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The Open Data Challenge:An Analysis of 124,000 Data Availability Statements and an Ironic Lesson about Data Management Plans

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Data Intelligence 2020年第4期2卷 554-568页

作者： Chris Graf Dave Flanagan lisa Wylie Deirdre Silver Wiley 9600 Garsington RoadOxford OX42DQUK

Data availability statements can provide useful information about how researchers actually share research *** used unsupervised machine learning to analyze 124,000 data availability statements submitted by research authors to 176 Wiley journals between 2013 and *** categorized the data availability statements,and looked at trends over *** found expected increases in the number of data availability statements submitted over time,and marked increases that correlate with policy changes made by *** open data challenge becomes to use what we have learned to present researchers with relevant and easy options that help them to share and make an impact with new research data.

关键词： Data availability statement(DAS) FAIR data Machine learning Trends Journal Policy

Crafting chirality in three dimensions via a novel fabrication technique for bound states in the continuum metasurfaces

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Light(Science & Applications) 2024年第3期13卷 390-392页

作者： Zaid Haddadin Anna My Nguyen lisa V.Poulikakos Department of Electrical&Computer Engineering University of California San DiegoLa JollaCAUSA Department of Mechanical&Aerospace Engineering University of California San DiegoLa JollaCAUSA Program of Materials Science&Engineering University of California San DiegoLa JollaCAUSA

An additional deposition step was added to a multi-step electron beam lithographic fabrication process to unlock the height dimension as an accessible parameter for resonators comprising unit cells of quasi-bound stat... 详细信息

关键词： dimensions dimension intrinsic

An updated inventory of marine opisthobranch(Mollusca,Gastropoda)from the territorial waters of the Republic of Mauritius

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Journal of Oceanology and Limnology 2024年第1期42卷 226-243页

作者： lisa AH SHEE TEE Chandani APPADOO Daneshwar PUCHOOA Vishwakalyan BHOYROO Department of Agricultural&Food Science Faculty of AgricultureUniversity of MauritiusRéduit 80837Mauritius Department of Biosciences&Ocean Studies Pole of Research Excellence Sustainable Marine BiodiversityFaculty of ScienceUniversity of MauritiusRéduit 80837Mauritius

Island ecosystems support diverse aquatic invertebrate communities comprising endemic *** of existing species is important for *** this study,a checklist of marine opisthobranch from the Republic of Mauritius is presented.A combination of benthic surveys(50 m×5 m in triplicates),rover diving techniques and photo documentation were used over two years(2018–2020)within 35 sheltered and unsheltered *** and molecular analysis were used for *** composition within sheltered and unsheltered areas in Mauritius was estimated using the Bray-Curtis *** checklist featured 117 species belonging to 61 genera and 28families,of which 13 are new *** findings increased the knowledge of opisthobranch diversity from the Mauritius by 15.4%.Among the listed species,the distribution range of Cyerce nigra,Actinocyclus papillatus,and Phyllidia picta extended from the Western Pacific to the South Western Indian *** analysis of the undescribed Gymnodoris *** it resembled Gymnodoris *** Hawaii and were different by a genetic distance value of 10.6%.The species richness and evenness were higher within the sheltered regions of Mauritius which harboured the food resource of *** areas as compared to unsheltered regions were heavily populated,suggesting the probable influence of wave actions on opisthobranch diversity and *** order Nudibranchia was reported as most speciose,with 86 *** Sacoglossa and Nudibranchia were observed only on macroalgae and sponges *** abundance was also recorded on shipwrecks which are the most common form of artificial *** the inclusion of observations from previous studies,201species belonging to 94 genera and 36 families are now known from the Mauritius.

关键词： marine opisthobranch inventory new record occurrence Republic of Mauritius Indian Ocean

Notch signaling and its emerging role in autoimmunity

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Frontiers in Biology 2013年第3期8卷 279-294页

作者： Tanapat PALAGA lisa M. MINTER Department of Microbiology Faculty of Science Medical Microbiology Interdisciplinary Program Graduate School ChulalongkornUniversity Pathumwan Bangkok 10330 Thailand Program in Molecular and Cellular Biology University of Massachusetts Amherst MA 01003 USA Department of Veterinary & Animal Sciences University of Massachusetts Amherst MA 01003 USA

Studies of notch signaling in immune cells have uncovered critical roles for this pathway both during the differentiation and effector function phases of immune responses. Cells of the myeloid lineage, including macrophages and dendritic cells, function as key components of innate immune defense against infection and, by acting as antigen presenting cells, can instruct cells of the adaptive immune response, specifically CD4 and CD8 T cells. Tight regulation of this functional interaction is needed to ensure a well-balanced immune response and its dysregulation may indirectly or directly cause the tissue damage characteristic of autoimmune diseases. In this review, the focus will be placed on those recent findings which support a role for notch signaling in inflammatory responses mediated by macrophages and other myeloid lineage cells, as well as peripheral T cells, and their relevance to inflammatory and autoimmne diseases.

关键词： notch signaling inflammation autoimmunity

Biomarkers for colitis-associated colorectal cancer

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World Journal of Gastroenterology 2016年第35期22卷 7882-7891页

作者： Ru Chen lisa A Lai Teresa A Brentnall Sheng Pan Department of Medicine University of Washington

Patients with extensive ulcerative colitis(UC) of more than eight years duration have an increased risk of colorectal cancer. Molecular biomarkers for dysplasia and cancer could have a great clinical value in managing cancer risk in these UC patients. Using a wide range of molecular techniques- including cutting-edge OMICS technologies- recent studies have identified clinically relevant biomarker candidates from a variety of biosamples, including colonic biopsies, blood, stool, and urine. While the challenge remains to validate these candidate biomarkers in multi-center studies and with larger patient cohorts, it is certain that accurate biomarkers of colitis-associated neoplasia would improve clinical management of neoplastic risk in UC patients. This review highlights the ongoing avenues of research in biomarker development for colitis-associated colorectal cancer.

关键词： Biomarker Colitis Dysplasia Colorectal cancer Surveillance Progressor Non-progressor

Evolving perspectives on biofuels in the United States

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Frontiers in Energy 2012年第4期6卷 379-393页

作者： lisa C. DIRKS Gary W. DIRKS Jianguo WU Global Institute of Sustainability and School of Life Sciences ArizonaState University Tempe Arizona 85287 USA Global Institute of Sustainability and School of Life Sciences ArizonaState University Tempe Arizona 85287 USA Sino-US Center forConservation Energy and Sustainability Science (SUCCESS) InnerMongolia University Hohhot 010021 China

Biofuels represent an important source of renewable energy and may play a crucial role in developing sustainable energy strategies for many countries and the world as a whole. The pros and cons of biofuels, however, have been debated both scientifically and politically. They remain a topic of controversy. In this paper, the evolvement of the perspectives and policies on biofuels in the United States in the past several decades was reviewed. Four different periods, that is, the period prior to 1978 （marked by the passage of the Energy Act in 1978）; 1978-1989 （ending with the passage of the Clean Air Act Amendments of 1990）; 1990-2004 （ending with the passage of the energy act of 2005）; and 2005 to the present, which were characterized by defining events of major policy importance were identified. Each time period was assessed using the Ostrom institutional analysis and development （IAD） framework to show the impact of the evolving interests and influences of global players on policy choices related to biofuels in the United States. The US has a long history of supporting corn-based ethanol and more recently advanced biofuels. Changes in perspectives on biofuels from largely unrelated groups led to changes in policy and market dynamics. Until the late 1990s, most perspectives and policies tended to be aligned and significantly supportive of corn-based ethanol in the United States. In the early 2000s, it became clear that the complications associated with first generation biofuels and corn-based ethanol in particular, were too numerous and too severe to overlook. The need for better options has spurred interest in new technologies and more environmentally benign feedstocks, but, there is little prospect forbiofuels playing a significant role in the near term without greater alignment among key players.

关键词： renewable energy biofuels energy sustain-ability

A silent network’s resounding success:how mutations of core metabolic genes confer antibiotic resistance

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Signal Transduction and Targeted Therapy 2021年第9期6卷 2601-2602页

作者： Gamal Wareth Heinrich Neubauer lisa D.Sprague Friedrich-Loeffler-Institut Institute of Bacterial Infection and ZoonosesJenaGermany Department of Bacteriology Mycology and ImmunologyFaculty of Veterinary MedicineBenha UniversityToukhEgypt

A largely underrated factor in antibiotic resistance is the role of metabolic *** a recent paper published in Science,Lopatkin et al.1 used different in vitro evolution protocols and extensive sequencing data analyses to demonstrate that metabolic mutations develop in response to antibiotic treatment in clinically relevant bacteria(Fig.1).

关键词： resistance network silent

Effect of particle shape and size on flow properties of lactose powders

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Particuology 2012年第2期10卷 203-208页

作者： Xiaowei Fu Deborah Huck lisa Makein Brian Armstrong Ulf Willen Tim Freeman Freeman Technology I Miller Court Severn Drive Tewkesbury Gloucestershire G1208DN UK Malvern Instruments Ltd Enigma Business Park Crovewood Rd. Malvern Worcestershire WRI4 IX.Z UK

The shape and size of particles are understood to affect the bulk behaviour of powders, though there are but few studies that present quantitative information on the relationship between particle shape and the flow properties of powder. This is due in part to the lack of techniques for rapidly determining both particle shape and the range of flow characteristics that describe the response of powders to the stress and shear experienced during their processing. This study presents data that quantifies the influence of particle shapeJsize of three different lactose powders on their respective flow and bulk characteristics. Two of the samples differ in size but have similar shapes; the third sample is more spherical but similar in size to one of the other two samples, The results demonstrate that in addition to particle size, particle shape significantly affect the flow characteristics of a powder over a wide range of stress conditions.

关键词： ParticleShapeSizePowder flowFlowability

Microfabrication of Bubbular Cavities in PDMS for Cell Sorting and Microcell Culture Applications

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Journal of Bionic Engineering 2008年第4期5卷 308-316页

作者： Ut-Binh T. Giang Michael R. King lisa A. DeLouise Department of Biomedical Engineering University of Rochester Department of Biomedical Engineering Cornell University Department of Dermatology University of Rochester Medical Center

We describe a novel technique, low surface energy Gas Expansion Molding （GEM）, to fabricate microbubble arrays in polydimethylsiloxane （PDMS） which are incorporated into parallel plate flow chambers and tested in cell sorting and microcell cuTture applications. This architecture confers several operational advantages that distinguish this technology approach from currently used methods. Herein we describe the GEM process and the parameters that are used to control microbubble formation and a Vacuum-Assisted Coating （VAC） process developed to selectively and spatially alter the PDMS surface chemistry in the wells and on the microchannel surface. We describe results from microflow image visualization studies conducted to investigate fluid streams above and within microbubble wells and conclude with a discussion of cell culture studies in PDMS.

关键词： polydimethylsiloxane microfabrication cell culture cell sorting molding