A comprehensive review of integrative pharmacology-based investigation:A paradigm shift in traditional Chinese medicine

作     者：Haiyu Xu Yanqiong Zhang Ping Wang Junhong Zhang Hong Chen Luoqi Zhang Xia Du Chunhui Zhao Dan Wu Feng Liu Hongjun Yang Changxiao Liu Haiyu Xu;Yanqiong Zhang;Ping Wang;Junhong Zhang;Hong Chen;Luoqi Zhang;Xia Du;Chunhui Zhao;Dan Wu;Feng Liu;Hongjun Yang;Changxiao Liu

作者机构：Institute of Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijing 100700China Shaanxi Institute of International Trade&CommerceXianyang 7120462China State Key Laboratory of Drug Delivery Technology and PharmacokineticsTianjin Institute of Pharmaceutical ResearchTianjin 300193China 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2021年第11卷第6期

页      面：1379-1399页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1001[医学-基础医学(可授医学、理学学位)] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by grants from the National Natural Science Foundation of China (Grant Nos. 81830111 and 81774201) National Key Research and Development Program of China (2017YFC1702104 and 2017YFC1702303) the Youth Innovation Team of Shaanxi Universities and Shaanxi Provincial Science and Technology Department Project (No. 2016SF-378, China) the Fundamental Research Funds for the Central public Welfare Research Institutes (ZXKT17058, China) the National Science and Technology Major Project of China (2019ZX09201005-001-003) 

主　　题：Integrative pharmacology-based traditional Chinese medicine PK-PD correlations Big data Mathematical modeling Multidimensional association network 

摘      要：Over the past decade,traditional Chinese medicine(TCM) has widely embraced systems biology and its various data integration approaches to promote its ***,integrative pharmacology-based traditional Chinese medicine(TCMIP) was proposed as a paradigm shift in *** review focuses on the presentation of this novel concept and the main research contents,methodologies and applications of ***,TCMIP is an interdisciplinary science that can establish qualitative and quantitative pharmacokinetics-pharmacodynamics(PK-PD) correlations through the integration of knowledge from multiple disciplines and techniques and from different PK-PD processes in ***,the main research contents of TCMIP are introduced as follows:chemical and ADME/PK profiles of TCM formulas;confirming the three forms of active substances and the three action modes;establishing the qualitative PK-PD correlation;and building the quantitative PK-PD correlations,*** that,we summarize the existing data resources,computational models and experimental methods of TCMIP and highlight the urgent establishment of mathematical modeling and experimental ***,we further discuss the applications of TCMIP for the improvement of TCM quality control,clarification of the molecular mechanisms underlying the actions of TCMs and discovery of potential new drugs,especially TCM-related combination drug disco very.