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Evolution of Acquired Humoral Immunity after Full Vaccination against SARS-CoV-2. IgG Levels in Healthcare Workers at 6 and 9 Months

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World Journal of Vaccines 2023年第2期13卷 13-32页

作者： Victoria Delicado-Useros Esther Navarro-Rodenas Indalecio-M Sánchez-Onrubia Carmen Ortega-Martínez Antonia Alfaro-Espín Juan-D Pérez-Serra Francisco García-Alcaraz Julia Lozano-Serra lorena Robles-fonseca Teresa Pérez-Domenech Nursing Faculty Castilla-La Mancha University Nursing & Society Research Group Albacete Spain Emergency Department General Hospital Almansa Spain Emergency Department General Hospital Albacete Spain Nursing Faculty Nursing & Society Research Group Universidad de Castilla-La Mancha Albacete Spain Emergency Department Son Espasses Universitary Hospital Palma de Mallorca Spain Departament of Clinical Microbiology in Albacete General Hospital Albacete Spain

Background: The COVID-19 pandemic continues to be a major worldwide health problem. The present study aims to contribute to surveillance of the immune and clinical response of vaccines to SARS-CoV-2. Methods: Observational medication study on acquired immunity and effectiveness of vaccines. Population: 620 workers in the health service of Almansa (Spain). Representative sample of 150 individuals. Sociodemographic, clinical, and epidemiological data and samples were recorded to determine anti-SARS-CoV-2 serum IgG levels 6 and 9 months after vaccination with Pfizer. Results: Mean age 46.45 years;76% women;85.1% working in a hospital. 19.3% had had COVID-19 in the year prior to vaccination. 96.7% were fully vaccinated with Pfizer/BioNTech. At 6 months, 100% seropositivity and mean IgG levels of 3017.2 AU/ml. Significant variations in IgG levels in individuals with prior COVID-19 infection and smokers. At 9 months, 99.3% remained seropositive;2.8% infected after vaccination. The repeated measures analysis showed a difference in means of 669.0 AU/ml (significant decrease in IgG levels of 28.9%). Conclusion: Antibody levels remained positive 6 and 9 months after vaccination, although IgG levels were found to decay.

关键词： Acquired Immunity SARS-CoV-2 Vaccine IgG level Healthcare Workers COVID-19 Incidence Rate

Novel genetic markers in inflammatory bowel disease

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World Journal of Gastroenterology 2007年第42期13卷 5560-5570页

作者： lorena Rodríguez-Bores Gabriela C fonseca Marco A Villeda Jesús K Yamamoto-Furusho IBD Clinic Department of Gastroenterology Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Vasco de Quiroga 15 colonia Sección XVI Tlalpan CP 14000 México

Genetic factors play a significant role in determining inflammatory bowel disease(IBD)*** data support genetic contribution to the pathogenesis of IBD,which include familial aggregation,twin studies,racial and ethnic differences in disease *** studies have identified several susceptibility genes contained in different genomic regions named IBD1 to *** oligomerization domain(NOD2)and human leukocyte antigen(HLA)genes are the most extensively studied genetic regions(IBD1 and IBD3 respectively)in *** of the NOD2 gene are associated with Crohn's disease(CD)and several HLA genes are associated with ulcerative colitis(UC)and *** like receptors(TLRs)have an important role in the innate immune response against infections by mediating recognition of pathogen-associated microbial *** single-nucleotide polymorphisms(SNPs)in molecules involved in bacterial recognition seems to be essential to define genetic backgrounds at risk of ***,numerous new genes have been identified to be involved in the genetic susceptibility to IBD:NOD1/Caspase-activation recruitment domains 4(CARD4),Chemokine ligand 20(CCL20),IL-11,and IL-18 among *** characterization of these novel genes potentially will lead to the identification of therapeutic agents and clinical assessment of phenotype and prognosis in patients with IBD.

关键词：肠炎遗传标记发病机理克罗恩氏病

Maternal and Child Care Assessment Focused on Prenatal Care and Birth

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Health 2015年第1期7卷 167-173页

作者： Isabelle Christine fonseca G.A.Silva Tainara lorena dos Santos Ferreira Dídia de Oliveira Pereira Joymara Railma Gomes de Assuncao Paloma Batista Costa Jovanka Bittencourt Leite de Carvalho Iris do Ceu Clara Costa Fábia barbosa de Andrade Nursing Faculty of Health Sciences of Trairi(FACISA)Federal University of Rio Grande do Norte(UFRN)Santa CruzBrazil Department of Nursing Federal University of Rio Grande do Norte(UFRN)NatalBrazil Department of Dentistry Federal University of Rio Grande do Norte(UFRN)NatalBrazil

Objective: This study aims at assessing maternal and child care provided from prenatal to birth, so that it can reveal the weaknesses and potentialities of prenatal program in order to guide the development of strategic plans. Methods: This is an exploratory descriptive study with a quantitative approach, conducted in the city of Santa Cruz, state of Rio Grande do Norte, Brazil, from November 2012 to February 2013. The sample consisted of 200 women, chosen by draw, mothers of children under two years old who had attended the Primary Health Care System. The study used a semi-structured questionnaire used by the Ministry of Health. Our research project was approved by the Research Ethics Committee of the Federal University of Rio Grande do Norte, under the approval No. 311.613. Results: It was found that most mothers were rated from good to very good in the quality of care during prenatal and birth. As to the performance of prenatal and birth care services, most women performed those services under the municipality’s Public Health System, and the prenatal care primarily under Basic Health Care Units. Conclusion: In this assessment study, indicators regarding maternal and child care provided during the prenatal period were found to be positive, which contributes to the reduction of maternal and child mortality. The study also shows that Primary Health Care is essential to ensuring an effective, humane and comprehensive health care.

关键词： Primary Health Care Health Assessment Nursing

Quality of Service to Users of Primary Health Care:A Study of Evaluation

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Health 2015年第2期7卷 201-206页

作者： Fábia barbosa de Andrade Iris do Ceu Clara Costa Tainara lorena dos Santos Ferreira Dayane Caroliny Pereira Justino Luanni Rayssa de Medeiros Souza Cláudia Janiele Batista fonseca Paula Thayse Costa Fernandes Andréia Geíse Gomes de Araújo Faculty of Health Sciences of Trairi(FACISA) Federal University of Rio Grande do Norte(UFRN)Santa CruzBrazil Department of Dentistry Federal University of Rio Grande do Norte(UFRN)NatalBrazil

The quality of service to people in Primary Healthcare (PHC) is linked to the provision of quality service by professionals who integrate this service in the community. Accordingly, this study aims to evaluate the service given by health professionals in primary health care, from the user’s perception. This is an evaluative and quantitative study, conducted with people who use the PHC service. 180 adults are interviewed in the city of Santa Cruz, Rio Grande do Norte, Brazil. The results show that most respondents are women. The average age is of 36.65, median of 34.00 and standard deviation of 11,554. With regards to the quality of service, it ranges from fair to good. When performing correlation between the quality of service and time spent to reach the service, most people say that they spend between 0 and 15 minutes from their house to the healthcare service unit. About reception, respondents reported being satisfied and that the service has been responsible and quality for health monitoring. Thus, it is noted that the user classifies the quality of the service in primary healthcare as regular, showing weaknesses that need to be corrected to prevent damage in service provision in Primary Healthcare.

关键词： Primary Healthcare Adult’s Health Public Health Nursing

Senior Citizens’Cultural Activity and Participation in Community Life

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Health 2015年第7期7卷 859-864页

作者： Fábia barbosa de Andrade Tainara lorena dos Santos Ferreira Dídia de Oliveira Pereira Ingrid Katianne Marques Araújo Joymara Railma Gomes de Assuncao Isabelle Christine fonseca G.A.Silva Jéssica Isabelle dos Santos Dutra Aline de Lima Cabral Faculty of Health Sciences of Trairi(FACISA) Federal University of Rio Grande do Norte(UFRN)Santa CruzBrazil

Objective: This study has the objective to know the cultural activities of the senior citizen and their participation in community life as encouraged by Primary Health Care professionals. Methods: This is a quantitative study that was performed on 130 senior citizens in the city of Santa Cruz, in the Brazil state of Rio Grande do Norte. Results: The participation of senior citizens in groups is very beneficial because it increases their autonomy and self-esteem, socialization, well-being and consequently, which leads to a higher quality of life. However, there were some failures in the promotion of healthy aging and the adoption of strategic activities. Conclusions: Based on this observation, it is expected that this study can provide resources for the primary health care professionals to try to stimulate senior citizens by carrying out cultural activities that value and increase their potential, quality of life and self-esteem and, thus, promote active and healthy aging.

关键词： Quality of Life Health of the Elderly Primary Health Care

Assessment of Comprehensive Health Care of the Elderly in Primary Health Care

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Health 2015年第3期7卷 365-370页

作者： Fábia barbosa de Andrade Iris do Ceu Clara Costa Tainara lorena dos Santos Ferreira Isabelle Christine fonseca G.A.Silva Ingrid Katianne Marques Araujo Dídia de Oliveira Pereira Joymara Railma Gomes de Assuncao Jéssica Isabelle dos Santos Dutra Aline de Lima Cabral Nursing Faculty of Health Sciences of Trairi(FACISA)Federal University of Rio Grande do Norte(UFRN)Santa CruzBrazil Department of Dentistry Federal University of Rio Grande do Norte(UFRN)NatalBrazil

Objective: To assess comprehensive care in the elderly population, as well as the quality of care in Primary Health Care. Methods: This is an exploratory descriptive study with a quantitative approach, conducted from July to December 2012, in the city of Santa Cruz, Rio Grande do Norte, Brazil. A sample of 130 subjects chosen by drawn was calculated, and data collection was performed at their homes. Results: There were interviewed 130 people, 92 (70.8%) women and 38 men (29.2%), with a minimum age of 60 and maximum of 96 years, with a mean of 72.8, median of 72.0 and a standard deviation of 8.3. Regarding the quality of care ratings of the PHC team, 48.5% (n = 63) of respondents stated this to be good, while 32.3% (n = 42) rated this as fair. Conclusions: In this perspective, one of the most appreciated meanings that were given to comprehensive care by health care professionals refers to holistic knowledge of each patient, resulting in the non-fragmentation of care. Thus, it is noticed that comprehensiveness has some weaknesses that need to be corrected, which shows the need for education and training of professionals assigned to primary health care services.

关键词： Comprehensive Health Care Health Evaluation Health of the Elderly Primary Health Care Professional Practice

Highlighting COVID-19:What the imaging exams show about the disease

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World Journal of Radiology 2021年第5期13卷 122-136页

作者： lorena Sousa de Carvalho Ronaldo Teixeira da Silva Júnior Bruna Vieira Silva Oliveira Yasmin Silva de Miranda Nara Lúcia fonseca Rebouças Matheus Sande Loureiro Samuel Luca Rocha Pinheiro Regiane Santos da Silva Paulo Victor Silva Lima Medrado Correia Maria José Souza Silva Sabrina Neves Ribeiro Filipe Antônio França da Silva Breno Bittencourt de Brito Maria Luísa Cordeiro Santos Rafael Augusto Oliveira Sodré Leal Márcio Vasconcelos Oliveira Fabrício Freire de Melo Department of Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

Coronavirus disease 2019(COVID-19),a global emergency,is caused by severe acute respiratory syndrome coronavirus *** gold standard for its diagnosis is the reverse transcription polymerase chain reaction,but considering the high number of infected people,the low availability of this diagnostic tool in some contexts,and the limitations of the test,other tools that aid in the identification of the disease are *** this scenario,imaging exams such as chest X-ray(CXR)and computed tomography(CT)have played important *** is useful for assessing disease progression because it allows the detection of extensive consolidations,besides being a fast and cheap *** the other hand,CT is more sensitive for detecting lung changes in the early stages of the disease and is also useful for assessing disease *** note,ground-glass opacities are the main COVID-19-related CT *** emission tomography combined with CT can be used to evaluate chronic and substantial damage to the lungs and other organs;however,it is an expensive *** ultrasound(LUS)has been shown to be a promising technique in that context as well,being useful in the screening and monitoring of patients,disease classification,and management related to mechanical ***,LUS is an inexpensive alternative available at the ***,magnetic resonance imaging,although not usually requested,allows the detection of pulmonary,cardiovascular,and neurological abnormalities associated with ***,it is important to consider the challenges faced in the radiology field in the adoption of control measures to prevent infection and in the follow-up of post-COVID-19 patients.

关键词： SARS-CoV-2 COVID-19 Pneumonia Pandemic Radiology Tomography