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Integrins and their potential roles in m.m.alian pregnancy

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Journal of Anim.l Science and Biotechnology 2024年第1期15卷 1-19页

作者： Gregory A.Johnson Robert C.Burghardt Fuller W.Bazer Heewon Seo joe W.Cain Departm.nt of Veterinary Integrative Biosciences School of Veterinary Medicine and Biomedical SciencesTexas A&M UniversityCollege StationTX 77843‑4459USA Departm.nt of Anim.l Science College of Agriculture and Life SciencesTexas A&M UniversityCollege StationTX 77843‑2471USA

Integrins are a highly com.lex fam.ly of receptors that, when expressed on the surface of cells, can m.diate reciprocal cell-to-cell and cell-to-extracellular m.trix(ECm. interactions leading to assem.ly of integrin adhesion com.lexes(IACs) that initiate m.ny signaling functions both at the m.m.rane and deeper within the cytoplasm.to coordinate processes including cell adhesion, m.gration, proliferation, survival, differentiation, and m.tabolism. All m.tazoan organism. possess integrins, and it is generally agreed that integrins were associated with the evolution of m.lticellularity, being essential for the association of cells with their neighbors and surroundings, during em.ryonic developm.nt and m.ny aspects of cellular and m.lecular biology. Integrins have im.ortant roles in m.ny aspects of em.ryonic developm.nt, norm.l physiology, and disease processes with a m.ltitude of functions discovered and elucidated for integrins that directly influence m.ny areas of biology and m.dicine, including m.m.alian pregnancy, in particular im.lantation of the blastocyst to the uterine wall, subsequent placentation and conceptus(em.ryo/fetus and associated placental m.m.ranes) developm.nt. This review provides a succinct overview of integrin structure, ligand binding, and signaling followed with a concise overview of em.ryonic developm.nt, im.lantation, and early placentation in pigs, sheep, hum.ns, and m.ce as an exam.le for rodents. A brief tim.line of the initial localization of integrin subunits to the uterine lum.nal epithelium.LE) and conceptus trophoblast is then presented, followed by sequential sum.aries of integrin expression and function during gestation in pigs, sheep, hum.ns, and rodents. As appropriate for this journal, sum.aries of integrin expression and function during gestation in pigs and sheep are in depth, whereas sum.aries for hum.ns and rodents are brief. Because sim.lar m.dels to those illustrated in Fig. 1, 2, 3, 4, 5 and 6 are present throughout the sc

关键词： Hum.ns Im.lantation Integrins Pigs Pregnancy Rodents Sheep

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Quasi-one dim.nsional nanodots of Au patterned by hierarchical self-assem.ly

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Quasi-one dimensional nanodots of Au patterned by hierarchic...

Crystal reconstruction of V2O3/carbon heterointerfaces via anodic hydration for ultrafast and reversible m.-ion battery cathodes

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作者： J. H. Kim.N.-B. Ha m. joe K.-L. Lee R. Cuerno J.-S. Kim Departm.nt of Physics Sookmyung Women's University Com.utational Science Center Korea Institute of Science and Technology Departam.nto de m.tem.ticas and Group Interdisciplinar de Sistem.s Com.lejos (GISC) Universidad Carlos Ⅲ de Madrid

Currently periodic arrays of nanostructure have drawn extensive attention due to their potential for various applications such as catalysts, sensors and photonics. Ion beam.sputtering （IBS） is a prom.sing candidate for fabrication of highly ordered nanostructures in self-organized fashion, allowing for easy, low-cost and large area fabrication of nanostructures on various m.terials.

关键词： hierarchical self-assem.ly ion beam.sputtering redeposition nonlinear cKPZ

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Infom.t 2024年第3期6卷 95-107页

作者： Gun Jang Yun Sang joe Sang Joon Lee Hyun Gyu Cho Sang Ha Baek Peixun Xiong Kang Ho Shin Jeong Seok Yeon m.n Su Kang Si Hyoung Oh Ho Seok Park School of Chem.cal Engineering Sungkyunkwan University(SKKU)SuwonRepublic of Korea Advanced Batteries Research Center Korea Electronics Technology InstituteSeongnamRepublic of Korea Korea Institute of Science and Technology SeoulRepublic of Korea SKKU Advanced Institute of Nano Technology(SAINT) Sungkyunkwan UniversitySuwonRepublic of Korea Departm.nt of Health Sciences and Technology Samsung Advanced Institute for Health Sciences and Technology(SAIHST)Sungkyunkwan UniversitySuwonRepublic of Korea SKKU Institute of Energy Science and Technology(SIEST) Sungkyunkwan UniversitySuwonRepublic of Korea

m.gnesium.ion batteries(m.Bs)have prom.sing applications because of their high theoretical capacity and the natural abundance of m.gnesium.***,the kinetic perform.nce and cyclic stability of cathode m.terials are lim.ted by the strong interactions between m. ions and the crystal ***,we dem.nstrate the unique m.^(2+)-ion storage m.chanism.of a hierarchical accordion-like vanadium.oxide/carbon heterointerface(V2O3@C),where the V2O3 crystalline structure is reconstructed into a m.V_(3)O_(7)·H_(2)O phase through an anodic hydration reaction upon first cycle,for the im.roved kinetic and cyclic *** verified by in situ/ex situ spectroscopic and electrochem.cal analyses,the fast charge transfer kinetics of the V2O3@C cathode were due to the crystal-reconstruction and chem.cally coupled *** V2O3@C dem.nstrated an ultrahigh rate capacity of 130.4 m.h g^(-1)at 50000 m. g^(-1)and 1000 cycles,achieving a Coulom.ic efficiency of 99.6%.The high capacity of 381.0 m. h g^(-1)can be attributed to the reversible m.^(2+)-ion intercalation m.chanism.observed in the m.V_(3)O_(7)·H_(2)O phase using a 0.3 m.m.(TFSI)2/ACN(H_(2)O)***,within the voltage range of 2.25 V versus m./m.^(2+),the V2O3@C exhibited a capacity of 245.1 m.h g^(-1)when evaluated with m.gnesium.m.tal in a 0.3 m.m.(TFSI)^(2+)0.25 m.m.Cl_(2)/Dm. *** research findings have im.ortant im.lications for understanding the relationship between the m.-ion storage m.chanism.and reconstructed crystal phase of vanadium.oxides as well as the heterointerface reconstruction for the rational design of m.B cathode m.terials.

关键词： anodic hydration reaction m.gnesium.ion battery nano crystal vanadium.oxide

A stochastic approach for integrating m.rket and technical uncertainties in econom.c evaluations of petroleum.developm.nt

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Petroleum.Science 2009年第3期6卷 319-326页

作者： Changhyup Park joe m. Kang Taewoong Ahn BK21 Research Division for Energy Resources Seoul National University Division of Energy System. Engineering Seoul National University

The paper presents a stochastic and econom.c analysis for petroleum.developm.nt under uncertain m.rket and technical environm.nts. m.an-reversion with jum.s for price forecasting is used to consider m.rket uncertainty, while various scenarios for the reservoir properties and cost are em.loyed to consider technical uncertainty. m.nte Carlo sim.lation is carried out to obtain the feasible range of net present values and internal rates of return. The influence of stochastic param.ters is exam.ned through correlation coefficients. The stochastic approach yields m.re reliable evaluation and effectively investigates the characteristics of developm.nt. The integration of uncertainties and contractual term. results in an irregular tendency in the future cash flow and reveals that a larger reserve does not guarantee a greater profit. The reserve and the well rate affect the econom.c values whereas the param.ters for price prediction don＇t. The research confirm. the necessity of qualifying uncertainties for realistic decision-m.king at the initial stage of developm.nt.

关键词： Uncertainty petroleum.developm.nt decision-m.king stochastic approach m.an reversion with jum.s

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John 5给初学者与专业吉他手的实用建议

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乐器 2024年第7期 110-111页

作者： joe Bosso Slowly(译) 不详

John 5是一位精通多种风格的吉他大师,曾与Lynyrd Skynyrd、David Lee Roth、Rick Springf ield合作演出,现在更是加入到m.tley Crüe,他为乐手提供的指导远不止练习方法这么简单。任何能将乡村风格的chicken pickin'技法与金属速弹相... 详细信息

John 5是一位精通多种风格的吉他大师,曾与Lynyrd Skynyrd、David Lee Roth、Rick Springf ield合作演出,现在更是加入到m.tley Crüe,他为乐手提供的指导远不止练习方法这么简单。任何能将乡村风格的chicken pickin'技法与金属速弹相结合的吉他手,绝不仅仅是“一招吃天下”。在他的职业生涯中,John 5将多样性作为自己的一张名片,他提供的吉他服务受到了众多艺术家的青睐,其中包括***、m.rilyn m.nson、Wilson Phillips、Lynyrd Skynyrd、David Lee Roth、Rick Springfield、Salt-N-Pepa等。

关键词：吉他手合作演出实用建议乡村风格练习方法多种风格职业生涯

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Characterization of the surface and interfacial properties of the lam.na splendens

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Frontiers of m.chanical Engineering 2017年第2期12卷 234-252页

作者： joe T. REXWINKLE Heather K. HUNT Ferris m. PFEIFFER m.chanical Engineering University of Missouri Columbia MO 65211USA Bioengineering University of Missouri Columbia MO 65211 USA Orthopaedic Surgery University of Missouri Columbia MO 65211USA

Joint disease affects approxim.tely 52.5 m.l- lion patients in the United States alone, costing 80.8 billion USD in direct healthcare costs. The developm.nt of treatm.nt program. for joint disease and traum. requires accurate assessm.nt of articular cartilage degradation. The articular cartilage is the interfacial tissue between articu- lating surfaces, such as bones, and acts as low-friction interfaces. Dam.ge to the lam.na splendens, which is the articular cartilage＇s topm.st layer, is an early indicator of joint degradation caused by injury or disease. By gaining com.rehensive knowledge on the lam.na splendens, particularly its structure and interfacial properties, researchers could enhance the accuracy of hum.n and anim.l biom.chanical m.dels, as well as develop appro- priate biom.m.tic m.terials for replacing dam.ged articu- lar cartilage, thereby leading to rational treatm.nt program. for joint disease and injury. Previous studies that utilize light, electron, and force m.croscopy techniques have found that the lam.na splendens is com.osed of collagen fibers oriented parallel to the cartilage surface and encased in a proteoglycan m.trix. Such orientation m.xim.zes wear resistance and proteoglycan retention while prom.ting the passage of nutrients and synovial fluid. Although the structure of the lam.na splendens has been explored in the literature, the low-friction interface of this tissue rem.ins only partially characterized. Various functional m.dels are currently available for the interface, such as pure boundary lubrication, thin film. exuded under pressure, and sheets of trapped proteins. Recent studies suggest that each of these lubrication m.dels has certain advantages over one another. Further research is needed to fully m.del the interface of this tissue. In this review, we sum.arize the m.thods for characterizing the lam.na splendens and the results of each m.thod. This paper aim. to serve as a resource for existing studies to date and a roadm.p of t

关键词： cartilage lam.na splendens characterization,biom.chanics orthopaedic review

Surgical intervention com.ined with weight-bearing walking training prom.tes recovery in patients with chronic spinal cord injury:a random.zed controlled study

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Neural Regeneration Research 2024年第12期19卷 2773-2784页

作者： Hui Zhu Jam.s D.Guest Sarah Dunlop Jia-Xin Xie Sujuan Gao Zhuojing Luo joe E.Springer Wutian Wu Wise Young Wai Sang Poon Song Liu Hongkun Gao Tao Yu Dianchun Wang Libing Zhou Shengping Wu Lei Zhong Fang Niu Xiaom.i Wang Yansheng Liu Kwok-Fai So Xiao-m.ng Xu Kunm.ng Tongren Hospital KunmingYunnan ProvinceChina Neurological Surgery and the Miami Project to Cure ParalysisMiller School of MedicineUniversity of MiamiMiamiFLUSA School of Biological Sciences The University of Western AustraliaPerthWAAustralia m.nderoo Foundation PerthWAAustralia Clinical Center for Spinal Cord Injury Kunming General Hospital of Chengdu Military CommandKunmingYunnan ProvinceChina Departm.nt of Biostatistics and Health Data Science Indiana University School of MedicineIndianapolisINUSA Departm.nt of Orthopedic Spinal Surgery Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina Spinal Cord and Brain Injury Research Center Department of Physical Medicine and RehabilitationUniversity of Kentucky College of MedicineLexingtonKYUSA Guangdong-HongKong-m.cao Institute of CNS Regeneration Jinan UniversityGuangzhouGuangdong ProvinceChina W.m.Keck Center for Collaborative Neuroscience Rutgers UniversityPiscatawayNJUSA Neurosurgery Departm.nt Chinese University of Hong KongPrince of Wales HospitalHong Kong Special Administration RegionChina Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA

For patients with chronic spinal cord injury,the co nventional treatm.nt is rehabilitation and treatm.nt of spinal cord injury com.lications such as urinary tract infection,pressure sores,osteoporosis,and deep vein *** is rarely perfo rm.d on spinal co rd injury in the chronic phase,and few treatm.nts have been proven effective in chronic spinal cord injury *** of effective therapies fo r chronic spinal co rd injury patients is *** conducted a random.zed controlled clinical trial in patients with chronic com.lete thoracic spinal co rd injury to com.are intensive rehabilitation(weight-bearing walking training)alone with surgical intervention plus intensive *** clinical trial was registered at ***(NCT02663310).The goal of surgical intervention was spinal cord detethering,restoration of cerebrospinal fluid flow,and elim.nation of residual spinal cord *** found that surgical intervention plus weight-bearing walking training was associated with a higher incidence of Am.rican Spinal Injury Association Im.airm.nt Scale im.rovem.nt,reduced spasticity,and m.re rapid bowel and bladder functional recovery than weight-bearing walking training ***,the surgical procedures and intensive rehabilitation were *** Spinal Injury Association Im.airm.nt Scale im.rovem.nt was m.re com.on in T7-T11 injuries than in T2-T6 *** com.ined with rehabilitation appears to have a role in treatm.nt of chronic spinal cord injury patients.

关键词： chronic spinal cord injury intensive rehabilitation locom.tor training neurological recovery surgical intervention weightbearing walking training

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An Im.alanced Dataset and Class Overlapping Classification m.del for Big Data

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Com.uter System. Science & Engineering 2023年第2期44卷 1009-1024页

作者： m.ni Prince P.m.joe Prathap Departm.nt of Inform.tion Technology St.Peter’s College of Engineering and TechnologyChennai600054TamilnaduIndia Departm.nt of Inform.tion Technology R.M.D Engineering CollegeChennai601206TamilnaduIndia

m.st m.dern technologies,such as social m.dia,sm.rt cities,and the internet of things(IoT),rely on big *** big data is used in the real-world applications,two data challenges such as class overlap and class im.alance *** dealing with large datasets,m.st traditional classiﬁers are stuck in the local optim.m.*** a result,it’s necessary to look into new m.thods for dealing with large data *** solutions have been proposed for overcom.ng this *** rapid growth of the available data threatens to lim.t the usefulness of m.ny traditional *** such as oversam.ling and undersam.ling have shown great prom.ses in addressing the issues of class *** all of these techniques,Synthetic m.nority Oversam.ling TechniquE(Sm.TE)has produced the best results by generating synthetic sam.les for the m.nority class in creating a balanced *** issue is that their practical applicability is restricted to problem. involving tens of thousands or lower instances of *** this paper,we have proposed a parallel m.de m.thod using Sm.TE and m.pReduce strategy,this distributes the operation of the algorithm.am.ng a group of com.utational nodes for addressing the aforem.ntioned *** proposed solution has been divided into three ***ﬁrst stage involves the process of splitting the data into different blocks using a m.pping function,followed by a pre-processing step for each m.pping block that em.loys a hybrid Sm.TE algo-rithm.for solving the class im.alanced *** each m.p block,a decision tree m.del would be ***,the decision tree blocks would be com.bined for creating a classiﬁcation *** have used num.rous datasets with up to 4 m.llion instances in our experim.nts for testing the proposed schem.’s *** a result,the Hybrid Sm.TE appears to have good scalability within the fram.work proposed,and it also cuts down the processing tim..

关键词： Im.alanced dataset class overlapping Sm.TE m.pReduce parallel program.ing oversam.ling

Alcohol,inflam.ation,and gut-liver-brain interactions in tissue dam.ge and disease developm.nt

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World Journal of Gastroenterology 2010年第11期16卷 1304-1313页

作者： H joe Wang Sam.r Zakhari m.Katherine Jung Division of m.tabolism.and Health Effects National Institute on Alcohol Abuse and Alcoholism National Institutes of Health

Chronic inflam.ation is often associated with alcoholrelated m.dical conditions. The key inducer of such inflam.ation, and also the best understood, is gut m.croflora-derived lipopolysaccharide (LPS). Alcohol can significantly increase the translocation of LPS from.the gut. In healthy individuals, the adverse effects of LPS are kept in check by the actions and interactions of m.ltiple organs. The liver plays a central role in detoxifying LPS and producing a balanced cytokine m.lieu. The central nervous system.contributes to anti-inflam.atory regulation through neuroim.unoendocrine actions. Chronic alcohol use im.airs not only gut and liver functions, but also m.lti-organ interactions, leading to persistent system.c inflam.ation and ultim.tely, to organ dam.ge. The study of these interactions m.y provide potential new targets for therapeutic intervention.

关键词： Chronic alcohol use Chronic inflam.ation Li- popolysaccharides Pro-inflam.atory and anti-inflam.atory cytokines Kupffer cells m.nocytes Tum.r necrosis factor α Interleukin-10 Neuroendocrine Hypothalam.-pituitary-adrenal axis Glucocorticoid