Notch signaling and its emerging role in autoimmunity

作     者：Tanapat PALAGA Lisa M. MINTER 

作者机构：Department of Microbiology Faculty of Science Medical Microbiology Interdisciplinary Program Graduate School ChulalongkornUniversity Pathumwan Bangkok 10330 Thailand Program in Molecular and Cellular Biology University of Massachusetts Amherst MA 01003 USA Department of Veterinary & Animal Sciences University of Massachusetts Amherst MA 01003 USA 

出 版 物：《Frontiers in Biology》 (生物学前沿（英文版）)

年 卷 期：2013年第8卷第3期

页      面：279-294页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 090502[农学-动物营养与饲料科学] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 0905[农学-畜牧学] 09[农学] 071006[理学-神经生物学] 0836[工学-生物工程] 0713[理学-生态学] 

基　　金：supported in part by the Special Task Force for Activating Research (STAR) from the Centenary Academic Development Project Chulalongkorn University and by the Thailand Chulalongkorn University and by the Thailand Research Fund (TRF) supported in part by grants from the American Heart Association the Charles H. Hood Foundation for Child Health Research and the Aplastic Anemia and MDS International Foundation 

主　　题：notch signaling inflammation autoimmunity 

摘      要：Studies of notch signaling in immune cells have uncovered critical roles for this pathway both during the differentiation and effector function phases of immune responses. Cells of the myeloid lineage, including macrophages and dendritic cells, function as key components of innate immune defense against infection and, by acting as antigen presenting cells, can instruct cells of the adaptive immune response, specifically CD4 and CD8 T cells. Tight regulation of this functional interaction is needed to ensure a well-balanced immune response and its dysregulation may indirectly or directly cause the tissue damage characteristic of autoimmune diseases. In this review, the focus will be placed on those recent findings which support a role for notch signaling in inflammatory responses mediated by macrophages and other myeloid lineage cells, as well as peripheral T cells, and their relevance to inflammatory and autoimmne diseases.