Characterization of the surface and interfacial properties of the lamina splendens

作     者：Joe T. REXWINKLE Heather K. HUNT Ferris M. PFEIFFER 

作者机构：Mechanical Engineering University of Missouri Columbia MO 65211USA Bioengineering University of Missouri Columbia MO 65211 USA Orthopaedic Surgery University of Missouri Columbia MO 65211USA 

出 版 物：《Frontiers of Mechanical Engineering》 (机械工程前沿（英文版）)

年 卷 期：2017年第12卷第2期

页      面：234-252页

核心收录：

学科分类：082802[工学-农业水土工程] 090707[农学-水土保持与荒漠化防治] 0907[农学-林学] 08[工学] 0828[工学-农业工程] 082502[工学-航空宇航推进理论与工程] 09[农学] 0815[工学-水利工程] 0802[工学-机械工程] 0825[工学-航空宇航科学与技术] 0801[工学-力学（可授工学、理学学位）] 

主　　题：cartilage lamina splendens characterization,biomechanics orthopaedic review 

摘      要：Joint disease affects approximately 52.5 mil- lion patients in the United States alone, costing 80.8 billion USD in direct healthcare costs. The development of treatment programs for joint disease and trauma requires accurate assessment of articular cartilage degradation. The articular cartilage is the interfacial tissue between articu- lating surfaces, such as bones, and acts as low-friction interfaces. Damage to the lamina splendens, which is the articular cartilage＇s topmost layer, is an early indicator of joint degradation caused by injury or disease. By gaining comprehensive knowledge on the lamina splendens, particularly its structure and interfacial properties, researchers could enhance the accuracy of human and animal biomechanical models, as well as develop appro- priate biomimetic materials for replacing damaged articu- lar cartilage, thereby leading to rational treatment programs for joint disease and injury. Previous studies that utilize light, electron, and force microscopy techniques have found that the lamina splendens is composed of collagen fibers oriented parallel to the cartilage surface and encased in a proteoglycan matrix. Such orientation maximizes wear resistance and proteoglycan retention while promoting the passage of nutrients and synovial fluid. Although the structure of the lamina splendens has been explored in the literature, the low-friction interface of this tissue remains only partially characterized. Various functional models are currently available for the interface, such as pure boundary lubrication, thin films exuded under pressure, and sheets of trapped proteins. Recent studies suggest that each of these lubrication models has certain advantages over one another. Further research is needed to fully model the interface of this tissue. In this review, we summarize the methods for characterizing the lamina splendens and the results of each method. This paper aims to serve as a resource for existing studies to date and a roadmap of t