A"three musketeers"tactic for inclining interferon-γ as a comrade-in-arm to reinforce the synergistic-tumoricidal therapy

作     者：Wenxi Li Lisi Xie Yi Ju Zhan Zhang Bei Li Jie Li Wei Sang Guohao Wang Hao Tian Yunlu Dai Wenxi Li;Lisi Xie;Yi Ju;Zhan Zhang;Bei Li;Jie Li;Wei Sang;Guohao Wang;Hao Tian;Yunlu Dai

作者机构：Cancer Centre and Institute of Translational MedicineFaculty of Health SciencesUniversity of MacaoMacao 999078China MOE Frontiers Science Center for Precision OncologyUniversity of MacaoMacao 999078China School of Health and Biomedical SciencesRMIT UniversityBundooraVictoria 3083Australia 

出 版 物：《Nano Research》 (纳米研究（英文版）)

年 卷 期：2022年第15卷第4期

页      面：3458-3470页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This work was supported by the National Natural Science Foundation of China(NSFC)(Nos.32171318 and 32101069) the Faculty of Health Sciences,University of Macao,the Start-up Research Grant(SRG)of University of Macao(No.SRG2018-00130-FHS) the Science and Technology Development Fund,Macao SAR(Nos.0109/2018/A3,0011/2019/AKP,0113/2019/A2,and 0103/2021/A) Shenzhen Science and Technology Innovation Commission,Shenzhen-Hong Kong-Macao Science and Technology Plan C(No.SGDX20201103093600004) We appreciate the assistance and support from the Proteomics,Metabolomics and Drug Development Core,Animal Research Core,and Biological Imaging and Stem Cell Core in the Faculty of Health Sciences,University of Macao 

主　　题：interferon-γ(IFN-γ) anti-PD-L1(aPD-L1) IDO-1 inhibitor(NLG919) neutralization tumoricidal positive anti-tumor feedback loop 

摘      要：Interferon-γ(IFN-γ),secreted by activated T cells predominantly,plays a crucial performance in the tumoricidal immune ***,a high level of IFN-γseverely ignites the immunosuppressive response,especially by increasing the expression of immune checkpoint programmed death-ligand 1(PD-L1)and immunoregulatory enzyme indoleamine 2,3-dioxygenase 1(IDO-1).Herein,we have explored a versatile IFN-γ-nano-integrator(aPD-L1-SH@Ce6@NLG919-PEG,simplified as CNDP)to establish a positive anti-tumor feedback loop to amplify the IFN-γ-mediated tumoricidal *** this nanointegrator,photosensitizer chlorin e6(Ce6)mediates photodynamic therapy(PDT)to re-shape immunogenicity and activate the adaptive immune response,followed by the secretion of high-level IFN-γto struggle tumor ***-1 inhibitor(NLG919)afterwards mitigates the immunosuppressive behavior of IFN-γby neutralizing the function of *** turn“wasteinto wealth,anti-PD-L1(aPD-L1)antibodies are technically integrated into the nano-integrator to propel the precise attack of breast cancer through ascending PD-L1 ***,this“three musketeersnano-integrator tumoricidal tactic may give a unique insight into the clinical anti-tumor therapy.