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Zebrafish embryo toxicity of 15 chlorinated, brominated, and iodinated disinfection by-products

Journal of Environmental Sciences 2017年第8期29卷 302-310页

作者： David Hanigan lisa Truong Michael Simonich Robert Tanguay Paul Westerhoff Department of Civil and Environmental Engineering University of Nevada School of Sustainable Engineering and the Built Environment Arizona State University Department of Environmental and Molecular Toxicology Oregon State University

Disinfection to protect human health occurs at drinking water and wastewater facilities through application of non-selective oxidants including chlorine. Oxidants also transform organic material and form disinfection by-products（DBPs）, many of which are halogenated and cyto-and genotoxic. Only a handful of assays have been used to compare DBP toxicity,and researchers are unsure which DBP（s） drive the increased cancer risk associated with drinking chlorinated water. The most extensive data set employs an in vitro model cell,Chinese hamster ovary cells. Traditionally, most DBP research focuses on the threat to human health, but the effects on aquatic species exposed to DBPs in wastewater effluents remain ill defined. We present the developmental toxicity for 15 DBPs and a chlorinated wastewater to a model aquatic vertebrate, zebrafish. Mono-halogenated DBPs followed the in vivo toxicity rank order： acetamides 〉 acetic acids 〉 acetonitriles ~ nitrosamines, which agrees well with previously published mammalian in vitro data. Di-and tri-halogenated acetonitriles were more toxic than their mono-halogenated analogues, and bromine-and iodine-substituted DBPs tended to be more toxic than chlorinated analogues. No zebrafish development effects were observed after exposure to undiluted or non-concentrated,chlorinated wastewater. We find zebrafish development to be a viable in vivo alternative or confirmatory assay to mammalian in vitro cell assays.

关键词： Zebrafish Disinfection by-product Developmental Ecological Toxicity

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Diversity-oriented synthesis of blue emissive nitrogen heterocycles and their conjugation with carbon nano-onions

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Frontiers of Chemical Science and Engineering 2020年第1期14卷 76-89页

作者： Viviana Maffeis lisa Moni Daniele Di Stefano Silvia Giordani Renata Riva Nano Carbon Materials Istituto Italiano di Tecnologia(IIT)10144 TorinoItaly Department of Chemistry and Industrial Chemistry University of Genova16146 GenovaItaly School of Chemical Sciences Dublin City UniversityDublin 9Ireland Department of Pharmacy University of Genova16147 GenovaItaly

The search for new fluorescent molecules for possible applications as functional p-electron systems and their conjugation with different nanomaterials is nowadays of paramount importance to broaden the availability of materials with different *** we present a diversity-oriented approach to heterocyclic luminophores based on a multicomponent Ugi reaction followed by a Pd-mediated cascade *** new molecules are coupled to carbon nano-onions,and hybrid systems represent the first example of blue emitters conjugated with these carbon nanoparticles.

关键词： carbon nano-onions multicomponent reactions blue emitters fluorescence isoquinolines

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The ethics of exercise in eating disorders:Can an ethical principles approach guide the next generation of research and clinical practice?

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Journal of Sport and Health Science 2017年第3期6卷 295-298页

作者： Brian Cook lisa Leininger Kinesiology Department California State University Monterey BaySeasideCA 93955USA

*** Eating disorders(ED)are the most common psychiatric disorders afflicting young women^1 and contribute to great detriments in psychological,social,and physical health.^(2,3)Unfortunately,ED treatments tend to be long lasting,intensive,and expensive.~4Additionally,individuals with ED seeking treatment use healthcare services more frequently than non-ED individu-

关键词： ED The ethics of exercise in eating disorders:Can an ethical principles approach guide the next generation of research and clinical practice

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ESCRT machinery:role of membrane repair mechanisms in escaping cell death

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Signal Transduction and Targeted Therapy 2022年第8期7卷 2655-2657页

作者： lisa Gregor Sophia Stock Sebastian Kobold Division of Clinical Pharmacology Department of Medicine IVUniversity HospitalLudwig Maximilian University(LMU)of MunichLindwurmstrasse 2a80337 MunichGermany Department of MedicineⅢ University HospitalLudwig Maximilian University(LMU)of MunichMarchioninistrasse 1581377 MunichGermany German Cancer Consortium(DKTK) Partner Site MunichPettenkoferstrasse 8a80336 MunichGermany Einheit für Klinische Pharmakologie(EKLiP) Helmholtz Zentrum MünchenGerman Research Center for Environmental Health(HMGU)Ingolstädter Landstrasse 185764 NeuherbergGermany

A recent research article published in Science by Ritter et *** that endosomal sorting complexes required for transport(ESCRT)proteins mediate repair of lesions in the cell membrane caused by the pore-forming toxin perforin at sites of cytotoxic T cell engagement.1 Subsequent entry of granzymes and initiation of apoptosis of cancer cells is thus limited,leading to reduced sensitivity against T cell‑mediated cytotoxicity.1 Along these lines,this could constitute a new critical resistance mechanism for T cellbased treatment approaches.

关键词： al. cytotoxicity death

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Epigenetic interventions for brain rejuvenation：anchoring age-related transposons

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Neural Regeneration Research 2018年第4期13卷 635-636页

作者： Adonis Sfera lisa Fayard Carolina Osorio Amy Price Department of Psychiatry Patton State HospitalPattonCAUSA Department of Psychiatry Loma Linda UniversityLoma LindaCAUSA Evidence-Based Medicine University of OxfordOxfordUK

Highlights：*** and homocysteine accumulation in aging neurons alter genomic *** altered methylome reactivates neuronal cell cycle,enabling transposable element *** R29/p53 axis restores age-related methylation shifts... 详细信息

关键词： Epigenetic interventions for brain rejuvenation:anchoring age-related transposons PUFAs DNA Figure TE cycle

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A promiscuous interaction of SARS-CoV-2 with bacterial products

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Journal of Molecular Cell Biology 2020年第12期12卷 914-915页

作者： Guillaume Carissimo lisa F.P.Ng A*STAR Infectious Disease laboratories(A*ID Labs) Agency for ScienceTechnology and ResearchImmunosSingapore 138648Singapore Singapore Immunology Network(SlgN) Agency for ScienceTechnology and ResearchlmmunosSingapore 138648Singapore Institute of Infection Veterinary and Ecological SciencesUniversity of LiverpoolLiverpool L73EAUK

SARS-CoV-2 is the virus responsible for COVID-19 disease,and since its emergence it has spread globally with the number of total cases in the tens of ***-19 presents with varied clinical manifestations that range from asymptomatic disease to severe respiratory disease(pneumonia)with multiple organ failure and *** risk factors have been associated with severe COVID-19 disease such as age,gender,diabetes,cardiovascular disease,treat-ments,and comorbidities that affect the immune system(Harrison et al,2020).

关键词： cardiovascular respiratory clinical

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Using weighted blankets in an inpatient mental health hospital to decrease anxiety

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Journal of Integrative Medicine 2021年第2期19卷 129-134页

作者： Annette L.Becklund lisa Rapp-Mc Call Jessica Nudo Annette L Becklund MSWLCSW&Associates LLCPO Box 3870Spring HillFL 34611USA Saint Leo University Saint LeoFL 33574-6665USA

Objective:Patients who are involuntarily committed to a psychiatric facility often experience anxiety or increased anxiety in response to being placed in the institutional *** weighted blanket introduced a proactive treatment *** purpose of this study was to evaluate patients’anxiety symptoms before and after weighted blanket,compared to a group that did not use a weighted blanket to control ***:This study was conducted in an inpatient mental health facility from June 10,2019,through November 7,2019,with psychiatric patients who were not actively *** were offered the choice of weighted or unweighted blankets for a 20-minute *** treatment group was comprised of individuals who had opted to use a 14-pound weighted blanket,20-pound weighted blanket or 5-pound weighted lap *** in the comparison group were active in a wider range of *** application of the blankets,pulse rate was measured using a pulse oximeter,and anxiety was measured using the Spielberger State-Trait Anxiety Inventory shortened form(STAI:Y-6).Both measures were taken again after the intervention.A two-way mixed analysis of variance(ANOVA)was run to examine the interaction effects between time(pre/post)and group(comparison/weighted blanket).Simple main effects were then further examined for the comparison/weighted blanket groups using a repeated measures *** the weighted blanket group,additional two-way mixed ANOVA was run to determine if gender or blanket weight made a statistically significant ***:There was a statistically significant difference(P<0.05)among those who used weighted blankets(n=61)and those who did not(n=61)based on the pre/post data for both the STAI:Y-6 inventory and the patients’pulse *** results of two-way ANOVA indicated a significant interaction effect between intervention time and group(P<0.001).Repeated measures ANOVA indicated a change between pre/post for the we

关键词： Weighted blanket Anxiety Mental health

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The Open Data Challenge:An Analysis of 124,000 Data Availability Statements and an Ironic Lesson about Data Management Plans

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Data Intelligence 2020年第4期2卷 554-568页

作者： Chris Graf Dave Flanagan lisa Wylie Deirdre Silver Wiley 9600 Garsington RoadOxford OX42DQUK

Data availability statements can provide useful information about how researchers actually share research *** used unsupervised machine learning to analyze 124,000 data availability statements submitted by research authors to 176 Wiley journals between 2013 and *** categorized the data availability statements,and looked at trends over *** found expected increases in the number of data availability statements submitted over time,and marked increases that correlate with policy changes made by *** open data challenge becomes to use what we have learned to present researchers with relevant and easy options that help them to share and make an impact with new research data.

关键词： Data availability statement(DAS) FAIR data Machine learning Trends Journal Policy

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人类学关于“礼物”和“交换”的解读

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青海民族研究 2024年第2期35卷 118-126页

作者：威尔克克里格特马建福(编译) 刘春燕(编译) 美国印第安纳大学美国肯塔基大学北方民族大学宁夏银川 750021

礼物赠送是一种窥视多重人性的行为,因为礼物可以同时被理解为理性交换、建立关系的方式以及道德观念和文化意义的表达。西方经济学家完全专注于货币交换研究,所以倾向于将礼物馈赠排除在人类文化的分析之外,只将礼物视为一种纯粹的经... 详细信息

礼物赠送是一种窥视多重人性的行为,因为礼物可以同时被理解为理性交换、建立关系的方式以及道德观念和文化意义的表达。西方经济学家完全专注于货币交换研究,所以倾向于将礼物馈赠排除在人类文化的分析之外,只将礼物视为一种纯粹的经济现象而已。然而,在人类学的研究中,经济活动不仅仅是货币,还包括礼物赠送方式。特别是通过节日期间的礼物馈赠在消费社会中所扮演的角色,就能发现消费社会中赠礼仪式其实是经济上独立和成功的表现。礼物是友好来往的基础,能模糊彼此的界限。正因为经济学家忽略了这些重要部分,所以人类学家才更有必要对其加以研究。

关键词：礼物交换互惠人类学解读

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Notch signaling and its emerging role in autoimmunity

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Frontiers in Biology 2013年第3期8卷 279-294页

作者： Tanapat PALAGA lisa M. MINTER Department of Microbiology Faculty of Science Medical Microbiology Interdisciplinary Program Graduate School ChulalongkornUniversity Pathumwan Bangkok 10330 Thailand Program in Molecular and Cellular Biology University of Massachusetts Amherst MA 01003 USA Department of Veterinary & Animal Sciences University of Massachusetts Amherst MA 01003 USA

Studies of notch signaling in immune cells have uncovered critical roles for this pathway both during the differentiation and effector function phases of immune responses. Cells of the myeloid lineage, including macrophages and dendritic cells, function as key components of innate immune defense against infection and, by acting as antigen presenting cells, can instruct cells of the adaptive immune response, specifically CD4 and CD8 T cells. Tight regulation of this functional interaction is needed to ensure a well-balanced immune response and its dysregulation may indirectly or directly cause the tissue damage characteristic of autoimmune diseases. In this review, the focus will be placed on those recent findings which support a role for notch signaling in inflammatory responses mediated by macrophages and other myeloid lineage cells, as well as peripheral T cells, and their relevance to inflammatory and autoimmne diseases.

关键词： notch signaling inflammation autoimmunity

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