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A comprehensive review of integrative pharmacology-based investigation:A paradigm shift in traditional Chinese medicine

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Acta Pharmaceutica Sinica B 2021年第6期11卷 1379-1399页

作者： Haiyu Xu Yanqiong zhang Ping Wang Junhong zhang Hong Chen luoqi zhang Xia Du Chunhui Zhao Dan Wu Feng Liu Hongjun Yang Changxiao Liu Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China Shaanxi Institute of International Trade&Commerce Xianyang 7120462China State Key Laboratory of Drug Delivery Technology and Pharmacokinetics Tianjin Institute of Pharmaceutical ResearchTianjin 300193China

Over the past decade,traditional Chinese medicine(TCM) has widely embraced systems biology and its various data integration approaches to promote its ***,integrative pharmacology-based traditional Chinese medicine(TCMIP) was proposed as a paradigm shift in *** review focuses on the presentation of this novel concept and the main research contents,methodologies and applications of ***,TCMIP is an interdisciplinary science that can establish qualitative and quantitative pharmacokinetics-pharmacodynamics(PK-PD) correlations through the integration of knowledge from multiple disciplines and techniques and from different PK-PD processes in ***,the main research contents of TCMIP are introduced as follows:chemical and ADME/PK profiles of TCM formulas;confirming the three forms of active substances and the three action modes;establishing the qualitative PK-PD correlation;and building the quantitative PK-PD correlations,*** that,we summarize the existing data resources,computational models and experimental methods of TCMIP and highlight the urgent establishment of mathematical modeling and experimental ***,we further discuss the applications of TCMIP for the improvement of TCM quality control,clarification of the molecular mechanisms underlying the actions of TCMs and discovery of potential new drugs,especially TCM-related combination drug disco very.

关键词： Integrative pharmacology-based traditional Chinese medicine PK-PD correlations Big data Mathematical modeling Multidimensional association network

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论基于群体动力学理论的广西高校硕士研究生导师组制的优化

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河池学院学报 2022年第1期42卷 40-47页

作者：王巨光张罗琦黄淮广西大学公共管理学院广西南宁530004

实施硕士研究生导师组制是提高硕士研究生培养质量、为社会发展提供所需高层次人才的重要途径。文章运用群体动力学理论,通过对广西高校硕士研究生导师组制的运行现状进行研究,发现硕士研究生导师组存在不同程度的虚化现象、人才培养质... 详细信息

实施硕士研究生导师组制是提高硕士研究生培养质量、为社会发展提供所需高层次人才的重要途径。文章运用群体动力学理论,通过对广西高校硕士研究生导师组制的运行现状进行研究,发现硕士研究生导师组存在不同程度的虚化现象、人才培养质量不高等问题,并进行主要原因分析。进而以群体动力学理论所强调的三大群体动力,即驱动力、约束力、凝聚力为着力点,探讨广西高校硕士研究生导师组制如何优化及增强其实施效果,以不断全面提升硕士研究生人才培养质量。

关键词：群体动力学理论硕士研究生导师组制硕士研究生培养

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液相色谱-稳定同位素比值质谱法测定针叶樱桃粉中抗坏血酸的碳稳定同位素比值

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食品与发酵工业 2024年第2期50卷 283-287,295页

作者：王道兵冯迪曹翠峰钟其顶翟鹏贵武竹英岳红卫童玲张燚洪玉玲张红霞徐胜张洛琪国家市场监管技术创新中心(轻工消费品质质量安全) 北京100015 中轻技术创新中心有限公司北京100015 中国食品发酵工业研究院有限公司北京100015 养生堂药业有限公司海南海口570216 农夫山泉股份有限公司浙江杭州310024

该文建立液相色谱-稳定同位素比值质谱联用(liquid chromatography-stable isotope ratio mass spectrometry,LC-IRMS)检测抗坏血酸δ^(13)C值的分析方法,用于鉴别针叶樱桃粉中抗坏血酸天然来源的真实性。样品中抗坏血酸经液相色谱在线... 详细信息

该文建立液相色谱-稳定同位素比值质谱联用(liquid chromatography-stable isotope ratio mass spectrometry,LC-IRMS)检测抗坏血酸δ^(13)C值的分析方法,用于鉴别针叶樱桃粉中抗坏血酸天然来源的真实性。样品中抗坏血酸经液相色谱在线分离纯化,优化后色谱条件为:Syncronis C18(250 mm×4.6 mm,5μm)色谱柱,流动相为水-pH 2的硫酸溶液(90∶10,体积比),流速0.250 mL/min,色谱柱温度30℃,进样量10μL,通过LC-IsoLink实现目标物全部氧化为CO_(2)气体,最终以气态形式进入稳定同位素质谱仪,直接检测样品中抗坏血酸的δ^(13)C,该方法结果稳定、准确。分别测定了7个合成来源的维生素C片和19个针叶樱桃粉,结果表明,天然来源抗坏血酸δ^(13)C值为-25.00‰~-22.01‰,合成来源抗坏血酸δ^(13)C值为-11.74‰~-10.28‰,两者分布显著性差异,该方法可用于抗坏血酸产品标识的真实性鉴别研究。

关键词：针叶樱桃粉抗坏血酸液相色谱-稳定同位素比值质谱天然合成 δ^(13)C

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白酒大生产过程中乙醇稳定碳同位素变化特征研究

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食品与发酵工业 2023年第2期49卷 63-67页

作者：岳涛王道兵李安军姜利李国辉岳红卫张洛琪钟其顶安徽古井贡酒股份有限公司安徽亳州236820 国家市场监管技术创新中心(轻工消费品质量安全) 北京100015 中轻食品检验认证有限公司北京100015

为了研究白酒大生产过程中乙醇稳定碳同位素的变化特征及其在掺假检测领域的应用可行性,该文利用稳定同位素比值质谱仪(isotope ratio mass spectrometry,IRMS)对蒸酒过程、酒醅与基础酒和发酵过程中的乙醇δ^(13)C的变化规律进行了研究... 详细信息

为了研究白酒大生产过程中乙醇稳定碳同位素的变化特征及其在掺假检测领域的应用可行性,该文利用稳定同位素比值质谱仪(isotope ratio mass spectrometry,IRMS)对蒸酒过程、酒醅与基础酒和发酵过程中的乙醇δ^(13)C的变化规律进行了研究,并分析了基础酒和成品白酒的稳定性特征,结果表明,蒸酒过程中出现了反蒸气压分馏效应,会影响不同摘酒段的乙醇δ^(13)C,而酒醅与基础酒之间不存在显著差异,基础酒和成品白酒存在一定波动范围,但无显著性差异。该研究对下一步应用碳同位素技术进行白酒真实性保障和掺假检测提供数据支持。

关键词：白酒真实性掺假检测乙醇碳同位素

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Glucocorticoid receptor signaling in the brain and its involvement in cognitive function

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Neural Regeneration Research 2025年第9期20卷 2520-2537页

作者： Chonglin Su Taiqi Huang Meiyu zhang Yanyu zhang Yan Zeng Xingxing Chen Brain Science and Advanced Technology Institute Hubei Province Key Laboratory of Occupational Hazard Identification and ControlSchool of MedicineWuhan University of Science and TechnologyWuhanHubei ProvinceChina

The hypothalamic-pituitary-adrenal axis regulates the secretion of glucoco rticoids in response to environmental *** the brain,a nuclear receptor transcription fa ctor,the glucocorticoid recepto r,is an important component of the hypothalamicpituitary-a d renal axis's negative feedback loop and plays a key role in regulating cognitive equilibrium and *** glucoco rticoid receptor influences cognitive processes,including glutamate neurotransmission,calcium signaling,and the activation of brain-derived neurotrophic factor-mediated pathways,through a combination of genomic and non-genomic *** interactions within the central nervous system can alter the expression and activity of the glucocorticoid receptor,there by affecting the hypothalamic-pituitary-a d renal axis and stress-related cognitive *** appropriate level of glucocorticoid receptor expression can improve cognitive function,while excessive glucocorticoid receptors or long-term exposure to glucoco rticoids may lead to cognitive *** with cognitive impairment-associated diseases,such as Alzheimer's disease,aging,depression,Parkinson's disease,Huntington's disease,stroke,and addiction,often present with dysregulation of the hypothalamic-pituitary-adrenal axis and glucocorticoid receptor *** review provides a comprehensive overview of the functions of the glucoco rticoid receptor in the hypothalamic-pituitary-a d renal axis and cognitive *** emphasizes that appropriate glucocorticoid receptor signaling fa cilitates learning and memory,while its dysregulation can lead to cognitive *** provides clues about how glucocorticoid receptor signaling can be targeted to ove rcome cognitive disability-related disorders.

关键词： brain-derived neurotrophic factor calcium signaling glucocorticoid receptor glucocorticoid glutamate transmission hypothalamic-pituitary-adrenal axis long-term potentiation neurocognitive disorders neuroplasticity stress

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Dielectric-ion-conductive ZnNb2O6 layer enabling rapid desolvation and diffusion for dendrite-free Zn metal batteries

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Journal of Energy Chemistry 2025年第1期100卷 693-701页

作者： Haifeng Yang Jian Wang Panpan zhang Xiaomin Cheng Qinghua Guan Jing Dong Bixian Chen Lujie Jia Jing zhang Yongzheng zhang Yunjian Liu Hongzhen Lin School of Materials Science and Engineering Jiangsu University i-Lab & CAS Key Laboratory of Nanophotonic Materials and Devices Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of Sciences Helmholtz Institute Ulm (HIU) Karlsruhe Institute of Technology (KIT) School of Materials Science and Engineering Xi'an University of Technology State Key Laboratory of Chemical Engineering East China University of Science and Technology

Rechargeable aqueous zinc-metal batteries （AZMBs） are promising candidates for large-scale energy storage systems due to their low cost and high ***,their performance and sustainability are significantly hindered by the sluggish desolvation kinetics at the electrode/electrolyte interface and the corresponding hydrogen evolution reaction where active water molecules tightly participate in the Zn（H2O）62+solvation ***,learnt from self-generated solid electrolyte interphase （SEI） in anodes,the dielectric but ion-conductive zinc niobate nanoparticles artificial layer is constructed on metallic Zn surface （ZNB@Zn）,acting as a rapid desolvation *** zincophilic and dielectric-conductive properties of ZNB layer accelerate interfacial desolvation/diffusion and suppress surface corrosion or dendrite formation,achieving uniform Zn plating/stripping behavior,as confirmed by electronic/optical microscopies and interface spectroscopical measurements together with theoretical ***,the as-prepared ZNB@Zn electrode exhibits excellent cycling stability of over 2000 h and robust reversibility （99.54%） even under high current density and depth of discharge ***,the assembled ZNB@Zn-based full cell displays high capacity-retention rate of 80.21%after 3000 cycles at 5 A g-1and outstanding rate performance up to 10 A *** large-areal pouch cell is stabilized for hundreds of cycles,highlighting the bright prospects of the dielectric but ion-conductive layer in further application of AZMBs.

关键词： Zn metal battery Dielectric artificial layer Rapid ion diffusion Zincophilic diffusion Active water inhibition

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Synergistically enhanced ORR and HER performance on Co-N-C coupled in-situ generated PtCo intermetallic

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Journal of Energy Chemistry 2025年第1期100卷 721-729页

作者： Guanyu Luo Min Song Lulu An Xiao Huang Qian zhang Chenhao zhang Tao Shen Shuang Wang Deli Wang Key Laboratory of Material Chemistry for Energy Conversion and Storage (Huazhong University of Science and Technology) Ministry of Education School of Chemistry and Chemical Engineering Huazhong University of Science and Technology

Integrating multi-scale sites in a composite catalyst is vital to realize efficient ***,a synergistic composite catalyst consisting of Co atomic sites and in-situ generated PtCo intermetallic compounds （IMCs）(o-PtCo@CoNC) is proposed through Co pre-anchoring and subsequent impregnation-reduction *** loading of Co atoms provides a chance for in-situ generating PtCo ordered intermetallic *** remaining Co single atoms and PtCo IMCs construct synergistic electrocatalytic *** from the ordered structure,synergistic effect of Pt Co IMCs and Co single atoms,o-PtCo@CoNC exhibits excellent electrocatalytic performance for oxygen reduction reaction （ORR） and hydrogen evolution reaction （HER） with mass activity of 1.21 A mgPt-1（at 0.9 V） and5.70 A mgPt-1（at an overpotential of 100 mV）,***,o-PtCo@CoNC delivers negligible loss of half-wave potential and overpotential during long-term stability test in acid solutions,with 13 mV decay after 50,000 potential cycles for ORR and a 2.7 mV decay after 20,000 potential cycles for *** integration strategy of single-atomic sites coupled IMCs paves the way for enhancing the activity and durability of Pt-based electrocatalysts.

关键词： Electrolytic reduction

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Satellite remote sensing reveals overwhelming recovery of forest from disturbances in Asia

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 46-51页

作者： Yiying Zhu Hesong Wang Anzhi zhang School of Ecology and Nature Conservation Beijing Forestry UniversityBeijingChina Key Laboratory of Regional Climate and Environment for Temperate East Asia Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina College of Forestry and Landscape Architecture Xinjiang Agricultural UniversityUrumqiChina

Forest ecosystems play key roles in mitigating human-induced climate change through enhanced carbon uptake;however,frequently occurring climate extremes and human activities have considerably threatened the stability of *** the same time,detailed accounts of disturbances and forest responses are not yet well quantified in *** study employed the Breaks For Additive Seasonal and Trend method-an abrupt-change detection method-to analyze the Enhanced Vegetation Index time series in East Asia,South Asia,and Southeast *** approach allowed us to detect forest disturbance and quantify the resilience after *** showed that 20%of forests experienced disturbance with an increasing trend from 2000 to 2022,and Southeast Asian countries were more severely affected by ***,95%of forests had robust resilience and could recover from disturbance within a few *** resilience of forests suffering from greater magnitude of disturbance tended to be stronger than forests with lower disturbance *** summary,this study investigated the resilience of forests across the low and middle latitudes of Asia over the past two *** authors found that most forests exhibited good resilience after disturbance and about two-thirds had recovered to a better state in *** findings of this study underscore the complex relationship between disturbance and resilience,contributing to comprehension of forest resilience through satellite remote sensing.

关键词： Forest ecosystem Enhanced vegetation index Breaks for additive seasonal and trend method Disturbance Resilience

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液相色谱-稳定同位素比值质谱测定燕窝中唾液酸的碳稳定同位素比值

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食品与发酵工业 2023年第11期49卷 267-272页

作者：冯迪王道兵王东亮钟其顶武竹英岳红卫张洛琪林小仙苗树陈楠楠国家市场监管技术创新中心(轻工消费品质质量安全) 北京100015 中国食品发酵工业研究院有限公司北京100015 中轻技术创新中心有限公司北京100015 北京小仙炖生物科技有限公司北京100020 河北省燕窝鲜炖技术创新中心河北廊坊065700 食品工业推广中心北京100015

该文建立了适合液相色谱-稳定同位素比值质谱(liquid chromatography-stable isotope ratio mass spectrometry,LC-IRMS)测定干燕窝中唾液酸δ^(13)C值的方法。样品前处理方法加标回收率为75.2%~100.6%,前处理方法可显著降低蛋白质等大... 详细信息

该文建立了适合液相色谱-稳定同位素比值质谱(liquid chromatography-stable isotope ratio mass spectrometry,LC-IRMS)测定干燕窝中唾液酸δ^(13)C值的方法。样品前处理方法加标回收率为75.2%~100.6%,前处理方法可显著降低蛋白质等大分子对色谱柱的影响且不会干扰碳稳定同位素的准确分析;研究并优化了LC-IRMS对唾液酸δ^(13)C值测定的影响,优化后的色谱条件:采用Hyper REZ XP Carbohydrate H+(300 mm×7.7 mm,8μm)柱,柱温30℃,在0.250 mL/min流速下用90%B(H_(2)O)+10%D(pH_(2)的H_(2)SO_(4))洗脱。方法稳定性、重复性均良好,可准确测定样品δ^(13)C值。对6个干燕窝样品和4个市售唾液酸进行测定,其唾液酸δ^(13)C值分别为(-29.55±0.39)‰和(-15.18±2.45)‰,2种不同来源唾液酸碳稳定同位素特征显著。可检测到燕窝中的非法掺入市售唾液酸比例最低为10%。该方法的建立可为后续鉴别燕窝制品外源添加唾液酸提供基础。

关键词：液相色谱-稳定同位素比值质谱燕窝唾液酸前处理 δ^(13)C

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Preparation of silver nanoparticles through the reduction of straw-extracted lignin and its antibacterial hydrogel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 504-514页

作者： Lou zhang Shuo Li Fu Tang Jingkai zhang Yuetong Kang Hean zhang Lidong Li State Key Laboratory for Advanced Metals and Materials School of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083China

Silver nanoparticles(Ag NPs)have attracted attention in the field of biomaterials due to their excellent antibacterial ***,the reducing and stabilizing agents used for the chemical reduction of Ag NPs are usually toxic and may cause water *** this work,Ag NPs(31.2 nm in diameter)were prepared using the extract of straw,an agricultural waste,as the reducing and stabilizing *** analysis revealed that the straw extract contained lignin,the structure of which possesses phenolic hydroxyl and methoxy groups that facilitate the reduction of silver salts into Ag *** surfaces of Ag NPs were negatively charged due to the encapsulation of a thin layer of lignin molecules that prevented their *** the prepared Ag NPs were added to the precursor solution of acrylamide,free radical polymerization was triggered without the need for extra heating or light irradiation,resulting in the rapid formation of an Ag NP-polyacrylamide composite *** inhibition zone test proved that the composite hydrogel possessed excellent antibacterial ability due to the presence of Ag *** prepared hydrogel may have potential applications in the fabrication of biomedical materials,such as antibacterial dressings.

关键词： silver nanoparticles hydrogel straw extraction antibacterial

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