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Benefit of stem cells and skeletal myoblast cells in dilated cardiomyopathies

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World Journal of cardiology 2011年第3期3卷 93-97页

作者： luiz césar guarita-souza Júlio césar Francisco Rossana Simeoni Jose Rocha Faria-Neto Katherine Athayde Teixeira de carvalho Department of Post Graduation Surgery Pontifical Catholic University of Parana The PeléPequeno Príncipe Institute Child and Adolescent Health Research and Pequeno Príncipe Faculty

Although some authors suggest that there is mitotic division in the heart,most cardiomyocytes do not have the capacity to regenerate after myocardial infarction and when this occurs there is a deterioration of contractile function,and if the area of infarction is extensive ventricular remodeling may occur,leading to the development of heart *** transplantation into the myocardium with the goal of recovery of cardiac function has been extensively studied in recent years. The effects of cell therapy are based directly on the cell type used and the type of cardiac *** myocardial ischemia in the hibernating myocardium, bone marrow cells have functional benefits,however these results in transmural fibrosis are not evident. In these cases there is a benefit of implantation with skeletal myoblasts,for treating the underlying cause of disease,the loss of cell contractility.

关键词： cell transplantation cardiomyopathy Skeletal myoblasts Stem cells

MicroRNAs in inflammatory bowel disease:What do we know and what can we expect?

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World Journal of Gastroenterology 2024年第16期30卷 2184-2190页

作者： Ellen cristina souza de Oliveira Ana Elisa Valencise Quaglio Thais Gagno Grillo luiz claudio Di Stasi Ligia Yukie Sassaki Department of Internal Medicine Medical SchoolSão Paulo State University(Unesp)Botucatu 18618-686São PauloBrazil Verum Ingredients Botucatu Technology ParkBotucatu 18605-525São PauloBrazil Department of Biophysics and Pharmacology Institute of BiosciencesSão Paulo State University(Unesp)Botucatu 18618-689São PauloBrazil

MicroRNAs(miRNAs),small non-coding RNAs composed of 18–24 nucleotides,are potent regulators of gene expression,contributing to the regulation of more than 30%of protein-coding *** that miRNAs are regulators of inflammatory pathways and the differentiation of intestinal epithelial cells,there is an interest in exploring their importance in inflammatory bowel disease(IBD).IBD is a chronic and multifactorial disease of the gastrointestinal tract;the main forms are crohn's disease and ulcerative *** studies have investigated the dysregulated expression of miRNAs in IBD,demonstrating their important roles as regulators and potential biomarkers of this *** editorial presents what is known and what is expected regarding miRNAs in *** the important regulatory roles of miRNAs in IBD are clearly established,biomarkers for IBD that can be applied in clinical practice are lacking,emphasizing the importance of further *** regarding the influence of miRNAs on the inflammatory process and the exploration of their role in gene regulation are expected to provide a basis for the use of miRNAs not only as potent biomarkers in IBD but also as therapeutic targets for the control of inflammatory processes in personalized medicine.

关键词： MicroRNAs Inflammatory bowel disease crohn’s disease Ulcerative colitis Biomarker Therapy

Phase Ⅰ of cardiac rehabilitation:A new challenge for evidence based physiotherapy

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World Journal of cardiology 2011年第7期3卷 248-255页

作者： Rafael Michel de Macedo JoséRocha Faria-Neto costantino Ortiz costantini Dayane casali Andrea Pires Muller costantino Roberto costantini Katherine Athayde Teixeira de carvalho luiz césar guarita-souza Department of Rehabilitation Costantini Cardiological HospitalCuritiba80320-320Brazil Graduate Program in Health Sciences Catholic Pontificia University of ParanáCuritiba80215-901Brazil Graduate Program in Biotechnology Applied to Health Pequeno Príncipe FacultyCuritiba80230-020Brazil

cardiac rehabilitation protocols applied during the inhospital phase(phaseⅠ)are subjective and their results are contested when evaluated considering what should be the three basic principles of exercise prescription:specificity,overload and *** this review,we focus on the problems associated with the models of exercise prescription applied at this early stage in-hospital and adopted today,especially the lack of clinical studies demonstrating its ***,we present the concept of"periodization"as a useful tool in the search for better results.

关键词： cardiac rehabilitation Exercise physiology Physical therapy

A remote sensing approach to estimate the load bearing capacity of soil

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Information Processing in Agriculture 2024年第1期11卷 109-116页

作者： Italo Rômulo Mendes de souza Edson Eyji Sano Renato Paiva de Lima Anderson Rodrigo da Silva Statistics and Geoprocessing Laboratory Instituto Federal GoianoGeraldo Silva Nascimento RoadKm 2.575790-000 UrutaíGoiásBrazil Embrapa cerrados BR-020 RoadKm 18Mailbox 0822373310-970 PlanaltinaDFBrazil Department of Soil Science ‘Luiz de Queiroz’College of AgricultureUniversity of São PauloAv.Pádua Dias235-AgronomiaPiracicabaSP 13418-900Brazil

Preconsolidation pressure(σp)of soil can be considered as an indicator of the Load Bearing capacity(LBc),which is the tolerated surface pressure before compaction,often caused by the traffic of agricultural *** this pioneering study,a remote sensing approach was introduced to estimate LBc throughσp from soils of the“Rio Preto”Hydrographic Basin,Bahia State,Brazil,in a monthly time lapse from 2016 to ***,σp is measured by a laborious and time demanding laboratory analysis,making it unfeasible to map large *** innovative methodology of this work consists of combining active–passive satellite data on soil moisture and pedotransfer functions of clay content and water matric potential to obtain geo-located estimates ofσ*** were analysed under different classes of soil use,land cover and slope;95%confidence intervals were built for the time series of mean values of LBc for each *** overall seasonal variation in LBc estimates is similar in areas with annual crops,grasslands and natural vegetation,and flat areas are less affected by soil moisture variations over the year(between seasons).LBc decreased,in general,at about 0.5%a year in flat ***,these areas demand attention,since they occupy 86%of the Basin and are mostly subjected to agricultural soil management and surface pressure by heavy machinery.

关键词： Soil compaction SMAP Preconsolidation stress Brazilian cerrado

concerns about the application of resistance exercise with blood-flow restriction and thrombosis risk in hemodialysis patients

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Journal of Sport and Health Science 2024年第4期13卷 548-558,F0003页

作者： Hugo de Luca correa Lysleine Alves Deus Dahan da cunha Nascimento Nicholas Rolnick Rodrigo Vanerson Passos Neves Andrea Lucena Reis Thais Branquinho de Araujo carmen Tzanno-Martins Fernanda Silveira Tavares luiz Sinesio Silva Neto claudio Avelino Rodrigues Santos Paolo Lucas Rodrigues-Silva Fernando Honorato souza Vitoria Marra da Motta Vilalva Mestrinho Rafael Lavarini dos Santos Rosangela Vieira Andrade Jonato Prestes Thiago dos Santos Rosa Post-graduate Program of Physical Education Catholic University of BrasıliaBrasılia 71966-700Brazil The Human Performance Mechanic Lehman CollegeNew YorkNY 10011USA clinical Group Home Dialysis center and Renalclass Sao Paulo 01239-040Brazil Department of Medicine Catholic University of BrasıliaBrasılia 71966-700Brazil Faculty of Medicine Federal University of TocantinsTocantins 77001-090Brazil Embrapa Genetic Resources and Biotechnology Brasılia 70770-917Brazil Graduate Program of Genomic Sciences and Biotechnology Brasılia 71966-700Brazil

Background:Hemodialysis(HD) per se is a risk factor for *** the growing body of evidence on blood-flow restriction(BFR) exercise in HD patients,identification of possible risk factors related to the prothrombotic agent D-dimer is required for the safety and feasibility of this training *** aim of the present study was to identify risk factors associated with higher D-dimer levels and to determine the acute effect of resistance exercise(RE) with BFR on this ***:Two hundred and six HD patients volunteered for this study(all with a glomerular filtration rate of consisted of 50% arterial occlusion pressure during 50 min sessions of HD(intradialytic exercise).RE repetitions included concentric and eccentric lifting phases(each lasting 2 s) and were supervised by a strength and conditioning ***:Several variables were associated with elevated levels of D-dimer,including higher blood glucose,citrate use,recent cardiovascular events,recent intercurrents,higher inflammatory status,catheter as vascular access,older patients(>70 years old),and HD ***,RE+BFR significantly increases D-dimer after 4 *** with borderline baseline D-dimer levels(400-490 ng/mL) displayed increased risk of elevating D-dimer over the normal range(≥500 ng/mL).conclusion:These results identified factors associated with a heightened prothrombotic state and may assist in the screening process for HD patients who wish to undergo RE+BFR.D-dimer and/or other fibrinolysis factors should be assessed at baseline and throughout the protocol as a precautionary measure to maximize safety during RE+BFR.

关键词： Blood-flow restriction chronic kidney disease coagulation Hemodialysis Vascular occlusion exercises

In vitro differentiation capacity of human breastmilk stem cells:A systematic review

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World Journal of Stem cells 2019年第11期11卷 1005-1019页

作者： camila Maria Ribeiro Pacheco Priscila Elias Ferreira claudia Sayuri Sacaki Luana Alves Tannous Idiberto Jose Zotarelli-Filho luiz cesar guarita-souza Katherine Athayde Teixeira de carvalho cell Therapy and Biotechnology in Regenerative Medicine Department Pele Pequeno Príncipe InstituteChild and Adolescent Health Research and Pequeno Príncipe FacultyCuritiba 80.240-020ParanáBrazil PUcPR-Institute of Biological and Health Sciences CCBSCuritiba 80.215-901ParanáBrazil Post Graduate and continuing Education(Unipos) Department of Scientific ProductionSao Jose do Rio Preto 15.020-040Sao PauloBrazil

BAcKGROUND Mesenchymal stem cells are pluripotent cells that have the ability to generate cells from a cell line or in other cell types from different tissues but from the same *** those cells have more limited differentiation capacity than embryonic stem cells,they are easily obtained from somatic tissue and can be grown in large *** characteristic of undifferentiated stem cells differentiating into different cell lines arouses strategies in regenerative medicine for the treatment of different diseases such as neurodegenerative *** To evaluate the cell differentiation capacity of human breastmilk stem cells for the three germ layers by a systematic *** The searched databases were PubMed,EMBASE,OVID,and cOcHRANE LIBRARY,published between 2007 and 2018 in the English *** were in vitro studies for analysis of the"cell differentiation potential"in the literature using the keywords“human breastmilk,”“stem cells,”and keywords combined with the Boolean operator“NOT”were used to exclude those articles that had the word“cANcER”and their respective synonyms,which were previously consulted according to medical subject heading *** 2009 guidelines were followed in this *** A total of 315 titles and abstracts of articles were *** these,21 were in common with more than one database,leaving 294 articles for *** that total,five publications met the inclusion *** analyzing the publications,it was demonstrated that human breastmilk stem cells have a high cellular plasticity,exhibiting the ability to generate cells of all three germ layers,endoderm,mesoderm,and ectoderm,demonstrating their *** cells expressed the genes,TRA-1-60/81,octamer-binding transcription factor 4,and NANOG,of which NANOG,a critical regulator for self-renewal and maintenance,was the most highly *** cells have the ability to differentiate in vitro into adipocytes,chondrocytes,osteocytes,oligod

关键词： Human breastmilk Stem cells cell differentiation Pluripotency Stemness

Ecological study of gastric cancer in Brazil:Geographic and time trend analysis

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World Journal of Gastroenterology 2014年第17期20卷 5036-5044页

作者： césar Augusto Amorim Jéssica Pronestino Moreira Luisa Rial Antonio José carneiro Homero Soares Foga?a celeste Elia Ronir Raggio luiz Heitor Siffert Pereira de souza Servi?o de Gastroenterologia Departamento de Clínica MédicaHospital UniversitárioUniversidade Federal do Rio de JaneiroRio de JaneiroRJ 21941-913Brazil Instituto de Epidemiologia e Saúde coletiva Universidade Federal do Rio de JaneiroRio de JaneiroRJ 21941-913Brazil

AIM: To investigate the geographic distributions and time trends of gastric cancer (Gc) incidence and mortality in Brazil.

关键词： Gastric cancer Ecological study Hospitalization Lethality rate

cOVID-19 impact in crohn’s disease patients submitted to autologous hematopoietic stem cell transplantation

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World Journal of Hematology 2024年第1期11卷 1-8页

作者： Milton Artur Ruiz Roberto luiz Kaiser Junior Lilian Piron-Ruiz Tainara souza Pinho Lilian castiglioni luiz Gustavo de Quadros Department of Bone Marrow Transplantation Associação Portuguesa de BeneficênciaSão Josédo Rio Preto SP 15090470Brazil Department of Surgery Kaiser Hospital DiaSão Josédo Rio Preto 08010-150São PauloBrazil Department of Bone Marrow Transplantation Beneficência Portuguesa HospitalSão Josédo Rio Preto 15090470São PauloBrazil FAMERP Faculdade de Medicina de São Josédo Rio PretoSão Josédo Rio Preto 15090000São PauloBrazil Beneficência Portuguesa Hospital ABC Medical SchoolSão Bernardo 15015110São PauloBrazil

BAcKGROUND Severe acute respiratory syndrome coronavirus 2 is the virus responsible for coronavirus disease 2019(cOVID-19),a disease that has been blamed for inducing or exacerbating symptoms in patients with autoimmune ***'s disease(cD)is an inflammatory bowel disease that affects genetically susceptible patients who develop an abnormal mucosal immune response to the intestinal *** who underwent hematopoietic stem cell transplantation(HScT)are considered at risk for *** To describe for the first time the impact of cOVID-19 in cD patients who had undergone autologous,non-myeloablative *** In this descriptive study a series of 19 patients were diagnosed with positive *** two patients there were reports of the occurrence of two infectious *** related to HScT,such as time elapsed since the procedure,vaccination status,cD status before and after infection,and clinical manifestations resulting from cOVID-19,were *** Among the patients with cOVID-19,three,who underwent Auto HScT less than six months ago,relapsed and one,in addition to the cD symptoms,started to present thyroid impairment with positive *** one of the patients required hospitalization for five days to treat cOVID-19 and remained in cD clinical *** patients reported late symptoms that may be related to *** were no deaths,and a statistical evaluation of the series of cOVID-19 patients compared to those who did not present any infectious episode did not identify significant differences regarding the analyzed *** Despite the change in cD status in three patients and the presence of nine patients with late symptoms,we can conclude that there was no significant adverse impact concerning cOVID-19 in the evaluated patients who underwent HScT to treat cD.

关键词： Inflammatory bowel disease crohn disease sarS-coV-2 cOVID-19 Autologous hematopoietic stem cell transplantation Stem cell therapy

Traits uncover quasi-neutral community assembly in a coastal heath vegetation

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Journal of Plant Ecology 2019年第4期12卷 703-712页

作者： Joséluiz Alves Silva Alexandre Fadigas souza Louis Stephen Santiago Programa de Pós-Graduação em Ecologia Departamento de EcologiaUniversidade Federal do Rio Grande do NorteNatal 59078-970Brazil Departamento de Ecologia Universidade Federal do Rio Grande do NorteNatal 59078-970Brazil Department of Botany and Plant Sciences University of California2150 Batchelor HallRiversideCA 92521USA Smithsonian Tropical Research Institute BalboaAncónPanamáRepublic of Panamá

Aims Trait-based approaches are increasingly being used in ecology due to their potential to explain and predict community structure and dynamic regardless of species ***,we asked whether coastal heath vegetation established in stressful habitats could be assembled by quasi-neutral mechanisms based on functional trait *** are organized through quasi-neutral dynamics if abiotic gradients and/or species interactions impose sorting on functional traits and species performances,but not on species phylogenetic relatedness and *** The study was conducted in a coastal area containing tall dunes near the sea,and relatively flat areas punctuated by short palaeodunes further inland,Northeastern South *** evaluated 10 traits of the 21 most abundant species,as well as eight abiotic variables in 70 plots(25 m^(2))established in dune tops,valleys,flat and steep *** effect of environmental filter was tested by linear mixed models(LMM)between each community-weighted mean(cWM)trait and the abiotic variables,and by two indices of environmental filtering based on intra-and interspecific-trait vari-ability relative to null *** evaluate the effect of species inter-actions,we used an index of niche overlap relative to null models,and LMMs between this index and the species richness of *** Findings The environmental filtering index did not deviate from null expect-ations for any *** that included individual variability per-formed similarly to models that used species mean ***,the explicit consideration of environmental gradients by cWM ana-lyses revealed functional patterns that would remain undetected if trait distribution was analyzed *** addition,intraspecific vari-ation in the stem length was an important driver of species diversity as suggested by the relationship between species richness and the niche overlap *** on the occurrence and phylogenetic re-latedness o

关键词： Restinga heath vegetation harsh environment stress-tolerant species response traits