检索结果-南通市图书馆

Satellite-enabled enviromics to enhance crop improvement

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular Plant 2024年第6期17卷 848-866页

作者： Rafael t.Resende Lee Hickey Cibele H.Amaral lucas L.Peixoto Gustavo E.Marcatti Yunbi Xu Universidade Federal de Goia´s(UFG) Agronomy DepartmentPlant Breeding SectorGoiania(GO)74690-900Brazil theCROP a Precision-Breeding Startup:EnviromicsPhenomicsand GenomicsNo Zip-codeOperating VirtuallyGoiania(GO)and Sete Lagoas(MG)Brazil Queensland Alliance for Agriculture and Food Innovation The University of QueenslandBrisbaneQLDAustralia Earth Lab Cooperative Institute for Research in Environmental SciencesUniversity of Colorado BoulderBoulderCO 80303USA Environmental Data Science Innovation&Inclusion Lab Cooperative Institute for Research in Environmental SciencesUniversity of Colorado BoulderBoulderCO 80303USA Universidade Federal de Sa˜o Joa˜o del-Rei Forest Engineering DepartmentCampus Sete LagoasSete Lagoas(MG)35701-970Brazil Institute of Crop Sciences Chinese Academy of Agricultural SciencesBeijing 100081China Peking University Institute of Advanced Agricultural Sciences WeifangShandong 261325China BGI Bioverse Shenzhen 518083China

Enviromics refers to the characterization of micro-and macroenvironments based on large-scale environmental *** providing genotypic recommendations with predictive extrapolation at a site-specific level,enviromics could inform plant breeding decisions across varying conditions and anticipate productivity in a changing ***-based integration of statistics,envirotyping(i.e.,determining environmental factors),and remote sensing could help unravel the complex interplay of genetics,environment,and *** support this goal,exhaustive envirotyping to generate precise environmental profiles would significantly improve predictions of genotype performance and genetic gain in ***,informatics management platforms aggregate diverse environmental datasets obtained using optical,thermal,radar,and light detection and ranging(LiDAR)sensors that capture detailed information about vegetation,surface structure,and *** wealth of information,coupled with freely available climate data,fuels innovative enviromics *** enviromics holds immense potential for breeding,a few obstacles remain,such as the need for(1)integrative methodologies to systematically collect field data to scale and expand observations across the landscape with satellite data;(2)state-of-the-art AI models for data integration,simulation,and prediction;(3)cyberinfrastructure for processing big data across scales and providing seamless interfaces to deliver forecasts to stakeholders;and(4)collaboration and data sharing among farmers,breeders,physiologists,geoinformatics experts,and programmers across research *** these challenges is essential for leveraging the full potential of big data captured by satellites to transform 21st century agriculture and crop improvement through enviromics.

关键词： envirotyping precision breeding genotype-environment interactions remote sensing predictive models enviromic information

Convective drying of wood chips:Accelerating coupled DEM-CFD simulations with parametrized reduced single particle models

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Particuology 2024年第1期84卷 158-167页

作者： lucas Reineking Jonas Fischer Ali Mjalled Enric Illana Siegmar Wirtz Viktor Scherer Martin Monnigmann Automatic Control and System theory Ruhr-Universität-BochumUniversitätstraße 150Bochum44801Germany Energy Plant technology Ruhr-Universität-BochumUniversitätstraße 150Bochum44801Germany

the simulation of industry-scale reactive bulks is challenging due to the complex interaction between fluid and *** particles in the bulk and their interaction with the fluid flow can be described by combined Discrete Element Method-Computational Fluid Dynamics(DEM-CFD)***,the computational cost of the Finite Volume(FV)methods deployed in these models can become prohibi-tively expensive,especially for high inner-particle *** particle Reduced Models(RMs)can be used to achieve both fast and accurate descriptions of the processes in each *** an example of bulk systems comprising heat and mass transfer,we compared FV and RM simulations for the drying of wood chips in a bulk reactor.A manifold-based nonlinear interpolation was applied to resolve changing boundary conditions for the *** simulations showed that RMs provide accurate values for the thermodynamic state variables of the ***,the time required for the bulk simulation was reduced by 67%with the *** is evident that simulations with high inner-particle resolution can be accelerated by RMs if manifold-based nonlinear interpolation is used to address changing boundary conditions.

关键词： Reduced model Reactive bulk Discrete element method Manifold-based interpolation Drying of porous mediaDEM-CFD

A metabolic signalling role for arginine in liver cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Life Metabolism 2024年第1期3卷 1-3页

作者： David Sokolov lucas B.Sullivan Human Biology Division Fred Hutchinson Cancer CenterSeattleWA 98109United States

In addition to their canonical roles in biosynthetic pathways,metabolites can be active participants in oncogenic signal-ling,but our understanding of these signalling mechanisms is *** a recent article published in Cell,Mossmann et *** a novel signalling role for accumulated arginine in hepato-cellular carcinoma(HCC)mediated by the RNA splicing factor and transcriptional modifier RNA-binding protein 39(RBM39).

关键词： incomplete cancer

Gut microbiome:A revolution in typeⅡdiabetes mellitus

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Diabetes 2024年第9期15卷 1874-1888页

作者： Madhan Jeyaraman tejaswin Mariappan Naveen Jeyaraman Sathish Muthu Swaminathan Ramasubramanian Gabriel Silva Santos lucas Furtado da Fonseca JoséFábio Lana Department of Orthopaedics ACS Medical College and HospitalDr MGR Educational and Research InstituteChennai 600077Tamil NaduIndia Department of Orthopaedics Brazilian Institute of Regenerative MedicineIndaiatuba 13334-170São PauloBrazil Department of Orthopaedics Orthopaedic Research GroupCoimbatore 641045Tamil NaduIndia Department of Community Medicine Government Stanley Medical College and HospitalChennai 600001Tamil NaduIndia Department of Orthopaedics Government Medical CollegeKarur 639004Tamil NaduIndia Department of Biotechnology Faculty of EngineeringKarpagam Academy of Higher EducationCoimbatore 641021Tamil NaduIndia Department of Orthopaedics Government Medical CollegeOmandurar Government EstateChennai 600002Tamil NaduIndia

typeⅡdiabetes mellitus(t2DM)has experienced a dramatic increase globally across countries of various income levels over the past three *** persistent prevalence of t2DM is attributed to a complex interplay of genetic and environmental *** numerous pharmaceutical therapies have been developed,there remains an urgent need for innovative treatment approaches that offer effectiveness without significant adverse *** this context,the exploration of the gut microbiome presents a promising *** has increasingly shown that the gut microbiome of individuals with t2DM exhibits distinct differences compared to healthy individuals,suggesting its potential role in the disease’s pathogenesis and *** emerging field offers diverse applications,particularly in modifying the gut environment through the administration of prebiotics,probiotics,and fecal microbiome *** interventions aim to restore a healthy microbiome balance,which could potentially alleviate or even reverse the metabolic dysfunctions associated with *** current results from clinical trials have not yet shown dramatic effects on diabetes management,the groundwork has been laid for deeper *** and future clinical trials are critical to advancing our understanding of the microbiome’s impact on *** further elucidating the mechanisms through which microbiome alterations influence insulin resistance and glucose metabolism,researchers can develop more targeted *** potential to harness the gut microbiome in developing new therapeutic strategies offers a compelling prospect to transform the treatment landscape of t2DM,potentially reducing the disease’s burden significantly with approaches that are less reliant on traditional pharmaceuticals and more focused on holistic,systemic health improvements.

关键词： typeⅡdiabetes Gut microbiome Probiotics Prebiotics Fecal microbiota transplantation

Artemisia vulgaris Induces tumor-Selective Ferroptosis and Necroptosis via Lysosomal Ca^(2+) Signaling

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2024年第6期30卷 525-533页

作者： lucas dos Santos Zamarioli Michele Rosana Maia Santos Adolfo Garcia Erustes Vanessa Marques Meccatti thais Cristine Pereira Soraya S Smaili Maria Cristina Marcucci Carlos Rocha Oliveira Gustavo JS Pereira Claudia Bincoletto Department of Pharmacology Paulista School of MedicineFederal University of São PauloSão PauloSP04044-020Brazil Research Group on Phytocomplexes and Cell Signaling School of Health SciencesAnhembi Morumbi UniversitySão PauloSP03164-000Brazil Department of Biosciences and Oral Diagnosis Institute of Science and TechnologySão Paulo State University(ICT-UNESP)São PauloSP12231-280Brazil

Objective to evaluate the chemical composition and effects of Artemisia vulgaris(AV)hydroalcoholic extract(HEAV)on breast cancer cells(MCF-7 and SKBR-3),chronic myeloid leukemia(K562)and NIH/3t3 *** Phytochemical analysis of HEAV was done by high-performance liquid chromatography-mass(HPLC)*** and cell death studies were performed using trypan blue and Annexin/FItC-7AAD,***-1(Fer-1)and necrostatin-1(Nec-1)were used to assess the mode of HEAV-induced cell death and acetoxymethylester(BAPtA-AM)was used to verify the involvement of cytosolic calcium in this *** calcium measurements were made using *** HEAV decreased the viability of MCF-7,SKBR-3 and K562 cells(Pthe viability of HEAV-treated K562 cells was reduced compared to HEAV-exposed fibroblasts(Ptreatment of K562 cells with HEAV induced cell death primarily by late apoptosis and necrosis in assays using annexin V-FItC/7-AAD(Pthe use of Nec-1 and Fer-1 increased the viability of K562 cells treated with HEAV relative to cells exposed to HEAV alone(Pthermore,BAPtA-AM,an intracellular Ca^(2+)chelator,decreased the number of non-viable cells treated with HEAV(Ptotoxic and activates several modalities of cell death,which are partially dependent on lysosomal release of Ca^(2+).these effects may be related to artemisinin and caffeoylquinic acids,the main compounds identified in HEAV.

关键词： Artemisia vulgaris necroptosis ferroptosis late apoptosis Ca^(2+)signaling

Dysregulated microRNAs in type 2 diabetes and breast cancer:Potential associated molecular mechanisms

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Diabetes 2024年第6期15卷 1187-1198页

作者： Alex Cleber Improta-Caria Filipe Ferrari João lucas Penteado Gomes Paloma Brasilio Villalta Úrsula Paula RenóSoci Ricardo Stein Edilamar M Oliveira Laboratory of Biochemistry and Molecular Biology of the Exercise Physical Education and Sport SchoolUniversity of São PauloSão Paulo 05508-030Brazil Graduate Program in Cardiology and Cardiovascular Sciences Federal University of Rio Grande do SulHospital de Clínicas de Porto AlegrePorto Alegre 90035003Brazil Laboratory of Metabolic Disorders(Labdime) School of Applied SciencesUniversity of Campinas-UNICAMPCampinas 13484-350Brazil Departments of Internal Medicine Molecular Pharmacology and PhysiologyCenter for Regenerative MedicineUSF Health Heart InstituteMorsani College of MedicineUniversity of South FloridaTampaFL 33602United States

type 2 diabetes(t2D)is a multifaceted and heterogeneous syndrome associated with complications such as hypertension,coronary artery disease,and notably,breast cancer(BC).the connection between t2D and BC is established through processes that involve insulin resistance,inflammation and other *** this comprehension the specific cellular and molecular mechanisms linking t2D to BC,especially through microRNAs(miRNAs),remain *** are regulators of gene expression at the post-transcriptional level and have the function of regulating target genes by modulating various signaling pathways and biological ***,the signaling pathways and biological processes regulated by miRNAs that are associated with t2D and BC have not yet been *** review aims to identify dysregulated miRNAs in both t2D and BC,exploring potential signaling pathways and biological processes that collectively contribute to the development of BC.

关键词： type 2 diabetes Breast cancer MicroRNAs Molecular mechanisms

tensorial tomographic Fourier ptychography with applications to muscle tissue imaging

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advanced Photonics 2024年第2期6卷 50-60页

作者： Shiqi Xu Xi Yang Paul Ritter Xiang Dai Kyung Chul Lee lucas Kreiss Kevin C.Zhou Kanghyun Kim Amey Chaware Jadee Neff Carolyn Glass Seung Ah Lee Oliver Friedrich Roarke Horstmeyer Duke University DurhamNorth CarolinaUnited States Friedrich-Alexander University ErlangenGermany UC San Diego La JollaCaliforniaUnited States Yonsei University SeoulRepublic of Korea UC Berkeley BerkeleyCaliforniaUnited States Duke University Medical Center DurhamNorth CarolinaUnited States

We report tensorial tomographic Fourier ptychography(t^(2)oFu),a nonscanning label-free tomographic microscopy method for simultaneous imaging of quantitative phase and anisotropic specimen information in *** upon Fourier ptychography,a quantitative phase imaging technique,t^(2)oFu additionally highlights the vectorial nature of *** imaging setup consists of a standard microscope equipped with an LED matrix,a polarization generator,and a polarization-sensitive *** tensors of anisotropic samples are computationally recovered from polarized intensity measurements across three *** demonstrate t^(2)oFu’s efficiency through volumetric reconstructions of refractive index,birefringence,and orientation for various validation samples,as well as tissue samples from muscle fibers and diseased heart *** reconstructions of healthy muscle fibers reveal their 3D fine-filament structures with consistent ***,we demonstrate reconstructions of a heart tissue sample that carries important polarization information for detecting cardiac amyloidosis.

关键词： computational imaging three-dimensional imaging phase retrieval microscopy polarization-sensitive imaging labelfree imaging

High-speed silicon photonic electro-optic Kerr modulation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Photonics Research 2024年第1期12卷 51-60页

作者： JONAtHAN PELtIER WEIWEI ZHANG LEOPOLD VIROt CHRIStIAN LAFFORGUE lucas DENIEL DELPHINE MARRIS-MORINI GUY AUBIN FARAH AMAR DENH tRAN XINGZHAO YAN CALLUM G.LIttLEJOHNS CARLOS ALONSO-RAMOS KE LI DAVID J.tHOMSON GRAHAM REED LAURENt VIVIEN University Paris-Saclay CNRSCentre for Nanoscience and Nanotechnology(C2N)Palaiseau 91120France University Grenoble Alpes CEALETIGrenoble 38000France Optoelectronics Research Centre Zepler Institute for Photonics and NanoelectronicsFaculty of Engineering and Physical SciencesUniversity of SouthamptonSouthampton SO171BJUK

Silicon-based electro-optic modulators contribute to easing the integration of high-speed and low-power consumption circuits for classical optical communications and data *** the plasma dispersion modulation,an alternative solution in silicon is to exploit the DC Kerr effect,which generates an equivalent linear electro-optical effect enabled by applying a large DC electric *** some theoretical and experimental studies have shown its existence in silicon,limited contributions relative to plasma dispersion have been achieved in high-speed modulation so *** paper presents high-speed optical modulation based on the DC Kerr effect in silicon PIN *** contributions of both plasma dispersion and Kerr effects have been analyzed in different waveguide configurations,and we demonstrated that the Kerr induced modulation is dominant when a high external DC electric field is applied in PIN ***-speed optical modulation response is analyzed,and eye diagrams up to 80 Gbit/s in NRZ format are obtained under a *** of 30 *** work paves the way to exploit the Kerr effect to generate high-speed Pockels-like optical modulation.

关键词： waveguide dispersion effect

toll-like receptor 9 polymorphisms and Helicobacter pylori influence gene expression and risk of gastric carcinogenesis in the Brazilian population

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2019年第11期11卷 998-1010页

作者： Manoela Dias Susi de Matos Lourenco Caroline lucas trevizani rasmussen Spencer Luis Marques Payao Ana Flavia teixeira Rossi Ana Elizabete Silva Juliana Garcia de Oliveira-Cucolo Department of Graduate-Level Research USCSacred Heart UniversityBauru 17011-970SPBrazil Department of Genetics and Molecular Biology FAMEMA-Marilia Medical SchoolMarília 17519-030SPBrazil Department of Biology Sao Paulo State University-UNESPSao Jose do Rio Preto 15054-000SPBrazil Department of Molecular Biological and Genetics and Molecular Biology Research Unit-UPGEMFaculty of Medicine of Sao Jose do Rio Preto-FAMERPSao Jose do Rio Preto 15090-000SPBrazil

BACKGROUND toll-like receptors(tLRs)are the first line of host defense,and are involved in Helicobacter pylori(***)recognition and activation of both inflammatory and carcinogenic *** presence of single nucleotide polymorphisms(SNPs)in genes that activate the immune response may modulate the risk of precancerous lesions and gastric cancer(GC).Among them,toll-like receptor 9(tLR9)polymorphisms have emerged with a risk factor of infectious diseases and cancer,however the studies are still *** to evaluate whether tLR9 rs5743836 and rs187084 SNPs contribute to the risk of gastric carcinogenesis,and its influence on mRNA *** A case-control study was conducted to evaluate two tLR9 SNPs(tLR9-1237 tCrs5743836 and tLR9-1486 Ct-rs187084)in chronic gastritis(CG)and GC patients.A total of 609 DNA samples of peripheral blood[248 CG,161 GC,and 200 samples from healthy individuals(C)]were genotyped by polymerase chain reaction-restriction fragment length *** samples were tested for the *** infection using Hpx1 and Hpx2 *** polymerase chain reaction by taqMan?assay was used to quantify tLR9 mRNA from fresh gastric tissues(48 GC,26 CG,and 14 C).RESULtS For tLR9-1237,the tC+CC or CC genotypes were associated with a higher risk of GC than C[recessive model odds ratio(OR)=5.01,95%confidence interval(CI):2.52-9.94,Pthe CG(recessive model OR=4.63;95%CI:2.44-8.79,PtLR9-1486,an association between the Ct+tt genotypes and increased risk of both GC(dominant model OR=2.72,95%CI:1.57-4.72,Pt model OR=1.79,95%CI:1.15-2.79,P=0.0094)was observed when compared to the C ***,the presence of tLR9-1237 tC/CC+tLR9-1486 CC genotypes potentiate the risk for this neoplasm(OR=18.57;95%CI:5.06-68.15,Pthe tLR9 mRNA level was significantly higher in the GC group(RQ=9.24,Ption to the CG group(RQ=1.55,P=0.0010)and normal mucosa(RQ=1.0).When the sa

关键词： toll-like receptor 9 Helicobacter pylori Gastric cancer Chronic gastritis Polymorphisms Gene expression