A silent network’s resounding success:how mutations of core metabolic genes confer antibiotic resistance

作     者：Gamal Wareth Heinrich Neubauer Lisa D.Sprague Gamal Wareth;Heinrich Neubauer;Lisa D.Sprague

作者机构：Friedrich-Loeffler-InstitutInstitute of Bacterial Infection and ZoonosesJenaGermany Department of BacteriologyMycology and ImmunologyFaculty of Veterinary MedicineBenha UniversityToukhEgypt 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2021年第6卷第9期

页      面：2601-2602页

核心收录：

学科分类：0710[理学-生物学] 1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：Projekt DEAL 

主　　题：resistance network silent 

摘      要：A largely underrated factor in antibiotic resistance is the role of metabolic *** a recent paper published in Science,Lopatkin et al.1 used different in vitro evolution protocols and extensive sequencing data analyses to demonstrate that metabolic mutations develop in response to antibiotic treatment in clinically relevant bacteria(Fig.1).