Antihyperglycemic and antihyperlipidemic activity of ethyl acetate fraction of Rhododendron arboreum Smith flowers in streptozotocin induced diabetic rats and its role in regulating carbohydrate metabolism

作     者：Neeraj Verma G Amresh PK Sahu Ch V Rao Anil Pratap Singh 

作者机构：Department of PharmacologyGoel Institute of Pharmacy&SciencesFaizabad Road(Near Indira Canal) Department of PharmacologySchool of Pharmaceutical SciencesSiksha'O' Anusandhan UniversityKalinga NagarGhatikia Pharmacognosy and Ethnopharmacology DivisionNational Botanical Research Institute(Council of Scientific and Industrial Research)Rana Pratap Marg 

出 版 物：《Asian Pacific Journal of Tropical Biomedicine》 (亚太热带生物医学杂志（英文版）)

年 卷 期：2012年第2卷第9期

页      面：696-701页

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Supported in part by grant Number GAP-274625 from Department of Science&Technology(DST) New Delhi India 

主　　题：Antihyperglycemic Antihyperlipidemic Ethanol Fraction Rhododendron arboreum Streptozotocin 

摘      要：Objective:To explore and identify the most potent antihyperglycemic fraction from the ethanol extract of Rhododendron arboreum(***)***:Normal and streptozotocin induced diabetic rats were treated with all four fractions of *** flowers for short term and with fraction 3 for long term *** completion of the treatment,a range of indicators were tested including fasting blood glucose,plasma protein,haemoglobin A1C,insulin secretion,body weight,blood lipid profile and carbohydrate metabolism regulating enzymes of ***:In short term study,the fraction 3(Active fraction)produced a significant(P0.0001)reduction(73.6%)in blood glucose level at a dose of 200 mg/kg after the treatment in the diabetic *** of active fraction(200 and 400 mg/kg)once daily for 30 d in streptozotocin diabetic rats resulted in a significant(P0.001 to P0.0001)fall in blood glucose level,hemoglobin A1C,serum urea and creatinine with significant but a increase in insulin level similar to standard drug ***,the active fraction showed antihyperlipidemic activity as evidenced by significant(P0.001 to P0.0001)decreases in serum serum total cholesterol,triglycerides,low density lipoprotein cholesterol and very low density cholesterol levels coupled together with elevation of high density lipoprotein cholesterol in the diabetic ***:The active fraction of *** flowers decreases streptozotocin induced hyperglycemia by promoting insulin secretion and glycolysis and by decreasing gluconeogenesis.