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From liver to hormones:The endocrine consequences of cirrhosis

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World Journal of Gastroenterology 2024年第9期30卷 1073-1095页

作者： Juan eduardo Quiroz-Aldave Elman Rolando Gamarra-Osorio María del Carmen Durand-Vásquez Luciana del Pilar Rafael-Robles Jhean Gabriel Gonzáles-Yovera María Alejandra Quispe-Flores luis Alberto Concepción-Urteaga Alejandro Román-González José Paz-Ibarra Marcio José Concepción-Zavaleta Non-communicable Diseases Endocrinology Research LineHospital de Apoyo ChepénChepén 13871Peru department of Endocrinology Hospital Víctor Lazarte EchegarayTrujillo 13006Peru department of Endocrinology Clínica Javier PradoLima 15046Peru department of Gastroenterology Hospital Nacional Guillermo Almenara IrigoyénLima 15018Peru department of Endocrinology Hospital de Emergencias GrauLima 15001Peru Internal Medicine Hospital Regional Docente de TrujilloTrujillo 13011Peru department of Endocrinology Hospital Universitario de San Vicente FundaciónMedellin 050010Colombia Internal Medicine Universidad de AntioquiaMedellín 050010Colombia School of Medicine Universidad Nacional Mayor de San MarcosLima 15081Peru department of Endocrinology Hospital Nacional Edgardo Rebagliati MartinsLima 15072Peru Carrera de Medicina Humana Universidad Científica del SurLima 15067Peru

Hepatocrinology explores the intricate relationship between liver function and the endocrine *** liver diseases such as liver cirrhosis can cause endocrine disorders due to toxin accumulation and protein synthesis *** its importance,assessing endocrine issues in cirrhotic patients is frequently *** article provides a comprehensive review of the epidemiology,pathophysiology,diagnosis,and treatment of endocrine disturbances in liver *** review was conducted using the PubMed/Medline,EMBASE,and Scielo databases,encompassing 172 *** cirrhosis is associated with endocrine disturbances,including diabetes,hypoglycemia,sarcopenia,thyroid dysfunction,hypogonadotropic hypogonadism,bone disease,adrenal insufficiency,growth hormone dysfunction,and secondary *** optimal tools for diagnosing diabetes and detecting hypoglycemia are the oral glucose tolerance test and continuous glucose monitoring system,*** can be assessed through imaging and functional tests,while other endocrine disorders are evaluated using hormonal assays and imaging *** options include metformin,glucagon-like peptide-1 analogs,sodium-glucose co-transporter-2 inhibitors,and insulin,which are effective and safe for diabetes *** standards are followed for managing hypoglycemia,and hormone replacement therapy is often necessary for other endocrine *** transplantation can address some of these problems.

关键词： Diabetes mellitus Hypoglycemia Thyroid diseases Hypogonadism Metabolic bone diseases Liver cirrhosis

Thermal and salinity effects on locomotor performance of Thoropa taophora tadpoles(Anura,Cycloramphidae)

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Integrative Zoology 2020年第1期15卷 40-54页

作者： Antonio C.GALLO Cinthia ABRASILEIRO Fábio Cury de BARROS Joséeduardo de carvalho department of Ecology and Evolutionary Biology Federal University of São PauloDiademaSão PauloBrazil

It is well known that environmental temperature influences several biological functions of ectotherms,notably in *** high permeability of anuran skin,associated with the effect of elevated environmental temperature,potentiates the dehydration process and this combination may restrict locomotor ***pa taophora is an endemic species from the Atlantic Rainforest whose tadpoles are semiterrestrial and predominantly diurnal,and are found in rocky seashores where they are exposed to sea spray and high *** this study we investigated how temperature and salinity conditions affect the locomotor performance in Thoropa taophora *** also assessed how different osmotic concentrations affect the activity of the metabolic pathways that support muscle *** measured the sprint speed of tadpoles of various sizes at different temperatures and salinities in the *** also measured the activity of the enzymes pyruvate kinase(PK),lactate dehydrogenase(LDH)and citrate synthase(CS)in different temperatures and osmotic concentrations,and calculated the thermal sensitivity and the activity constants for each *** results showed that,in general,sprint speed decreased with increasing temperature and ***,whereas the effect of increased salinity was similar in smaller and larger tadpoles,increased temperature had a higher negative impact on sprint speed of larger tadpoles,thus indicating low thermal sensitivity of small *** and LDH thermal sensitivities and LDH constant of activity decreased as the osmolality *** conclusion,the locomotor capacity of tadpoles was decreased by temperature and salinity,which may be related to a decrease in anaerobic metabolism both in terms of sensitivity and total energy turnover through enzymatic *** discuss the ecological consequences,including the potential impacts on predator escape behavior promoted by changes in metabolism and locomotor performance

关键词： amphibians energy metabolism enzyme activity sprint speed

Methods for the analysis of neuronal plasticity and brain connectivity during neurological recovery

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Neural Regeneration Research 2016年第11期11卷 1701-1703页

作者： eduardo H.Sanchez-Mendoza Tayana Silva de carvalho Dirk M.Hermann department of Neurology University of Duisburg-Essen

The study of neuronal plasticity under pathological conditions is now a major point of focus on the field of neurological recovery. After the repeated failure of acute neuroprotection strategies for stroke treatment, the design of studies aimed at promoting the reconstruction of neuronal networks has become essential. Methods for the delivery of therapeutic agents on a steady dosage, thus preventing pharmacological peaks or excessive manipulation of experimental animals, are thus required. Additionally, methods that allow the visualization of neurological remodeling processes are fundamental to the understanding of how a therapeutic agent exerts its function. Here we describe how the use of miniosmotic pumps for the steady delivery of such agents, together with tract tracer injections, can be combined to unveil important information on how the brain changes after stroke and how therapeutic agents promote brain remodeling recovery.

关键词： stroke blood brain barrier neuroplasticity drug delivery

Old climatically-buffered infertile landscapes(OCBILs):more than harsh habitats,Atlantic Forest inselbergs can be drivers of evolutionary diversity

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Journal of Mountain Science 2022年第9期19卷 2528-2543页

作者： Felipe de carvalho ARAÚJO Natália de AGUIAR-CAMPOS Cleber Rodrigo de SOUZA eduardo de Paiva PAULA Rubens Manoel dos SANTOS Laboratory of Phytogeography and Evolutionary Ecology Department of Forest SciencesFederal University of LavrasLavrasMinas GeraisBrazil

Granite-gneiss rock outcrop inselbergs are ancient stable ecosystems with old,climaticallybuffered infertile landscapes(OCBILs).Although inselbergs provide key ecosystem services,little is done for their conservation and,so far,a lot of their unknown evolutionary history has already been lost by human *** a fine-scale approach,here we tested if habitat and environmental filtering(the inselberg’s harshness)affect the evolutionary diversity of an Atlantic Forest inselberg in *** recorded all trees with a diameter at breast height≥5cm in 20 plots in four habitat types(total sampled area of 0.8 hectares),from highest to lowest:island,hillside,foothill,and semideciduous forest(matrix).We also collected soil samples for chemical,textural and physical soil *** fitted linear models to test the effects of soil and habitat on plotlevel metrics of phylogenetic diversity and structure,lineage diversity,phylogeneticβ-diversity,and evolutionary *** found that the upper inselberg habitats contain a distinct set of ancient,closely related,harsh-tolerant lineages,as well as a subset of lineages that persist under harsh conditions with a certain degree of water *** inferior inselberg habitats harbor higher lineage diversity than expected by *** strongly predicted evolutionary *** concluded that soil depth,slope,nutrients and texture(environmental filtering)and habitat types and topography(habitat filtering)shape the evolutionary history contained in fine-scale inselberg habitats,which should encourage the conservation of these ancient ecosystems.

关键词： Phylogenetic diversity Atlantic Forest Niche conservatism Environmental filters Soil fertility Terrestrial Island

Foliar application of rare earth elements on soybean(Glycine max(L)):Effects on biometrics and characterization of phytotoxicity

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Journal of Rare Earths 2020年第10期38卷 1131-1139,I0005页

作者： eduardo S.Rodrigues Gabriel S.Montanha Joao P.R.Marques eduardo de Almeida Lauren N.M.Yabuki Amauri A.Menegario Hudson W.Pereira de carvalho Laboratory of Nuclear Instrumentation(LIN) Center for Nuclear Energy in Agriculture(CENA)University of Sao Paulo(USP)PiracicabaSP13416-000Brazil Environmental Studies Center Sao Paulo State University(UNESP)Rio ClaroSP13506-900Brazil

This study aims at investigating the effects of foliar application of aqueous solutions of La3+and Ce3+nitrates on soybean plants(Glycine max).First,we observe that Triton HW 1000 surfactant at 0.01 vol%reduces droplets contact angle and increases their drying *** greenhouse conditions,the foliar treatments do not affect chlorophyll content,plant height,number of leaves,number of pods,number of seeds per pod,and average seed ***,the treatments induce phytotoxicity since foliar injuries appear after the *** X-ray fluorescence spectroscopy combined to scanning electron microscopy shows that the leaf lesions are positively correlated to accumulation of Ce and La on the leaf surface and also promote structural alteration to the epidermal cells.X-ray absorption near edge structure shows that the La and Ce nitrates are partially bio transformed into oxides by the leaves which might explain the harmful effects.

关键词： Leaf fertilization Rare earth elements Soybean X-ray fluorescence spectroscopy X-ray absorption spectroscopy

A Data Security Framework for Cloud Computing Services

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Computer Systems Science & Engineering 2021年第5期37卷 203-218页

作者： luis-eduardo Bautista-Villalpando Alain Abran department of Electronic Systems Autonomous University of AguascalientesAguascalientes20131Mexico department of Software Engineering and Information Technology ETSUniversity of QuebecMontrealH3C 1K3Canada

Cyberattacks are difficult to prevent because the targeted companies and organizations are often relying on new and fundamentally insecure cloudbased technologies,such as the Internet of *** increasing industry adoption and migration of traditional computing services to the cloud,one of the main challenges in cybersecurity is to provide mechanisms to secure these *** work proposes a Data Security Framework for cloud computing services(CCS)that evaluates and improves CCS data security from a software engineering perspective by evaluating the levels of security within the cloud computing paradigm using engineering methods and techniques applied to *** framework is developed by means of a methodology based on a heuristic theory that incorporates knowledge generated by existing works as well as the experience of their *** paper presents the design details of the framework,which consists of three stages:identification of data security requirements,management of data security risks and evaluation of data security performance in CCS.

关键词： Cloud computing services computer security data security data security requirements data risk data security measurement

Temporal and phenological profiles of open and dense Caatinga using remote sensing:response to precipitation and its irregularities

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Journal of Forestry Research 2021年第3期32卷 1067-1076页

作者： Janisson Batista de Jesus Tatiana Mora Kuplich íkaro Daniel de carvalho Barreto Cristiano Niederauer da Rosa Fernando luis Hillebrand Postgraduate Program in Remote Sensing Federal University of Rio Grande Do SulAv.Bento GoncalvesCEP 91501-970Porto AlegreRio Grande do Sul 9500Brazil National Institute for Space Research(INPE)Southern Regional Centre(CRS) CEP 97105-970Santa MariaRio Grande do SulBrazil Postgraduate Program in Applied Biometrics and Statistics Rural Federal University of PernambucoDom Manuel de Medeiross/nDois IrmaosCEP 52171-900RecifePernambucoBrazil

Caatinga is a typical biome of Brazil's semiarid regions and subject to climate *** is needed on the relation of its features to climate *** study analyzed the infl uence of rainfall and its irregularities in open and dense woody Caatinga *** curves were generated by means of Normalized Difference Vegetation Index(NDVI)time profiles in the Grota do Angico Conservation Unit study area in Sergipe *** data from 2000 to 2018 were collected and phenological curves generated using various estimate methods that produced the following variables:[start of season,end of season,peak of season position,length of season,mean growing season and maximum seasonal].Rainfall showed a standard intra-annual behavior,with inter-annual variations related to irregularities infl uencing Caatinga *** Caatinga vegetation had higher values of NDVI in all periods,even in anomalous years compared to open Caatinga,in addition to having longer leaf coverage over the year,with an anticipated start and a more extended seasonal *** analysis of the rainfall regime made it possible to assess its infl uence on the Caatinga and phenological profiles proved to be fundamental to understand periods of physiological change of open and dense *** results indicate that dense Caatinga maintains physiological activity longer,which may be associated with greater moisture maintenance in a semiarid *** addition,because it has a greater leaf cover for longer periods,the soil may be preserved and maintain its characteristics longer,reducing the effects of *** results may be associated with the type of forest management and conservation in this *** total or partial suppression of individual remnants of Caatinga should be avoided,since the most open areas have lower photosynthetic capacity,affected to a considerable extent from the effects of adverse climatic ***,open Caatinga has a reduced cap

关键词： Semiarid Tropical dry forest NDVI MODIS Phenopix

Relationship between Physical and Chemical Soil Attributes and Plant Species Diversity in Tropical Mountain Ecosystems from Brazil

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Journal of Mountain Science 2014年第4期11卷 875-883页

作者： Ferna de carvalho Edward luis GODOY Francy J. G. LISBOA Fatima Maria de Souza MOREIRA Francisco Adriano de SOUZA Ricardo luis Louro BERBARA G Wilson FERNES Laboratory of Evolutionary Ecology and Biodiversity Department of Geral Biology Institute of Biology Sciences Federal University of Minas Gerais Belo Horizonte MG 30161-901 P.O. Box 486 Brazil department of Biology Microbiology and Biological Processes Department of Soil Science Federal University of LavrasLavras Minas Gerais 37200-000 P.O.Box 3037 Brazil department of Biological Sciences Ferderal University of S?o Jo?o Del Rei S?o Jo?o del-Rei Minas Gerais 36307-352Brazil Laboratory of Soil Biology Department of Soil Science Federal Rural University of Rio de Janeiro Seropédica Rio de Janeiro 23890-000 Brazil Embrapa Maize and Sorghum Center for Applied Biology Rod. MG 424 KM 45 Caixa Postal Sete Lagoas Minas Gerais 35701-970 P.O. Box 285 Brazil

Although the high diversity of plant species in the rupestrian fields has been primarily attributed to the existence of a set of distinct habitats, few studies support this assertion. The present study aimed to further investigate the relationship between physical and chemical attributes of soils with the diversity of plant species in this unique ecosystem. The rupestrian field is a unique vegetation formation that covers some of the southeastern Brazilian mountains in the transition of the Atlantic rain forest and the Cerrado(savanna). Different habitats occur according to soil characteristics(e.g., presence of rocks, sand, fertility, hydrology, etc.). These attributes ultimately influence the vegetation that is highly adapted to the harsh edaphic and climatic mountain conditions. Five distinct habitats were studied by us: rocky outcrops, peat bogs, sandy bogs, quartz gravel fields, and "cerrado"(savanna). A floristic survey indicated that four families are found at greater frequency: Poaceae, Asteraceae, Cyperaceae, and Leguminosae. The greatest diversity of plant species was found in the rocky outcrops habitat, followed by cerrado, peat bog, quartz gravel grassland, and sandy bogs, respectively. The main difference in the floristic composition among these habitats was related to the dominant species. Trachypogon spicatus(Poaceae) was the most dominant species in the rocky outcrops, Axonopus siccus(Poaceae) in the peat bogs, Lagenocarpus rigidus(Cyperaceae) in the sandy bogs, Schizachyrium tenerum(Poaceae) in the cerrado, while Vellozia sp. 8(Velloziaceae) dominated the vegetation in the quartz gravel grassland. This study demonstrated that physical and chemical soil properties strongly related the diversity of plant species occurring in the different habitats of rupestrian fields.

关键词： Floristic diversity Plant-soilrelationships Espinhaqo Range Biodiversity Mountain ecology Plant habitat

Urbanization has opposite effects on the territory size of two passerine birds

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Avian Research 2020年第2期11卷 191-199页

作者： Roselvy Juárez eduardo Chacón‑Madrigal luis Sandoval Escuela de Biología Universidad de Costa RicaCP:11501‑2060San PedroMontes de OcaSan JoséCosta Rica Ambientey desarrollo Universidad ZamoranoCarretera a Danlíkm 30Francisco MorazánHonduras.

Background:Urban expansion has been identified as one of the leading drivers of biodiversity change or *** birds,urbanization is specifically related to survival,breeding success,and territory *** how different birds adjust territory size in response to urbanization is essential for their conservation in urban environments and to better understand why some species are lost and others persist under this *** evaluated the effect of urbanization on the territory size of an urban avoider species,White-eared Ground-Sparrow(Melozone leucotis),and an urban adapter species,House Wren(Troglodytes aedon),at five Costa Rican ***:We measured the size of 30 ground-sparrow and 28 wren territories using a total of 296 h of *** followed each individual for at least 1 h per day for at least 2 days of two consecutive years,and geo-referenced their *** size was estimated using the minimum convex polygon *** measured the urban surfaces(roads,buildings,any other paved area,soccer fields,lawns,and gardens with short grass)within ***:Ground-sparrow territories were larger at the highly urbanized site than at the non-urbanized *** territories were larger at the low urbanized site than at the highly urbanized *** found a positive relationship between urban surface and territory size for the ground-sparrow,but not for the ***:Our results showed that not all birds adjust territory size in the same way in response to *** showed that urban avoiders probably need to defend larger territories in urban environments to find all the resources required to survive because urban environments may provide insufficient resources such as food or *** adapters on the other hand defend smaller territories in urban environments because even small territories may provide sufficient *** results suggest specific behavioral adaptations developed by Neotropical birds inha

关键词： House Wren Melozone leucotis Troglodytes aedon Urban adapter Urban avoider Urban-rural gradient Territory size White‑eared Ground‑Sparrow