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Relationship of High Sensitivity c-Reactive Protein with cardiovascular,Diabetic, and Hepatic Biomarkers

International Journal of clinical Medicine（临床医学国际期刊） 2023年第9期

作者： Hari Krishnan Krishnamurthy Swarnkumar reddy Vasanth Jayaraman Karthik Krishna Qi Song Karenah E.Rajasekaran Tianhao Wang Kang Bei John J.Rajasekaran

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Enantioseparation of Palonosetron Hydrochloride and Its Related Enantiomeric Impurities by computer Simulation and Validation

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American Journal of Analytical chemistry 2011年第4期2卷 437-446页

作者： M.Vishnu Murthy c.Krishnaiah Kodithyala Jyothirmayi Katkam Srinivas K.Mukkanti Ramesh Kumar Gautam Samanta Analytical Research and Development Integrated Product Development OperationsDr.Reddy’s Laboratories Ltd.BachupallyQutubullapurAndhra PradeshIndia Department of chemistry Jawaharlal Nehru Technological UniversityHyderabadIndia

A rapid, simple and single stereo selective high-performance liquid chromatographic (HPLc) method was developed and validated for enantiomers of palonosetron hydrochloride (PALO) and its process related chiral impurities. A computer simulating software was used for the development of chiral method. The developed method was able to separate not only the enantiomers of palonosetron hydrochloride but also its process related chiral impurities within 12 min. The chromatographic separation was carried out by normal phase chromatography using a 3 μm column of cellulose based chiral stationary phase (chiralcel-OD 250mm × 4.6mm) with a mobile phase comprised of n-hexane: ethanol: methanol: heptafluoro butyric acid: diethyl amine (70:15:15:0.05:0.1, v/v) at a flow rate of 1.0 mL/min. The effects of additive concentration as well as nature of polar organic modifier, flow rate, and temperature on enantioselectivity were investigated. The limit of detection (LOD) and limit of quantification (LOQ) of the palonosetron isomers and its related chiral impurities were found to be in the range 0.06-0.10 μg/mL and 0.14 - 0.24 μg/mL respectively. The method showed excellent linearity (R2 > 0.998) over a range of 0.14 to 1.125 μg/mL. The percentage recovery of the isomers in bulk drug samples ranged from 87.0 to 116.0.

关键词： High Performance Liquid chromatography Palonosetron Hydrochloride chiral Impurities Drylab^(█) Software Method Development Method Validation

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酒精的使用、种族和病毒的交叉感染对美国退伍军人HcV自然清除的影响

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世界核心医学期刊文摘（胃肠病学分册） 2005年第2期1卷 51-51页

作者： Piasecki B.A. Lewis J.D. reddy K.R. 沈才飞 Penn Medicine Radnor GastroenterologyClinic 250 King of Prussia Road Radnor PA 19087 Unite d StatesDr.

Hepatitis c virus (HcV) is spontaneously cleared in 15%to 45%of individuals during primary infection. To define the role of alcohol, race, and HBV or HIV co infections in natural HcV clearance, we examined these parameters in 203 spontan eously HcV-recovered subjects (HcV Ab+/RNA-subjects without prior antiviral t herapy) and 293 chronically HcV-infected patients (HcV Ab+/RNA+). Subjects we re identified from 1,454 HcV antibody-seropositive US veterans tested for HcV R NA between January 2000 and July 2002 at the Philadelphia Veterans Affairs Medic al center. In univariate analysis, alcohol use disorder (odds ratio > 0.52; 9 5%cI, 0.31-0.85; P = .006) and black race (OR 0.65;95%cI, 0.44-0.96;P = .024 ) were both associated with decreased likelihood of spontaneous HcV clearance. I n multivariate analyses adjusting for race, HIV infection, age, and alcohol use disorder, alcohol remained strongly associatedwith reduced HcV clearance (OR0.49 ;95%cI, 0.30-0.81; P = .005). In contrast, the association between black race and viral clearance was no longer statistically significant (adjusted OR 0.72; 9 5%cI, 0.48-1.09; P = .125). HIV coinfection was negatively associated with HcV clearance (OR 0.37; 95%cI, 0.16-0.83; P = .016), while HBV coinfection was po sitively associated with HcV clearance (unadjusted OR 5.0; 95%cI, 1.26-28.6; P = .008). In conclusion, the likelihood of spontaneous clearance of HcV may be i nfluenced by alcohol and viral coinfections.

关键词： HcV 黑色人种 RNA 单变量分析负相关多变量分析

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2个患严重颗粒状角膜营养不良的印度家系中基因-表型间的关系

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世界核心医学期刊文摘（眼科学分册） 2005年第12期1卷 28-29页

作者： Kannabiran c Sridhar M.S chakravarthi S.K 韩静 Kallam Anji reddy Molecular Genetics Laboratory Professor Brien Holden Eye Research Centre L. V. Prasad Eye Institute L. V. Prasad Marg Banjara Hills Hyderabad 500 034 India.Dr

Objectives: To determine genotypes in 2 Indian families with severe granular corneal dystrophy, to document clinical and histopathologic features, and to attempt a genotype-phenotype correlation. Methods: Mutation analysis of exon 12 of the TGFBI gene was carried out in 9 individuals from 2 families. Results: A c→ T mutation at residue 1710 of TGFBI complementary DNA, corresponding to an Arg555Trp mutation in keratoepithelin, was found in affected members of both families. In 5 patients, this mutation was homozygous, and it was heterozygous in the other 4. clinical examination revealed a severe form of granular corneal dystrophy with early onset and superficial lesions in the homozygous individuals and a milder phenotype in the heterozygous individuals. Histopathologic evaluation of corneal specimens from 2 homozygous patients confirmed the presence of superficial granular deposits. conclusions: To our knowledge, this is the first molecular and clinical characterization of severe granular corneal dystrophy in India. Genotype-phenotype correlation and comparison with earlier reports on this entity highlight the uniform expressivity of the Arg555Trp allele in homozygous individuals. clinical Relevance: Homozygous granular corneal dystrophy has a severe phenotype and can be recognized based on clinical and histopathologic features, especially in association with consanguinity or inbreeding.

关键词：角膜上皮颗粒状纯合子严重型沉着物组织病理学突变分析分子学杂合子病理学检查

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cHOP THER APY INDUcED MITOcHONDRIAL REDOX STATE ALTERATION IN NON-HODGKIN'S LYMPHOMA XENOGRAFTS

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Journal of Innovative Optical Health Sciences 2013年第2期6卷 29-35页

作者： H.N.XU H.ZHAO T.A.MIR S.c.LEE M.FENG R.cHOE J.D.GLIcKSON L.Z.LI Department of Radiology University of Pennsylvania PhiladelphiaPAUSA Britton chance Laboratory of Redox Imaging Johnson Research Foundation Department of Biochemistry and Biophysics University of Pennsylvania PhiladelphiaPAUSA Biostatistics and Data Management core The children's Hospital of Philadelphia(cHOP) PhiladelphiaPAUSA Department of Biomedical Engineering University of Rochester RochesterNYUSA Abramson cancer center University of Pennsylvania PhiladelphiaPAUSA Institute of Translational Medicine and Therapeutics University of Pennsylvania PhiladelphiaPAUSA

We are interested in investigating whether cancer therapy may alter the mitochondrial redox state in cancer cells to inhibit their growth and *** redox state can be imaged by the redox scanner that collects the fuorescence signals from both the oxidized-fAavoproteins(Fp)and the reduced form of nicotinamide adenine dinucleotide(NADH)in snap frozen tissues and has been previously employed to study tumor aggressiveness and treatment ***,with the redox scanner we investigated the effects of chemotherapy on mouse xenografts of a human diffuse large *** lymphoma cell line(DLcL2).The mice were treated with cHOP therapy,i.e,cyclophosphamide(c)+hydroxydoxorubicin(H)+Oncovin(O)+prednisone(P)with cHO administration on day 1 and prednisone administration on days *** Fp content of the treated group was significantly decreased(p=0.033)on day 5,and the mitochondrial redox state of the treated group was slightly more reduced than that of the control group(p=0.048).The decrease of the Fp heterogeneity(measured by the mean st andard deviation)had a border-line statistical significance(p=0.071).The result suggests that the mitochondrial metabolism of lymphoma cells was slightly suppressed and the lymphomas became less aggressive after the cHOP therapy.

关键词： NA DH flavoprotein DLcL2 therapeutic effect tumor metabolism

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A Validated Model for the Imaging Diagnosis of cystic Lung Disease

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Open Journal of Radiology（放射学期刊） 2023年第1期

作者： Wallace T. Miller1 Karen c. Patterson2 3 Shweta Sood2 James E. Schmitt4 Arshad A. Wani2 Robert Borden5 Maya Galperin-Aisenberg4 Mary K. Porteus2 Michelle L. Hershman4 Michael Hewitt4 Jennifer Levy4 Victor D. Babatunde4 Tetiana Glushko6 Timothy J. Niesen4 Sergey Leshchinskiy4 Karine Sahakyan7 Keyur Desai4 Jennifer A. Gillman4 Sandeep reddy4 Michael Shriver4 Nathaniel B. Linna4 Abass M. Noor4 Aysenur Buz8 Matthew E. Biron4 Scott Simpson4

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