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Parameters Sensitivity Characteristics of Highly Integrated Valve-Controlled Cylinder Force Control System

Chinese Journal of Mechanical Engineering 2018年第2期31卷 159-175页

作者： Kai-Xian Ba Bin Yu Xiang-Dong kong Chun-He Li Qi-Xin Zhu Hua-Long Zhao ling-jian kong School of Mechanical Engineering Yanshan University State Key Laboratory of Fluid Power and Mechatronic System Zhejiang University Columbia University

Nowadays, a highly integrated valve?controlled cylinder(HIVC) is applied to drive the joints of legged robots. Although the adoption of HIVC has resulted in high?performance robot control, the hydraulic force system still has problems, such as strong nonlinearity, and time?varying parameters. This makes HIVC force control very diffcult and complex. How to improve the control performance of the HIVC force control system and find the influence rule of the system parameters on the control performance is very significant. Firstly, the mathematical model of HIVC force control system is established. Then the mathematical expression for parameter sensitivity matrix is obtained by applying matrix sensitivity analysis(PSM). Then, aimed at the sinusoidal response under(three factors and three levels) working conditions, the simulation and the experiment are conducted. While the error between the simulation and experiment can’t be avoided. Therefore, combined with the range analysis, the error in the two performance indexes of sinusoidal response under the whole working condition is analyzed. Besides, the sensitivity variation pattern for each system parameter under the whole working condition is figured out. Then the two sensitivity indexes for the three system parameters, which are supply pressure, proportional gain and initial displacement of piston, are proved experimentally. The proposed method significantly reveals the sensitivity characteristics of HIVC force control system, which can make the contribution to improve the control performance.

关键词： Highly integrated valve?controlled cylinder system Force control system Matrix sensitivity analysis Orthogonal test design Sensitivity index

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Magnetoresistance hysteresis in topological Kondo insulator SmB6 nanowire

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Chinese Physics B 2019年第10期28卷 105-108页

作者： ling-jian kong Yong Zhou Hua-Ding Song Da-Peng Yu Zhi-Min Liao State Key Laboratory for Mesoscopic Physics School of PhysicsPeking UniversityBeijing 100871China Shenzhen Institute for Quantum Science and Engineering and Department of Physics Southern University of Science and TechnologyShenzhen 518055China Beijing Key Laboratory of Quantum Devices Peking UniversityBeijing 100871China Collaborative Innovation Center of Quantum Matter Beijing 100871China

SmB6, a topological Kondo insulator, with a gapped bulk state and metallic surface state has aroused great research interest. Here, we report an exotic hysteresis behavior of magnetoresistance in individual SmB6 nanowire in a temperature range in which both surface and bulk states contribute to the total conductance. Under a magnetic field parallel to the SmB6 nanowire, the resistance suddenly increases at the turning point from up-sweep to down-sweep of the magnetic field. The magnetoresistance hysteresis loops are well consistent with the magnetocaloric effect. Our results suggest that the SmB6 nanowires possess potential applications in the magnetic cooling technology.

关键词： topological Kondo insulator magnetocaloric effect magnetoresistance hysteresis

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Improved AR-Based GLRT Detector for Range-Spread Targets in Compound-Gaussian Clutter without Secondary Data

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Journal of Electronic Science and Technology 2011年第2期9卷 180-184页

作者： Xiao-Fei Shuai ling-jiang kong jian-Yu Yang School of Electronic Engineering University of Electronic Science and Technology of ChinaChengdu 610054China

The problem of adaptive radar detection in compound-Gaussian clutter without secondary data is considered in this *** most practical applications,the number of training data is *** overcome the lack of training data,an autoregressive（AR）-process-based covariance matrix estimator is ***,with the estimated covariance matrix the one-step generalized likelihood ratio test（GLRT） detector is designed without training ***,detection performance of our proposed detector is assessed.

关键词： Autoregressive model compound Gaussian distributed targets generalized likelihood ratio test

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Survivin、COX-2及VEGF在大肠癌中的表达及与肿瘤微血管密度的关系

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世界华人消化杂志 2009年第20期17卷 2048-2053页

作者：孔令建赵晶曲波樊微微高善玲哈尔滨医科大学附属第二医院消化内科黑龙江省哈尔滨市150086

目的:研究Survivin,COX-2,VEGF和肿瘤微血管密度(MVD)在大肠癌组织中的表达,探讨其与大肠癌肿瘤血管生成的关系.方法:2007-09/2008-05哈尔滨医科大学附属第二临床医学院内镜下取材的大肠癌、肠息肉及肠炎标本.所有标本均经病理检查证实... 详细信息

目的:研究Survivin,COX-2,VEGF和肿瘤微血管密度(MVD)在大肠癌组织中的表达,探讨其与大肠癌肿瘤血管生成的关系.方法:2007-09/2008-05哈尔滨医科大学附属第二临床医学院内镜下取材的大肠癌、肠息肉及肠炎标本.所有标本均经病理检查证实诊断.试验对象共分3组,分别为大肠癌组织26例,大肠息肉组织10例,大肠黏膜慢性炎症组织7例.采用免疫组织化学方法检测Survivin,COX-2,VEGF和CD34在大肠组织中的表达.结果:Survivin,COX-2与VEGF蛋白在大肠癌组织中阳性表达率分别为76.9%,80.8%和69.28%,明显高于大肠息肉组与肠炎组的表达(P<0.01或0.05).大肠癌组织中MVD(CD34)明显高于大肠息肉组与肠炎组(23.69±9.96vs13.10±7.05,10.43±4.24,均P<0.01).Survivin,COX-2和VEGF蛋白在大肠癌组中的表达与MVD相关(均P<0.05),Survivin和促血管形成因子COX-2,VEGF在大肠癌组织中的表达密切相关(χ2=11.18,4.72,均P<0.005).结论:Survivin可能通过COX-2,VEGF促进大肠癌肿瘤血管的形成.

关键词： Survivin 环氧合酶-2 血管内皮生长因子 CD34 大肠瘤

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Anti-breast cancer effect of quercetin nanoparticles based on MOFs for chemo-phototherapy and heat shock proteins inhibition

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Nano Research 2025年第1期18卷 545-558页

作者： Rongyue Zhu Shilang Liao Mengru Cai Dongge Yin Tingting Fu Jing Liu Yuji Du Jiahui kong Rongrong Chang jian Ni Xingbin Yin Beijing University of Chinese Medicine Fangshan DistrictBeijing 102488China

Phototherapy, including photodynamic therapy(PDT) and photothermal therapy (PTT), is a promisingmethod of tumor treatment, which has the advantages ofstrong specificity and small side effects. However, PDT willaggravate the hypoxic environment in tumor cells, and PTTwill lead to heat-resistant reaction, both of which will make theorganism quickly produce heat shock proteins (HSPs) toprotect itself, thus seriously hindering the therapeuticefficiency of phototherapy. As a natural HSPs inhibitor,quercetin (QR) provides a feasible way to solve this ***, a kind of metal organic framework (MOF), Fe-TCPP(FT), was used as a delivery material and photosensitizer tobuild a chemo-phototherapy platform, and QR was used as achemotherapy drug and HSPs inhibitor. On this basis, the nanoparticles (NPs) were modified with PEG-CPP30 (a cellpenetratingpeptide that specifically recognizes human breast cancer MCF-7 cells), which showed excellent targetingcapacity and biocompatibility. The combination of chemotherapy and phototherapy significantly improved the anti-cancereffect. At the same time, NPs also showed prominent anti-HSPs effect. The effective connection of the two played acomplementary role in the process of tumor treatment, which provided a new strategy for the accurate and efficienttreatment of tumors in the future.

关键词： quercetin Fe-metal organic frameworks(MOFs) phototherapy anti-cancer heat shock proteins inhibition

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Enhanced rate and specific capacity in nanorod-like core-shell crystalline NiMoO_(4)@amorphous cobalt boride materials enabled by Mott-Schottky heterostructure as positive electrode for hybrid supercapacitors

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Journal of Energy Chemistry 2023年第10期85卷 276-287,I0009页

作者： Jing-Feng Hou jian-Fei Gao ling-Bin kong State Key Laboratory of Advanced Processing and Recycling of Non-ferrous Metals Lanzhou University of TechnologyLanzhou 730050GansuChina School of Materials Science and Engineering Lanzhou University of TechnologyLanzhou 730050GansuChina

The supercapacitor electrode materials suffer from structure pulverization and sluggish electrode kinetics under high current ***,a unique NiMoO_(4)@Co-B heterostructure composed of highly conductive Co-B nanoflakes and a semiconductive NiMoO_(4) nanorod is designed as an electrode material to exert the energy storage effect on *** formed Mott-Schottky heterostructure is helpful to overcome the ion diffusion barrier and charge transfer resistance during charging and ***,this crystalline-amorphous heterogeneous phase could provide additional ion storage sites and better strain ***,the optimized NiMoO_(4)@Co-B hierarchical nanorods(the mass ratio of NiMoO_(4)/Co-B is 3:1)present greatly enhanced electrochemical characteristics compared with other components,and show superior specific capacity of 236.2 mA h g^(-1)at the current density of 0.5 A g^(-1),as well as remarked rate *** present work broadens the horizons of advanced electrode design with distinct heterogeneous interface in other energy storage and conversion field.

关键词： Crystalline-amorphous heterophase Mott-Schottky heterostructure Energy storage Nickel molybdate

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Electrolyte effect on electrochemical behaviors of manganese fluoride material for aqueous asymmetric and symmetric supercapacitors

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Rare Metals 2024年第3期43卷 1048-1061页

作者： Zheng-Hua He jian-Fei Gao ling-Bin kong State Key Laboratory of Advanced Processing and Recycling of Non-Ferrous Metals Lanzhou University of TechnologyLanzhou730050China School of Materials Science and Engineering Lanzhou University of TechnologyLanzhou730050China

Exploring wide voltage window materials is not only an available measure to enhance the energy density of hybrid supercapacitor(HSCs),but also avoids the dynamic mismatch caused by different energy storage mechanisms of two electrodes in assembled symmetrical ***,there are few reports about the wide potential window materials except Bi_(2)O_(3)and VO_(2).Therefore,the MnF_(2)synthesized by solvothermal reaction was served as the electrode for *** MnF_(2)exhibited electrochemical activity in alkaline solution in three-electrode system,especially with a wide potential window from-0.8 to+0.5 V in 2 mol·L^(-1)***,the assembled MnF_(2)//MnF_(2)symmetrical HSC had a potential window of 1.5 V,and it exhibited outstanding long-cycle ***,when MnF_(2)was taken as the negative and positive respectively,the potential windows of asymmetric devices CoMoO_(4)//MnF_(2)and MnF_(2)//Activated Carbon(AC)could reach 1.3 and 1.45 V,respectively,showing excellent cycle *** work shows that MnF_(2)material has great research value in HSC,and provides a new research direction for developing high-performance devices.

关键词： Manganese fluoride Potential window Hybrid supercapacitors Electrochemical performance

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Pilot plant study on ozonation and biological activated carbon process for drinking water treatment

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Journal of Environmental Sciences 2006年第2期18卷 232-235页

作者： kong ling-yu ZHANG Xiao-jian WANG Zhan-sheng Department of Environmental Science and Engineering Tsinghua University Beijing 100084 China

A study on advanced drinking water treatment was conducted in a pilot scale plant taking water from conventional treatment process. Ozonation-biological activated carbon process （O3-BAC） and granular activated carbon process （GAC） were evaluated based on the following parameters： CODMn, UV254, total organic carbon （TOC）, assimilable organic carbon （AOC） and biodegradable dissolved organic carbon （BDOC）. In this test, the average removal rates of CODMn, UV254 and TOC in O3-BAC were 18.2%, 9.0% and 10.2% higher on （AOC） than in GAC, respectively. Ozonation increased 19.3-57.6 μg Acetate-C/L in AOC-P17, 45.6-130.6 μg Acetate-C/L in AOC-NOX and 0.1-0.5 mg/L in BDOC with ozone doses of 2 8 mg/L. The optimum ozone dose for maximum AOC formation was 3 mgO3/L. BAC filtration was effective process to improve biostability.

关键词： ozonation biological activated carbon CODMn UV254 TOC AOC BDOC biostability

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人脐带间充质干细胞抑制脓毒症小鼠肺组织细胞的焦亡

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中国组织工程研究 2025年第31期29卷 6642-6648页

作者：何长良王炎罗玲刘坚中山市古镇人民医院呼吸与危重症医学科广东省中山市528400 湘潭市中心医院/湖南大学附属医院综合ICU 湖南省湘潭市411100

背景:急性肺损伤是脓毒症患者的常见严重并发症,其发病机制复杂,目前尚无有效的药物治疗方案。人脐带间充质干细胞通过抑制细胞过度焦亡从而改善脓毒症急性肺损伤的作用机制愈发受到重视。目的:探索人脐带间充质干细胞对脓毒症所致急性... 详细信息

背景:急性肺损伤是脓毒症患者的常见严重并发症,其发病机制复杂,目前尚无有效的药物治疗方案。人脐带间充质干细胞通过抑制细胞过度焦亡从而改善脓毒症急性肺损伤的作用机制愈发受到重视。目的:探索人脐带间充质干细胞对脓毒症所致急性肺损伤小鼠肺组织细胞焦亡的影响及机制。方法:48只Balb/c雄性小鼠按随机数字法分为假手术组、模型组、治疗组(n=16)。模型组、治疗组行盲肠结扎穿孔建立脓毒症所致急性肺损伤模型,假手术组仅开腹后缝合。治疗组术后6 h尾静脉注射200μL人脐带间充质干细胞悬液(5×105个细胞),模型组及假手术组术后6 h尾静脉注射200μL生理盐水。术后28 h,各组随机取5只小鼠予以尾静脉注射伊文思蓝检测肺血管通透性;收集各组剩余小鼠肺泡灌洗液和肺组织,ELISA检测肺泡灌洗液中白细胞介素1β、白细胞介素18水平,计数肺泡灌洗液中细胞总数及巨噬细胞数;苏木精-伊红染色观察肺组织病理学形态,TUNEL染色观察肺组织细胞焦亡情况,RT-PCR、Western blot检测肺组织中Toll样受体4、GSDMD及Caspase-11的mRNA和蛋白表达。结果与结论:与模型组相比,治疗组术后28 h肺血管通透性显著下降(P<0.05),肺泡灌洗液中白细胞介素1β、白细胞介素18水平降低(P<0.05),细胞总数及巨噬细胞数降低(P<0.05),肺损伤程度减轻,肺组织细胞焦亡指数降低(P<0.05),肺组织Toll样受体4、GSDMD、GSDMD-N及Caspase-11 mRNA及蛋白表达水平均显著下降(P<0.05)。结果表明,人脐带间充质干细胞可能通过抑制Toll样受体4/Caspase-11/GSDMD信号通路活化,改善肺组织细胞焦亡,从而在一定程度上改善脓毒症小鼠肺损伤的严重程度。

关键词：人脐带间充质干细胞 Toll样受体4 Caspase-11 GSDMD 急性肺损伤急性呼吸窘迫综合征细胞焦亡脓毒症工程化干细胞

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A new Lycopodium alkaloid from Phlegmariurus fargesii

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Chinese Journal of Natural Medicines 2014年第5期12卷 373-376页

作者： PAN Ke LUO jian-Guang kong ling-Yi State Key Laboratory of Natural Medicines Department of Natural Medicinal Chemistry China Pharmaceutical University

AIM: To investigate the chemical constituents from the whole plants of Phlegmariurus fargesii. METHOD: Compounds were isolated by repeated silica gel column chromatography. Their structures were elucidated by spectroscopic methods and chemical correlation. The acetylcholinesterase(AChE) inhibitory activity of the isolated compounds was evaluated. RESULTS: A new Lycopodium alkaloid, lycopodine N-oxide(1), along with lycopodine(2), 8,15-dehydrolycopodine(3), 6α-hydroxylycopodine(4), deacetyllycoclavine(5), N-methylhuperzine B(6), lycodine(7), and phlegmarine(8), was isolated. CONCLUSION: Compound 1 is a new Lycopodium alkaloid, and compound 3 was obtained from nature for the first time. Other alkaloids are isolated from this plant for the first time.

关键词： Phlegmariurusfargesii Lycopodium alkaloids Lycopodine N-oxide

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