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《武汉防汛图卷》的创作基础与视觉解读

肇庆学院学报 2024年第4期45卷 15-21页

作者：余丽莹肇庆学院美术学院、设计学院广东肇庆526061

以20世纪的中国画改造为背景,结合近年来学界整理的关于黎雄才西北写生和创作《武汉防汛图卷》的文献资料,以黎雄才先生在20世纪40年代创作的“西北写生卷”和50年代创作的《武汉防汛图卷》为研究对象,从技法、构图、人物三个角度论证... 详细信息

以20世纪的中国画改造为背景,结合近年来学界整理的关于黎雄才西北写生和创作《武汉防汛图卷》的文献资料,以黎雄才先生在20世纪40年代创作的“西北写生卷”和50年代创作的《武汉防汛图卷》为研究对象,从技法、构图、人物三个角度论证“西北写生卷”到《武汉防汛图卷》是一个写生到创作的探索过程,也是一个把传统符号与现实生活相结合的实践过程。这一实践开启了山水画新的创作源泉,使山水画艺术民众化,具有了新的社会功用,代表时代的新功能。

关键词：《武汉防汛图卷》 “西北写生卷” 探索

A molecular dynamics and computational study of human KAT3 involved in KYN pathway

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Science China Chemistry 2013年第4期56卷 514-523页

作者： XU yu ZHENG QingChuan yu liying ZHANG HongXing SUN ChiaChung State Key Laboratory of Theoretical and Computational Chemistry Institute of Theoretical Chemistry Jilin University

Kynurenine aminotransferases （KATs） catalyze the transamination of kynurenine （KYN） pathway and endogenous KYNs have been suggested to highly correlate to abnormal brain diseases. HKAT3 is a key member of KAT family, while the binding mechanism of KYN and cofactor with HKAT3 has not been determined yet. In this study, we focus on the structure-function relationship among KYN, cofactor and HKAT3. The binding models of KYN complex and KYN＆cofactor complex were ob- tained and were studied by molecular dynamics （MD） simulations. We identified several critical residues and influence of conformational changes in human kynurenine aminotransferase 3 （HKAT3） complexes. The cofactor may contribute largely not only to the catalysis, but also to the binding. In addition, a hypothesis is proposed that a strong hydrophobic interaction between Tyr159 and Lys280 may influence the binding mode and the binding region of the substrate and the cofactor. Our re- suits will be a good starting point for further determination of the biological role.

关键词： kynurenine (KYN) kynurenine aminotransferases (KATs) ^-~ interaction molecular dynamic (MD) simulation interaction energy

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Toll样受体9对原虫的天然免疫识别

中国兽医学报 2024年第6期44卷 1336-1341页

作者：于丽颖张乃文范芮铭张义伟姜宁沈阳农业大学动物科学与医学学院辽宁省人兽共患病研究重点实验室/辽宁省人兽共患病研究工程实验室辽宁沈阳110866

先天性免疫系统对病原体的识别作用是宿主保护自身免受微生物入侵的第一道防线。Toll样受体(TLRs)是特征明确的模式识别受体,对病原体相关分子模式(PAMPs)的识别、调节抗原呈递细胞和关键细胞因子的激活至关重要。TLR9对原虫基因组DNA... 详细信息

先天性免疫系统对病原体的识别作用是宿主保护自身免受微生物入侵的第一道防线。Toll样受体(TLRs)是特征明确的模式识别受体,对病原体相关分子模式(PAMPs)的识别、调节抗原呈递细胞和关键细胞因子的激活至关重要。TLR9对原虫基因组DNA的识别会激活NF-κB、IRF3/7和MAPK等细胞通路,诱导促炎症细胞因子和Ⅰ型干扰素的产生。在原虫感染中MyD88是TLR9识别PAMPs的关键接头分子,本综述主要总结了TLR9-MyD88信号途径在几种常见原虫感染期间诱导的炎症反应中的重要性,还讨论了TLR9的亚细胞定位对原虫感染的影响,以期为进一步理解原虫与宿主相互作用的复杂性,为原虫寄生虫病的防制奠定基础。

关键词： Toll样受体9 原虫感染 CpG DNA 疟色素

激光增材制造Al_(x)CoCrFeNi高熵合金的组织与性能

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材料工程 2024年第1期52卷 220-230页

作者：于丽莹王晨朱礼龙张华黄海亮阮晶晶张尚洲江亮周鑫烟台大学精准材料高等研究院山东烟台264005 中南大学粉末冶金国家重点实验室长沙410083

为了研究Al含量对FeCoCrNi合金组织性能的影响,采用多路送粉激光熔覆设备高通量制备Al_(x)CoCrFeNi高熵合金(0≤x≤0.9),通过X射线衍射仪、金相显微镜、扫描电子显微镜、电子探针和显微硬度计测试合金的相组成、显微组织结构、成分和硬... 详细信息

为了研究Al含量对FeCoCrNi合金组织性能的影响,采用多路送粉激光熔覆设备高通量制备Al_(x)CoCrFeNi高熵合金(0≤x≤0.9),通过X射线衍射仪、金相显微镜、扫描电子显微镜、电子探针和显微硬度计测试合金的相组成、显微组织结构、成分和硬度。结果表明:随着Al含量的增加,Al_(x)CoCrFeNi高熵合金由单一FCC相(x≤0.35)转变为FCC+BCC双相结构(0.35

关键词：激光熔覆高熵合金 Al_(x)CoCrFeNi 相组成微观组织

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Biodegradation of geosmin in drinking water by novel bacteria isolated from biologically active carbon

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Journal of Environmental Sciences 2011年第5期23卷 816-823页

作者： Beihai Zhou Rongfang yuan Chunhong Shi liying yu Junnong Gu Chunlei Zhang Department of Environmental Engineering University of Science and Technology Beijing Beijing 100083 China. E-mail: zhoubeihai@ *** Water Quality Monitoring Center Beijing Waterworks Group Beijing 100085 China

Three strains of Gram-negative bacteria capable of removing geosmin from drinking water were isolated from biologically active carbon and identified to be Chryseobacterium sp., Sinorhizobium sp. and Stenotrophomonas sp. based on physio-biochemistry analysis and 16S rRNA gene sequence analysis. Removal efficiencies of 2 mg/L geosmin in mineral salts medium were 84.0%, 80.2% and 74.4% for Chryxeobacterium sp., Sinorhizobium sp. and Stenotrophomonas sp., respectively, while removal efficiencies of 560 ng/L geosmin in filter influent were 84.8%, 82.3% and 82.5%, respectively. The biodegradation of geosmin was determined to be a pseudo first-order reaction, with rate constants at 2 mg/L and 560 ng/L being 0.097 and 0.086 day-1, 0.089 and 0.084 day-1, 0.074 and 0.098 day-1 for the above mentioned degraders, respectively. The biomass of culture in the presence of geosmin was much higher than that in the absence of geosmin.

关键词： geosmin biodegradation pseudo first-order reaction Chryseobacterium sp. Sinorhizobium sp. Stenotrophomonas sp.

Synthesis, Structure and Properties of Two New Coordination Polymers Based on 4-[（8-Hydroxy-5-quinolinyl）azo]-benzenesulfonic Acid

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Chemical Research in Chinese Universities 2014年第1期30卷 27-31页

作者： LUO Yanan XU Xianzhu SUN Fuxing yu Xiaoyang ZHANG Xiao ZHANG Ting yu liying State Key Laboratory of Urban Water Resource and Environment Harbin Institute of TechnologyHarbin 150080 P. R. China State Key Laboratory of Inorganic Synthesis & Preparative Chemistry Jilin University Changchun 130012 P. R. China College of Chemical and Pharmaceutical Engineering Jilin Institute of Chemical Technology Jilin 132022 P. R. China

Two new coordination polymers based on 4-[（8-hydroxy-5-quinolinyl）azo]-benzenesulfonic acid（H2L）,{[CdL（H2O）2]·H2O}n（1） and {[CdL（en）]·EtOH}n（2）（en=ethylenediamine）,were solvothermally synthesized and structurally characterized by single-crystal X-ray *** 1 and 2 exhibit infinite 1D ladder-shaped chain structures,which are isostructural except that the two coordinating water molecules in compound 1 were replaced by one en molecule in compound 2 due to the use of different organic *** 1 and 2 were constructed into different supramolecular frameworks by hydrogen bonding and π…π stacking *** addition,the fluorescent properties of compounds 1 and 2 were ***,they were also investigated via IR spectral analysis,elemental analysis,powder X-ray diffraction（PXRD） and thermogravimetric analysis（TGA）.

关键词： 4-[(8-Hydroxy-5-quinolinyl)azo]-benzenesulfonic acid Solvothermal synthesis Coordination polymer Fluorescent property

Biodegradation of 2-methylisoborneol by bacteria enriched from biological activated carbon

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Frontiers of Environmental Science & Engineering 2012年第5期6卷 701-710页

作者： Rongfang yuAN Beihai ZHOU Chunhong SHI liying yu Chunlei ZHANG Junnong GU Department of Environmental Engineering University of Science and Technology BeijingBeijing 100083China Water Quality Monitoring Center Beijing Waterworks GroupBeijing 100085China

One of the most common taste and odour compounds （TOCs） in drinking water is 2-methylisobor- neol （2-MIB） which cannot be readily removed by conventional water treatments. Four bacterial strains for degrading 2-MIB were isolated from the surface of a biological activated carbon filter, and were characterized as Micrococcus spp., Flavobacterium spp., Brevibacterium spp. and Pseudomonas spp. based on 16S rRNA analysis. The removal efficiencies of 2-MIB with initial concentra- tions of 515 ng.L i were 98.4%, 96.3%, 95.0%, and 92.8% for Micrococcus spp., Flavobacterium spp., Brevibacter- ium spp. and Pseudomonas spp., respectively. These removal efficiencies were slightly higher than those with initial concentration at 4.2 mg. L~ （86.1%, 84.4%, 86.7% and 86.0%, respectively）. The kinetic model showed that biodegradation of 2-MIB at an initial dose of 4.2 mg. L1 was a pseudo-first-order reaction, with rate constants of 0.287, 0.277, 0.281, and 0.294d-1, respectively. These degraders decomposed 2-MIB to form 2-methylenebor- nane and 2-methyl-2-bornane as the products.

关键词： 2-methylisoborneol (2-MIB) biodegradation,2-methylenebornane 2-methyl-2-bornane pseudo-first-order reaction

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新工科视域下工程案例课程教学模式的研究

山西建筑 2024年第9期50卷 188-190页

作者：王贵禄陈燕菲于丽颖贵阳信息科技学院土木工程系贵州贵阳550025 贵阳市花溪区英语实验学校贵州贵阳550025

课程是人才培养的核心要素,课程工程素养与实践创新能力培养是保障人才培养目标实现的基础。专业科学知识教育体系是由众多课程集合体组成,新工科专业教育包括专业核心课程和专业拓展课程群,新型建筑工业化的快速推进,智能建造与建筑工... 详细信息

课程是人才培养的核心要素,课程工程素养与实践创新能力培养是保障人才培养目标实现的基础。专业科学知识教育体系是由众多课程集合体组成,新工科专业教育包括专业核心课程和专业拓展课程群,新型建筑工业化的快速推进,智能建造与建筑工业化的协同发展快速助推土木建筑业转型升级,高等建筑教育对土木工程人才培养业务规格提出了新的需求。分析了土木工程专业教学背景,以《房屋建筑学》课程为范例,基于课程能力目标的达成,提出了工程案例课程教学创新模式,探索土木工程课程工程教育改革新范式,以期为新工科课程体系改革和课程建设提供借鉴与启示。

关键词：新工科课程改革工程素养工程案例课程教学模式

子宫炎性肌纤维母细胞瘤3例临床病理分析并文献复习

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肿瘤基础与临床 2024年第1期37卷 37-41页

作者：张哲孙淼淼许跃罗婷于丽莹余兰燕陈奎生郑州大学第一附属医院病理科河南郑州450052

目的探讨子宫炎性肌纤维母细胞瘤(IMT)的临床病理特征、免疫表型、分子遗传学特征、鉴别诊断及治疗方法。方法回顾性分析郑州大学第一附属医院3例子宫IMT的临床病理学特征,并复习相关文献。结果患者发病年龄30~60岁。肿瘤均位于子宫体... 详细信息

目的探讨子宫炎性肌纤维母细胞瘤(IMT)的临床病理特征、免疫表型、分子遗传学特征、鉴别诊断及治疗方法。方法回顾性分析郑州大学第一附属医院3例子宫IMT的临床病理学特征,并复习相关文献。结果患者发病年龄30~60岁。肿瘤均位于子宫体黏膜下,质地中等或稍软、有黏液感。其中2例组织形态学以黏液型为主,黏液样变的基质中见梭形细胞稀疏排列,区域密集的梭形细胞呈束状,类似平滑肌瘤,间质炎细胞浸润,局灶肿瘤细胞轻度异型,核分裂相少见。另外1例伴有妊娠,组织形态学以富于细胞型为主,具有提示侵袭性生物学的特点:浸润性生长、核分裂相多见、血管内生长。局灶可见蜕膜样变的肿瘤细胞。免疫组化显示3例肿瘤均不同程度表达间变性淋巴瘤激酶(ALK),荧光原位杂交检测证实2例肿瘤存在ALK基因重排,患者术后随访均未见转移和复发。结论子宫IMT的临床病理特征与平滑肌肿瘤、子宫内膜间质肿瘤有重叠,建议诊断时应结合病理组织学特征及免疫组化标记,必要时进行基因检测。

关键词：子宫肿瘤间变性淋巴瘤激酶免疫组织化学荧光原位杂交