Recent Advances in Understanding of Alzheimer’s Disease Progression Through Mass Spectrometry-Based Metabolomics

作     者：Jericha Mill Lingjun Li 

作者机构：Department of ChemistryUniversity of Wisconsin-MadisonMadisonWI 53706USA School of PharmacyUniversity of Wisconsin-MadisonMadisonWI 53705USA 

出 版 物：《Phenomics》 (表型组学（英文）)

年 卷 期：2022年第2卷第1期

页      面：1-17页

学科分类：0710[理学-生物学] 1002[医学-临床医学] 10[医学] 

基　　金：supported by the National Institutes of Health(NIH)grants RF1AG052324 and R21AG065728 J.M.acknowledges a predoctoral traineeship supported by the NIH T32 training grant on Biology of Aging and Age-related Diseases(T32AG000213) funding provided by the Wisconsin Alumni Research Foundation and University of Wisconsin-Madison School of Pharmacy 

主　　题：Alzheimer’s disease Mass spectrometry Metabolomics 

摘      要：Alzheimer’s disease(AD)is the leading cause of dementia in the aging population,but despite extensive research,there is no consensus on the biological cause of *** AD research is dominated by protein/peptide-centric research based on the amyloid hypothesis,a theory that designates dysfunction in beta-amyloid production,accumulation,or disposal as the primary cause of AD,many studies focus on metabolomics as a means of understanding the biological processes behind AD *** this review,we discuss mass spectrometry(MS)-based AD metabolomics studies,including sample type and preparation,mass spectrometry data acquisition strategies,and data analysis,as well as biological insights gleaned from these studies,with the hope of informing future AD metabolomic studies.