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In vitro differentiation capacity of human breastmilk stem cells:A systematic review

World Journal of Stem Cells 2019年第11期11卷 1005-1019页

作者： Camila Maria Ribeiro Pacheco Priscila Elias Ferreira Claudia Sayuri Sacaki Luana Alves Tannous Idiberto Jose Zotarelli-Filho luiz cesar guarita-souza Katherine Athayde Teixeira de Carvalho Cell Therapy and Biotechnology in Regenerative Medicine Department Pele Pequeno Príncipe InstituteChild and Adolescent Health Research and Pequeno Príncipe FacultyCuritiba 80.240-020ParanáBrazil PUCPR-Institute of Biological and Health Sciences CCBSCuritiba 80.215-901ParanáBrazil Post Graduate and Continuing Education(Unipos) Department of Scientific ProductionSao Jose do Rio Preto 15.020-040Sao PauloBrazil

BACKGROUND Mesenchymal stem cells are pluripotent cells that have the ability to generate cells from a cell line or in other cell types from different tissues but from the same *** those cells have more limited differentiation capacity than embryonic stem cells,they are easily obtained from somatic tissue and can be grown in large *** characteristic of undifferentiated stem cells differentiating into different cell lines arouses strategies in regenerative medicine for the treatment of different diseases such as neurodegenerative *** To evaluate the cell differentiation capacity of human breastmilk stem cells for the three germ layers by a systematic *** The searched databases were PubMed,EMBASE,OVID,and COCHRANE LIBRARY,published between 2007 and 2018 in the English *** were in vitro studies for analysis of the"cell differentiation potential"in the literature using the keywords“human breastmilk,”“stem cells,”and keywords combined with the Boolean operator“NOT”were used to exclude those articles that had the word“CANCER”and their respective synonyms,which were previously consulted according to medical subject heading *** 2009 guidelines were followed in this *** A total of 315 titles and abstracts of articles were *** these,21 were in common with more than one database,leaving 294 articles for *** that total,five publications met the inclusion *** analyzing the publications,it was demonstrated that human breastmilk stem cells have a high cellular plasticity,exhibiting the ability to generate cells of all three germ layers,endoderm,mesoderm,and ectoderm,demonstrating their *** cells expressed the genes,TRA-1-60/81,octamer-binding transcription factor 4,and NANOG,of which NANOG,a critical regulator for self-renewal and maintenance,was the most highly *** cells have the ability to differentiate in vitro into adipocytes,chondrocytes,osteocytes,oligod

关键词： Human breastmilk Stem cells Cell differentiation Pluripotency Stemness

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Physical Exercise and Gene p53—A Mini Review

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Journal of Cancer Therapy 2020年第8期11卷 463-469页

作者： Tayane Horstmann Cabral Ana luiza Lozinski Gabriel Massao Tanaka Marco André Cardoso Rossana Baggio Simeoni Péricles Varella Gomes Zair Candido Oliveira Netto luiz cesar guarita-souza Julio cesar Francisco Ricardo Correa Cunha School of Health Sciences Positivo University Curitiba Brazil School of Medical Sciences Pontifical Catholic University of Paraná Curitiba Brazil School of Medical Sciences Pontifical Catholic University of Paraná Curitiba Brazil GEL LAB Michigan State University East Lansing East Lansing USA

Cancer is a global problem that in addition to physical, emotional and physiological causes economic and social impacts. The p53 gene is a tumor suppressor gene found in many malignant and benign tumors;this has the primary function of keeping cells at rest after damaging to DNA. The p53 acts in the maintenance of cellular homeostasis, mainly through autophagy, playing a role in cell cycle arrest, when necessary, thus avoiding mutated DNA replication. When in the oncogenic environment in many cases it is mutated, losing much of its efficiency allowing tumor development. Studies show that exercise can in the regular part of its pro-autophagic function even in the oncology setting. Stimuli of moderate-intensity aerobic and predominance of submaximal seem to trigger the protective function of p53 in various cancer settings. Among the many changes that these pathology triggers were the objective of this mini review is to relate the changes that exercise generates in p53 protein functions and their possible influence on tumor cells.

关键词： p53 Physical Exercise Gene Mutations Autophagy

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Amniotic membrane as a potent source of stem cells and a matrix for engineering heart tissue

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Journal of Biomedical Science and Engineering 2013年第12期6卷 1178-1185页

作者： Julio cesar Francisco Ricardo Correa Cunha Rossana Baggio Simeoni luiz cesar guarita-souza Reginaldo Justino Ferreira Ana Carolina Irioda Carolina Maria C.Oliveira souza Garikipati Venkata Naga Srikanth Soniya Nityanand Juan Carlos Chachques Katherine Athayde Teixeira de Carvalho Bioprocess Engineering and Biotechnology Department Federal University of ParanáCuritibaBrazil Cell Therapy and Biotechnology in Regenerative Medicine Research Group Pele Pequeno Príncipe InstituteCuritibaBrazil Experimental Laboratory of Institute of Biological and Health Sciences Pontificial Catholic University of Paraná(PUCPR)Rua Imaculada ConceicaoCuritibaBrazil Federal University of Technology CuritibaBrazil Department of Hematology Stem Cell Research FacultySanjay Gandhi Post-Graduate Institute of Medical SciencesLucknowIndia Laboratory of Biosurgical Research Pompidou HospitalUniversity of Paris DescartesParisFrance

Existing therapies for the treatment of chronic heart failure still have some limitations and there is a pressing need for the development of new therapeutic modalities. The amniotic membrane has been used for the treatment of various diseases, such as conjunctive defects;however, the mechanisms behind its repair functions are still unclear. Regenerative medicine is seeking newer alternatives and among them, biomaterials have emerged in recent years for developing and manipulating molecules, cells, tissues or organs grown in laboratories in order to replace human body parts. Many such materials have been used for this purpose, either synthetically or biologically, in order to provide new medical devices. This review provides a wider view of the regeneration potential of the use of amniotic membrane as a potential biomaterial to facilitate the implementation of new research in surgical procedures. Amniotic membrane appears to be an alternative source of stem cells as well as an excellent biomaterial for cell-based therapeutic applications in engineering heart tissue.

关键词： Amniotic Membrane Heart Tissue Engineering Stem Cells

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Acellular Amniotic Membrane Patch Regeneration for Burn Injury: The Future for Wound Healing

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Journal of Biomedical Science and Engineering 2019年第8期12卷 409-413页

作者： Tayná Dias Kalyane Machado Kátia Renata Antunes Kochla Ricardo Cunha Marco André Cardoso Rossana Baggio Simeoni Vinicius Coneglian Santos Péricles Varella Gomes luiz Claudio Sobrinho do Nascimento Maria Elisa Brum do Nascimento luiz cesar guarita-souza Alessandro Brawerman Julio cesar Francisco School of Health Sciences Positivo University Curitiba Brazil School of Medical Sciences Pontifical Catholic University of Paraná Curitiba Brazil The Paraná Institute of Technology Curitiba Brazil Gel Lab Michigan State University East Lansing USA

Acellular amniotic membrane (AAM) is a biodegradable and biocompatible natural that has a wide range of applications in the field of pharmaceutics, biomedical, chemical and cosmetics industry. One of the most interesting characteristics of AAM is its antibacterial and anti-inflammatory, anti-angiogenic, anti-fibrosis activity is an attractive approach for treating inflammatory disorders, wounds, and burns. The isolated use of AAM may not be sufficient to produce an adequate anti-inflammatory and antimicrobial effect to fulfill different purposes, has attracted considerable attention that has similar properties to the native tissues. This mini-review offers a focuses on modern aspects of the biomaterials, growth factors, biocompatibility, and acellular matrix which are the basic elements for use in the tissue regeneration and replacement after an injury.

关键词： Skin Regeneration Amniotic Membrane Wound Healing Tissue Engineering

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The Impact of Fibromyalgia on Daily Women: A Contribution to Nursing Assistants

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Journal of Biomedical Science and Engineering 2019年第3期12卷 197-200页

作者： Gabriela Carneiro Ana Paola Geronasso Maria Elisa Brum do Nascimento luiz Claudio Sobrinho do Nascimento Denise Faucz Kletemberg Giovanna Batista Leite Veloso Ricardo C. Cunha luiz cesar guarita-souza Rossana B. Simeoni Julio C. Francisco Kátia Renata Antunes Kochla School of Nursing & Health Studies Positivo University Curitiba Brazil School of Medical Sciences Pontifical Catholic University of Paraná Curitiba Brazil The Paraná Institute of Technology Curitiba Brazil

Objective: To evaluate the impact of fibromyalgia in daily and associated factors in women treated at the polyclinic in Paraná. Method: A descriptive, cross-sectional study was conducted with individualized data for 52 women ≥ 50 years from the policlinic of the Curitiba of Paraná State, Brazil. Data were collected an online survey and the quality of life was assessed by one specific instrument, the Fibromyalgia Impact Questionnaire (FIQ). Verbal or written informed consent was obtained from all participants. Results: A total of 157 patients completed the survey. The average age was approximately 50 years (range 29 - 77 years). The most frequent comorbidities were depression (61.5%) and (19%) arthrosis. Conclusion: The understanding of the commodities associated with fibromyalgia helps health professionals to reach the patient efficiently in their orientations about nursing care in women with fibromyalgia.

关键词： Fibromyalgia Depression Nursing Pain Quality of Life

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Preclinical stem cell therapy in Chagas Disease: Perspectives for future research

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World Journal of Transplantation 2013年第4期3卷 119-126页

作者： Katherine Athayde Teixeira de Carvalho Eltyeb Abdelwahid Reginaldo Justino Ferreira Ana Carolina Irioda luiz cesar guarita-souza Cell Therapy and Biotechnology in Regenerative Medicine Research Group Pequeno Príncipe FacultyPelé Pequeno Príncipe InstituteCuritiba 80250-200ParanáBrazil Bioprocess Engineering and Biotechnology Department Federal University of ParanáCuritiba 81531-970ParanáBrazil CBRC Massachusetts General Hospital/Harvard Medical SchoolCharlestownMa 02129United States Federal University of Technology Curitiba 80230-901ParanáBrazil Experimental Laboratory of Institute of Biological and Health Sciences of Pontifical Catholic University of Parana Curitiba 80215-901ParanáBrazil

Chagas cardiomyopathy still remains a challenging problem that is responsible for high morbidity and mortality in Central and Latin America. Chagas disease disrupts blood microcirculation via various autoimmune mechanisms, causing loss of cardiomyocytes and severe impairment of heart function. Different cell types and delivery approaches in Chagas Disease have been studied in both preclinical models and clinical trials. The main objective of this article is to clarify the reasons why the benefits that have been seen with cell therapy in preclinical models fail to translate to the clinical setting. This can be explained by crucial differences between the cellular types and pathophysiological mechanisms of the disease, as well as the differences between human patients and animal models. We discuss examples that demonstrate how the results from preclinical trials might have overestimated the efficacy of myocardial regeneration therapies. Future research should focus, not only on studying the best cell type to use but, very importantly, understanding the levels of safety and cellular interaction that can elicit efficient therapeutic effects in human tissue. Addressing the challenges associated with future research may ensure the success of stem cell therapy in improving preclinical models and the treatment of Chagas disease.

关键词： Chagas Disease preclinical stem cell therapy co-cultured translation pathophysiologie myoblasts

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Antibiofilm and immunomodulatory resorbable nanofibrous filing for dental pulp regenerative procedures

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Bioactive Materials 2022年第10期7卷 173-186页

作者： Mauricio Gonçalves da Costa Sousa Gabriela Conceiçao de Almeida Danilo cesar Martins Mota Rosiane Andrade da Costa Simoni Campos Dias Samuel Nunes Limberger Frank Ko Li Ting Lin Evan FHaney Hashem Etayash Beverlie Baquir Michael J.Trimble Ya Shen Zheng Su Markus Haapasalo Daniel Pletzer Letícia Chaves de souza Glaucia Schuindt Teixeira Renato M.Silva Robert E.W.Hancock Octavio luiz Franco Taia Maria Berto Rezende Post-Graduation Program in Genomic Sciences and Biotechnology Catholic University of BrasíliaBrasíliaBrazil Dentistry Course Catholic University of BrasíliaBrasíliaBrazil Post-Graduation Program in Health Sciences University of BrasíliaBrazil LIMA Chemistry InstituteUniversity of Brasília-UNBBrasíliaBrazil Animal Biology Department Campus Darcy RibeiroUniversidade de BrasíliaBrazil Department of Materials Engineering Faculty of Applied ScienceUniversity of British ColumbiaVancouverCanada Department of Microbiology and Immunology University of British ColumbiaVancouverBCCanada Department of Oral Biological and Medical Sciences Faculty of DentistryUniversity of British ColumbiaVancouverCanada Department of Microbiology and Immunology University of OtagoDunedinNew Zealand Department of Endodontics School of DentistryUniversity of Texas Health Science Center at HoustonHoustonUSA Department of Prosthesis Faculty of DentistryRio de Janeiro State UniversityRio de JaneiroBrazil Post-Graduation Program in Biotechnology Catholic University Dom BoscoCampo GrandeMato Grosso do SulBrazil

Multifunctional scaffolds with host defense peptides designed for regenerative endodontics are desirable nanobiotechnological tools for ***,different scaffolds were tested for use during the pulp revascularization process,including poly(vinyl alcohol)-PVA hydrogels or resins,collagen hydrogels and poly(vinyl alcohol)PVA/Chitosan(PVA/CS)*** on time to degradation(21 days),nanofibers were chosen to be incorporated with ciprofloxacin and IDR-1002(each at 50 mg/g).Nanofibers containing ciprofloxacin and IDR-1002 had anti-biofilm activity against Enterococcus faecalis,Staphylococcus aureus and a multispecies oral biofilm,besides anti-inflammatory *** in vivo subcutaneous tissue response to tooth fragments filled with nanofibers demonstrated a pulp-like tissue formation,when compared to empty teeth ***,we designed a strong antimicrobial,immunomodulatory and regenerative candidate for pulp revascularization and regeneration procedures.

关键词： Regenerative endodontics Scaffolds Nanofibers Host defense peptides Ciprofloxacin IDR-1002

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Economic Feasibility of Canola Production in the Region of Campos Gerais, Paraná, Brazil

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American Journal of Plant Sciences 2018年第5期9卷 958-965页

作者： Eriton luiz Mainardes luiz Cláudio Garcia Pedro Henrique Weirich Neto Carlos Hugo Rocha Thiago Inagaki Natali Maidl de souza Guilherme Pedrollo Mazer Jaime Alberti Gomes Ivan cesar Furmann Moura éverson Pedro Zeny State University of Ponta Grossa Campus Uvaranas Ponta Grossa Brasil

This study aimed to analyze the economic feasibility of canola production (Brassica napus var oleifera) for the region Campos Gerais-PR. We interviewed eight producers, and used information from four of them for economic analysis of agricultural crops in 2012, 2013 and 2014. The variables analyzed were: grain production cost, economical analysis (hurdle rate, net present value, internal rate of return, payback, lucratively index, profitability index and sensitivity analysis) and vegetable oil production costs. We compared the performance of canola, wheat (Triticum aestivum)—as the main crop in the autumn/winter—and soybean (Glycine max)—by liquidity in the world market. It was concluded that although the economic analysis indicates superior results of canola production compared to the wheat crop and vegetable oil production is more attractive financially than soybean, but the culture of canola is still insignificant in the region of Campos Gerais (PR). The producers interviewed pointed to limit the expansion of culture financing the limited farming, production technology in consolidation, the need for machine adjustments and canola be host of the white mold disease (Sclerotinia sclerotiorun).

关键词： Brassica napus Production Systems Profitability

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Benefit of stem cells and skeletal myoblast cells in dilated cardiomyopathies

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World Journal of Cardiology 2011年第3期3卷 93-97页

作者： luiz César guarita-souza Júlio César Francisco Rossana Simeoni Jose Rocha Faria-Neto Katherine Athayde Teixeira de Carvalho Department of Post Graduation Surgery Pontifical Catholic University of Parana The PeléPequeno Príncipe Institute Child and Adolescent Health Research and Pequeno Príncipe Faculty

Although some authors suggest that there is mitotic division in the heart,most cardiomyocytes do not have the capacity to regenerate after myocardial infarction and when this occurs there is a deterioration of contractile function,and if the area of infarction is extensive ventricular remodeling may occur,leading to the development of heart *** transplantation into the myocardium with the goal of recovery of cardiac function has been extensively studied in recent years. The effects of cell therapy are based directly on the cell type used and the type of cardiac *** myocardial ischemia in the hibernating myocardium, bone marrow cells have functional benefits,however these results in transmural fibrosis are not evident. In these cases there is a benefit of implantation with skeletal myoblasts,for treating the underlying cause of disease,the loss of cell contractility.

关键词： Cell transplantation Cardiomyopathy Skeletal myoblasts Stem cells

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Phase Ⅰ of cardiac rehabilitation:A new challenge for evidence based physiotherapy

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World Journal of Cardiology 2011年第7期3卷 248-255页

作者： Rafael Michel de Macedo JoséRocha Faria-Neto Costantino Ortiz Costantini Dayane Casali Andrea Pires Muller Costantino Roberto Costantini Katherine Athayde Teixeira de Carvalho luiz César guarita-souza Department of Rehabilitation Costantini Cardiological HospitalCuritiba80320-320Brazil Graduate Program in Health Sciences Catholic Pontificia University of ParanáCuritiba80215-901Brazil Graduate Program in Biotechnology Applied to Health Pequeno Príncipe FacultyCuritiba80230-020Brazil

Cardiac rehabilitation protocols applied during the inhospital phase(phaseⅠ)are subjective and their results are contested when evaluated considering what should be the three basic principles of exercise prescription:specificity,overload and *** this review,we focus on the problems associated with the models of exercise prescription applied at this early stage in-hospital and adopted today,especially the lack of clinical studies demonstrating its ***,we present the concept of"periodization"as a useful tool in the search for better results.

关键词： Cardiac rehabilitation Exercise physiology Physical therapy

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