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Erythrocyte sphingolipid species as biomarkers of Alzheimer's disease

Journal of Pharmaceutical Analysis 2022年第1期12卷 178-185页

作者： Jericha Mill Vihar Patel Ozioma Okonkwo lingjun li Thomas Raife Department of Chemistry University of Wisconsin-MadisonMadisonWI53706USA Department of Pathology and Laboratory Medicine University of Wisconsin School of Medicine and Public HealthMadisonWI53705USA Clinical Science Center Wisconsin Alzheimer's Disease Research CenterUniversity of Wisconsin School of Medicine and Public HealthMadisonWI53792USA School of Pharmacy University of Wisconsin-MadisonMadisonWI53705USA

Diagnosing Alzheimer’s disease(AD)in the early stage is challenging.Informative biomarkers can be of great value for population-based screening.Metabolomics studies have been used to find potential biomarkers,but commonly used tissue sources can be difficult to obtain.The objective of this study was to determine the potential utility of erythrocyte metabolite profiles in screening for AD.Unlike some commonly-used sources such as cerebrospinal fluid and brain tissue,erythrocytes are plentiful and easily accessed.Moreover,erythrocytes are metabolically active,a feature that distinguishes this sample source from other bodily fluids like plasma and urine.In this preliminary pilot study,the erythrocyte metabolomes of 10 histopathologically confirmed AD patients and 10 patients without AD(control(CTRL))were compared.Whole blood was collected post-mortem and erythrocytes were analyzed using ultraperformance liquid chromatography tandem mass spectrometry.Over 750 metabolites were identified in AD and CTRL erythrocytes.Seven were increased in AD while 24 were decreased(Plites increased in AD were associated with amino acid metabolism and all of the decreased metabolites were associated with lipid metabolism.Prominent among the potential biomarkers were 10 sphingolipid or sphingolipid-related species that were consistently decreased in AD patients.Sphingolipids have been previously implicated in AD and other neurological conditions.Furthermore,previous studies have shown that erythrocyte sphingolipid concentrations vary widely in normal,healthy adults.Together,these observations suggest that certain erythrocyte lipid phenotypes could be markers of risk for development of AD.

关键词： Alzheimer’s disease Neurodegenerative disease Mass spectrometry Erythrocytes Biomarkers Metabolomics

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Recent Advances in Understanding of Alzheimer’s Disease Progression Through Mass Spectrometry-Based Metabolomics

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Phenomics 2022年第1期2卷 1-17页

作者： Jericha Mill lingjun li Department of Chemistry University of Wisconsin-MadisonMadisonWI 53706USA School of Pharmacy University of Wisconsin-MadisonMadisonWI 53705USA

Alzheimer’s disease(AD)is the leading cause of dementia in the aging population,but despite extensive research,there is no consensus on the biological cause of AD.While AD research is dominated by protein/peptide-centric research based on the amyloid hypothesis,a theory that designates dysfunction in beta-amyloid production,accumulation,or disposal as the primary cause of AD,many studies focus on metabolomics as a means of understanding the biological processes behind AD progression.In this review,we discuss mass spectrometry(MS)-based AD metabolomics studies,including sample type and preparation,mass spectrometry data acquisition strategies,and data analysis,as well as biological insights gleaned from these studies,with the hope of informing future AD metabolomic studies.

关键词： Alzheimer’s disease Mass spectrometry Metabolomics

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B-doped and La_(4)NiliO_(8)-coated Ni-rich cathode with enhanced structural and interfacial stability for lithium-ion batteries

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Journal of Energy Chemistry 2022年第8期31卷 588-594,I0016页

作者： lingjun li lizhi Fu Miao li Chu Wang Zixiang Zhao Shangchen Xie Haichen lin Xianwen Wu Haodong liu li Zhang Qiaobao Zhang Lei Tan School of Materials Science and Engineering Changsha University of Science and TechnologyChangsha 410114HunanChina Department of Materials Science and Engineering College of MaterialsXiamen UniversityXiamen 361005FujianChina School of Energy and Power Engineering Changsha University of Science and TechnologyChangsha 410114HunanChina School of Chemistry and Chemical Engineering Jishou UniversityJishou 416000HunanChina Chemical Engineering UC San DiegoLa Jolla 92093CAUnited States College of Chemistry and Chemical Engineering Xiamen UniversityXiamen 361005FujianChina

Ni-rich layered oxides are considered promising cathodes for advanced lithium-ion batteries(liBs)in the future,owing to their high capacity and low cost.However,the issues on structural and interfacial stability of Ni-rich cathodes still pose substantial obstacles in the practical application of advanced liBs.Here,we employ a one-step method to synthesize a B-doped and La_(4)NiliO_(8)-coated liNi_(0.82)5Co_(0.115)Mn_(0.06)O_(2)(BL-1)cathode with reliable structure and interface,for the first time.The La_(4)NiliO_(8)coating layer can prevent cathodes from electrolyte assault and facilitate li+diffusion kinetics.Moreover,B-doping can effectively restrain the pernicious H_(2)-H_(3) phase transition and adjust the orientation of primary particles to a radial alignment,which is obstructive to the arise of microcracks induced by the change of anisotropic volume.Specifically,when tested in pouch cells,the BL-1 cathode exhibits outstanding capacity retention of 93.49%after 500 cycles at 1 C.This dual-modification strategy dramatically enhances the stability of the structure and interface for Ni-rich cathode materials,consequently accelerating the commercialization process of high-energy–density liBs.

关键词： B-doped and La_(4)NiliO_(8)-coated Nickel-rich layered cathode Cycle stability lithium-ion battery

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Unveiling the impact of residual li conversion and cation ordering on electrochemical performance of Co-free Ni-rich cathodes

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Nano Research 2022年第10期15卷 9038-9046页

作者： Chu Wang Lei Tan Hongling Yi Zixiang Zhao Xiaoli Yi Youyuan Zhou Junchao Zheng Jiexi Wang lingjun li School of Materials Science and Engineering Changsha University of Science and TechnologyChangsha 410114China School of Energy and Power Engineering Changsha University of Science and TechnologyChangsha 410114China School of Metallurgy and Environment Central South UniversityChangsha 410083China Hunan Changyuan lico Co. Ltd.Changsha 410205China

The residual li and li^(+)/Ni_(2)+cation mixing play essential roles in the electrochemical properties of Ni-rich cathodes.However,a general relationship between the residual li conversion,cation mixing,and their effects on the li^(+)kinetics and structural stability has yet to be established,due to the presence of cobalt in the cathode.Here,we explore the synergistic impact of the residual li conversion and cation ordering on a Co-free Ni-rich cathode(i.e.,liNi0.95Mn0.05O_(2)).It discloses that the rate capability is mainly affected by residual li contents and operating voltage.Specifically,residual li can be electrochemically converted to cathode electrolyte interphase(CEI)below 4.3 V,thus inducing high interphase resistance,and decomposes to produce CO_(2)-dominated gas at 4.5 V,causing temporary enhancement of li^(+)diffusivity but severe surface degradation during cycling.Moreover,the cycling performance of Co-free Ni-rich cathode is not only determined by li^(+)/Ni_(2)+cation-ordered superlattice,which enhances the structural stability as it functions as the pillar to impede lattice collapse at a highly charged state,but also by the robust CEI layers which protect the bulk from electrolyte attack under 4.3 V.These findings promote an in-depth understanding of residual li conversion and li^(+)/Ni_(2)+cation ordering on Co-free Ni-rich cathode.

关键词： li-ion batteries Co-free Ni-rich cathodes residual li conversion cation ordering

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Difluorocarbene-derived rapid late-stage trifluoromethylation of 5-iodotriazoles for the synthesis of^(18)F-labeled radiotracers

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Chinese Chemical Letters 2023年第6期34卷 336-340页

作者： Fang Yuan Hongbao Sun Cheng Yang Haojie Yang lili Pan Xiaoyang Zhang Rong Tian lingjun li Wei Chen Xiaoai Wu Haoxing Wu Huaxi MR Research Center Department of RadiologyFunctional and Molecular Imaging Key Laboratory of Sichuan ProvinceFrontiers Science Center for Disease-Related Molecular NetworkWest China HospitalSichuan UniversityChengdu 610041China Department of Nuclear Medicine Laboratory of Clinical Nuclear MedicineWest China HospitalSichuan UniversityChengdu 610041China School of Chemistry and Chemical Engineering Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine ChemicalsState Key Laboratory of Cell Differentiation Regulation and Target DrugHenan Normal UniversityXinxiang 453007China

Difluorocarbene has emerged as a valuable intermediate to synthesize fluorides.However,difluorocarbene-derived synthesis of^(19)F/^(18)F-trifluoromethyl triazoles has not been explored.Herein,we reported the Cu(I)-promoted difluorocarbene-derived^(19)F/^(18)F-trifluoromethylation of iodotriazoles using KF/K^(18)F as the fluorine source.This approach rapidly generated a wide range of 5-trifluoromethyl-1,2,3-triazoles in good yields showing high functional group compatibility.The reaction was effective for late-stage functionalization of bioactive molecules and^(18)F-trifluoromethylation of iodotriazoles.This work provides a practical synthetic methodology for the development of triazole drugs and^(18)F-radiotracers for positron emission tomography.

关键词： Difluorocarbene Trifluoromethylation Triazole Late-stage functionalization ^(18)F-Labeled radiotracer

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Mass spectrometry-based proteomics and peptidomics for systems biology and biomarker discovery

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Frontiers in Biology 2012年第4期7卷 313-335页

作者： Robert CUNNINGHAM Di MA lingjun li Department of Chemistry University of Wisconsin-Madison 777 Highland Avenue 1101 University Avenue Madison WI 53706 USA School of Pharmacy University of Wisconsin-Madison 777 Highland Avenue Madison WI 53 705-2222 USA

The scientific community has shown great interest in the field of mass spectrometry-based proteomics and peptidomics for its applications in biology. Proteomics technologies have evolved to produce large data sets of proteins or peptides involved in various biologic and disease progression processes generating testable hypothesis for complex biologic questions. This review provides an introduction to relevant topics in proteomics and peptidomics including biologic material selection, sample preparation, separation techniques, peptide fragmentation, post-translational modifications, quantification, bioinformatics, and biomarker discovery and validation. In addition, current literature, remaining challenges, and emerging technologies for proteomics and peptidomics are presented.

关键词： mass spectrometry proteomics peptidomics review post-translational modifications fragmentation separation,protein quantitation sample preparation biomarker discovery validation bioinforrnatics

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Human β-defensin 3 gene modification promotes the osteogenic differentiation of human periodontal ligament cells and bone repair in periodontitis

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International Journal of Oral Science 2020年第2期12卷 162-171页

作者： lingjun li Han Jiang Rixin Chen Jing Zhou Yin Xiao Yangheng Zhang Fuhua Yan Nanjing Stomatological Hospital Medical School of Nanjing UniversityNanjingChina People’s Hospital of Suzhou National New&Hi-Tech Industrial Development Zone SuzhouChina The Affiliated Stomatological Hospital Zhejiang University School of MedicineKey Laboratory of Oral Biomedical Research of Zhejiang ProvinceZhejiang University School of StomatologyHangzhouChina Institute of Health and Biomedical Innovation&the Australia-China Centre for Tissue Engineering and Regenerative Medicine Queensland University of TechnologyBrisbaneAustralia

Efforts to control inflammation and achieve better tissue repair in the treatment of periodontitis have been ongoing for years.Humanβ-defensin 3,a broad-spectrum antimicrobial peptide has been proven to have a variety of biological functions in periodontitis;however,relatively few reports have addressed the effects of human periodontal ligament cells(h PDLCs)on osteogenic differentiation.In this study,we evaluated the osteogenic effects of h PDLCs with an adenoviral vector encoding humanβ-defensin 3 in an inflammatory microenvironment.Then humanβ-defensin 3 gene-modified rat periodontal ligament cells were transplanted into rats with experimental periodontitis to observe their effects on periodontal bone repair.We found that the humanβ-defensin 3 gene-modified h PDLCs presented with high levels of osteogenesis-related gene expression and calcium deposition.Furthermore,the p38 MAPK pathway was activated in this process.In vivo,humanβ-defensin 3 gene-transfected rat PDLCs promoted bone repair in SD rats with periodontitis,and the p38 mitogen-activated protein kinase(MAPK)pathway might also have been involved.These findings demonstrate that humanβ-defensin 3 accelerates osteogenesis and that humanβ-defensin 3 gene modification may offer a potential approach to promote bone repair in patients with periodontitis.

关键词： period periodontal ligament

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当归挥发油的化学成分和药理作用研究进展

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中国现代应用药学 2024年第7期41卷 1006-1014页

作者：石玉李梦琦杨诗宇胡豫孙文秀李凌军山东中医药大学济南250355

当归是中国常用的药食同源药材之一,素有“十方九归”的美称。当归挥发油是当归的主要药效成分,主要由苯酞类、萜烯类及烷烃类等多种化合物组成,其化学成分复杂,且当归的生长环境、炮制工艺、提取方法等因素均会引起当归挥发油成分含量... 详细信息

当归是中国常用的药食同源药材之一,素有“十方九归”的美称。当归挥发油是当归的主要药效成分,主要由苯酞类、萜烯类及烷烃类等多种化合物组成,其化学成分复杂,且当归的生长环境、炮制工艺、提取方法等因素均会引起当归挥发油成分含量的变化。当归挥发油具有降血压、保护缺血再灌注损伤部位、平喘、抗炎及抗肿瘤等多种药理活性,临床应用价值较高。本文通过查阅近十年来国内外有关文献,对当归挥发油的化学成分进行梳理,汇总了影响当归挥发油化学成分的诸多因素,重点综述了其降血压、保护缺血再灌注损伤部位、平喘等多种活性作用,以期为当归挥发油的进一步开发利用提供参考。

关键词：当归挥发油化学成分药理作用

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夏枯草抗肿瘤活性成分及其作用机制研究进展

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中国现代应用药学 2024年第5期41卷 716-726页

作者：李梦琦石玉杨诗宇李杰雨胡豫孙文秀李凌军山东中医药大学药学院济南250000

夏枯草作为一味临床常用中药,具有清肝泻火、明目、散结消肿的功效,对甲状腺癌、乳腺癌、肝癌等多种肿瘤表现出较强的抗肿瘤作用。夏枯草提取物及其有效成分可通过多种途径发挥抗肿瘤作用,其主要途径包括诱导细胞凋亡、抑制细胞侵袭及... 详细信息

夏枯草作为一味临床常用中药,具有清肝泻火、明目、散结消肿的功效,对甲状腺癌、乳腺癌、肝癌等多种肿瘤表现出较强的抗肿瘤作用。夏枯草提取物及其有效成分可通过多种途径发挥抗肿瘤作用,其主要途径包括诱导细胞凋亡、抑制细胞侵袭及转移、抑制细胞增殖、诱导自噬、抗肿瘤血管生成、逆转肿瘤多药耐药性和调节免疫功能等,并通过调控miRNA和Wnt/β-catenin、PI3/Akt、AMPK/mTOR/ULK1、RANKL/RANK/OPG等信号通路发挥作用。本文对夏枯草提取物抗肿瘤的作用机制等进行总结,以期为其进一步的研究和应用提供参考。

关键词：夏枯草抗肿瘤提取物活性成分作用机制临床应用

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煅烧温度对钠离子电池P2-Na_(0.67)Ni_(0.1)Fe_(0.1)Mn_(0.8)O_(2)正极材料性能的影响

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中国有色金属学报 2024年第6期34卷 1884-1892页

作者：吴奇峰谭磊任延杰邹康宇宁天翔李灵均长沙理工大学能源与动力工程学院长沙410114 长沙理工大学材料科学与工程学院长沙410114

层状氧化物材料因其容量高被认为是钠离子电池(SIBs)的候选正极材料,其中,锰基P2型层状氧化物因成本低、稳定性好,是具有发展前景的钠离子电池层状正极材料。本文采用固相烧结法制备一种P2-Na_(0.67)Ni_(0.1)Fe_(0.1)Mn_(0.8)O_(2)正极... 详细信息

层状氧化物材料因其容量高被认为是钠离子电池(SIBs)的候选正极材料,其中,锰基P2型层状氧化物因成本低、稳定性好,是具有发展前景的钠离子电池层状正极材料。本文采用固相烧结法制备一种P2-Na_(0.67)Ni_(0.1)Fe_(0.1)Mn_(0.8)O_(2)正极材料,研究煅烧温度对正极材料性能的影响。结果表明:在875℃下获得的Na_(0.67)Ni_(0.1)Fe_(0.1)Mn_(0.8)O_(2)正极材料具有结晶良好的P2纯相,表现出优异的电化学性能。在1.5~4.3 V的电压范围内,0.05C下所制备正极材料的初始放电容量为232 mA·h/g,且循环100次后,正极材料的容量保持率为69.5%。

关键词：钠离子电池 Ni/Fe/Mn基正极材料煅烧温度电化学性能

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