A metabolic signalling role for arginine in liver cancer

作     者：David Sokolov Lucas B.Sullivan David Sokolov;Lucas B.Sullivan

作者机构：Human Biology DivisionFred Hutchinson Cancer CenterSeattleWA 98109United States 

出 版 物：《Life Metabolism》 (生命代谢（英文）)

年 卷 期：2024年第3卷第1期

页      面：1-3页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：support from the National Institute of General Medical Sciences R35GM147118 to LS and PHS NRSA T32GM007270 to DS 

主　　题：incomplete cancer 

摘      要：In addition to their canonical roles in biosynthetic pathways,metabolites can be active participants in oncogenic signal-ling,but our understanding of these signalling mechanisms is *** a recent article published in Cell,Mossmann et *** a novel signalling role for accumulated arginine in hepato-cellular carcinoma(HCC)mediated by the RNA splicing factor and transcriptional modifier RNA-binding protein 39(RBM39).