Complement factor H in molecular regulation of angiogenesis
作者机构：Laboratory of Translational Medicine in Microvascular RegulationInstitute of Microvascular MedicineMedical Research CenterThe First Affiliated Hospital of Shandong First Medical University&Shandong Provincial Qianfoshan HospitalJinanShandong Province250014China Shandong Provincial Key Medical and Health Laboratory of Translational Medicine in Microvascular AgingJinanShandong ProvinceChina Medical Research CenterShandong Provincial Qianfoshan HospitalShandong UniversityJinanShandong Province 250014China Gomel State Medical UniversityGomelBelarus Institute of Radiobiology of NAS of BelarusGomelBelarus Department of BiologyTrent UniversityPeterboroughONCanada Department of OphthalmologyYale School of MedicineNew HavenCTUSA
出 版 物：《Medical Review》 (医学评论（英文）)
年 卷 期：2024年第4卷第5期
页 面：452-466页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：supported by the National Nature Science Foundation of China (82171318,82241030,82011530024) the State Program of Scientific Research“Natural resources and the Environment” (3.01,2020–2021,Belarus) Academic Promotion Program of Shandong First Medical University (2019QL014)and Shandong Taishan Scholarship (J.L)
主 题：complement factor H angiogenesis mechanical properties therapeutic target
摘 要：Angiogenesis,the process of formation of new capillaries from existing blood vessels,is required for multiple physiological and pathological *** factorH(CFH)is a plasma protein that inhibits the alternative pathway of the complement *** of CFH enhances the alternative pathway and increases complement activation fragments with pro-angiogenic capacity,including complement 3a,complement 5a,and membrane attack *** protein contains binding sites for C-reactive protein,malondialdehyde,and endothelial heparan *** of CFH prevents its interaction with these molecules and initiates pro-angiogenic *** in the CFH gene have been found in patients with age-related macular degeneration characterized by choroidal *** Cfh-deficient mice show an increase in angiogenesis,which is decreased by administration of recombinant CFH pro*** this review,we summarize the molecular mechanisms of the anti-angiogenic effects of CFH and the regulatory mechanisms of CFH *** therapeutic potential of recombinant CFH protein in angiogenesisrelated diseases has also been discussed.
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