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The correlation and overlaps between PD-L1 expression and classical genomic aberrations in Chinese lung adenocarcinoma patients: a single center case series

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Cancer Biology & Medicine 2019年第4期16卷 811-821页

作者： jianghua Wu Wei Sun Haiyue Wang Xiaozheng Huang Xinyu Wang Weiyang jiang ling jia Ping Wang Qin Feng Dongmei Lin Department of Pathology Peking University Cancer Hospital&InstituteKey Laboratory of Carcinogenesis and Translational Research(Ministry of Education)Beijing 100142China Department of Pathology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center of CancerKey Laboratory of Cancer Prevention and TherapyTianjin 300060China

Objective:To investigate the correlation and overlaps between PD-L1 expression and classical genomic aberrations in Chinese lung adenocarcinoma(LADC)***:We reviewed 428 consecutive,surgically resected cases of LADC from October 2015 to December 2016 from our ***-L1 expression was evaluated based on tumor proportion score(TPS).Correlation and co-occurrence of PD-L1 expression level with those of classical driver genes,such as EGFR,ALK,ROS-1,and KRAS and with clinical variables and disease-free survival(DFS)were ***:Seventy of the 428 cases(16.4%)showed TPS≥1%,and 21 cases(4.9%)showed TPS≥50%.PD-L1 positive expression was significantly associated with male gender,smoking,advanced TNM stage,and solid histologic *** TPS≥1% and ≥50%were correlated with the absence of an EGFR mutation(P<0.001)and the presence of ALK rearrangement(P=0.024).KRAS mutation was associated with TPS≥50%(P=0.035).PD-L1 positivity commonly overlapped with the alterations of classical driver oncogenes(58.5%with TPS≥1% and 42.9% with TPS≥50%).Approximately three-quarters of PD-L1 positive cases co-occurred with classical therapeutic-gene aberrations in cases with stage III/IV cancer or cancer *** could be divided into four subgroups based on the expression profile of current routine biomarkers for potential therapeutic ***:PD-L1 expression is not only closely correlated with classic gene alterations but also commonly overlaps with the aberrations of classical driver oncogenes in Chinese LADC *** findings provide a useful overview of clinical strategies that rely on the profile of routinely used molecular biomarkers.

关键词： Lung adenocarcinoma PD-L1 expression classical genomic aberrations molecular biomarkers

Thickness and sp3 bond modulation of（Ti/tetrahedral amorphous carbon）_n multilayer coatings

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Tungsten 2025年第1期7卷 152-160页

作者： Zhi-Jun Xie jia-Lin Li ling Gong Xiang-Li Zhong Hong-jia Song Jin-Bin Wang National-Provincial Laboratory of Special Function Thin Film Materials School of Materials Science and Engineering Xiangtan University

The durability of wear-resistant tetrahedral amorphous carbon（ta-C） coatings is intimately linked to their thickness and the concentration of *** enhance the lifespan of the coatings,we have prepared a multilayer coating consisting of alternating layers of Ti and ta-C,denoted as（Ti/ta-C）_n,using arc ion plating.A multi-layer structure in conjunction with stage cooling is employed to enhance the thickness and promote *** results indicate that the ID/IGvalue,representing the ratio of the intensity of the D peak to that of the G peak in Raman spectroscopy,decreases from 0.85 when no stage cooling is applied to 0.35 when stage cooling is employed,suggesting an enhancement in the fraction of sp3bonds within the *** obtained（Ti/ta-C）_n multilayer coating without peeling off has a maximum thickness of 1.14 μm,which is almost double that of the ta-C coating single layer *** the same time,the coating has a low coefficient of friction,down to 0.069,and maintains excellent friction properties with a wear rate of 3.4×10-6mm3·N-1·*** results conclusively show that the preparation technology can enhance both thickness and sp3bonding in ta-C coatings,significantly expanding their utility across tools,molds,and precision engineering components.

关键词： Arc ion plating Multilayer structure sp3 bond Ta-C coating Wear resistance

FREE GRAFT TWO-STAGE URETHROPLASTY FOR HYPOSPADIAS REPAIR

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Chinese Medical Sciences Journal 2005年第2期20卷 119-122,页

作者： Zhong-jinYue ling-junZuo jia-jiWang Gan-pingZhong jian-mingDuan Zhi-pingWang Da-shanQin DepartmentofUrology theSecondHospitalLanzhouUniversityLanzhou730030

Objective To evaluate the effectiveness of free graft transplantation two-stage urethroplasty for hypospadias repair. Methods Fifty-eight cases with different types of hypospadias including 10 subcoronal, 36 penile shaft, 9 scrotal, and 3 perineal were treated with free full-thickness skin graft or (and) buccal mucosal graft transplantation two-stage urethroplasty. Of 58 cases, 45 were new cases, 13 had history of previous failed surgeries. Operative procedure included two stages: the first stage is to correct penile curvature (chordee), prepare transplanting bed, harvest and prepare full-thickness skin graft, buccal mucosal graft, and perform graft transplantation. The second stage is to complete urethroplasty and glanuloplasty. Results After the first stage operation, 56 of 58 cases (96.6%) were successful with grafts healing well, another 2 foreskin grafts got gangrened. After the second stage operation on 56 cases, 5 cases failed with newly formed urethras opened due to infection, 8 cases had fistulas, 43 (76.8%) cases healed well. Conclusions Free graft transplantation two-stage urethroplasty for hypospadias repair is a kind of effective treatment with broad indication, comparatively high success rate, less complications and good cosmatic results, indicative of various types of hypospadias repair.

关键词： hypospadias two-stage operation free graft transplantation

The cohomology group of weak entwining structure

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Science China Mathematics 2007年第5期50卷 665-674页

作者： ling jia & Fang LI Department of Mathematics, Ludong University, Yantai 264025, China Department of Mathematics, Zhejiang University, Hangzhou 310027, China Department of Mathematics Ludong University Yantai China Department of Mathematics Zhejiang University Hangzhou China

In this paper, we reveal that a weak entwining structure admits a rich cohomology theory. As an application we compute the cohomology of a weak entwining structure associated to a weak coalgebra-Galois extension.

关键词： weak entwining structure cohomology group 16W80 16W99

Effects of TRPA1 activation and inhibition on TRPA1 and CGRP expression in dorsal root ganglion neurons

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Neural Regeneration Research 2019年第1期14卷 140-148页

作者： Xiao-Lei Wang Li-Wei Cui Zhen Liu Yue-Ming Gao Sheng Wang Hao Li Hu-Xiang Liu ling-jia Yu Department of Rheumatology Qilu Hospital of Shandong University Department of Respiratory Medicine Qilu Hospital of Shandong University Department of Orthopedics Qilu Hospital of Shandong University

Transient receptor potential ankyrin 1 （TRPA1） is a key player in pain and neurogenic inflammation, and is localized in nociceptive primary sensory dorsal root ganglion （DRG） neurons. TRPA1 plays a major role in the transmission of nociceptive sensory signals. The generation of neurogenic inflammation appears to involve TRPAl-evoked release of calcitonin gene-related peptide （CGRP）. However, it remains unknown whether TRPA1 or CGRP expression is affected by TRPA 1 activation. Thus, in this study, we examined TRPA 1 and CGRP expression in DRG neurons in vitro after treatment with the TRPA1 activator tbrmaldehyde or the TRPA1 blocker menthol. In addition, we examined the role of extracellular signal-regulated protein kinase 1/2 （ERK1/2） in this process. DRG neurons in culture were exposed to formaldehyde, menthol, the ERK1/2 inhibitor PD98059 ＋ formaldehyde, or PD98059 ＋ menthol. After treatment, real-time polymerase chain reaction, western blot assay and double immunofluorescence labeling were performed to evaluate TRPA1 and CGRP expression in DRG neurons. Formaldehyde elevated mRNA and protein levels of TRPA 1 and CGRP, as well as the proportion of TRPA1- and CGRP-positive neurons. In contrast, menthol reduced TRPA1 and CGRP expression. Furthermore, the effects of lbrmaldehyde, but not menthol, on CGRP expression were blocked by pretreatment with PD98059. PD98059 pretreatment did not affect TRPA1 expression in the presence of formaldehyde or menthol.

关键词： nerve regeneration TRPA1 TRPV1 formaldehyde menthol CGRP dorsal root ganglion neuron neurogenic inflammation nociceptive signal ERK1/2 neural regeneration

Severe acute respiratory syndrome: vaccine on the way

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Chinese Medical Journal 2005年第17期118卷 1468-1476页

作者： ZHANG Ding-mei WANG Guo-ling LU jia-hai School of Public Health Sun Yat-sen University Guangzhou 510080 China

In November 2002, a new disease-severe acute respiratory syndrome, or SARS-first emerged in Guangdong Province, China. Subsequently, it spread to more than 30 countries worldwide.1 The causative agent was identified to be a previously unknown member of the coronaviridae family, and was named SARS coronavirus （SARS-CoV）. SARS coronavirus is a large, enveloped, positive-sense RNA virus. The genome is about 30 kb, which is predicted to contain 14 functional open reading frames （ORFs）. Two large 5＇-terminal ORFs （1a and 1b） encode the polymerases that are required for viral RNA synthesis. The remaining twelve ORFs encode four structural proteins [spike protein （S）, envelope protein （E）, membrane protein （M） and nucleocapsid protein （N）] and eight accessory proteins. Though the SARS-CoV genome is clear, a great deal more work will be required to develop an efficient vaccine and effective drugs. Neutralizing antibodies were detectable in the convalescent sera of SARS patients, and sera from recovered patients could be used to treat newly infected individuals. The data suggest that protective humoral immunity is achievable and that vaccines can be developed for prevention of SARS. In this article, we review and discuss progress towards development of a SARS vaccine.

关键词： severe acute respiratory syndrome conoravirus vaccine

Qiming granule in treating type 2 diabetic kidney disease patients:study protocol for a randomized controlled trial

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Traditional Medicine Research 2021年第1期6卷 7-15页

作者： jian Huo Jun-Guo Duan Xue-Jing Lu Fu-Wen Zhang Wen-Yuan jian jia-Qing Sui jia-ling Ai Li-Sha Liu College of Ophthalmology Chengdu University of Traditional Chinese MedicineChengdu 610075China Chengdu Women’s and Children’s Central Hospital School of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 611731China Ineye Hospital Chengdu 610084China

Background:Diabetic kidney disease(DKD)is a chronic renal microvascular complication associated with abnormal glucose *** to traditional Chinese medicine(TCM)theory,Qi and Yin deficiency with blood stasis(the name of TCM symptoms,its main clinical features are fatigue,dry mouth,red or pale tongue,weak pulse,etc.)is the primary TCM syndrome of DKD,and Qiming granule(QMG)is suitable for the treatment of Qi and Yin deficiency with blood stasis *** view of this,we designed a randomized controlled trial to assess whether QMG is efficacious and safe in treating DKD ***:This protocol is for a randomized,double-blind,placebo-controlled,parallel group,six-centre clinical trial.A total of 180 participants will be randomized into the QMG group or placebo group,with a 1:1 *** study will last for 50 weeks,including a 2-week run-in period,24 weeks of intervention,and 24 weeks of *** experimental intervention will be QMG,and the control intervention will be a *** primary outcome will be the 24h urinary albumin excretion ratio and the change in the albumin-to-creatinine *** secondary outcome will be evaluation of renal function,fundus changes,management of blood lipids,TCM symptom improvement and safety *** events will be recorded during the ***:This study is a randomized controlled trial to test the effectiveness and safety of QMG for DKD *** findings of this study will help to provide evidence-based recommendations in treating DKD *** registration:Chinese Clinical Trial Registry,*** 23 December 2012.

关键词： Diabetic kidney disease Qiming granule Traditional Chinese medicine Randomized controlled trial

Visual fatigue relief zone in an extra-long tunnel using virtual reality with wearable EEG-based devices

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Journal of Central South University 2021年第12期28卷 3871-3881页

作者： LI Xiao-jun ling jia-xin SHEN Yi Department of Geotechnical Engineering Tongji UniversityShanghai 200092China Key Laboratory of Geotechnical and Underground Engineering of the Ministry of Education Tongji UniversityShanghai 200092China

Long-time driving and monotonous visual environment increase the safety risk of driving in an extra-long tunnel. Driving fatigue can be effectively relieved by setting the visual fatigue relief zone in the tunnel. However, the setting form of visual fatigue relief zone, such as its length and location, is difficult to be designed and quantified. By integrating virtual reality(VR) apparatus with wearable electroencephalogram(EEG)-based devices, a hybrid method was proposed in this study to assist analyzers to formulate the layout of visual fatigue relief zone in the extra-long *** virtual environment of this study was based on an 11.5 km extra-long tunnel located in Yunnan Province in *** results indicated that the use of natural landscape decoration inside the tunnel could improve driving fatigue with the growth rate of attention of the driver increased by more than 20%. The accumulation of driving fatigue had a negative effect on the fatigue relief. The results demonstrated that the optimal location of the fatigue relief zone was at the place where driving fatigue had just occurred rather than at the place where a certain amount of driving fatigue had accumulated.

关键词： virtual reality visual environment driving fatigue extra-long tunnel EEG-based device

Recent Strategies and Advances in Hydrogel‑Based Delivery Platforms for Bone Regeneration

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Nano-Micro Letters 2025年第3期17卷 389-439页

作者： Xiao Wang jia Zeng Donglin Gan Kun ling Mingfang He jianshu Li Yongping Lu Scientific and Technological Innovation Center for Biomedical Materials and Clinical Research Guangyuan Key Laboratory of Multifunctional Medical HydrogelGuangyuan Central HospitalGuangyuan 628000People’s Republic of China jiangsu Collaborative Innovation Center of Biomedical Functional Materials Jiangsu Key Laboratory of Bio‑Functional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023People’s Republic of China College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065People’s Republic of China

Bioactive molecules have shown great promise for effectively regulating various bone formation processes,rendering them attractive therapeutics for bone ***,the widespread application of bioactive molecules is limited by their low accumulation and short half-lives in *** have emerged as ideal carriers to address these challenges,offering the potential to prolong retention times at lesion sites,extend half-lives in vivo and mitigate side effects,avoid burst release,and promote adsorption under physiological *** review systematically summarizes the recent advances in the development of bioactive molecule-loaded hydrogels for bone regeneration,encompassing applications in cranial defect repair,femoral defect repair,periodontal bone regeneration,and bone regeneration with underlying ***,this review discusses the current strategies aimed at improving the release profiles of bioactive molecules through stimuli-responsive delivery,carrier-assisted delivery,and sequential ***,this review elucidates the existing challenges and future directions of hydrogel encapsulated bioactive molecules in the field of bone regeneration.

关键词： Hydrogel Bone regeneration Bioactive molecules Drug delivery Nano-/microscale carriers