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In vitro differentiation capacity of human breastmilk stem cells:A systematic review

World Journal of Stem Cells 2019年第11期11卷 1005-1019页

作者： Camila Maria Ribeiro Pacheco Priscila Elias Ferreira Claudia Sayuri Sacaki luana alves tannous Idiberto Jose Zotarelli-Filho Luiz Cesar Guarita-Souza Katherine Athayde Teixeira de Carvalho Cell Therapy and Biotechnology in Regenerative Medicine Department Pele Pequeno Príncipe InstituteChild and Adolescent Health Research and Pequeno Príncipe FacultyCuritiba 80.240-020ParanáBrazil PUCPR-Institute of Biological and Health Sciences CCBSCuritiba 80.215-901ParanáBrazil Post Graduate and Continuing Education(Unipos) Department of Scientific ProductionSao Jose do Rio Preto 15.020-040Sao PauloBrazil

BACKGROUND Mesenchymal stem cells are pluripotent cells that have the ability to generate cells from a cell line or in other cell types from different tissues but from the same *** those cells have more limited differentiation capacity than embryonic stem cells,they are easily obtained from somatic tissue and can be grown in large *** characteristic of undifferentiated stem cells differentiating into different cell lines arouses strategies in regenerative medicine for the treatment of different diseases such as neurodegenerative *** To evaluate the cell differentiation capacity of human breastmilk stem cells for the three germ layers by a systematic *** The searched databases were PubMed,EMBASE,OVID,and COCHRANE LIBRARY,published between 2007 and 2018 in the English *** were in vitro studies for analysis of the"cell differentiation potential"in the literature using the keywords“human breastmilk,”“stem cells,”and keywords combined with the Boolean operator“NOT”were used to exclude those articles that had the word“CANCER”and their respective synonyms,which were previously consulted according to medical subject heading *** 2009 guidelines were followed in this *** A total of 315 titles and abstracts of articles were *** these,21 were in common with more than one database,leaving 294 articles for *** that total,five publications met the inclusion *** analyzing the publications,it was demonstrated that human breastmilk stem cells have a high cellular plasticity,exhibiting the ability to generate cells of all three germ layers,endoderm,mesoderm,and ectoderm,demonstrating their *** cells expressed the genes,TRA-1-60/81,octamer-binding transcription factor 4,and NANOG,of which NANOG,a critical regulator for self-renewal and maintenance,was the most highly *** cells have the ability to differentiate in vitro into adipocytes,chondrocytes,osteocytes,oligod

关键词： Human breastmilk Stem cells Cell differentiation Pluripotency Stemness

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Antecedent Precipitation Index to Estimate Soil Moisture and Correlate as a Triggering Process in the Occurrence of Landslides

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International Journal of Geosciences 2024年第1期15卷 70-86页

作者： Marcio Augusto Ernesto De Moraes Walter Manoel Mendes Filho Rodolfo Moreda Mendes Cassiano Antonio Bortolozo Daniel Metodiev Marcio Roberto Magalhães De Andrade Harideva Marturano Egas Tatiana Sussel Gonçalves Mendes luana Albertani Pampuch CEMADEN - National Centre for Monitoring and Early Warnings of Natural Disasters General Coordination of Research and Development S&#227o José dos Campos Brazil Faculty of Science and Technology Goias Federal University Aparecida de Goi&#226nia Brazil Institute of Science and Technology S&#227o Paulo State University (Unesp) S&#227o José dos Campos Brazil

Landslides are highly dangerous phenomena that occur in different parts of the world and pose significant threats to human populations. Intense rainfall events are the main triggering process for landslides in urbanized slope regions, especially those considered high-risk areas. Various other factors contribute to the process;thus, it is essential to analyze the causes of such incidents in all possible ways. Soil moisture plays a critical role in the Earth’s surface-atmosphere interaction systems;hence, measurements and their estimations are crucial for understanding all processes involved in the water balance, especially those related to landslides. Soil moisture can be estimated from in-situ measurements using different sensors and techniques, satellite remote sensing, hydrological modeling, and indicators to index moisture conditions. Antecedent soil moisture can significantly impact runoff for the same rainfall event in a watershed. The Antecedent Precipitation Index (API) or “retained rainfall,” along with the antecedent moisture condition from the Natural Resources Conservation Service, is generally applied to estimate runoff in watersheds where data is limited or unavailable. This work aims to explore API in estimating soil moisture and establish thresholds based on landslide occurrences. The estimated soil moisture will be compared and calibrated using measurements obtained through multisensor capacitance probes installed in a high-risk area located in the mountainous region of Campos do Jordão municipality, São Paulo, Brazil. The API used in the calculation has been modified, where the recession coefficient depends on air temperature variability as well as the climatological mean temperature, which can be considered as losses in the water balance due to evapotranspiration. Once the API is calibrated, it will be used to extrapolate to the entire watershed and consequently estimate soil moisture. By utilizing recorded mass movements and comparing them with AP

关键词： Landslides Antecedent Precipitation Index Soil Moisture Threshold Water Balance

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ARHCS (Automatic Rainfall Half-Life Cluster System): A Landslides Early Warning System (LEWS) Using Cluster Analysis and Automatic Threshold Definition

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International Journal of Geosciences 2024年第1期15卷 54-69页

作者： Cassiano Antonio Bortolozo luana Albertani Pampuch Marcio Roberto Magalhães De Andrade Daniel Metodiev Adenilson Roberto Carvalho Tatiana Sussel Gonçalves Mendes Tristan Pryer Harideva Marturano Egas Rodolfo Moreda Mendes Isadora Araújo Sousa Jenny Power Cemaden - National Center for Monitoring and Early Warning of Natural Disasters General Coordination of Research and Development S&#227o José dos Campos Brazil Environmental Engineering Department Institute of Science and Technology S&#227o Paulo State University S&#227o José dos Campos Brazil Department of Mathematical Sciences University of Bath Bath UK Institute for Mathematical Innovation University of Bath Bath UK

A significant portion of Landslide Early Warning Systems (LEWS) relies on the definition of operational thresholds and the monitoring of cumulative rainfall for alert issuance. These thresholds can be obtained in various ways, but most often they are based on previous landslide data. This approach introduces several limitations. For instance, there is a requirement for the location to have been previously monitored in some way to have this type of information recorded. Another significant limitation is the need for information regarding the location and timing of incidents. Despite the current ease of obtaining location information (GPS, drone images, etc.), the timing of the event remains challenging to ascertain for a considerable portion of landslide data. Concerning rainfall monitoring, there are multiple ways to consider it, for instance, examining accumulations over various intervals (1 h, 6 h, 24 h, 72 h), as well as in the calculation of effective rainfall, which represents the precipitation that actually infiltrates the soil. However, in the vast majority of cases, both the thresholds and the rain monitoring approach are defined manually and subjectively, relying on the operators’ experience. This makes the process labor-intensive and time-consuming, hindering the establishment of a truly standardized and rapidly scalable methodology on a large scale. In this work, we propose a Landslides Early Warning System (LEWS) based on the concept of rainfall half-life and the determination of thresholds using Cluster Analysis and data inversion. The system is designed to be applied in extensive monitoring networks, such as the one utilized by Cemaden, Brazil’s National Center for Monitoring and Early Warning of Natural Disasters.

关键词： Landslides Early Warning System (LEWS) Cluster Analysis Landslides Brazil

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Obtaining 2D Soil Geotechnical Profiles from Cokriging Interpolation of Sample Data and Electrical Resistivity Tomography (ERT)—Applications in Mass Movements Studies

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International Journal of Geosciences 2024年第7期15卷 525-548页

作者： Cassiano Antonio Bortolozo Noel Howley Andy Legg Tristan Pryer Danielle Silva de Paula Tatiana Sussel Gonçalves Mendes Daniel Metodiev Marcio Roberto Magalhães de Andrade Silvio Jorge Coelho Simões Maiconn Vinicius de Moraes Marcio Augusto Ernesto de Moraes luana Albertani Pampuch Rodolfo Moreda Mendes Harideva Marturano Egas Institute of Science and Technology So Paulo State University (UNESP) So Jos dos Campos Brazil Cemaden-National Center for Monitoring and Early Warning of Natural Disasters General Coordination of Research and Development So Jos dos Campos Brazil Institute for Mathematical Innovation University of Bath Bath UK Department of Mathematical Sciences University of Bath Bath UK

Brazil annually faces significant challenges with mass movements, particularly in areas with poorly constructed housing, inadequate engineering, and lacking sanitation infrastructure. Campos do Jordão, in São Paulo state, is a city currently grappling with these issues. This paper details a study conducted within a pilot area in Campos do Jordão, where geophysical surveys and geotechnical borehole data were integrated. The geophysical surveys provided 2D profiles, and samples were collected to analyse soil moisture and plasticity. These datasets were combined using a Cokriging-based model to produce an accurate representation of the subsurface conditions. The enhanced modelling of subsurface variability facilitates a deeper understanding of soil behavior, which can be used to improve landslide risk assessments. This approach is innovative, particularly within the international context where similar studies often do not address the complexities associated with urban planning deficits such as those observed in some areas of Brazil. These conditions, including the lack of proper sanitation and irregular housing, significantly influence the geological stability of the region, adding layers of complexity to subsurface assessments. Adapting geotechnical evaluation methods to local challenges offers the potential to increase the efficacy and relevance of geological risk management in regions with similar socio-economic and urban characteristics.

关键词： Mass Movements Geophysics ERT Geotechnical Surveys Campos do Jordão Cokriging

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Association between Anisometropia as Well as Visual Acuity, Aniseikonia, and Stereopsis in the Absence of Strabismus

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Open Journal of Ophthalmology 2022年第2期12卷 129-141页

作者： David Tayah Marcelo tannous Youssef Sabba Tayah Milton Ruiz alves Universidade de Sã o Paulo S&#227 o Paulo Brazil Universidade Federal do Amazonas Manaus Brazil Universidade Nilton Lins Manaus Amazonas Brazil

Objective: The current study aimed to assess the association between the type of anisometropia and its effects on monocular and binocular best-corrected vision acuity (BCVA), aniseikonia, and stereopsis in the absence of strabismus. Methods: In total, 162 individuals with anisometropia and healthy eyes and without a previous history of amblyopia therapy and eye surgery were included in the analysis. According to spherical and cylindrical components and spherical equivalent, they were divided into the spherical hyperopic anisometropia (SHA, n = 31), spherical myopic anisometropia (SMA, n = 45), astigmatic or cylindrical hyperopic anisometropia (CHA, n = 22), and astigmatic or cylindrical myopic anisometropia (CMA, n = 64) groups. Patients without anisometropia (NA, n = 188) were classified under the control group. The effects of anisometropia on monocular and binocular BCVA, aniseikonia, and stereoacuity were examined. Results: The NA group had a significantly lower LogMAR of BCVA of the right eye (RE), left eye (LE), worse eye than the SHA, SMA, CMA, and CHA groups. Moreover, the SMA group had significantly lower LogMAR of BCVA than the CHA group (p Conclusion: Worse visual levels of the RE, LE, worse eye, BCVA difference, and lower stereopsis were evidenced in each type of anisometropia defined in this study. Cylindrical hyperopic anisometropia (CHA) resulted in a statically significant worsening VA level and stereopsis than cylindrical myopic (CMA) or spherical myopic anisometropia.

关键词： Anisometropia Visual Acuity Aniseiconia Stereoacuity Depth Perception

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Foodborne outbreaks in Brazil associated with fruits and vegetables:2008 through 2014

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Food Quality and Safety 2018年第4期2卷 173-181页

作者： Susana de Oliveira Elias luana Tombini Decol Eduardo Cesar Tondo Departamento de Ciências dos Alimentos-Universidade Federal do Rio Grande do Sul Instituto de Ciência e Tecnologia de Alimentos-Av.Bento Gonçalves9500 Prédio 43212 Agronomia CEP:91505-970-Porto Alegre-RS-Brasil

Objectives:Foodborne disease outbreaks linked to fruits and vegetables have been increasing in occurrence worldwide;therefore,the aim of this study was to identify the reported foodborne outbreaks associated with fruit and vegetable consumption in Brazil from 2008 to *** And Limitations:Thirty produce related outbreaks resulted in 2926 illnesses,347 hospitalizations,and no *** bacterial pathogens were identified as etiological *** these,Salmonella was the most frequent(30 per cent of outbreaks)followed by Staphylococcus aureus(23.3 per cent),Escherichia coli(10 per cent),Bacillus cereus(6.6 per cent),and thermotolerant coliforms(3.3 per cent),whereas etiological agents could not be determined for 26.6 per cent of *** most common food vehicles implicated in outbreaks were generically named as fruits and vegetables(46.6 per cent of outbreaks).The term salad was used generically and specifically like salads(two outbreaks),raw/cooked salads(four outbreaks),vegetable salad,tropical salad,Caesar salad,and raw salad of cabbage and *** one outbreak was related exclusively to fruit(fruit pulp),whereas other outbreaks were related to cooked carrot,lettuce,cucumber,watermelon/cabbage,and chard/*** sources and issues related to the future control of produce-related foodborne disease outbreaks are discussed.

关键词： produce pathogens Salmonella foodborne illness disease surveillance notification

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Distinct physiological mechanisms underpin growth and rehydration of Hymenaea courbaril and Hymenaea stigonocarpa upon short-term exposure to drought stress

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Journal of Forestry Research 2023年第1期34卷 113-123页

作者： luana M.Luz Ediane C.alves Nariane Q.Vilhena Tamires B.Oliveira Zara G.B.Silva Joze M.N.Freitas Candido F.O.Neto Roberto C.L.Costa Lucas C.Costa Universidade Federal Rural da AmazOia CapanemaPA 68700-665Brazil Universidade Federal Rural da AmazEia BelémPA 66077-830Brazil

Plants hold biochemical and physiological mechanisms to withstand drought ***,depending on water deficit interval,plant rehydration relies on how it can retain growth or a positive water balance—or rarely *** this study,two species of Hymenaea,one from the Amazon and the other from the Brazilian Cerrado,were investigated for their physiological mechanism associated with growth rehydration upon short-term exposure to drought *** findings demonstrate that Hymenaea courbaril tends to invest in nitrogen to the detriment of carbon compounds,-as it is limited by lower net photosynthesis-and adjust root growth to attenuate drought stress *** contrast,Hymenaea stigonocarpa takes advantage of higher water potential and a basal rate of lower net photosynthesis to support aboveground growth under such ***,it is postulated that there are distinct ways of controlling water status and growth between *** and ***,which are determined either by the ability of the species to keep net photosynthesis at low levels of water content or by favoring the accumulation of nitrogen *** mechanisms were effective with regards to water use efficiency and thus it is reasonable to suggest that strategies are not exclusive and may work under adverse conditions,as observed in Amazon and Brazilian Cerrado ***.

关键词： Hymenaea courbaril Hymenaea stigonocarpa Growth Photosynthesis Water deficit

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Stereopsis, Aniseikonia, and Associated Symptoms in Patients with Bilateral Pseudophakia with and without Anisometropia: A Comparative Study

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Open Journal of Ophthalmology 2022年第1期12卷 107-120页

作者： Marcelo tannous Daniel Dantas Paulo Roberto de Arruda Zantut David Tayah Pedro Carricondo Amaryllis Avakian Milton Ruiz alves Departament of Ophthalmology and Otolaryngology of HOSPITAL das Clinicas from University of Sã o Paulo Medical School Sao Paulo Brazil Department of Computer Federal University of Sergipe Aracaju Brazil

Objectives: The study aimed to compare stereopsis, aniseikonia, and associated symptoms in bilateral pseudophakia with and without anisometropia. Methods: Patients with senile cataracts, previously scheduled for phacoemulsification with an IOL implant in both eyes were included in this cross-sectional study. Patients were divided into two groups: control group (n = 69) with an interocular post-surgical refraction difference in Spherical Equivalent (SE) ?;Stereotest. Ten symptoms related to aniseikonia were evaluated with a questionnaire. Statistical evaluation of data included models of univariate, multivariate, and regression analyses. Results: Cataract surgery-induced aniseikonia was 0.64% ± 1.41% in control group and 0.62% ± 1.76% in anisometropia group with an insignificant difference (p = 0.766). Measured stereoacuity was 1.95 ± 0.17 log10 seconds of arc in the control group and 2.12 ± 0.22 log10 seconds of arc in the anisometropia group with a significant difference (p Conclusions: The study showed that stereopsis, aniseikonia, and associated symptoms did not stand for a substantial problem for visual comfort of bilateral pseu- dophakia with anisometropia less than 3D.

关键词： Cataract Phacoemulsification Pseudophakia Aniseikonia Depth Perception Anisometropia

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Osmoregulators in Hymenaea courbaril and Hymenaea stigonocarpa under water stress and rehydration

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Journal of Forestry Research 2018年第6期29卷 1475-1479页

作者： Luma Castro de Souza luana Moraes da Luz Je′ssica Taynara da Silva Martins Candido Ferreira de Oliveira Neto Juscelino Goncalves Palheta Tamires Borges de Oliveira Ediane Conceicao alves Risely Ferraz de Almeida Raimundo Leonardo Lima de Oliveira Roberto Cezar Lobo da Costa Nariane Quaresma Vilhena Universidade estadual paulista ju′lio de mesquita filho JaboticabalSP 14884-900Brazil Universidade Federal Rural da Amazonia(UFRA) Campus CapanemaCapanema 68700-030Brazil Universidade Federal Rural da Amazonia Campus BelemBelem 66077-830Brazil Universidade Federal de Vicosa(UFV) Vicosa 36570-900Brazil Universidade Estadual Paulista Ju′lio de Mesquita Fiho(UNESP) Jaboticabal 14884-900Brazil Universidade do Estado do Para′(UEPA) Bele′m 66113-200Brazil

The objective of this work was to evaluate the effect of different water deficiency and rehydration levels on the concentrations of osmoregulators in two plant species（Hymenaea courbaril and H. Stigonocarpa） in the Amazon. We adopted a 2×5×5 factorial system,referring to 2 species（H. courbaril and H. stigonocarpa）and 5 stages of hydration and rehydration. The five hydration and rehydration stages were established in:（1）Control treatment E0;（2） Plants with 13 days of stress after incubation—E13;（3） Plants with 26 days of stress E26;（4）The plants that were established after 26 days after incubation and rehydrated for two days（RD2）;（5） rehydrated for two days（RD4）. The plants that were established after 26 days after incubation and rehydrated for four days. The experiment totaled fifty young plants with five *** measurements were performed at the beginning of the experiment（E0） at 13（E13） and 26（E26） days after the water stress, in which the plants were rehydrated,repeating the analyses after two（RD2） and four（RD4）days. Both species increased the sucrose concentration by18%, with a decrease of 52% in starch content. The RD4 time presented the highest mean starch concentration(0.19 mmol g-1 of the residue for H. courbaril and0.27 mmol g;of residue for H. stigonocarpa). Increased proline concentrations were recorded for controls until RD2 for both species. For glycine betaine, the highest increases in treatments E26 and RD2 were observed for the H. courbaril species. Our rehydration period was not sufficient for total recovery of pre-stress concentrations of all studied solutes.

关键词： Amazonia Water stress Osmotic adjustment Proline Sucrose

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Thresholds of Instability: Precipitation, Landslides, and Early Warning Systems in Brazil

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International Journal of Geosciences 2023年第10期14卷 895-912页

作者： Maiconn Vinicius de Moraes luana Albertani Pampuch Cassiano Antonio Bortolozo Tatiana Sussel Gonçalves Mendes Marcio Roberto Magalhães de Andrade Daniel Metodiev Tristan Pryer Environmental Engineering Department Institute of Science and Technology S&#227o Paulo State University S&#227o José dos Campos Brazil Cemaden—National Center for Monitoring and Early Warning of Natural Disasters General Coordination of Research and Development S&#227o José dos Campos Brazil Department of Mathematical Sciences University of Bath Bath UK

Rainfall accumulation thresholds are crucial for issuing landslide warnings by identifying when soil saturation from rain could potentially trigger a landslide. Two essential types of thresholds are considered: environmental and operational. The environmental threshold indicates the minimum rainfall level required to potentially initiate a landslide. Conversely, the operational threshold is set lower to enable agencies to issue alerts before reaching environmental thresholds. Establishing these thresholds improves the accuracy of landslide predictions in terms of location and timing. This study introduces an innovative approach for determining these thresholds. Our approach employs cluster analysis and historical landslide data from the Metropolitan Region of Recife, Pernambuco State, Brazil. We applied our defined values to a significant landslide event in 2022, validating their robustness as the foundation for the operational threshold used by Cemaden, Brazil’s National Center for Monitoring and Early Warning of Natural Disasters.

关键词： Cluster Analysis Landslides Environmental Thresholds Rainfall Brazil

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