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China Ocean Engineering 2024年第4期38卷 636-647页

作者： HOU Fu-heng JIA lu-sheng CHEN Yan-fei ZHANG Qi ZHONG Rong-feng WANG Chun-sha School of Mechanical and Transportation Engineering China University of PetroleumBeijingBeijing 102249China CNOOC Research Institute Ltd.Beijing 100028 China

A dent is a common type of defects for submarine *** submarine pipelines,high hydrostatic pressure and internal pressure are the main *** pipelines bend due to complex subsea conditions,the compression strain capacity may be *** into the local buckling failure and accurate prediction of the compressive strain capacity are important.A finite element model of a pipeline with a dent is *** buckling failure under a bending moment is investigated,and the compressive strain capacity is *** effects of different parameters on pipeline local buckling are *** results show that the dent depth,external pressure and internal pressure lead to different local buckling failure modes of the pipeline.A higher internal pressure indicates a larger compressive strain capacity,and the opposite is true for external *** the ratio of external pressure to collapse pressure of intact pipeline is greater than 0.1,the deeper the dent,the greater the compressive strain capacity of the *** as the ratio is less than 0.1,the opposite is *** the basis of these results,a regression equation for predicting the compressive strain capacity of a dented submarine pipeline is proposed,which can be referred to during the integrity assessment of a submarine pipeline.

关键词： submarine pipeline dent defect bending load local buckling compressive strain capacity

Application of nanoscale metal–organic frameworks in tumor immunotherapy

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Rare Metals 2024年第10期43卷 4867-4883页

作者： Xiao-Xuan Zeng Jing-sheng lu Dong-Wei Ma Yu-Ting Huang Ling Chen Gang Wang Qing Chen Ning Lin College of Pharmacy Guangxi Scientific Research Center of Traditional Chinese MedicineGuangxi University of Chinese Medicine Guangxi Zhuang Yao Medicine Center of Engineering and Technology

Immunotherapy has attracted wide attention because it can not only kill tumor cells but also effectively prevent tumor recurrence. However, due to the poor efficacy of the monotherapy in tumor immunotherapy, combination therapies are needed to enhance their efficacy,such as chemodynamic therapy/immunotherapy, photodynamic therapy/immunotherapy, sonodynamic therapy/immunotherapy and so on. Nanoscale metal–organic frameworks(nMOFs) are widely used for drug delivery because of their rich and variable composition, high drug loading capacity and good biodegradability. Compared with other conventional drug delivery systems(DDSs),nMOFs play more advantageous role in inducing immune cell death of tumor cells and combination therapies. This article focuses on the application of n MOFs in tumor immunotherapy in terms of their use as gatekeepers, supplementary agents and drug carriers, respectively, with the aim of providing some ideas and references for the design of smart nanoscale DDS for tumor immunotherapy.

关键词： Drug delivery system Immunotherapy Metal–organic frameworks Tumor

Revealing the Structure-Property Difference of Natural Rubber Prepared by Different Methods: Protein and Gel Content are Key Factors

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Chinese Journal of Polymer Science 2024年第4期42卷 457-467页

作者： Shao-Qi Huang Jun-Qi Zhang Yong Zhu Ling-Min Kong lu-sheng Liao Fu-Quan Zhang Zheng-Tian Xie Jin-Rong Wu State Key Laboratory of Polymer Materials Engineering College of Polymer Science and EngineeringSichuan UniversityChengdu610065China Hainan Provincial Key Laboratory of Natural Rubber Processing Agricultural Products Processing Research Institute of Chinese Academy of Tropical Agricultural SciencesZhanjiang524001China

Natural rubber (NR) is widely used in various fields including aerospace, military industry and transportation due to its superior elasticity and comprehensive mechanical properties. Nonetheless, the commercial NR prepared by different methods usually exhibits different mechanical properties, primarily due to variations in processing conditions during the conversion from latex to bulk rubber material. Consequently, this poses challenges in scientific research and industrial production of NR. In order to assess the properties of various commercially available NR and identify key structural and compositional components, this study systematically compares and analyzes four representative NR raw materials: air dried sheet (ADS), ribbed smoked sheets (RSS), constant viscidity NR (CV), and whole field latex rubber (WF). The investigation focuses on evaluating their static mechanical behavior, SIC behavior, wear resistance, and fatigue resistance. The findings indicate that protein and gel content exhibit a crucial influence on the NR properties. These constituents contribute to the formation of a high-crosslinking density region, generating a heterogeneous network structure within the rubber. This structure amplifies strains during deformation, leading to earlier and stronger strain-induced crystallization (SIC). Among the four commercial NR brands, RSS demonstrates superior overall mechanical and dynamic properties owing to its high protein and gel content. This study serves as a valuable reference for comprehending the differences in properties among various commercial NR, thereby offering guidance for the actual processing and selection of NR.

关键词： Natural rubber Processingmethod Protein Gel content Property

Zinc-based metal-organic frameworks as efficient carriers for anticancer drug to reduce toxicity and increase efficacy

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Rare Metals 2024年第10期43卷 5152-5163页

作者： Dong-Wei Ma Jing-sheng lu Xiang-Xin Cao Yan-Wei Cheng Gang Wang Zi-Qian Zhang Bo-Cheng Chen Ning Lin Qing Chen College of Pharmacy Guangxi Scientific Research Center of Traditional Chinese MedicineGuangxi University of Chinese Medicine Guangxi Zhuang Yao Medicine Center of Engineering and Technology

The rational design of a specific co-drug delivery platform that can address the unavoidable resistance, toxic side effects and low targeting efficiency of traditional cancer treatments is of great ***, Zn-based MOF-zeolitic imidazole framework-90(ZIF-90) was selected as the drug delivery carrier, with the cancer therapeutic drug mercaptopurine(6-MP) and glucose oxidase(GOD) as the drug models, hyaluronic acid(HA) was used for protection and targeted delivery, which designed and fabricated an intelligent drug delivery platform(6-MP@ZIF-90@GOD@HA). This platform aims to reduce the toxic side effects of 6-MP and enhance its efficacy while improving the targeting ability of GOD,thereby further enhancing the treatment outcome. Notably,results from both in vitro and in vivo experiments demonstrate that the targeted synergistic chemo/reactive oxygen species(ROS)-mediated/starvation therapy inhibited the cancer cell growth while reducing the chemotherapy toxicity, which provides new possibilities for the development of more precise and effective treatment strategies.

关键词： Cancer treatment Combination therapy Drug delivery Metal-organic framework Reduced toxicity

Decoding the fish genome opens a new era in important trait research and molecular breeding in China

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Science China(Life Sciences) 2024年第10期67卷 2064-2083页

作者： Qian Zhou Jialin Wang Jiongtang Li Zhangfan Chen Na Wang Ming Li Lei Wang Yufeng Si sheng lu Zhongkai Cui Xuhui Liu Songlin Chen State Key Laboratory of Mariculture Biobreeding and Sustainable Goods Yellow Sea Fisheries Research InstituteChinese Academy of Fishery SciencesQingdaoShandong 266071China Laboratory for Marine Fisheries Science and Food Production Processes Qingdao Marine Science and Technology CenterQingdaoShandong 266237China Key Laboratory of Aquatic Genomics Ministry of Agriculture and Rural AffairsBeijing Key Laboratory of Fishery BiotechnologyChinese Academy of Fishery SciencesBeijing 100041China

Aquaculture represents the fastest-growing global food production sector,as it has become an essential component of the global food *** has the world's largest aquaculture industry in terms of production ***,the sustainable development of fish culture is hindered by several concerns,including germplasm degradation and disease *** practice of genomic breeding,which relies heavily on genome information and genotypephenotype relationships,has significant potential for increasing the efficiency of aquaculture *** 2014,the completion of the genome sequencing and annotation of the Chinese tongue sole signified the beginning of the fish genomics era in *** then,domestic researchers have made dramatic progress in functional genomic *** date,the genomes of more than 60 species of fish in China have been assembled and *** on these reference genomes,evolutionary,comparative,and functional genomic studies have revolutionized our understanding of a wide range of biologically and economically important traits of fishes,including growth and development,sex determination,disease resistance,metamorphosis,and ***,genomic tools and breeding techniques such as SNP arrays,genomic selection,and genome editing have greatly accelerated genetic improvement through the incorporation of functional genomic information into breeding *** review aims to summarize the current status,advances,and perspectives of the genome resources,genomic study of important traits,and genomic breeding techniques of fish in *** review will provide aquaculture researchers,fish breeders,and farmers with updated information concerning fish genomic research and breeding *** summary will help to promote the genetic improvement of production traits and thus will support the sustainable development of fish aquaculture.

关键词： fish genomics economic traits genomic selection genome editing genomic breeding

Pig H3K4me3,H3K27ac,and gene expression profiles reveal reproductive tissue-specific activity of transposable elements

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Zoological Research 2024年第1期45卷 138-151页

作者： Tao Jiang Zhi-Min Zhou Zi-Qi Ling Qing Zhang Zhong-Zi Wu Jia-Wen Yang Si-Yu Yang Bin Yang lu-sheng Huang National Key Laboratory of Pig Genetic Improvement and Germplasm Innovation Jiangxi Agricultural UniversityNanchangJiangxi 330045China

Regulatory sequences and transposable elements(TEs)account for a large proportion of the genomic sequences of species;however,their roles in gene transcription,especially tissue-specific expression,remain largely *** serve as an excellent animal model for studying genomic sequence biology due to the extensive diversity among their wild and domesticated ***,we conducted an integrated analysis using H3K27ac ChIP-seq,H3K4me3 ChIP-seq,and RNA-seq data from 10 different tissues of seven fetuses and eight closely related adult *** aimed to annotate the regulatory elements and TEs to elucidate their associations with histone modifications and mRNA expression across different tissues and developmental *** on correlation analysis between mRNA expression and H3K27ac and H3K4me3 peak activity,results indicated that H3K27ac exhibited stronger associations with gene expression than ***,1.45%of TEs overlapped with either the H3K27ac or H3K4me3 peaks,with the majority displaying tissue-specific ***,a TE subfamily(LTR4C_SS),containing binding motifs for SIX1 and SIX4,showed specific enrichment in the H3K27ac peaks of the adult and fetal ***-seq analysis also revealed widespread expression of TEs in the exons or promoters of genes,including 4688 TE-containing transcripts with distinct development stage-specific and tissue-specific *** note,1967 TE-containing transcripts were enriched in the *** identified a long terminal repeat(LTR),MLT1F1,acting as a testis-specific alternative promoter in SRPK2(a cell cycle-related protein kinase)in our pig *** element was also conserved in humans and mice,suggesting either an ancient integration of TEs in genes specifically expressed in the testes or parallel evolutionary ***,our findings demonstrate that TEs are deeply embedded in the genome and exhibit important tissue-specific biological functions,particularly in the reproductive

关键词： Transposable elements Porcine Histone modification Alternative promoter TE-containing transcript

Single-cell profiling of the pig cecum at various developmental stages

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Zoological Research 2024年第1期45卷 55-68页

作者： Yan-Yuan Xiao Qing Zhang Fei Huang Lin Rao Tian-Xiong Yao Si-Yu Yang Lei Xie Xiao-Xiao Zou Li-Ping Cai Jia-Wen Yang Bin Yang lu-sheng Huang National Key Laboratory for Swine Genetic Improvement and Germplasm Innovation Ministry of Science and Technology of ChinaJiangxi Agricultural UniversityNanchangJiangxi 330045China

The gastrointestinal tract is essential for food digestion,nutrient absorption,waste elimination,and microbial ***-cell transcriptome profiling of the intestinal tract has greatly enriched our understanding of cellular diversity,functional heterogeneity,and their importance in intestinal tract development and *** such profiling has been extensively conducted in humans and mice,the single-cell gene expression landscape of the pig cecum remains ***,single-cell RNA sequencing was performed on 45572 cells obtained from seven cecal samples in pigs at four different developmental stages(days(D)30,42,150,and 730).Analysis revealed 12 major cell types and 38 subtypes,as well as their distinctive genes,transcription factors,and regulons,many of which were conserved in *** increase in the relative proportions of CD8^(+)T and Granzyme A(low expression)natural killer T cells(GZMA^(low)NKT)cells and a decrease in the relative proportions of epithelial stem cells,Tregs,RHEX^(+)T cells,and plasmacytoid dendritic cells(pDCs)were noted across the developmental ***,the post-weaning period exhibited an up-regulation in mitochondrial genes,COX2 and ND2,as well as genes involved in immune activation in multiple cell ***-cell crosstalk analysis indicated that IBP6^(+)fibroblasts were the main signal senders at D30,whereas IBP6^(−)fibroblasts assumed this role at the other *** cells established interactions with epithelial cells and IBP6^(+)fibroblasts in the D730 cecum through mediation of GZMA-F2RL1/F2RL2 *** study provides valuable insights into cellular heterogeneity and function in the pig cecum at different development stages.

关键词： Single-cell RNA-seq Cecum Bama Xiang pigs Various developmental stages Cellular heterogeneity

冲击速度对单晶镍层裂行为的影响规律及作用机制

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物理学报 2024年第16期73卷 118-129页

作者：王路生罗龙刘浩杨鑫丁军宋鹍路世青黄霞重庆理工大学机械工程学院重庆400054 西南科技大学环境与资源学院绵阳621000

为了阐明冲击速度对单晶镍冲击层裂行为的影响机理,采用非平衡分子动力学方法获得了不同冲击速度下单晶镍自由面的速度、径向分布函数、原子晶体结构、位错和孔洞演化过程.结果表明单晶镍层裂行为的临界冲击速度为1.5 km/s,当冲击速度U_... 详细信息

为了阐明冲击速度对单晶镍冲击层裂行为的影响机理,采用非平衡分子动力学方法获得了不同冲击速度下单晶镍自由面的速度、径向分布函数、原子晶体结构、位错和孔洞演化过程.结果表明单晶镍层裂行为的临界冲击速度为1.5 km/s,当冲击速度U_(p)≤1.5 km/s时,层裂机制为经典层裂损伤,而U_(p)>1.5 km/s时表现出微层裂损伤.相比经典层裂,微层裂下孔洞数量显著增加,分布更为分散,应力区域宽.分析了冲击速度对经典层裂损伤行为(U_(p)≤1.5 km/s)的影响,并获得了相应的层裂强度,当U_(p)=1.3 km/s时,发生层裂强度突变.单晶镍的层裂强度与层错、相变和位错机制共同作用.随着位错形核和发射位错数量增加,导致层裂强度先下降.当冲击速度U_(p)1.3 km/s,层裂强度主要由BCC相变机制影响,其相变机制为相变路径为FCC→BCT→BCC的马氏体相变机制.本文揭示了冲击速度对层裂损伤和断裂影响规律及作用机制,可为镍基材料在极端冲击条件下的防护应用提供理论基础.

关键词：冲击速度单晶镍层裂相变分子动力学

3D打印导板技术在脊柱外科的应用现状与展望

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中华解剖与临床杂志 2024年第5期29卷 283-288页

作者：陆声辛欣云南省第一人民医院骨科/昆明理工大学附属医院骨科/云南省数字骨科重点实验室昆明650032 陕西省安康市中心医院数字骨科中心安康725000

脊柱区域解剖结构复杂,毗邻脊髓神经、血管,使得脊柱外科手术过程中置钉、截骨的偏移可能导致灾难性后果。3D打印导板技术的应用为脊柱外科手术操作提供一种个性化、精准化、数字化的方案。通过术前计算机辅助设计螺钉路径、截骨范围,... 详细信息

脊柱区域解剖结构复杂,毗邻脊髓神经、血管,使得脊柱外科手术过程中置钉、截骨的偏移可能导致灾难性后果。3D打印导板技术的应用为脊柱外科手术操作提供一种个性化、精准化、数字化的方案。通过术前计算机辅助设计螺钉路径、截骨范围,术中通过导板执行引导,提高了置钉与截骨的准确性,减少了手术的并发症。本文介绍3D打印导板技术在脊柱外科的发展历史和临床应用现状,论述导板的局限性及其可能的发展方向。

关键词：脊柱外科手术,计算机辅助三维打印手术导板截骨椎弓根螺钉

上海市社区卫生服务中心口腔诊室建设情况调查及城郊差异分析

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中华全科医师杂志 2024年第3期23卷 251-257页

作者：陈斌徐先国盛璐上海市闵行区华漕社区卫生服务中心上海201107 上海市浦东新区张江社区卫生服务中心上海201210 上海市口腔医院口腔颌面外科上海200237

目的了解上海市社区卫生服务中心口腔诊室的建设情况及城郊差异。方法该研究为横断面研究。于2023年3月10—17日,采用问卷调查的形式通过自行设计的《上海市社区卫生服务中心口腔诊疗服务能力调查表》,收集上海市249家社区卫生服务中心... 详细信息

目的了解上海市社区卫生服务中心口腔诊室的建设情况及城郊差异。方法该研究为横断面研究。于2023年3月10—17日,采用问卷调查的形式通过自行设计的《上海市社区卫生服务中心口腔诊疗服务能力调查表》,收集上海市249家社区卫生服务中心的口腔诊室相关信息,根据上海市卫生统计年鉴的分区类型分为中心城区、近郊地区、远郊地区3类,从口腔诊室基本设施、开展的临床诊疗项目、人员结构等方面比较城郊差异情况。结果调查有效问卷回收率为100.0%(249/249)。(1)全市249家社区卫生服务中心中,220家设置了口腔诊室(88.4%),29家(11.6%)未设置,近郊地区、中心城区和远郊地区设置了口腔诊室的社区卫生服务中心占比分别为98.2%(107/109)、95.0%(76/80)和61.7%(37/60),近郊地区>中心城区>远郊地区(H=35.44,P中心城区>远郊地区(H=25.07,P中心城区>远郊地区(H=66.35、50.33、11.19、42.17,均P<0.05)。结论上海市社区卫生服务中心口腔服务能力具备一定的基础,但中心城区、近郊地区和远郊地区差异较大,其中近郊地区发展较好,中心城区在建筑面积等方面需要加强,远郊在设施设备、人才队伍方面需要加强。

关键词：社区卫生服务问卷调查口腔保健牙科诊室