway In.titute of Oral Biology University of Oslo0372OsloNorway Departm.n. of Physiology Federal University of SergipeS~ao Cristov~ao49100-000SergipeBrazil Cen.re of m.lecular In.lam.ation.Research Department of Clinical and Molecular MedicineNorwegian University of Science and Technology7491TrondheimNorway Kavli In.titute for System. n.uroscien.e Centre for Neural Computationand Egil and Pauline Braathen and Fred Kavli Centre for Cortical MicrocircuitsNorwegian University of Science and Technology7030TrondheimNorway K.G.Jebsen.Cen.re for Alzheim.r’s Disease Norwegian University of Science and Technology7030TrondheimNorway

Backgroun.:Exercise train.n. prom.tes brain.plasticity an. is associated with protection.again.t cogn.tive im.airm.n. an. Alzheim.r’s disease(AD).These ben.ficial effects m.y be partly m.diated by blood-born. *** we used an.in.vitro m.del of AD to in.estigate effects of blood plasm. from.exercise-train.d don.rs on.n.uron.l viability,an. an.in.vivo rat m.del of AD to test whether such plasm. im.acts cogn.tive fun.tion.am.loid pathology,an. ***:m.use hippocam.al n.uron.l cells were exposed to AD-like stress usin. am.loid-βan. treated with plasm. collected from.hum.n.m.le don.rs 3 h after a sin.le bout of high-in.en.ity *** in.vivo studies,blood was collected from.exercise-train.d youn. m.le Wistar rats(high-in.en.ity in.ervals 5 days/week for 6 weeks).Tran.gen.c AD rats(m.Gill-R-Thyl-APP)were in. ected 5 tim.s/fortn.ght for 6 weeks at2 m.n.hs or 5 m.n.hs of age with either(a)plasm. from.the exercise-train.d rats,(b)plasm. from.seden.ary rats,or(c)*** fun.tion.am.loid plaque pathology,an. n.urogen.sis were *** plasm. used for the treatm.n. was an.lyzed for 23 ***:Plasm. from.exercised don.rs en.an.ed cell viability by 44.1%(p=0.032)an. reduced atrophy by 50.0%(pn.am.loid-β-treated *** vivo exercised plasm. treatm.n. did n.t alter cogn.tive fun.tion.or am.loid plaque pathology but did in.rease hippocam.al n.urogen.sis by~3 fold,regardless of pathological stage,when.com.ared to salin.-treated *** of 7 cytokin.s were sign.fican.ly reduced in.exercised plasm. com.ared to seden.ary ***:Our proof-of-con.ept study dem.n.trates that plasm. from.exercise-train.d don.rs can.protect n.uron.l cells in.culture an. prom.te adult hippocam.al n.urogen.sis in.the AD rat *** effect m.y be partly due to reduced pro-in.lam.atory sign.lin. m.lecules in.exercised plasm..

关键词： Cytokin.s High-in.en.ity in.erval train.n. In.lam.ation n.uron. Plasm. tran.fusion

Rain.all Sen.itivity to m.crophysics an. Plan.tary Boun.ary Layer Param.terization. in.Con.ection.Perm.ttin. Sim.lation. over n.rthwestern.South Am.rica

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Journ.l of m.teorological Research 2024年第4期38卷 805-825页

作者： K.San.iago HERn.n.EZ Sebastian.GOm.Z-RIOS Juan.J.HEn.O Van.ssa ROBLEDO Alvaro RAm.REZ-CARDOn. An.ela m.REn.On Geolim.a Escuela AmbientalFacultad de IngenieriaUniversidad de AntioquiaMedellin 050010Colombia Grupo de In.en.eria y Gestion.Am.ien.al(GIGA) Escuela AmbientalFacultad de IngenieriaUniversidad de AntioquiaMedellin 050010Colombia Division.of Atm.spheric Scien.es Desert Research InstituteRenoNV 89512USA

Con.ection.perm.ttin. m.delin. allows us to un.erstan. m.chan.sm. that in.luen.e rain.all in.specific ***,m.crophysics param.terization.m.) an. plan.tary boun.ary layer(PBL) schem.s rem.in.an.im.ortan. source of un.ertain.y,affectin. rain.all in.en.ity,occurren.e,duration.an. ***,we study the sen.itivity of rain.all to three m. [Weather Research an. Forecastin.(WRF) Sin.le-m.m.n. 6-class(WSm.),Thom.son.an. m.rrison. an. two PBL [the Yon.ei Un.versity(YSU) an. m.llor–Yam.da n.kan.shi n.in.(m.n.)] schem.s with a con.ection.perm.ttin. resolution.4 km. over n.rthwestern.South Am.rica(n.SA).Sim.lation. were perform.d by usin. the WRF m.del an. the results were evaluated again.t soun.in.s,rain.gauges,an. satellite data,con.iderin. the spatio-tem.oral variability of rain.all over diverse region. pron. to deep con.ection.in.*** an. PBL schem.s largely in.luen.ed sim.lated rain.all,with better results for the less com.utation.lly expen.ive WSm. m. an. YSU PBL *** rain.gauges an. satellite estim.tes,sim.lation. with m.rrison.m. overestim.ted rain.all,especially westward of the An.es,whereas the m.n. PBL un.erestim.ted precipitation.in.the Am.zon.Savan.as *** foun. that the un.ertain.y in.the rain.all represen.ation.is highly depen.en. on.the region.with a higher in.luen.e of m. in.the Colom.ian.Pacific an. PBL in.the Am.zon.Savan.as *** an.lyzin. rain.all-related processes,the selection.of both m. an. PBL param.terization. exerted a large in.luen.e on.the sim.lated lower tropospheric m.isture flux an. m.isture *** schem.s sign.fican.ly in.luen.ed the down.ard shortwave radiation.with m.n. sim.latin. a greater am.un. of low clouds,which decreased the radiation.***,laten. heat fluxes were greater for YSU,favorin. m.ist con.ection.an. *** schem.s had a m.rked im.act on.vertical ***,m.rrison.m. showed stron.er con.ection.an. higher precipitation.rates,which is assoc

关键词： sen.itivity m.crophysics plan.tary boun.ary layer(PBL) Weather Research an. Forecastin.(WRF) processes

Recen. advan.es an. opportun.ties in.m.en.-based liquid crystals

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In.om.t 2024年第3期6卷 1-21页

作者： Ken.Aldren.S.Usm.n.Jizhen.Zhan. Kevin.lo P.m.rquez m.a An.ela n.Judicpa Peter A.Lyn.h An.abelle Bedford Babak An.sori Joselito m.Razal In.titute for Fron.ier m.terials Deakin UniversityGeelongVictoriaAustralia m.n.facturin. Commonwealth Scientific and Industrial Research Organization(CSIRO)Waurn PondsVictoriaAustralia In.titute of Chem.stry University of the Philippines-Los BañosLagunaPhilippines School of m.terials En.in.erin. Purdue UniversityWest LafayetteIndianaUSA Departm.n. of m.chan.cal an. En.rgy En.in.erin. Indiana University-Purdue UniversityIndianapolisIndianaUSA

The recen. progress on.the liquid crystallin.(LC)dispersion.of two-dim.n.ion.l(2D)tran.ition.m.tal carbides(m.en.s)has propelled this un.que n.n.m.terial in.o a realm.of high-perform.n.e architectures,such as film. an. ***ally,com.ared to architectures m.de from.typical n.n.LC dispersion.,those derived from.LC m.en. possess tun.ble ion.tran.port routes an. en.an.ed con.ductivity an. physical properties,dem.n.tratin. great poten.ial for a wide ran.e of application.,such as electron.c displays,sm.rt glasses,an. therm.l cam.uflage *** review provides an.overview of the progress achieved in.the production.an. processin. of LC m.en.s,in.ludin. critical discussion. on.satisfyin. the required con.ition. for LC *** also highlights how acquirin. LC m.en.s has broaden.d the curren. solution.based m.n.facturin. paradigm.of m.en.-based architectures,resultin. in.un.receden.ed perform.n.es in.their con.en.ion.l application.(e.g.,en.rgy storage an. strain.sen.in.)an. in.their em.rgin. uses(e.g.,tribology).Opportun.ties for in.ovation.an. foreseen.challen.es are also discussed,offerin. future research direction. on.how to further ben.fit from.the excitin. poten.ial of LC m.en.s with the aim.of prom.tin. their widespread use in.design.n. an. m.n.facturin. advan.ed m.terials an. application..

关键词： liquid crystals m.lti-fun.tion.l m.terials m.en.s solution.based processin.

Hydroelectrolytic an. En.rgetic Replen.sher in.Horses Un.ergoin. m.rcha Train.n.

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Open.Journ.l of Veterin.ry m.dicin. 2024年第8期14卷 203-216页

作者： José D. Ribeiro Filho Brun. m. Ribeiro m.chelin. O. Silva Sam.el R. Alves An.ïs C. Ben.tez Waleska m. F. Dan.as m.rcel F. B. Avan.a Raffaella B. C. Teixeira Pedro An.elm. n. Erm.ta Laice A. Silva Rin.ldo B. Vian. Hélio C. m.n.o Filho Departm.n. of Veterin.ry Federal University of Viosa Viosa Brazil In.titute of Studies of the Wet Tropic Federal University of Southern and Southeastern Par Xinguara Brazil Departm.n. of Veterin.ry Clin.c an. Surgery Federal University of Minas Gerais Belo Horizonte Brazil In.titute of An.m.l Health an. Production Federal Rural University of Amazonia Belm Brazil Zootecn.cs Departm.n. Federal Rural University of Pernambuco Recife Brazil

The study aim.d to assess the clin.cal, laboratory, an. blood gas an.lysis of horses un.ergoin. m.rcha train.n. an. the effects of volun.ary in.estion.of hydroelectrolytic an. en.rgy replen.shers after exercise. Eight horses of both gen.ers aged between.5 an. 10 years, were in.luded in.the study. The exercise con.isted of a 10-m.n.warm.up followed by 45 m.n.un.n.errupted m.rcha on.a flat dirt track in.the m.rn.n.. After exercise, the horses received on. of the followin. treatm.n.s: Drin.in. water (con.rol group);Hydroelectrolytic an. en.rgy replen.sher con.ain.n. sodium.chloride, potassium.chloride, calcium.acetate, m.gn.sium.chloride, sodium.citrate, dextrose, m.ltodextrin. an. sucrose in.three differen. con.en.ration. (Replen.shers A, B, an. C). The horses were distributed across the four treatm.n.s in.a 4 × 4 Latin.Squares design.usin. a Split-plot system.with 48-hr in.ervals. Clin.cal an. laboratory evaluation. were con.ucted at four tim. poin.s: T0 - 5 m.n.before exercise;T1 - up to 5 m.n.after exercise;T2 - 2 hr after startin. treatm.n.;an. T4 - 4 hr after begin.in. treatm.n.. Con.en.ration. of urea, creatin.n., lactate, phosphorus, an. ion.zed calcium.sign.fican.ly chan.ed after exercise. An.in.rease in.blood pH an. a decrease in.chloride con.en.ration. were observed when.replen.shers B an. C were offered after exercise. The replacem.n.s were in.ested spon.an.ously by the an.m.ls in.a volum. greater than.that of the con.rol group (water). Replacem.n. B was the m.st in.ested by the an.m.ls, dem.n.tratin. its greatest poten.ial.

关键词： Dehydration Electrolyte Replacem.n. Exercise Rehydration Volun.ary In.ake

Perform.n.e of the geom.tric approach to fault detection.an. isolation.in.SISO,m.SO,SIm. an. m.m. system.

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Journ.l of Zhejian. Un.versity-Scien.e A(Applied Physics & En.in.erin.) 2007年第9期8卷 1443-1451页

作者： RAHIm. n. SADEGHI m. H. m.HJOOB m. J. m.chan.cal En.in.erin. Departm.n. University of TabrizTabriz ***Iran m.chan.cal En.in.erin. Departm.n. University of TehranTehran ***Iran

In.this paper, a geom.tric approach to fault detection.an. isolation.（FDI） is applied to a m.ltiple-In.ut m.ltipie-Output （m.m.） m.del of a fram. an. the FDI results are com.ared to the on.s obtain.d in.the Sin.le-In.ut Sin.le-Output （SISO）, m.ltiple-In.ut Sin.le-Output （m.SO）, an. Sin.le-In.ut m.ltiple-Output （SIm.） cases. A proper distan.e fun.tion.based on.param.ters obtain.d from.param.tric system.iden.ification.m.thod is used in.the geom.tric approach. ARX （Auto Regressive with exogen.us in.ut） an. VARX （Vector ARX） m.dels with 12 param.ters are used in.all of the above-m.n.ion.d m.dels. The obtain.d results reveal that by in.reasin. the n.m.er of in.uts, the classification.errors reduce, even.in.the case of applyin. on.y on. of the in.uts in.the com.utation.. Furtherm.re, in.reasin. the n.m.er of m.asured outputs in.the FDI schem. results in.decreasin. classification.errors. Also, it is shown.that by usin. probabilistic space in.the distan.e fun.tion. fault diagn.sis schem. has better perform.n.e in.com.arison.with the determ.n.stic on..

关键词： Fault detection.an. isolation.(FDI) m.ltivariate system. Param.tric system.iden.ification Lin.ar regression Distan.e fun.tion.

Com.lem.n. factor H in.m.lecular regulation.of an.iogen.sis

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m.dical Review 2024年第5期4卷 452-466页

作者： Jian. Li Kaili Wan. m.ria n.Starodubtseva Eldar n.dyrov Carolyn.m.Kapron.Josephin. Hoh Ju Liu Laboratory of Tran.lation.l m.dicin. in.m.crovascular Regulation Institute of Microvascular MedicineMedical Research CenterThe First Affiliated Hospital of Shandong First Medical University&Shandong Provincial Qianfoshan HospitalJinanShandong Province250014China Shan.on. Provin.ial Key m.dical an. Health Laboratory of Tran.lation.l m.dicin. in.m.crovascular Agin. JinanShandong ProvinceChina m.dical Research Cen.er Shandong Provincial Qianfoshan HospitalShandong UniversityJinanShandong Province 250014China Gom.l State m.dical Un.versity GomelBelarus In.titute of Radiobiology of n.S of Belarus GomelBelarus Departm.n. of Biology Trent UniversityPeterboroughONCanada Departm.n. of Ophthalm.logy Yale School of MedicineNew HavenCTUSA

An.iogen.sis,the process of form.tion.of n.w capillaries from.existin. blood vessels,is required for m.ltiple physiological an. pathological *** factorH(CFH)is a plasm. protein.that in.ibits the altern.tive pathway of the com.lem.n. *** of CFH en.an.es the altern.tive pathway an. in.reases com.lem.n. activation.fragm.n.s with pro-an.iogen.c capacity,in.ludin. com.lem.n. 3a,com.lem.n. 5a,an. m.m.ran. attack *** protein.con.ain. bin.in. sites for C-reactive protein.m.lon.ialdehyde,an. en.othelial heparan.*** of CFH preven.s its in.eraction.with these m.lecules an. in.tiates pro-an.iogen.c *** in.the CFH gen. have been.foun. in.patien.s with age-related m.cular degen.ration.characterized by choroidal *** Cfh-deficien. m.ce show an.in.rease in.an.iogen.sis,which is decreased by adm.n.stration.of recom.in.n. CFH pro*** this review,we sum.arize the m.lecular m.chan.sm. of the an.i-an.iogen.c effects of CFH an. the regulatory m.chan.sm. of CFH *** therapeutic poten.ial of recom.in.n. CFH protein.in.an.iogen.sisrelated diseases has also been.discussed.

关键词： com.lem.n. factor H an.iogen.sis m.chan.cal properties therapeutic target

Role of m.rin. n.tural products in.the developm.n. of an.iviral agen.s again.t SARS‑CoV‑2:poten.ial an. prospects

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m.rin. Life Scien.e & Techn.logy 2024年第2期6卷 280-297页

作者： D.P.n.gahawatta n.m.Liyan.ge Thilin. U.Jayawarden. H.H.A.C.K.Jayawardhan. Seon.‑Hun.Jeon. Hyun.‑Jun.Kwon.You‑Jin.Jeon Departm.n. of m.rin. Life Scien.es Jeju National UniversityJeju 690-756Republic of Korea Departm.n. of Chem.stry Biochemistry and PhysicsUniversitédu QuébecàTrois-RivièresTrois-RivièresQC G8Z 4M3Canada m.rin. Scien.e In.titute Jeju National UniversityJeju 63333Republic of Korea Fun.tion.l Biom.terial Research Cen.er Korea Research Institute of Bioscience and BiotechnologyJeongeup-siRepublic of Korea

A n.vel coron.virus,kn.wn.as severe acute respiratory syn.rom. coron.virus 2(SARS-CoV-2),has surfaced an. caused global con.ern.owin. to its ***-CoV-2 is the causative agen. of coron.virus disease 2019;however,it was on.y discovered at the en. of the year an. was con.idered a pan.em.c by the World Health ***,the develop-m.n. of n.vel poten. in.ibitors again.t SARS-CoV-2 an. future outbreaks is urgen.ly *** n.turally occurrin. bioactive substan.es have been.studied in.the clin.cal settin. for diverse *** in.ricate in.ection.an. replication.m.chan.sm.of SARS-CoV-2 offers diverse therapeutic drug targets for developin. an.iviral m.dicin.s by em.loyin. n.tural products that are safer than.syn.hetic *** n.tural products(m.Ps)have received in.reased atten.ion.in.the developm.n. of n.vel drugs owin. to their high diversity an. ***,this review article in.estigates the in.ection.an. replication.m.chan.sm.,in.ludin. the fun.tion.of the SARS-CoV-2 gen.m. an. ***,we highlighted an.i-SARS-CoV-2 therapeutic in.erven.ion.efforts utilizin. m.Ps an. predicted SARS-CoV-2 in.ibitor design.

关键词： SARS-CoV-2 m.rin. n.tural products Drug targets In.ibitors

The m.cropolar fluid m.del for blood flow through a tapered artery with a sten.sis

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Acta m.chan.ca Sin.ca 2008年第6期24卷 637-644页

作者： Kh.S.m.kheim.r m.A.El kot Departm.n. of m.them.tics Faculty of ScienceAl-Azhar UniversityNasr CityCairo 11884Egypt Departm.n. of m.them.tics Faculty of EducationSuez Canal UniversitySuezEgypt

A m.cropolar m.del for axisym.etric blood flow through an.axially n.n.ym.etreic but radially sym.etric m.ld sten.sis tapered artery is presen.ed. To estim.te the effect of the sten.sis shape, a suitable geom.try has been.con.idered such that the axial shape of the sten.sis can.be chan.ed easily just by varyin. a param.ter （referred to as the shape param.ter）. The m.del is also used to study the effect of the taper an.le Ф. Flow param.ters such as the velocity, the resistan.e to flow （the resistan.e im.edan.e）, the wall shear stress distribution.in.the sten.tic region.an. its m.gn.tude at the m.xim.m.height of the sten.sis （sten.sis throat） have been.com.uted for differen. values of the shape param.ter n. the taper an.le Ф, the couplin. n.m.er n.an. the m.cropolar param.ter m. It is shown.that the resistan.e to flow decreases with in.reasin. the shape param.ter n.an. the m.cropolar param.ter m.while it in.reases with in.reasin. the couplin. n.m.er n. So, the m.gn.tude of the resistan.e im.edan.e is higher for a m.cropolar fluid than.that for a n.wton.an.fluid m.del. Fin.lly, the velocity profile, the wall shear stress distribution.in.the sten.tic region.an. its m.gn.tude at the m.xim.m.height of the sten.sis are discussed for differen. values of the param.ters in.olved on.the problem.

关键词： m.cropolar fluid Blood flow Tapered artery

Im.act of STAT-sign.lin. pathway on.can.er-associated fibroblasts in.colorectal can.er an. its role in.im.un.suppression

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World Journ.l of Gastroin.estin.l On.ology 2024年第5期16卷 1705-1724页

作者： Dam.án.Sán.hez-Ram.rez m.n.ca G m.n.oza-Rodríguez Om.r R Alem.n.Fern.n.o A Can.an.do-Gon.ález m.riam.Rodríguez-Sosa Juan.Josém.n.esin.s-m.n.esin.s m.uricio Salcedo Ism.el Brito-Toledo Felipe Vaca-Pan.agua Luis I Terrazas Un.dad de In.estigacion.en.Biom.dicin. Facultad de Estudios Superiores IztacalaUniversidad Nacional Autonoma de MexicoTlalnepantla 54090Estado de MexicoMexico Departm.n. of Biology Facultad de QuimicaUniversidad Nacional Autonoma de MexicoCiudad UniversitariaMexico City 04510Mexico Departm.n. of Pathology National Medical Center Century XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Laboratorio de Células Tron.ales m.sen.uim.les Unidad de Investigación Médica en Enfermedades OncológicasHospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Un.dad de In.estigacion.en.Biom.dicin. y On.ologia Gen.m.ca Instituto Mexciano del Seguro SocialMexico City 07300Mexico Servicio de Colon.y Recto Hospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Laboratorio n.cion.l en.Salud Facultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla 54090Estado de MexicoMexico

Colorectal can.er(CRC)rem.in. on. of the m.st com.on.y diagn.sed an. deadliest types of can.er *** displays a desm.plastic reaction.DR)that has been.in.ersely associated with poor progn.sis;less DR is associated with a better *** reaction.gen.rates excessive con.ective tissue,in.which can.er-associated fibroblasts(CAFs)are critical cells that form.a part of the tum.r *** are directly in.olved in.tum.rigen.sis through differen. ***,their role in.im.un.suppression.in.CRC is n.t well un.erstood,an. the precise role of sign.l tran.ducers an. activators of tran.cription.STATs)in.m.diatin. CAF activity in.CRC rem.in. *** the m.riad chem.cal an. biological factors that affect CAFs,differen. cytokin.s m.diate their fun.tion.by activatin. STAT sign.lin. ***,the harm.ul effects of CAFs in.favorin. tum.r growth an. in.asion.m.y be m.dulated usin. STAT ***,we an.lyze the im.act of differen. STATs on.CAF activity an. their im.un.regulatory role.

关键词： Can.er-associated fibroblasts Sign.l tran.ducer an. activator of tran.cription.sign.lin. Colorectal can.er Im.un.ty Im.un.suppression