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Association of initial assessm.nt variables and m.rtality in severe pediatric traum.tic brain injury

World Journal of Pediatric Surgery 2024年第2期7卷 125-133页

作者： Katherine C Bergus Kelli N Patterson lindsey Asti Josh Bricker Tariku J Beyene Lauren N schulz Dana m.schwartz Rajan K Thakkar Eric A Sribnick Pediatric Surgery Nationwide Children's HospitalColumbusOhioUSA CenterforSurgical Outcom.s Research Nationwide Children's HospitalColumbusOhioUSA Neurologic Surgery The Ohio State UniversityColumbusOhioUSA Neurologic Surgery Nationwide Children's HospitalColumbusOhioUSA

Background Predictive scales have been used to prognosticate long-term.outcom.s of traum.tic brain injury(TBI),but gaps rem.in in predicting m.rtality using initial traum. resuscitation *** sought to evaluate the association of clinical variables collected during the initial resuscitation of intubated pediatric severe patients with TBI with in-hospital *** Intubated pediatric traum. patientsm. scale(GCS)score≤8)from.January 2011 to Decem.er 2020 were *** between initial traum. resuscitation variables(tem.erature,pulse,m.an arterial blood pressure,GCS score,hem.globin,international norm.lized ratio(INR),platelet count,oxygen saturation,end tidal carbon dioxide,blood glucose and pupillary response)and m.rtality were evaluated with m.ltivariable logistic *** Am.ng 314 patients,m.dian age was 5.5 years(interquartile range(IQR):2.2-12.8),GCS score was 3(IQR:3-6),Head Abbreviated Injury score(hAIS)was 4(IQR:3-5),and m.st had a severe(25-49)Injury Severity score(ISS)(48.7%,153/314).Overall m.rtality was 26.8%.GCS score,hAIS,ISS,INR,platelet count,and blood glucose were associated with in-hospital m.rtality(all pscore increased,the odds of m.rtality *** 1-point increase in GCS score was associated with a 35%decrease in odds of *** hAIS,INR,and blood glucose increased,the odds of m.rtality *** each 1.0 unit increase in INR,the odds of m.rtality increased by 1427%.Conclusions Pediatric patients with severe TBI are at substantial risk for in-hospital *** are needed to exam.ne whether earlier interventions targeting specific param.ters of INR and blood glucose im.act m.rtality.

关键词： m.rtality pediatric traum.tic

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Effects of m.ltiple shapes for steady flow with transform.r oil+Fe_(3)O_(4)+TiO_(2) between two stretchable rotating disks

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Applied m.them.tics and m.chanics(English Edition) 2024年第2期45卷 373-388页

作者： m.RAHm.N m.TURKYILm.ZOGLU Z.m.SHTAQ Departm.nt of m.them.tics Mirpur University of Science and TechnologyMirpur 10250Pakistan Departm.nt of m.them.tics Hacettepe UniversityBeytepeAnkara 06532Turkiye

In this study,we exam.ne the effects of various shapes of nanoparticles in a steady flow of hybrid nanofluids between two stretchable rotating *** steady flow of hybrid nanofluids with transform.r oil as the base fluid and Fe_(3)O_(4)+TiO_(2)as the hybrid nanofluid is *** shapes of Fe_(3)O_(4)+TiO_(2)hybrid nanofluids,including sphere,brick,blade,cylinder,and platelet,are *** shape exists in the sam. volum. of a *** leading equations(partial differential equations(PDEs))are transform.d to the nonlinear ordinary differential equations(ODEs)with the help of sim.larity *** system.of equations takes the form.of ODEs depending on the boundary conditions,whose solutions are com.uted num.rically by the bvp4c m.TLAB *** outputs are com.ared with the previous findings,and an intriguing pattern is discovered,such that the tangential velocity is increased for the rotation param.ter,while it is decreased by the stretching values because of the lower *** the reaction rate param.ter,the concentration boundary layer becom.s shorter,and the activation energy com.onent increases the rate at which m.ss transfers com. to the higher disk but have the opposite effect on the bottom.*** ranges of various param.ters taken into account are Pr=6.2,Re=2,m.1.0,φ_(1)=φ_(2)=0.03,K=0.5,S=-0.1,Br=0.3,sc=2.0,α_(1)=0.2,γ=0.1,E_(n)=2.0,and q=1.0,and the rotation factor K is within the range of 0 to 1.

关键词： transform.r oil Brinkm.n num.er skin friction coefficient double rotating disk Nusselt num.er Sherwood num.er

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Hem.tological m.lignancies in Sickle Cell Disease Patients: Report of Four Cases in Togo and Literature Review

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Open Journal of Blood Diseases 2024年第1期14卷 31-41页

作者： Padaro Essohana Guedenon m. Koffi m.gnang Hèzouwè Wom.y m. C. Kodzovi Layibo Yao Kalaissi m.ndjam.na Agate R. Pikiliwè Departm.nt of Hem.tology Campus Teaching Hospital University of Lomé Lomé Togo Departm.nt of Pediatrics Sylvanus Olympio Teaching Hospital University of Lomé Lomé Togo National Center of Research and Treatem.nt of Sickle Cell Disease Patients (CNRSD) Lomé Togo Departm.nt of Hem.tology Sylvanus Olympio Teaching Hospital University of Lomé Lomé Togo

Background: Hem.pathies were rarely observed in m.jor sickle cell disease patients som. thirty years ago, probably due to the high m.rtality rate am.ng the latter as a result of progressive com.lications. Thanks to advances in the m.nagem.nt of sickle cell disease, patients' life expectancy has increased considerably, exposing them.m.re frequently to neoplasia, including hem.tological m.lignancies. The increased risk of leukem.genesis is m.ltifactorial and linked to the pathophysiological m.chanism. of the clinical m.nifestations of sickle cell disease. Study Setting: The clinical haem.tology departm.nt of cam.us teaching hospital and the paediatric onco-haem.tology unit of Sylvanus Olym.io teaching hospital in Lom. were used as study settings. Observations: Four hem.tologic m.lignancies were collected in a cohort of 5847 m.jor sickle cell syndrom.s. The m.dian age of the patients was 31.25 years (extrem.s: 14 and 58 years) and they were predom.nantly fem.le (sex ratio m.F = 0.25). Two were on background therapy with hydroxyurea. Am.ng the four patients, there were two cases of acute lym.hocytic leukem.a, including ALL3 in a 58-year-old SS wom.n and T-ALL2 in a 12-year-old sc. Then, a case of lym.hocytic lym.hom. in a 20-year-old SS m.n was reported and finally a case of chronic m.elocytic leukem.a in a 33-year-old wom.n of Sβ+ thalassaem.a phenotype. Conclusion: To further report this coexistence, it is therefore essential to system.tically consider hem.tological m.lignancies during m.jor sickle cell syndrom.s even if there are sim.larities in the sym.tom.tology of these two serious pathological situations.

关键词： Hem.tological m.lignancies Sickle Cell Disease Lom.-Togo

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Num.rical m.deling of m.ss Transfer in the Interaction between River Biofilm.and a Turbulent Boundary Layer

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Open Journal of Fluid Dynam.cs 2024年第1期14卷 1-23页

作者： Falilou Coundoul Evrad m. D. Ngom.Frédéric Y. m.ulin Institut Polytechnique de Saint-Louis Université Gaston Berger Saint-Louis Senegal Institut de m.canique des Fluides de Toulouse UMR 5502-Université de Toulouse Occitanie France

In this article dedicated to the m.deling of vertical m.ss transfers between the biofilm.and the bulk flow, we have, in the first instance, presented the m.thodology used, followed by the presentation of various results obtained through analyses conducted on velocity fields, different fluxes, and overall transfer coefficients. Due to num.rical constraints (resolution of relevant spatial scales), we have restricted the analysis to low schm.dt num.ers (Sc=0.1, Sc=1, and Sc=10) and a single roughness Reynolds num.er (Re*=150). The analysis of instantaneous concentration fields from.various sim.lations revealed logarithm.c concentration profiles above the canopy. In this zone, the concentration is relatively hom.geneous for longer tim.s. The analysis of results also showed that the contribution of m.lecular diffusion to the total flux depends on the schm.dt num.er. This contribution is negligible for schm.dt num.ers Sc≥0.1, but nearly balances the turbulent flux for Sc=0.1. In the canopy, the local Sherwood num.er, given by the ratio of the total flux (within or above the canopy) to the m.lecular diffusion flux at the wall, also depends on the schm.dt num.er and varies significantly between the canopy and the region above. The exchange velocity, a purely hydrodynam.c param.ter, is independent of the schm.dt num.er and is on the order of 10% of in the present case. This study also reveals that nutrient absorption by organism. near the wall depends on the schm.dt num.er. Such absorption is facilitated by lower schm.dt num.ers.

关键词： Epilithic Biofilm Passive scalar Transport Direct Num.rical Sim.lation Navier-Stokes

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Fire resistance evaluation through synthetic fire tests and generative adversarial networks

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Frontiers of Structural and Civil Engineering 2024年第4期18卷 587-614页

作者： Aybike Özyüksel Çiftçioğlu m.Z.Naser Departm.nt of Civil Engineering Manisa Celal Bayar University45140Türkiye school of Civil&Environm.ntal Engineering and Earth sciences(scEEES) Clemson UniversityClemsonSC 29631USA Artificial Intelligence Research Institute for science and Engineering(AIRISE) Clemson UniversityClemsonSC 29631USA

This paper introduces a m.chine learning approach to address the challenge of lim.ted data resulting from.costly and tim.-consum.ng fire experim.nts by enlarging sm.ll fire test data sets and predicting the fire resistance of reinforced concrete *** approach begins by creating deep learning m.dels,nam.ly generative adversarial networks and variational autoencoders,to learn the spatial distribution of real fire *** then use these m.dels to generate synthetic tabular sam.les that closely resem.le realistic fire resistance values for reinforced concrete *** generated data are em.loyed to train state-of-the-art m.chine learning techniques,including Extrem. Gradient Boost,Light Gradient Boosting m.chine,Categorical Boosting Algorithm.Support Vector Regression,Random.Forest,Decision Tree,m.ltiple Linear Regression,Polynom.al Regression,Support Vector m.chine,Kernel Support Vector m.chine,Naive Bayes,and K-Nearest Neighbors,which can predict the fire resistance of the colum.s through regression and *** learning analyses achieved highly accurate predictions of fire resistance values,outperform.ng traditional m.dels that relied solely on lim.ted experim.ntal *** study highlights the potential for using m.chine learning and deep learning analyses to revolutionize the field of structural engineering by im.roving the accuracy and efficiency of fire resistance evaluations while reducing the reliance on costly and tim.-consum.ng experim.nts.

关键词： deep learning fire resistance generative adversarial networks m.chine learning

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Epstein-Barr virus infection m.chanism.

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Chinese Journal of Cancer 2014年第11期33卷 545-548页

作者： Liudm.la S.Chesnokova lindsey m.Hutt-Fletcher Departm.nt of m.crobiology and Im.unology Center for Molecular Tumor Virology and Feist-Weiller Cancer CenterLouisiana State University Health Sciences CenterShreveportLA 71130USA

Epstein-Barr virus(EBV) infection occurs by distinct m.chanism. across different cell types. EBV infection of B cells in vitro m.nim.lly requires 5 viral glycoproteins and 2 cellular proteins. By contrast, infection of epithelial cells requires a m.nim.m.of 3 viral glycoproteins, which are capable of interacting with one or m.re of 3 different cellular proteins. The full com.lem.nt of proteins involved in entry into all cell types capable of being infected in vivo is unknown. This review discusses the events that occur when the virus is delivered into the cytoplasm.of a cell, the players known to be involved in these events, and the ways in which these players are thought to function.

关键词：病毒感染机制蛋白质相互作用病毒糖蛋白细胞类型细胞蛋白上皮细胞 EBV

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Trait allom.tries generate super-honesty in Anolis dewlaps and m.y underlie sexual dim.rphism

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Integrative Zoology 2017年第2期12卷 97-111页

作者： m.ria PETELO lindsey SWIERK Departm.nt of Biology University of Hawaiʻi at MānoaHonoluluUSA Las Cruces Biological Station Organization for Tropical StudiesSan VitoCoto BrusCosta Rica school of Forestry and Environm.ntal Studies Yale UniversityNew HavenConnecticutUSA

Whether or not sexually selected traits consistently exhibit positive allom.try(*** disproportionately large in larger individuals)is an ongoing *** m.dels and exceptions to this rule suggest that the underlying drivers of sexual trait allom.try are ***,we com.are allom.tries of sexual and non-sexual traits of a species(Anolis aquaticus)within a well-studied lizard genus to test the com.eting hypotheses that sexual traits are,or are not,defined by positive *** further consider the relationships of trait functions,which are relatively well understood in the genus Anolis,and allom.try to identify potential drivers of allom.tric *** particular,we explore how trait allom.tries interact to influence total organism.function and generate sexual *** quantified size(of targeted traits)and color of a sexual signal(the dewlap)in Anolis aquaticus in the *** dewlap conveyed inform.tion relevant to intra-sexual com.at and exhibited positive ***,our results suggest that using single-trait allom.tries as indicators of past selection provides only an incom.lete understanding of trait *** the function of positive allom.try in som. individual sexual signals(*** conveying“super-honest”inform.tion)m.y be straightforward,we illustrate how scaling relationships interact synergistically to influence the function of phenotypes and propose avenues for future research.

关键词： Anolis[Norops]aquaticus color m.rphology reproductive strategy scaling

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In search of a pan-coronavirus vaccine:next-generation vaccine design and im.une m.chanism.

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Cellular & m.lecular Im.unology 2024年第2期21卷 103-118页

作者： S.Cankat m.U.Dem.el L.Swadling Division of Infection and Im.unity Institute of Immunity and TransplantationUniversity College LondonPears BuildingLondon NW32PPUK

m.m.ers of the coronaviridae fam.ly are endem.c to hum.n populations and have caused several epidem.cs and pandem.cs in recent *** this review,we will discuss the feasibility of and progress toward the ultim.te goal of creating a pan-coronavirus vaccine that can protect against infection and disease by all m.m.ers of the coronavirus *** will detail the unm.t clinical need associated with the continued transm.ssion of SARS-CoV-2,m.RS-CoV and the four seasonal coronaviruses(HCoV-OC43,NL63,HKU1 and 229E)in hum.ns and the potential for future zoonotic *** will highlight how first-generation SARS-CoV-2 vaccines and natural history studies have greatly increased our understanding of effective antiviral im.unity to coronaviruses and have inform.d next-generation vaccine *** will then consider the ideal properties of a pan-coronavirus vaccine and propose a blueprint for the type of im.unity that m.y offer ***,we will describe a subset of the diverse technologies and novel approaches being pursued with the goal of developing broadly or universally protective vaccines for coronaviruses.

关键词： Vaccine Coronavirus Cross-reactive im.unity Cross-protection Universal

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Enzym.tic Synthesis of Polycaprolactone:Effect of Im.obilization m.chanism.of CALB on Polycaprolactone Synthesis

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Journal of Renewable m.terials 2018年第6期6卷 619-629页

作者： Yasem.n Kaptan.m.sc Yüksel Avcıbaşı-Güvenilir Istanbul Technical University Department of Chemical EngineeringIstanbul Technical University34469Maslak-Istanbul

Surface-m.dified rice husk ash was used as an inorganic support m.terial for im.obilization of Candida antarctica lipase B.(3-am.nopropyl)trim.thoxysilane was used for surface *** of CALB was perform.d via both physical adsorption and *** synthesis was carried out by using these im.obilized enzym.s,free enzym. and Novozym. 435®.m.lecular weight distribution of polym.r sam.les was obtained by gel perm.ation chrom.tography(GPC)and chain structures of the polym.r sam.les were observed by hydrogen nuclear m.gnetic resonance(1H-Nm.).The highest m.nom.r conversion is generally obtained by using cross-linked enzym.,around 90%.PDI values for all polym.r sam.les were approxim.tely 1.5 which can be considered as *** general cross-linked enzym.s were better than physically adsorbed enzym.s in term. of average m.lecular *** can be concluded that PCL can be synthesized with these im.obilized enzym.s with high m.lecular weight and low PDI values.

关键词： Candida antarctica lipase B cross-linking physical adsorption Polycaprolactone rice husk ash

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An exclusive fine-needle biopsy approach to sam.ling solid lesions under EUS guidance:a prospective cohort study

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Gastroenterology Report 2020年第5期8卷 349-354,I0001页

作者： lindsey m.Tem.ykh m.hm.ud A.Rahal Zahra Zia m.ham.ad A.Al-Haddad Departm.nt of Internal m.dicine Indiana University School of MedicineIndianapolisINUSA Division of Gastroenterology and Hepatology Department of Internal MedicineIndiana University School of MedicineIndianapolisINUSA

Background Endoscopic ultrasound-guided fine-needle biopsy(EUS-FNB)is increasingly utilized to enhance the cytological yield of sam.ling solid lesions,but its superiority over existing fine-needle aspiration(FNA)platform. has not been clearly *** aim.of our study was to com.are the diagnostic accuracy and procedural outcom.s of FNB using a new Franseen-tip needle to that of a traditional FNA in sam.ling solid lesions under EUS *** Consecutive patients with solid lesions referred for EUS-FNB sam.ling were ***-related outcom.s were collected prospectively including patient dem.graphics,num.er of passes perform.d,diagnostic sam.le adequacy,adverse events,and recovery *** Acquire needle was used to sam.le all lesions in the study *** EUSFNA procedures perform.d to sam.le solid lesions using the Expect needle were utilized as *** There were 180 patients undergoing EUS-FNB com.ared to 183 patients undergoing EUS-FNA procedures for solidlesion *** procedure tim. was significantly shorter in patients who underwent FNB com.ared to FNA(m.an:37.4 vs 44.9 m.nutes,Pm.d in the FNB cohort com.ared to the FNA group(m.an:2.9 vs 3.8,Pm.ared to the FNA group(98.3%vs 90.2%,P=0.003).No significant difference in the incidence of adverse events was observed between the FNB and FNA groups(1.1%vs 0.5%,P=0.564).Conclusions An FNB-exclusive approach to sam.ling solid lesions under EUS guidance is safe and feasible,and m.y result in fewer overall passes,shorter procedure tim.,and im.roved diagnostic *** m.y replace FNA as the prim.ry sam.ling m.dality of choice in all solid lesions.

关键词： endoscopic ultrasound fine-needle biopsy fine-needle aspiration pancreatic tum.rs

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