In vitro differentiation capacity of human breastmilk stem cells:A systematic review

作     者：Camila Maria Ribeiro Pacheco Priscila Elias Ferreira Claudia Sayuri Sacaki Luana Alves Tannous Idiberto Jose Zotarelli-Filho Luiz Cesar Guarita-Souza Katherine Athayde Teixeira de Carvalho 

作者机构：Cell Therapy and Biotechnology in Regenerative Medicine DepartmentPele Pequeno Príncipe InstituteChild and Adolescent Health Research and Pequeno Príncipe FacultyCuritiba 80.240-020ParanáBrazil PUCPR-Institute of Biological and Health SciencesCCBSCuritiba 80.215-901ParanáBrazil Post Graduate and Continuing Education(Unipos)Department of Scientific ProductionSao Jose do Rio Preto 15.020-040Sao PauloBrazil 

出 版 物：《World Journal of Stem Cells》 (世界干细胞杂志（英文版）（电子版）)

年 卷 期：2019年第11卷第11期

页      面：1005-1019页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by Araucária Foundation(ParanáState-Brazil) the Coordination for the Improvement of Higher Education Personnel-Brazil(Capes),Financial code 001 

主　　题：Human breastmilk Stem cells Cell differentiation Pluripotency Stemness 

摘      要：BACKGROUND Mesenchymal stem cells are pluripotent cells that have the ability to generate cells from a cell line or in other cell types from different tissues but from the same *** those cells have more limited differentiation capacity than embryonic stem cells,they are easily obtained from somatic tissue and can be grown in large *** characteristic of undifferentiated stem cells differentiating into different cell lines arouses strategies in regenerative medicine for the treatment of different diseases such as neurodegenerative *** To evaluate the cell differentiation capacity of human breastmilk stem cells for the three germ layers by a systematic *** The searched databases were PubMed,EMBASE,OVID,and COCHRANE LIBRARY,published between 2007 and 2018 in the English *** were in vitro studies for analysis of thecell differentiation potentialin the literature using the keywords“human breastmilk,“stem cells,and keywords combined with the Boolean operator“NOTwere used to exclude those articles that had the word“CANCERand their respective synonyms,which were previously consulted according to medical subject heading *** 2009 guidelines were followed in this *** A total of 315 titles and abstracts of articles were *** these,21 were in common with more than one database,leaving 294 articles for *** that total,five publications met the inclusion *** analyzing the publications,it was demonstrated that human breastmilk stem cells have a high cellular plasticity,exhibiting the ability to generate cells of all three germ layers,endoderm,mesoderm,and ectoderm,demonstrating their *** cells expressed the genes,TRA-1-60/81,octamer-binding transcription factor 4,and NANOG,of which NANOG,a critical regulator for self-renewal and maintenance,was the most highly *** cells have the ability to differentiate in vitro into adipocytes,chondrocytes,osteocytes,oligod