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A"three musketeers"tactic for inclining interferon-γ as a comrade-in-arm to reinforce the synergistic-tumoricidal therapy

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Nano Research 2022年第4期15卷 3458-3470页

作者： Wenxi Li lisi xie Yi Ju Zhan Zhang Bei Li Jie Li Wei Sang Guohao Wang Hao Tian Yunlu Dai Cancer Centre and Institute of Translational Medicine Faculty of Health SciencesUniversity of MacaoMacao 999078China MOE Frontiers Science Center for Precision Oncology University of MacaoMacao 999078China School of Health and Biomedical Sciences RMIT UniversityBundooraVictoria 3083Australia

Interferon-γ(IFN-γ),secreted by activated T cells predominantly,plays a crucial performance in the tumoricidal immune ***,a high level of IFN-γseverely ignites the immunosuppressive response,especially by increasing the expression of immune checkpoint programmed death-ligand 1(PD-L1)and immunoregulatory enzyme indoleamine 2,3-dioxygenase 1(IDO-1).Herein,we have explored a versatile IFN-γ-nano-integrator(aPD-L1-SH@Ce6@NLG919-PEG,simplified as CNDP)to establish a positive anti-tumor feedback loop to amplify the IFN-γ-mediated tumoricidal *** this nanointegrator,photosensitizer chlorin e6(Ce6)mediates photodynamic therapy(PDT)to re-shape immunogenicity and activate the adaptive immune response,followed by the secretion of high-level IFN-γto struggle tumor ***-1 inhibitor(NLG919)afterwards mitigates the immunosuppressive behavior of IFN-γby neutralizing the function of *** turn“waste”into wealth,anti-PD-L1(aPD-L1)antibodies are technically integrated into the nano-integrator to propel the precise attack of breast cancer through ascending PD-L1 ***,this“three musketeers”nano-integrator tumoricidal tactic may give a unique insight into the clinical anti-tumor therapy.

关键词： interferon-γ(IFN-γ) anti-PD-L1(aPD-L1) IDO-1 inhibitor(NLG919) neutralization tumoricidal positive anti-tumor feedback loop

ITO@TiO_(2)nanoarray:An efficient and robust nitrite reduction reaction electrocatalyst toward NH_(3)production under ambient conditions

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eScience 2022年第4期2卷 382-388页

作者： Shaoxiong Li Jie Liang Peipei Wei Qian Liu lisi xie Yonglan Luo Xuping Sun Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province School of Chemistry and Chemical EngineeringChina West Normal UniversityNanchong637002SichuanChina Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu610054SichuanChina Institute for Advanced Study Chengdu UniversityChengdu610106SichuanChina

Ambient electrochemical nitrite(NO_(2)^(-))reduction is viewed as an effective and sustainable approach for simul-taneously removing NO_(2)^(-)and producing ammonia(NH_(3)).However,the complex multi-electron transfer steps involved in the NO_(2)^(-)reduction reaction(NO_(2)^(-)RR)lead to sluggish kinetics and low product selectivity toward NH_(3),underscoring the need for NH_(3)synthesis electrocatalysts with high activity and ***,we report amorphous indium-tin oxide sputtered on a TiO_(2)nanobelt array on a Ti plate(ITO@TiO_(2)/TP)as a 3D NH_(3)-producing catalyst for the NO_(2)^(-).In 0.5 M LiClO_(4)with 0.1 M NO_(2)^(-),it shows greatly boosted NO_(2)^(-)RR activity toward NH_(3)production,with excellent selectivity,achieving a large NH_(3)yield of 411.3μmol h^(-1)cm^(-2)and a high Faradaic efficiency of 82.6%.It also shows high durability for continuous electrolysis.A Zn-NO_(2)^(-)battery with ITO@TiO_(2)/TP cathode offers an NH_(3)yield of 23.1μmol h^(-1)cm^(-2)and a peak power density of 1.22 m.

关键词： ITO Electrocatalysis Magnetron sputtering Nitrite reduction reaction NH_(3)electrosynthesis

Enhanced N_(2)-to-NH_(3)conversion efficiency on Cu3P nanoribbon electrocatalyst

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Nano Research 2022年第8期15卷 7134-7138页

作者： Qian Liu Yiting Lin Shuang Gu Ziqiang Cheng lisi xie Shengjun Sun Longcheng Zhang Yongsong Luo Abdulmohsen Ali Alshehri Mohamed SHamdy Qingquan Kong Jiahong Wang Xuping Sun Institute for Advanced Study Chengdu UniversityChengdu 610106China Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054China Shenzhen Engineering Center for the Fabrication of Two-Dimensional Atomic Crystals Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Chemistry Department Faculty of Science&Center of Excellence for Advanced Materials ResearchKing Abdulaziz UniversityP.O.Box 80203Jeddah 21589Saudi Arabia Catalysis Research Group(CRG) Department of ChemistryCollege of ScienceKing Khalid UniversityP.O.Box 9004Abha 61413Saudi Arabia

Ambient electroreduction of nitrogen(N_(2))is considered as a green and feasible approach for ammonia(NH_(3))synthesis,which urgently demands for efficient *** has close relationship with catalytic activity of heterogeneous *** is attractive nanostructure,which possesses the flexibility of one-dimensional nanomaterials,the large surface area of two-dimensional nanomaterials,and lateral size confinement *** this work,Cu_(3)P nanoribbon is proposed as a highly efficient electrocatalyst for N_(2)-to-NH_(3)conversion under benign *** measured in N_(2)-saturated 0.1 M HCl,such Cu_(3)P nanoribbon achieves high performance with an excellent Faradaic efficiency as high as 37.8%and a large yield of 18.9μg·h^(−1)·mgcat.−1 at−0.2 *** also demonstrates outstanding stability in long-term electrolysis test at least for 45 h.

关键词： Cu_(3)P nanoribbon nitrogen reduction reaction ammonia electrosynthesis electrocatalysis

A cobalt(Ⅱ)porphyrin with a tethered imidazole for efficient oxygen reduction and evolution electrocatalysis

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Journal of Energy Chemistry 2023年第1期76卷 617-621,I0015页

作者： Xialiang Li Ping Li Jindou Yang lisi xie Ni Wang Haitao Lei Chaochao Zhang Wei Zhang Yong-Min Lee Weiqiang Zhang Shunichi Fukuzumi Wonwoo Nam Rui Cao Key Laboratory of Applied Surface and Colloid Chemistry Ministry of EducationSchool of Chemistry and Chemical EngineeringShaanxi Normal UniversityXi'an 710119 ShaanxiChina Department of Chemistry and Nano Science Ewha Womans UniversitySeoul 03760Republic of Korea

Electrocatalytic oxygen reduction and evolution reactions are involved in new energy conversion and storage technologies,such as various fuel cells and metal-air batteries and also water splitting devices[1,2].However... 详细信息

关键词： Molecular electrocatalysis Cobalt porphyrin Axial ligand effect Oxygen reduction reaction Oxygen evolution reaction

In situ grown Fe_(3)O_(4)particle on stainless steel:A highly efficient electrocatalyst for nitrate reduction to ammonia

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Nano Research 2022年第4期15卷 3050-3055页

作者： Xiaoya Fan lisi xie Jie Liang Yuchun Ren Longcheng Zhang Luchao Yue Tingshuai Li Yonglan Luo Na Li Bo Tang Yang Liu Shuyan Gao Abdulmohsen Ali Alshehri Qian Liu Qingquan Kong Xuping Sun Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054China Institute for Advanced Study Chengdu UniversityChengdu 610106China College of Chemistry Chemical Engineering and Materials ScienceShandong Normal UniversityJinan 250014China School of Materials Science and Engineering Henan Normal UniversityXinxiang 453007China Chemistry Department Faculty of ScienceKing Abdulaziz UniversityP.O.Box 80203Jeddah 21589Saudi Arabia

NH_(3)is an essential feedstock for fertilizer ***-scale NH_(3)synthesis mostly relies on the Haber-Bosch method,however,which suffers from massive CO_(2) emission and high energy *** NO_(3)-reduction is an attractive substitute to the Haber-Bosch method for synthesizing NH_(3)under mild *** this reaction will produce a variety of products,it highly desires efficient and selective electrocatalyst for NH_(3)***,we report in situ grown Fe_(3)O_(4)particle on stainless steel(Fe_(3)O_(4)/SS)as a high-efficiency electrocatalyst for NO_(3)^(-)reduction to NH_(3).In 0.1 M NaOH with 0.1 M NaNO_(3),such Fe_(3)O_(4)/SS reaches a remarkable Faradaic efficiency of 91.5%and a high NH_(3)yield of 10,145μg·h^(-1)·cm^(-2)at-0.5 V *** hydrogen electrode(RHE).Furthermore,it owns robust structural and electrochemical *** work provides useful guidelines to expand the scope of metallic oxide electrocatalysts for NH_(3)*** catalytic mechanism is uncovered and discussed further by theoretical calculations.

关键词： Fe_(3)O_(4)particle NO_(3)–reduction reaction NH_(3)synthesis electrocatalysis

NIR-Ⅱ-absorbing conjugated polymer-based theranostic agent for NIR-Ⅱfluorescence imaging-guided photothermal therapy acting synergistically with tumor microenvironment-responsive nitric oxide therapy

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ChemPhysMater 2022年第1期1卷 51-55页

作者： Jie Li lisi xie Wei Sang Wenxi Li Guohao Wang Hao Tian Zhan Zhang Jianhua Liu Quli Fan Yunlu Dai Cancer Centre and Institute of Translational Medicine Faculty of Health SciencesUniversity of MacaoMacao SAR 999078China Department of Radiology The Second Hospital of Jilin UniversityChangchun 130041China Key Laboratory for Organic Electronics and Information Displays&Institute of Advanced Materials(IAM) Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM)Nanjing University of Posts&TelecommunicationsNanjing 210023China MoE Frontiers Science Center for Precision Oncology University of MacaoMacao SAR 999078China

Despite tremendous advances in gas therapy,there are major concerns about the inevitable concentration of toxicity and the ability to perform real-time tracking of drug *** near-infrared(NIR-Ⅱ)window absorbing nanoplatforms hold great promise for precision medicine because of their excellent tissue penetration of light and non-invasive *** this study,we engineered an NIR-Ⅱlaser-activated theranostic agent(named CP-bF@PEG)that was composed of amphiphilic polymers(Pluronic F127,with polyethylene glycol,PEG,moieties)coated with an NIR-Ⅱ-absorbing conjugated polymer(PTTBBT,CP)and nitric oxide(NO)donor(benzofuroxan,bF),which served as an NIR-Ⅱphotothermal inducer and NO *** deep tissue penetration of NIR-Ⅱlaser irradiation,CP-bF@PEG was found to possess fluorescence imaging ability to accurately identify tumor and excellent photothermal ***,CP-bF@PEG could generate NO via glutathione activation in the tumor microenvironment in a controllable *** NIR-Ⅱ-absorbing polymer for high-contrast NIR-Ⅱfluorescence imaging-guided precision photothermal therapy achieved synergistic effects with NO therapy,as evidenced by pronounced tumor therapeutic efficacy and few side *** nanotheranostic agent is a highly promising candidate for high-contrast NIR-Ⅱimaging-guided precision photothermal therapy combined with gas therapy against cancer.

关键词： Conjugated polymer NIR-II fluorescence Photothermal therapy Tumor environment response Nitric oxide therapy

Tuning Electronic Structures of Covalent Co Porphyrin Polymers for Electrocatalytic CO_(2) Reduction in Aqueous Solutions

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CCS Chemistry 2022年第9期4卷 2959-2967页

作者： Yabo Wang Xue-Peng Zhang Haitao Lei Kai Guo Gelun Xu lisi xie Xialiang Li Wei Zhang Ulf-Peter Apfel Rui Cao Key Laboratory of Applied Surface and Colloid Chemistry Ministry of EducationSchool of Chemistry and Chemical EngineeringShaanxi Normal UniversityXi’an 710119 Fakultät für Chemie und Biochemie Ruhr-Universität Bochum44801 Bochum Fraunhofer UMSICHT 46047 Oberhausen

Improving the selectivity of the electrocatalytic CO_(2) reduction reaction(CO_(2)RR)over hydrogen evolution in aqueous solutions is required but challenging because the two reactions occur at close thermodynamic potentials and compete with each ***,we report on the selective CO_(2)RR in aqueous solutions utilizing covalent Co porphyrin polymers with fine-tuned electronic structures.

关键词： carbon dioxide reduction molecular electrocatalysis covalent porphyrin polymer electronic structure selectivity

多磺酸黏多糖乳膏协同硝酸舍他康唑乳膏治疗鳞屑角化型足癣的临床疗效

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中华皮肤科杂志 2022年第6期55卷 542-544页

作者：陈艳谢丽斯邓新杰马琳温州医科大学附属衢州医院衢州市人民医院皮肤科衢州324000

目的探讨多磺酸黏多糖乳膏协同硝酸舍他康唑乳膏治疗鳞屑角化型足癣的疗效。方法采用随机数字表法将2019年3月至2020年1月鳞屑角化型足癣患者100例平均分为2组:对照组单纯外用硝酸舍他康唑乳膏0.5~1g/次,每天2次;联合组先外用多磺酸黏... 详细信息

目的探讨多磺酸黏多糖乳膏协同硝酸舍他康唑乳膏治疗鳞屑角化型足癣的疗效。方法采用随机数字表法将2019年3月至2020年1月鳞屑角化型足癣患者100例平均分为2组:对照组单纯外用硝酸舍他康唑乳膏0.5~1g/次,每天2次;联合组先外用多磺酸黏多糖乳膏0.5~1 g/次,30 min后再外用硝酸舍他康唑乳膏0.5~1g/次,每天2次。共治疗4周。比较2组临床症状缓解时间、疗效及不良反应发生率,于治疗0、2、4周分析2组皮肤病生活质量指数(DLQI)评分。统计分析采用两独立样本t检验及重复测量方差分析。结果治疗后,联合组瘙痒及脱屑缓解时间分别为(6.05±1.98)d、(12.03±3.92)d,显著短于对照组[(8.39±2.11)d、(15.11±4.05)d,t值分别为5.72、3.86,均P0.05)。结论多磺酸黏多糖乳膏可提高硝酸舍他康唑乳膏治疗鳞屑角化型足癣的疗效。

关键词：脚癣鳞屑角化型足癣多磺酸黏多糖乳膏硝酸舍他康唑乳膏

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动态对比增强MRI在鼻咽癌中的应用进展

中国介入影像与治疗学 2022年第7期19卷 441-444页

作者：谢力斯赵长江余成新三峡大学第一临床医学院湖北宜昌443000 宜昌市中心人民医院放射科湖北宜昌443000

鼻咽癌(NPC)是鼻咽部最常见恶性肿瘤,其发生发展与血管生成密切相关。动态对比增强MRI(DCE-MRI)能定量反映病灶内的血流灌注及血管通透性,从形态学和功能学角度准确评估肿瘤恶性程度,有助于指导临床选择治疗方案。本文对DCE-MRI在NPC中... 详细信息

鼻咽癌(NPC)是鼻咽部最常见恶性肿瘤,其发生发展与血管生成密切相关。动态对比增强MRI(DCE-MRI)能定量反映病灶内的血流灌注及血管通透性,从形态学和功能学角度准确评估肿瘤恶性程度,有助于指导临床选择治疗方案。本文对DCE-MRI在NPC中的应用进展进行综述。

关键词：鼻咽肿瘤磁共振成像动态对比增强磁共振成像