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Bat-derived oligopeptide LE6 inhibits the contact-kinin pathway and harbors anti-thromboinflammation and stroke potential

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Zoological Research 2024年第5期45卷 1001-1012页

作者： Li-Na Cha Juan Yang Jin-Ai Gao Xin Lu Xiao-long Chang Rebecca Caroline Thuku Qi Liu Qiu-Min Lu Dong-Sheng Li Ren Lai Ming-Qian Fang Engineering Laboratory of Peptides of Chinese Academy of Sciences Key Laboratory of Bioactive Peptides of Yunnan ProvinceKIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesNational Resource Center for Non-Human PrimatesNational Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility)Key Laboratory of Genetic Evolution&Animal ModelsSino-African Joint Research Centerand New Cornerstone Science LaboratoryKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650201China School of Molecular Medicine Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhouZhejiang 310024China First Affiliated Hospital of Kunming Medical University KunmingYunnan 650032China

Thrombosis and inflammation are primary contributors to the onset and progression of ischemic *** contact-kinin pathway,initiated by plasma kallikrein(pk)and activated factor XII(FXIIa),functions bidirectionally with the coagulation and inflammation cascades,providing a novel target for therapeutic drug development in ischemic *** this study,we identified a bat-derived oligopeptide from Myotis myotis(Borkhausen,1797),designated LE6(Leu-Ser-Glu-Glu-Pro-Glu,702 Da),with considerable potential in stroke therapy due to its effects on the contact kinin ***,LE6 demonstrated significant inhibitory effects on pk and FXIIa,with inhibition constants of 43.97μmol/L and 6.37μmol/L,*** vitro analyses revealed that LE6 prolonged plasma recalcification time and activated partial thromboplastin *** murine models,LE6 effectively inhibited carrageenan-induced mouse tail thrombosis,FeCl3-induced carotid artery thrombosis,and photochemically induced intracerebral ***,LE6 significantly decreased inflammation and stroke injury in transient middle cerebral artery occlusion ***,the low toxicity,hemolytic activity,and bleeding risk of LE6,along with its synthetic simplicity,underscore its clinical *** conclusion,as an inhibitor of FXIIa and pk,LE6 offers potential therapeutic benefits in stroke treatment by mitigating inflammation and preventing thrombus formation.

关键词： pk FXIIa Anti-thromboinflammation Ischemic stroke therapies Oligopeptide

Influencing factors analysis of hard limestone reformation and strength weakening under acidic effect

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Journal of Central South University 2024年第7期31卷 2446-2466页

作者： HOU Ming-xiao HUANG Bing-xiang ZHAO Xing-long JIAO Xue-jie ZHENG Chen-yang State Key Laboratory for Fine Exploration and Intelligent Development of Coal Resources China University of Mining and TechnologyXuzhou 221116China

Roof disaster has always been an important factor restricting coal mine safety *** effect can reform the rock mass structure to weaken the macroscopic strength characteristics,which is an effective way to control the hard limestone *** this study,the effects of various factors on the reaction characteristics and mechanical properties of limestone were *** results show that the acid with stronger hydrogen production capacity after ionization(pk_(a)pka increases from−8.00 to 15.70,uniaxial compressive strength and elastic modulus of limestone increase by 117.22%and 75.98%.The influence of acid concentration is manifested in the dissolution behavior of mineral crystals,the crystal defects caused by large-scale acid action will lead to the deterioration of limestone strength,and the strength after 15%concentration reformation can be reduced by 59.42%.The effect of acidification time on limestone has stages and is the most obvious in the initial metathesis reaction stage(within 60 min).The key to the strength damage of acidified limestone is the participation of hydrogen ions in the reaction *** on the analytic hierarchy process method,the influence weights of acid type,acid concentration and acidification time on strength are 24.30%,59.54% and 16.16%,*** research results provide theoretical support for the acidification control of hard limestone roofs in coal mines.

关键词： hard roof acidic effect structural reformation strength weakening influencing factors

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洪泛区软基处理施工技术

工程建设与设计 2024年第8期 148-150页

作者：张龙中铁十四局集团第一工程发展有限公司山东日照276826

简述了阿尔及利亚东西高速东标段项目pk360~pk363段洪泛区软土地基处理施工技术。结合沉降观测方法,对抛石挤淤法处理洪泛区软土地基技术进行优化,并提出现场沉降控制措施。填筑完成后,由观测数据验算路基的稳定性可知,施工过程中沉降可... 详细信息

简述了阿尔及利亚东西高速东标段项目pk360~pk363段洪泛区软土地基处理施工技术。结合沉降观测方法,对抛石挤淤法处理洪泛区软土地基技术进行优化,并提出现场沉降控制措施。填筑完成后,由观测数据验算路基的稳定性可知,施工过程中沉降可控,并最大限度地避免了工后沉降。该段软土地基处理满足阿尔及利亚相关规范的要求。

关键词：软土地基处理沉降观测洪泛区

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Reduced clinical severity during 2022 Shanghai Spring epidemic of SARS-CoV-2 omicron BA.2 variant infection——an integrated account of virus pathogenicity and vaccination effectiveness

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National Science Review 2024年第4期11卷 24-27页

作者： Xingyue Wu Yao Chen Kangli Cao Yao Shen Xueling Wu Yilin Yang Zhongshu Kuang Qingrun Li Zhenzhen Lu Yichen Jia Mian Shao Guorong Gu Xiangwei Wang Ye Yao Ying Wang Shaodie Chen Zhigao Yu Wei Wei longfei Ding Lulu Lan Tianwen Gu Xiangyu long Jian Sun Lingyu Xing Jiayuan Shen Yi Han Yue Luo Sucheng Mu Mengna Lin Xiaoyan Zhang Rong Zeng Jianqing Xu Guoping Zhao Lihong Huang Zhenju Song Department of Emergency Medicine Clinical Center for Bio-Therapy Department of Biostatistics and Department of UrologyShanghai Key Laboratory of Lung Inflammation and Injury Zhongshan Hospital Fudan University Department of Respiratory and Critical Care Medicine Shanghai Pudong Hospital Fudan University Department of Pulmonology Renji Hospital Shanghai Jiao Tong University School of Medicine Key Laboratory of Systems Biology Center for Excellence in Molecular Cell Science Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Sciences Shanghai Public Health Clinical Center Fudan University Department of Biostatistics School of Public Health Key Laboratory of Public Health Safety of Ministry of Education and Shanghai Institute of Infectious Disease and Biosecurity School of Public Health Fudan University Shanghai Institute of Immunology Department of Immunology and Microbiology Shanghai Institute of Virology Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of EducationSchool of Medicine Shanghai Jiao Tong University State Key Laboratory of Genetic Engineering Fudan Microbiome CenterSchool of Life Sciences Fudan University Bio-Med Big Data Center Shanghai Institute of Nutrition and Health Chinese Academy of Sciences

The emergence of SARS-Co V-2 variant of concern omicron BA.2 led to high infection incidence rates as well as reduced severity of COVID-19 during the Shanghai Spring epidemic of 2022 [1]. We assessed the role of viral pathogenicity and the effectiveness of inactivated vaccines in a retrospective observational study including 10 258 confirmed COVID-19cases identified between April and June of 2022, from four COVID-19 designated hospitals located in two areas of Shanghai, namely the West Bund and the East Bund, where the populations’ demographic characteristics varied significantly (Table S1, Fig. S1).

关键词： REPLICATION

鄱阳湖湿地细菌群落多样性和可培养细菌功能基因丰度

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环境科学 2024年第4期45卷 2223-2232页

作者：喻江王淳龙永刘贵花李春杰范国权于镇华哈尔滨商业大学食品工程学院哈尔滨150028 江西师范大学地理与环境学院鄱阳湖湿地与流域研究教育部重点实验室南昌330022 中国科学院东北地理与农业生态研究所黑土区农业生态重点实验室哈尔滨150081 黑龙江省农业科学院经济作物研究所哈尔滨150086

鄱阳湖湿地中蕴含着丰富的微生物资源,参与并维持着湿地生态系统的物质循环和稳定.为探明鄱阳湖湿地土壤细菌分布规律,分析可培养细菌群落结构和功能特征,采用Illumina MiSeq高通量测序技术分析了鄱阳湖湿地土壤全部细菌(AW)和湿地外围... 详细信息

鄱阳湖湿地中蕴含着丰富的微生物资源,参与并维持着湿地生态系统的物质循环和稳定.为探明鄱阳湖湿地土壤细菌分布规律,分析可培养细菌群落结构和功能特征,采用Illumina MiSeq高通量测序技术分析了鄱阳湖湿地土壤全部细菌(AW)和湿地外围周边土壤全部细菌(AS)群落结构多样性特征;又结合可培养方法和qPCR功能基因芯片技术,分析了湿地可培养细菌(CW)和湿地外围周边土壤可培养细菌(CS)功能基因丰度差异.研究发现鄱阳湖湿地土壤细菌多样性低于湿地外围周边土壤细菌,变形菌门和酸杆菌门是两种土壤环境中共有的细菌优势菌门,放线菌门、厚壁菌门、绿弯菌门和热脱硫杆菌门也是存在于两种土壤中的主要菌门,但相对丰度均差异显著;网络分析显示湿地土壤较周边土壤细菌网络结构更简单.采用可培养方法获得的不同采样点土壤细菌群落多样性差异不明显.但湿地土壤可培养细菌功能基因的拷贝数高于周边土壤,其中参与氮循环的UreC基因和参与碳固定的acsE基因在两种土壤可培养细菌中相对丰度较高.研究结果可为深入挖掘调控、维持湿地土壤养分循环和促进鄱阳湖湿地生态系统功能稳定性的潜在有益微生物提供理论依据.

关键词：鄱阳湖湿地细菌多样性 Illumina MiSeq高通量测序可培养细菌分子生态网络

Responses of plant diversity and primary productivity to nutrient addition in a Stipa baicalensis grassland, China

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Journal of Integrative Agriculture 2015年第10期14卷 2099-2108页

作者： YU Li SONG Xiao-long ZHAO Jian-ning WANG Hui BAI long YANG Dian-lin Agro-Environmental Protection Institute Ministry of Agriculture College of Horticulture Shenyang Agricultural University Key Laboratory of Original Agro-Environment Quality Ministry of Agriculture

Nutrient addition can affect the structure and diversity of grassland plant communities, thus alter the grassland productivity. Studies on grassland plant community composition, structure and diversity in response to nutrient addition have an important theoretical and practical significance for the scientific management of grassland, protection of plant diversity and the recovery of degraded grassland. A randomized block design experiment was conducted with six blocks of eight treatments each： control（no nutrient addition） and K, P, N, pk, NK, NP, and Npk addition. We evaluated plant composition, height, coverage, density, and aboveground biomass to estimate primary productivity and plant diversity. Results showed that all treatments increased primary productivity significantly（P〈0.05） with the exception of the K and the Npk treatments had the greatest effect, increasing aboveground biomass 2.46 times compared with the control（P〈0.05）. One-way ANOVA and factorial analysis were used for the species richness, Shannon-Wiener index, Pielou index and aboveground biomass, and the relationships between the diversity indices and aboveground biomass were determined through linear regression. We found that fertilization altered the community structure; N（but not P or K） addition increased the proportion of perennial rhizome grasses and significantly reduced that of perennial forbs（P〈0.05）, thus it presented a trend of decrease in species richness, Shannon-Wiener and Pielou indexex, respectively. Only the main effects of N had significant impacts on both the diversity indices and the aboveground biomass（P〈0.05）, and the interactions between N-P, N-K, P-K and N-P-K could be neglected. With fertilization, plant diversity（correlation coefficient, –0.61）, species richness（–0.49）, and species evenness（–0.51） were all negatively linearly correlated with primary productivity. The correlations were all significant（P〈0.01）. Scientific nutrient management is an effective way to improve

关键词： aboveground biomass nitrogen phosphorus plant diversity potassium temperate meadow steppe

异功散中陈皮对脾虚大鼠MTL分泌和人参皂苷Rb1药动学影响及pk-PD相关性分析

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时珍国医国药 2024年第7期35卷 1781-1786页

作者：段新屹兰昀羲沈龙宇朱昕昀黄巍成都中医药大学四川成都610000

目的通过比较异功散全方组与异功散去陈皮方组脾虚大鼠体内MTL分泌结果和人参皂苷Rb1药代动力学特征的差异,分析参数pk-PD相关性,探讨行气药能否增效补益剂。方法采用脾虚大鼠灌胃给药异功散全方(Y组)、异功散去陈皮方(Y-C组)、单味陈皮... 详细信息

目的通过比较异功散全方组与异功散去陈皮方组脾虚大鼠体内MTL分泌结果和人参皂苷Rb1药代动力学特征的差异,分析参数pk-PD相关性,探讨行气药能否增效补益剂。方法采用脾虚大鼠灌胃给药异功散全方(Y组)、异功散去陈皮方(Y-C组)、单味陈皮方(C组)及生理盐水(M组),于颈静脉不同时间点取血,运用液质联用方法检测人参皂苷Rb1血浆浓度、ELISA法检测MTL血浆浓度,拟合pk-PD模型。结果2个组药时曲线均呈双峰,Cmax、Tmax均有两个值,Y组两次达峰浓度均明显高于Y-C组(P0.05),Y组>Y-C组>C组。PD结果为Y组EC_(50)、γ平均值低于Y-C组、Emax平均值高于Y-C组,与pk-PD模型拟合结果基本一致。pk-PD模型拟合结果为Y组Ka1、Ka2、AUC0-t、CL1、CL2、CL3、F、Tlag、EC_(50)、Emax平均值更大;Y-C组Vd1、Vd2、γ、Ke0值更大。结论脾虚大鼠体内人参皂苷Rb1及MTL血药浓度改变与灌胃所用异功散含陈皮有一定相关性。异功散中陈皮发挥增强补益剂补益功效的作用机制之一可能是通过促进异功散中人参皂苷Rb1的吸收增多、吸收速率增快,分布更集中于效应部位,使人参皂苷Rb1与MTL之间亲和力更强,从而导致MTL分泌增多,促进胃肠运动。

关键词：异功散陈皮脾虚人参皂苷Rb1 MTL 药动学药效学 pk-PD结合模型

Nuclear chart in covariant density functional theory with dynamic correlations: From oxygen to tin

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Chinese Physics C 2020年第3期44卷 73-79页

作者： Yi-long Yang Ya-Kun Wang State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China

Nuclear masses of even-even nuclei with the proton number 8≤Z≤50(O to Sn isotopes)from the proton drip line to neutron drip line are investigated using the triaxial relativistic Hartree-Bogoliubov theory with the relativistic density functional ***,the dynamical correlation energies(DCEs)associated with the rotational motion and quadrupole-shaped vibrational motion are taken into account by the five-dimensional collective Hamiltonian(5DCH)*** root-mean-square deviation with respect to the experimental masses reduces from 2.50 to 1.59 MeV after the consideration of *** inclusion of DCEs has little influence on the position of drip lines,and the predicted numbers of bound even-even nuclei between proton and neutron drip lines from O to Sn isotopes are 569 and 564 with and without DCEs,respectively.

关键词： nuclear mass table covariant density functionals triaxial relativistic Hartree-Bogoliubov theory O to Sn isotopes

Antihyperglycemic and antihyperlipidemic activity of ethyl acetate fraction of Rhododendron arboreum Smith flowers in streptozotocin induced diabetic rats and its role in regulating carbohydrate metabolism

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Asian Pacific Journal of Tropical Biomedicine 2012年第9期2卷 696-701页

作者： Neeraj Verma G Amresh pk Sahu Ch V Rao Anil Pratap Singh Department of Pharmacology Goel Institute of Pharmacy&SciencesFaizabad Road(Near Indira Canal) Department of Pharmacology School of Pharmaceutical SciencesSiksha'O' Anusandhan UniversityKalinga NagarGhatikia Pharmacognosy and Ethnopharmacology Division National Botanical Research Institute(Council of Scientific and Industrial Research)Rana Pratap Marg

Objective:To explore and identify the most potent antihyperglycemic fraction from the ethanol extract of Rhododendron arboreum(***)***:Normal and streptozotocin induced diabetic rats were treated with all four fractions of *** flowers for short term and with fraction 3 for long term *** completion of the treatment,a range of indicators were tested including fasting blood glucose,plasma protein,haemoglobin A1C,insulin secretion,body weight,blood lipid profile and carbohydrate metabolism regulating enzymes of ***:In short term study,the fraction 3(Active fraction)produced a significant(P<0.0001)reduction(73.6%)in blood glucose level at a dose of 200 mg/kg after the treatment in the diabetic *** of active fraction(200 and 400 mg/kg)once daily for 30 d in streptozotocin diabetic rats resulted in a significant(P<0.001 to P<0.0001)fall in blood glucose level,hemoglobin A1C,serum urea and creatinine with significant but a increase in insulin level similar to standard drug ***,the active fraction showed antihyperlipidemic activity as evidenced by significant(P<0.001 to P<0.0001)decreases in serum serum total cholesterol,triglycerides,low density lipoprotein cholesterol and very low density cholesterol levels coupled together with elevation of high density lipoprotein cholesterol in the diabetic ***:The active fraction of *** flowers decreases streptozotocin induced hyperglycemia by promoting insulin secretion and glycolysis and by decreasing gluconeogenesis.

关键词： Antihyperglycemic Antihyperlipidemic Ethanol Fraction Rhododendron arboreum Streptozotocin