A new Lycopodium alkaloid from Phlegmariurus fargesii

作     者：PAN Ke LUO Jian-Guang KONG Ling-Yi 

作者机构：State Key Laboratory of Natural Medicines Department of Natural Medicinal Chemistry China Pharmaceutical University 

出 版 物：《Chinese Journal of Natural Medicines》 (中国天然药物（英文版）)

年 卷 期：2014年第12卷第5期

页      面：373-376页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(No.81073009) the Cultivation Fund of the Key Scientific and Technical Innovation Project,Ministry of Education of China(No.707033) the Scaling Project for Innovation Scholars,Natural Science Foundation of Jiangsu Province,China(BK2008039) a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions 

主　　题：Phlegmariurusfargesii Lycopodium alkaloids Lycopodine N-oxide 

摘      要：AIM: To investigate the chemical constituents from the whole plants of Phlegmariurus fargesii. METHOD: Compounds were isolated by repeated silica gel column chromatography. Their structures were elucidated by spectroscopic methods and chemical correlation. The acetylcholinesterase(AChE) inhibitory activity of the isolated compounds was evaluated. RESULTS: A new Lycopodium alkaloid, lycopodine N-oxide(1), along with lycopodine(2), 8,15-dehydrolycopodine(3), 6α-hydroxylycopodine(4), deacetyllycoclavine(5), N-methylhuperzine B(6), lycodine(7), and phlegmarine(8), was isolated. CONCLUSION: Compound 1 is a new Lycopodium alkaloid, and compound 3 was obtained from nature for the first time. Other alkaloids are isolated from this plant for the first time.