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Recent progress in single crystal perovskite X-ray detectors

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Science China(Information Sciences) 2024年第3期67卷 5-19页

作者： Xiao LIU Jun REN Yu-Ang CHEN Xiangshun geng Dan XIE Tian-ling REN Tsinghua University Beijing National Research Center for Information Science and Technology (BNRist) School of Integrated Circuits

Perovskites have attracted extensive attention as radiation detection material due to their long carrier diffusion length and lifetime, high absorption coefficient, and flexible manufacturing process. Compared with polycrystalline structures, single crystal perovskites improve the performance of optoelectronic devices due to their low defect state density, better photoelectric characteristics, and chemical stability.Herein, we review the recent progress of single crystal perovskite X-ray detectors. First, we briefly introduced the basic concepts, detection mechanisms, figure of merits of perovskite X-ray detectors, and the preparation methods of single crystal perovskites. Then, we summarized the significant advancements in single crystal perovskite X-ray detectors in recent times. Finally, we discussed the critical challenges and some practicable solutions for developing high-performance X-ray detectors.

关键词： single crystal perovskites carrier transport radiation detection X-ray detectors X-ray imaging

LA-D-B1,a novel Abemaciclib derivative,exerts anti-breast cancer effects through CDK4/6

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BIOCELL 2024年第5期48卷 847-860页

作者： ling MA ZIRUI JIANG XIAO HOU YUTING XU ZIYUN CHEN SIYI ZHANG HANXUE LI SHAOJIE MA geng ZHANG XIUJUN WANG JING JI Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening College of PharmacyJiangsu Ocean UniversityLianyungang222000China School of Medicine Xiamen UniversityXiamen361102China

Background:Regulatory proteins involved in human cellular division and proliferation,cyclin-dependent kinases 4 and 6(CDK4/6)are overexpressed in numerous cancers,including triple-negative breast cancer(TNBC).TNBC is a common pathological subtype of breast cancer that is prone to recurrence and metastasis,and has a single treatment method.As one of the CDK4/6 inhibitors,abemaciclib can effectively inhibit the growth of breast tumors.In this study,we synthesized LA-D-B1,a derivative of Abemaciclib,and investigated its anti-tumor effects in breast cancer.Methods:Cellular viability was assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)assay.Cell cloning and migration abilities were determined by colony formation assay and wound healing assay.Cell invasion abilities and adhesion were determined by cell invasion assay and cell adhesion assay.The impact of compound LA-D-B1 on cell proliferation and the cell cycle was analyzed through Western blotting,which quantified the levels of proteins associated with the cyclin-dependent kinase(CDK)4/6-cyclin D-Rb-E2F pathway.The in vivo anti-tumor activity of compound LA-D-B1 was investigated using a chick chorioallantoic membrane(CAM)model.Results:The study demonstrated that LA-D-B1 effectively suppressed breast cancer cell proliferation,induced apoptosis,and caused cell cycle arrest.Furthermore,LA-D-B1 reduced the expression of key proteins in the CDK4/6-cyclin D-Rb-E2F pathway,including CDK4,CDK6 and E2F1.The results also indicated significant antitumor activity of LA-D-B1 in a transplanted tumor model.Conclusion:In this study,LA-D-B1 demonstrated a potent anti-tumor effect by effectively suppressing cell proliferation and inhibiting cell cycle progression in breast cancer.These findings highlight the potential of LA-D-B1 as a valuable compound for enhancing therapeutic outcomes and controlling the progression of breast cancer.

关键词： CDK4/6 inhibitor Breast cancer Antitumor activity Cell cycle

Effects of a periodic intermittent theta burst stimulation in Alzheimer's disease

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General Psychiatry 2024年第1期37卷 53-63页

作者： Xingqi Wu Yibing Yan Panpan Hu Lu Wang Yue Wu Pan Wu Zhi geng Guixian Xiao Shanshan Zhou Gongjun Ji Bensheng Qiu ling Wei Yanghua Tian Hesheng Liu Kai Wang Department of Neurology First ffiliated Hospital of Anhui Medical UniversityHefeiAnhuiChina School of Mental Health and Psychological Sciences Anhui Medical UniversityHefeiAnhuiChina Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders HefeiAnhuiChina Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health HefeiAnhuiChina Department of Psychology and Sleep Medicine The Second Affliated Hospital of Anhui Medical UniversityHefeiAnhuiChina Center for Biomedical Imaging University of Science and Technology of ChinaHefeiAnhuiChina institute of Artificial Intlligence Hefei Comprehensive National Science CenterHefeiAnhuiChina Department of Neuroscience Medical University of South CarolinaCharlestonSouth CarolinaUSA

Background Previous studies havedemonstrated that excitatory repetitive transcranial magnetic stimulation(rTMS)can improve the cognitive function of patients with Alzheimer's disease(AD).Intermittent theta burst stimulation(iTBS)is a novel excitatory rTMS protocol for brain activity stimulation with the ability to induce long-term potentiation-like plasticity and represents a promising treatment for AD.However,the long-term effects of iTBS on cognitive decline and brain structure in patients with AD areunknown.Aims We aimed to explore whether repeating accelerated iTBS every three months could slow down the cognitive decline in patients with AD.Methods In this randomised,assessor-blinded,controlled trial,iTBS was administered to the left dorsolateral prefrontal cortex(DLPFC)of 42 patients with AD for 14days every 13weeks.Measurements included the Montreal Cognitive Assessment(MoCA),a comprehensive neuropsychological battery,and the grey matter volume(GMV)of the hippocampus.Patients were evaluated at baseline and after follow-up.The longitudinal pipeline of the Computational Anatomy Toolbox for SPM was used to detect significant treatment-related changes over time.Results The iTBS group maintained MoCA scores relative to the control group(t=3.26,p=0.013)and reduced hippocampal atrophy,which was significantly correlated with global degeneration scale changes.The baseline Mini-Mental State Examination(MMSE)score,apolipoprotein E genotype and Clinical Dementia Rating were indicative of MoCA scores at follow-up.Moreover,the GMV of the left(t=0.08,p=0.996)and right(t=0.19,p=0.977)hippocampus were maintained in the active group but significantly declined in the control group(left:t=4.13,p<0.001;right:t=5.31,p<0.001).GMV change in the left(r=0.35,p=0.023)and right(r=0.36,p=0.021)hippocampus across the intervention positively correlated with MoCA changes;left hippocampal GMV change was negatively correlated with global degeneration scale(r=-0.32,p=0.041)changes.Conclusions DLPFC-iTBS maybe a feasible and easy-to-implement

关键词： stimulation Alzheimer maintained

Marginal zone lymphoma with severe rashes: A case report

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World Journal of Clinical Cases 2024年第3期12卷 565-574页

作者： Si-Jun Bai Ye geng Yi-Nan Gao Cai-Xia Zhang Qian Mi Chen Zhang Jia-ling Yang Si-Jie He Zhen-YingYan Jian-Xia He Department of Hematology Shanxi Provincial People’s HospitalTaiyuan 030012Shanxi ProvinceChina

BACKGROUND Marginal zone lymphoma(MZL)is an indolent subtype of non-Hodgkin lymphoma(NHL),which is rare clinically with severe rashes as the initial symptom.CASE SUMMARY This study reports a case of MZL with generalized skin rashes accompanied by pruritus and purulent discharge.First-line treatment with rituximab combined with zanubrutinib had poor effects.However,after switching to obinutuzumab combined with zanubrutinib,the case was alleviated,and the rashes disappeared.CONCLUSION For patients with advanced stage MZL not benefiting from type I anti-CD20 monoclonal antibody(mAb)combination therapy,switching to a type II anti-CD20 mAb combination regimen may be considered.This approach may provide a new perspective in the treatment of MZL.

关键词： Marginal zone lymphoma Mucosa-associated lymphoid tissue Extranodal marginal zone lymphoma Primary cutaneous marginal zone lymphoma Rituximab,Obinutuzumab Zanubrutinib Case report

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基于物理信息神经网络的同步发电机建模

中国电机工程学报 2024年第12期44卷 4924-4932,I0027页

作者：杨珂王鑫凌佳杰耿光超江全元浙江大学电气工程学院浙江省杭州市310027

采用物理机理建立的同步发电机模型在表达发电机真实的非线性特性方面存在不足,电力系统正在不断研究和采纳新的同步发电机模型以增强模型的准确性。数据驱动模型具有更强的非线性表达能力,但在同步发电机建模实际应用中面临着模型泛化... 详细信息

采用物理机理建立的同步发电机模型在表达发电机真实的非线性特性方面存在不足,电力系统正在不断研究和采纳新的同步发电机模型以增强模型的准确性。数据驱动模型具有更强的非线性表达能力,但在同步发电机建模实际应用中面临着模型泛化性不强和所需数据量大等问题。为克服上述问题,该文结合神经元建模原理,以循环神经网络为基本框架,在同步发电机物理机理的引导下,提出基于物理信息神经网络的同步发电机模型。经过算例验证,所提模型可准确表达同步发电机磁饱和特性,并且具有较强的泛化性。该模型可在小规模数据下对同步发电机各阶模型达到更高的拟合准确度,并可应用于现有机电暂态仿真算法。

关键词：物理信息神经网络数据驱动同步发电机磁饱和效应

高中化学必修新教科书中技术内容的分析及建议

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化学教育（中英文） 2024年第1期45卷 20-25页

作者：耿淑玲陈曦叶玲邹何悦湖南师范大学化学化工学院湖南长沙410081

技术素养是现代公民适应社会发展的必备素养,化学教育是培养技术素养的重要途径。依据技术素养的技术内容分析框架,对人教版、苏教版、鲁科版等高中化学必修新教科书中的技术内容进行文本分析,归纳出其特点如下:内容广泛多元,以技术知... 详细信息

技术素养是现代公民适应社会发展的必备素养,化学教育是培养技术素养的重要途径。依据技术素养的技术内容分析框架,对人教版、苏教版、鲁科版等高中化学必修新教科书中的技术内容进行文本分析,归纳出其特点如下:内容广泛多元,以技术知识为主;组织编排灵活,长短篇幅结合;文字呈现为主,图像类型多样。基于此,建议教科书编写应:丰富技术史知识;注重技术内容的编排与呈现;强化技术理性的地位。在教学中可以:创设真实的技术情境;重视技术理性的培养;开展技术实践活动。

关键词：技术素养化学必修新教科书技术内容

The effect of SARS-CoV-2 infection on human embryo early development:a multicenter prospective cohort study

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Science China(Life Sciences) 2023年第7期66卷 1697-1700页

作者： Xiaolei Chen Huangcong Shi Cheng Li Wanxia Zhong Linlin Cui Wenjun Zhang ling geng Kuona Hu Mei Fang Daimin Wei Junhao Yan Yun Sun Keliang Wu Han Zhao Zi-Jiang Chen Center for Reproductive Medicine Shandong UniversityJinan 250012China Research Unit of Gametogenesis and Health of ART-Offspring Chinese Academy of Medical SciencesJinan 250012China Key Laboratory of Reproductive Endocrinology of Ministry of Education Shandong UniversityShandong Key Laboratory of Reproductive MedicineShandong Provincial Clinical Research Center for Reproductive HealthJinan 250012China National Research Center of Assisted Reproductive Technology and Reproductive Genetics Shandong UniversityJinan 250012China Center for Reproductive Medicine The Second HospitalCheeloo College of MedicineShandong UniversityJinan 250012China Center for reproductive medicine Ren Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai Key Laboratory for Assisted Reproduction and Reproductive GeneticsShanghai 200127China

Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARSCo V-2)infection has swept the globe for 3 years(Zhou et al.,2020).With the nationwide relaxation of controls on the coronavirus disease 2019(COVID-19)epidemic since December 2022 in China,fertility and in vitro fertilization(IVF)centers are receiving increasing numbers of infected patients.

关键词： infection acute

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磁传感器检测磁性纳米粒子方法研究

传感器与微系统 2024年第3期43卷 22-25,30页

作者：耿跃华王欣瑜翁玲河北工业大学省部共建电工装备可靠性与智能化国家重点实验室天津300130 河北工业大学河北省电磁场与电器可靠性重点实验室天津300130

磁性纳米粒子表面修饰后,可以与核酸、蛋白质、重金属离子等物质结合,通过检测磁粒子的磁响应信号,可以得到待测物的含量。基于电磁学理论与隧道磁阻效应,设计了一种用于检测不同质量磁性纳米粒子磁信号的测试平台。利用COMSOL Multiphy... 详细信息

磁性纳米粒子表面修饰后,可以与核酸、蛋白质、重金属离子等物质结合,通过检测磁粒子的磁响应信号,可以得到待测物的含量。基于电磁学理论与隧道磁阻效应,设计了一种用于检测不同质量磁性纳米粒子磁信号的测试平台。利用COMSOL Multiphysics有限元分析软件优化了磁场产生装置,改进后的线圈在通入直流电流不变的情况下,能将磁场的均匀区域扩大1.5倍,数值提高2 Gs。新型三匝线圈的实验结果与仿真结果相比最大误差为6.25%。选择了适合常规样品的磁场检测装置,分析了各类传感器的最优测量方向,测得了磁粒子质量与输出信号的关系曲线。实验结果表明:随着悬浮液中磁粒子含量的增加,隧道磁阻(TMR)传感器的输出信号也呈上升趋势,两者为线性正比关系。

关键词：定量检测磁性纳米粒子亥姆霍兹线圈隧道磁阻传感器

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基于链路关联度模型的绿色节能路由框架

计算机科学 2024年第3期51卷 289-299页

作者：王玲金子琨吴勇耿海军山西大学自动化与软件学院太原030006 山西大学计算机与信息技术学院太原030006

随着信息技术的高速发展,互联网的规模逐渐增大,与此同时,网络的能耗也随之攀升。业界普遍采用关闭利用率较低的链路来降低网络能耗。然而,目前的网络节能方案并不能有效平衡能量节约率、计算开销和路径拉伸度三者之间此消彼长的关系。... 详细信息

随着信息技术的高速发展,互联网的规模逐渐增大,与此同时,网络的能耗也随之攀升。业界普遍采用关闭利用率较低的链路来降低网络能耗。然而,目前的网络节能方案并不能有效平衡能量节约率、计算开销和路径拉伸度三者之间此消彼长的关系。为了应对上述问题,文中提出了一种基于链路关联度模型的绿色节能路由框架。该框架支持不同的链路关联度模型,仅需要网络拓扑结构,而不需要网路中的实时流量矩阵,更易于在实际网络中部署。基于提出的链路关联度模型的绿色节能路由算法的框架,文中实现了链路行关联度算法LRC(Link Row Correlation)、链路列关联度算法LCC(Link Column Correlation)、链路行-列关联度算法LRCC(Link Row Column Correlation)和链路介数关联度LBC(Link Betweenness Correlation)4种不同的绿色节能路由算法。实验结果表明,在The Internet Topology Zoo公布的真实拓扑和由Brite模拟生成的拓扑中,LRC,LCC,LRCC和LBC的平均能量节约率比DLF算法的平均能量节约率高12.65%和7.17%,且它们的平均路径拉伸度比DLF算法的平均路径拉伸度低3.00%和13.75%。

关键词：绿色节能路由链路关联度模型路径拉伸度能量节约率