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Laboratory Assessment of Lubricants for Wheel/Rail Lubrication

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Journal of Materials Science & Technology 1997年第1期13卷 57-60页

作者： Zhao, XZ liu, jj Zhu, BL Wang, CY ZHENGZHOU RES INST MECH ENGN ZHENGZHOU 450052PEOPLES R CHINA

The antiwear properties of two wheel/rail lubricating oils were tested and compared on an Amsler machine. Under same testing conditions, oil A (developed by authors) showed much better wear resistance and higher load-carrying capacity than oil B (imported from abroad). The X-ray diffraction (XRD) analyses of the worn surfaces showed that different extreme pressure (EP) lubricating films were formed on the surfaces when the rollers were lubricated with different oils under boundary lubrication condition. The EP film of oil A was a composite film containing three compounds, FeO, FeSx and FeP, while oil B formed only a simple EP film of FePO4. The composite EP film showed lower shear strength and better antiwear property than the simple EP film, which brought about different wear resistance df the two wheel/rail lubricating oils.

关键词： Lubricating oils

Sliding Wear of Ceramic/Metal Pairs under Boundary Lubrication of Water and Oil

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Journal of Materials Science & Technology 1997年第5期13卷 409-415页

作者： Zhao, XZ liu, jj Zhu, BL Luo, ZB Miao, HZ Tribology Research Institute Tsinghua University Beijing 100084 China

In order to reveal the wear mechanism of ceramic cutting tools in real cutting process, a simulation test was carried out on a block-on-ring tribometer. The investigation was conducted at ambient temperature to determine the wear behaviour of ceramic/metal tribe-systems under boundary lubrication of water and oil. In this test, the boundary lubrication conditions were provided by dropping oil or water into contact area at a rate of 5 drops per minute (about 0.1 ml/min). The tested materials are Al2O3-Ti(CN) composite ceramic, Al(purity>99.5 wt pet), Fe(C<0.04 wt pet) and a stainless steel (ASTM 302), which combined into three ceramic/metal frictional pairs. The test results indicate that wear loss of the materials increases with load and speed. Compared with unlubricated conditions, the boundary lubrication condition made the materials wear more serious, which show that lubricating method is very important to a tribe system, and unsuitable lubricating method could increase the wear of materials instead of reducing it. The surfaces of the ceramic and the metallic samples were analysed by using a scanning electron microscope with energy-dispersive X-ray attachment, which indicate that material transfer occurred between the ceramic and metallic materials. The wear mechanism was discussed.

关键词： Ceramic cutting tools

ANTI-CANCER　DRUGS　COMPOSED　OF　NONNOBLEMETAL　COORDINATION　COMPOUNDS

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Chinese Chemical Letters 1995年第9期6卷 771-772页

作者： liu, jj Wang, YZ Han, R liu, HY Nankai Univ Tianjin 300071 Peoples R China Chinese Acad Med Sci Inst Mat Med Beijing 100050 Peoples R China

Abstract: The designed and synthesized compounds are the coordination compounds between MCl2(M = Cu, Co,Mn) and the Mannich base made by methyl piperizine and tetracycline bydrochloride. The cancer cells or HCT-8, KB,A2780, MGC80-1 and Be17402 are signincantly inhibited by the drugs in vitro. The inhibition ratio or s-180 tumor by the compound or M - Cu is 30% on ling / kglevel or feed the in vivo experiments or female white mice.

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Effect of Helicobacter pylori infection on gastric epithelial cell proliferation

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World Journal of Gastroenterology 2000年第3期6卷 442-444页

作者： Gao H Wang JY Shen XZ liu jj Shanghai Med Univ Zhongshan Hosp Dept Internal Med Shanghai 200032 Peoples R China

INTRODUCTION Helicobacter pylori(***)infection is one ofthe main pathogens of chronic gastritis and duodenalulcer(DU),and it may be considered as a riskfactor in the incidence of gastric *** infection may lead to the anomaly of gastricepithelial cell proliferation which is closely relatedto the development of gastric ***(VacA)is an important virulence andvacA subtype determines the toxic *** to its signal sequence,it can be groupedinto type sla,slb,slc and *** harboringvacAsla are more closely related with digestivediseases and may be the strains with high *** effect of *** infection on

关键词： Helicobacter pylori cell proliferation vacAsla strain gastric epithelial cell

Glyco-poly-L-lysine is better than liposomal delivery of exogenous genes to rat liver

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World Journal of Gastroenterology 2000年第4期6卷 526-531页

作者： Yang, CQ Wang, JY He, BM liu, jj Guo, JS Shanghai Med Univ Zhongshan Hosp Div Gastroenterol Shanghai 200032 Peoples R China

AIM To compare the effects of liposomes andglyco-poly-L-lysine on liver targeted uptake andexpression of plasmid in rat *** After binding with lipofectamine orgalactose-terminal glyco-poly-L-lysine,theplasmid could be expressed in eukaryotic cellswhen injected into Wistar rats by *** different time intervals after the injection,the distribution and expression of the plasmid inliver of rats were observed and compared using insitu hybridization and *** The expression of the plasmid bindingto liposomes or G-PLL could be markedly observed24 h later,and began to decrease one week later,but it still could be observed up to three *** liposomes and G-PLL could deliver theplasmid to the liver effectively,but the effect of thelatter was better than the former concerning thedistribution and expression of the plasmid targeteduptake in the *** G-PLL is better than liposome asthe targeted carrier for delivering exogenous genesto the liver.

关键词： liposomes glyco-poly-L-lysine targeted liver uptake exogenous gene

A comparison between intravenous and peritoneal route on liver targeted uptake and expression of plasmid delivered by Glyco-poly-L-lysine

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World Journal of Gastroenterology 2000年第4期6卷 508-512页

作者： Yang CQ Wang JY Fang GT liu jj Guo JS Shanghai Med Univ Zhongshan Hosp Div Gastroenterol Shanghai 200032 Peoples R China

AIM To compare the effects of intravenous routeand peritoneal route on liver targeted uptake andexpression of plasmid delivered by galactose-terminal glyco-poly-L-lysine(G-PLL).METHODS The plasmid pTM/MMP-1 which couldbe expressed in eukaryotic cells was bound to G-PLL,and was then transferred into Wistar rats byintravenous and intraperitoneal *** and distribution of the plasmid wereobserved at different time periods by in situhybridization and *** The plasmid could be expressedsignificantly within 24 h after being transferred invivo by both intravenous and *** week later the expression began todecrease,and could still be observed three *** both the intravenous andintraperitoneal route could target-specificallydeliver the plasmid to the liver,the effect of theformer was better as compared to that of the *** Intravenous route is better for livertargeted uptake and expression of G-PLL-boundplasmids than the peritoneal route.

关键词： intraperitoneal injection intraperitoneal injection glyco-poly-L-lysine lwcr targeted uptake

AZGP1P2/UBA1/RBM15 Cascade Mediates the Fate Determinations of Prostate Cancer Stem Cells and Promotes Therapeutic Effect of Docetaxel in Castration-Resistant Prostate Cancer via TPM1 m6A Modification

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Research 2024年第3期6卷 151-167页

作者： Hong Wang jj liu Xiaojun Zhu Bin Yang Zuping He Xudong Yao Department of Urology Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghaiChina Urologic Cancer Institute School of MedicineTongji UniversityShanghaiChina. Department of Urology Surgery The Affiliated Hospital of Inner Mongolia Medical UniversityHohhotChina. The Key Laboratory of Model Animals and Stem Cell Biology in Hunan Province School of MedicineHunan Normal UniversityThe Engineering Research Center of Reproduction and Translational Medicine of Hunan ProvinceChangshaChina Shanghai Key Laboratory of Reproductive Medicine Shanghai Jiao Tong University School of MedicineShanghaiChina.

Prostate cancer(PCa)is a common malignant tumor with high morbidity and mortality *** prostate cancer stem cell(PCSC)model provides novel insights into the pathogenesis of PCa and its therapeutic ***,the roles and molecular mechanisms of specific genes in mediating fate decisions of PCSCs and carcinogenesis of PCa remain to be *** this study,we have explored the expression,function,and mechanism of AZGP1P2,a pseudogene of AZGP1,in regulating the stemness and apoptosis of PCSCs and treatment resistance of docetaxel in castration-resistant prostate cancer(CRPC).We revealed that AZGP1P2 was downregulated in CRPC cell lines and PCSCs,while it was positively associated with progression-free *** of the AZGP1P2 enhanced the sensitivity of docetaxel treatment in CRPCs via inhibiting their *** pull-down associated with mass spectrometry analysis,co-immunoprecipitation assay,and RNA immunoprecipitation assay demonstrated that AZGP1P2 could bind to UBA1 and RBM15 as a“writer”of methyltransferase to form a ***1,an E1 ubiquitin-activating enzyme,contributed to RBM15 protein degradation via ubiquitination *** RNA immunoprecipitation assay displayed that RBM15 controlled the mRNA decay of TPM1 in m6A ***,a xenograft mouse model and patient-derived organoids showed that the therapeutic effect of docetaxel in CRPC was increased by AZGP1P2 in ***,these results imply that AZGP1P2 mediates the stemness and apoptosis of PCSCs and promotes docetaxel therapeutic effect by suppressing tumor growth and metastasis via UBA1/RBM15-mediated TPM1 mRNA decay in CRPC.

关键词： Prostate TPM1 m6A

Experimental Research on a Feasible Building Insulation Material Based Reed in China

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Journal of Thermal Science 2025年第1期34卷 176-187页

作者： liu Tiantian PENG Yizhe liu Lifang CAI Chenghan WANG Shuang LI Hongqiang College of Civil Engineering Hunan University College of Civil Engineering Hunan University of Science and Technology School of Energy and Power Jiangsu University of Science and Technology National Center for International Research Collaboration in Building Safety and Environment (NCIRCBSE) Hunan University Key Laboratory of Building Safety and Energy Efficiency of the Ministry of Education Hunan University

The seemingly useless reeds are prepared as thermal insulation materials,which not only meet the requirements of environmental sustainability but also enhance the added value of reeds,creating new economic *** hydrophobicity of raw biomass surfaces leads to problems such as weak bonding strength and non-dense structure in the formed materials,as well as issues related to the residual insect infestations on the *** this study,reed straw was used as the raw material,and foamed geopolymer was used as the binder to prepare building insulation materials based *** improve the interfacial adhesion performance between reed straw and foamed geopolymer,a thermochemical modification method-thermal carbonization,was *** this study,the mechanical properties and hydraulic properties of the studied materials with different degrees of surface thermal modification were tested,especially the fire resistance performance,and weathering resistance performance rarely found in published *** the surface thermal modification condition of reed straw was 250℃（30 min）,the comprehensive performance of reed-based building insulation materials was the best,when the studied material density was 321.3 kg/m3;the compressive strength was 0.59 MPa;the thermal conductivity was 0.101 W/（m·K）;the pH was 11.27;the moisture absorption rate was 25.1%,and the compressive strength loss rate in wet-dry cycles was 18.5%.In addition,it had excellent fire resistance performance and weathering resistance *** new material can be widely used to improve the thermal insulation of traditional buildings and as sandwich filler in prefabricated buildings,such as preparing insulating walls.

关键词： building insulation material based reed fire resistance performance interface adhesion properties pre-treatment of reeds weathering resistance performance

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共病致大肠癌漏诊情况分析55例

世界华人消化杂志 2006年第10期14卷 1019-1021页

作者：刘剑君詹俊赖林刘建平湖南省新化县人民医院内科湖南省新化县417600 中山大学附属第二医院消化内科广东省广州市510120

目的:总结共病状态下大肠癌漏诊的具体原因.方法:回顾性分析55例漏诊大肠癌的临床资料,对率的比较采用卡方检验.结果:被漏诊的疾病中,大肠癌合并痔疮18例,合并消化性溃疡10例,合并结直肠息肉7例,合并急性阑尾炎5例,合并缺铁性贫血5例,... 详细信息

目的:总结共病状态下大肠癌漏诊的具体原因.方法:回顾性分析55例漏诊大肠癌的临床资料,对率的比较采用卡方检验.结果:被漏诊的疾病中,大肠癌合并痔疮18例,合并消化性溃疡10例,合并结直肠息肉7例,合并急性阑尾炎5例,合并缺铁性贫血5例,合并慢性胆囊炎4例,合并溃疡性结肠炎3例,合并慢性盆腔炎2例,合并阑尾周围脓肿1例.结论:不少临床医师拘泥于“一因论”的思维模式而忽视了共病的存在,这是导致共病状态下大肠癌漏诊的主要原因.

关键词：共病大肠癌误诊