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Diagnostic Delay and Associated Clinical Features of Tuberculosis among Adult Patients with Acute Myeloid Leukemia in Doha, Qatar

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Journal of Tuberculosis Research 2018年第1期6卷 49-62页

作者： Halima el Omri Ruba taha Wanis Ibrahim Nancy Kassem Lajos Szabados Hesham el Sabah Fatma Ben Abid Amna Gamiel Aisha Al Khinji Wojciech Szmeigielski Saba Hasan Ibrahim Al Hijji Hematology and Medical Oncology Hamad Medical Corporation Doha Qatar Internal Medicine Hamad Medical Corporation Doha Qatar Clinical Pharmacy NCCCR Hamad Medical Corporation Doha Qatar Nuclear Medicine and PET-CT Hamad Medical Corporation Doha Qatar Infection Disease Hamad Medical Corporation Doha Qatar Radiology NCCCR Hamad Medical Corporation Doha Qatar

Background: Tuberculosis is currently the world’s leading cause of death arising from a single infectious condition. While T cell mediated immunity is recognized to have a major contribution to tuberculosis activation, the present investigation confirmed that TB was more prevalent among patients with acute myeloid rather than lymphoid leukemia and such association was frequently overlooked. The primary objective of this study is to estimate the diagnostic delay of tuberculosis among patients with acute myeloid leukemia (AML) and compare it to the general population in Qatar. Secondary objective is to study the clinical and epidemiologic characteristics of tuberculosis in patients with AML. Methods: This is a retrospective study of tuberculosis cases diagnosed in subjects with AML during the period from January 2008 till December 2016. Results: Among 215 subjects with AML identified during the study period, 12 (5.58%) received the diagnosis of tuberculosis. The estimated incidence of tuberculosis among AML cases was 7.14 cases per 1000 per year. The mean delay in diagnosis of tuberculosis was 64.2 days (95% CI: 26.8 - 101.5) and the median was 45 days (interquartile range;Q1 - Q3, 29.5 - 97.5). Prolonged fever was the most common presentation (100% of cases). Parenchymal lung involvement was the most common radiologic abnormality (83.3% of cases). Three patients (25%) died and 8 patients completed 9 to 12 months of anti-tuberculous treatment with clinical and radiological remission. Conclusion: Infections caused by Mycobacterium tuberculosis are not uncommon in patients with AML especially in patients from tuberculosis endemic regions. It constitutes a diagnostic challenge so high index of suspicion is of paramount importance.

关键词： Tuberculosis Acute Myeloid Leukemia Neutropenia

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Hydrothermal preparation of TiO_(2)-Ag nanoparticles and its antimicrobial performance against human pathogenic microbial cells in water

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BIOCelL 2018年第3期42卷 93-97页

作者： Mahmoud MOUSTAFA Saad ALAMRI Mohamed elNOUBY Tarek taha M.A.ABU-SAIED Ali SHATI Mohamed AL-KAHTANI Sulaiman ALRUMMAN Department of Biology College of ScienceKing Khalid University9004AbhaKingdom of Saudi Arabia(KSA Department of Botany Faculty of ScienceSouth Valley UniversityQenaEgypt Composite and Nanostructured Materials Research Department Advanced Technology and New Materials Research InstituteCity of Scientific Research and Technological Applications(SRTA-CITY)New Borg El-Arab City21934AlexandriaEgypt Environmental Biotechnology Department Genetic Engineering and Biotechnology Research Institute(GEBRI)City of Scientific Research and Technological Applications(SRTA-CITY)New Borg El-Arab City21934AlexandriaEgypt Polymer Materials Research Department Advanced Technology and New Materials Research InstituteCity of Scientific Research and Technological Applications(SRTA-CITY)New Borg El-Arab City21934AlexandriaEgypt

Water contaminated with pathogenic microbes is considered as one of the most common routes for transmitting diseases in human *** methods have been applied for the decontamination of microbes in contaminated *** the current study,an easy to do hydrothermal method has been used for the preparation of TiO_(2)-Ag *** obtained material was characterised using a scanning electron microscope(SEM)and fourier transform infra-red spectroscopy(FTIR).The morphological appearance of the obtained nanoparticles was in the shape of a sphere with a size range of 60-90 *** antimicrobial activity of the prepared nanoparticles was tested against several pathogenic bacteria and *** obtained results proved that the nanoparticles succeeded to affect all the tested microbes in the following order:Bacillus cereus ATCC6633>Pseudomonas aeruginosa ATCC9027=Klebsiella pneumoniae ATCC13883>Vibrio cholera ATCC700=Candida albicans ATCC 700=Escherichia coli NCTC10418>Staphylococcus aureus *** minimum inhibitory concentration(MIC)of the prepared nanoparticles varied among the tested microbes at range of 12 mg/ml and 25 mg/*** results encourage the application of prepared TiO_(2)-Ag nanoparticles for treatment of microbe-contaminated waters.

关键词： TiO_(2)-Ag nanoparticles Hydrothermal Antimicrobial activity Water treatment

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Relationship of Cognition, Depression and Anxiety to Glycemic Control in Older Adults with Diabetes

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Advances in Aging Research 2014年第2期3卷 142-151页

作者： Moatassem Salah Amer Tomader taha Abdel Rahman Salma Mohamed Samir el Said Nermien Naim Adly Shaimaa Nabil Rohaiem Randa Abdel Wahab Reda Clinical Pathology Department Faculty of Medicine Ain Shams University Cairo Egypt Geriatrics and Gerontology Department Cairo Egypt

Objective: This study aimed to assess the relationship of cognition, depression and anxiety to glycemic control in elders with diabetes. DM is a chronic medical condition. Its control depends on adherence to medical therapy and making decisions related to lifestyle changes. This decision making capacity is affected by many factors including cognition and psychological status. Design: It was a case control study. Setting: It was done in Ain Shams University Hospital inpatients and DM outpatient clinic, Cairo, Egypt. Participants: Of the one hundred diabetic patients aged ≥ 60 years, 50 had Hemoglobin A1c (HbA1c) ≥ 7.5 (cases) and 50 had Hb A1c 7.5 (controls). Measurements: Cognition was assessed using minimental status examination (MMSE) test, Mattis Organic Mental Syndrome Screening Examination (MOMSSE) and Cambridge Cognitive Examination (CAMCOG) test. Geriatric depression scale-15 (GDS-15) was performed for depression assessment, while anxiety was assessed by DSM IV criteria. Laboratory investigations included: fasting blood sugar (FBS), post-prandial blood sugar (PPBS), glycated haemoglobin (Hb A1c), low density lipoprotein (LDL), high-density lipoprotein (HDL), total cholesterol, and triglycerides (TG). Results: Significant difference was found between the two groups regarding scores of cognitive tests: MMSE score (p = 0.004);below average (p = 0.02) and average scores (p = 0.05) of MOMSSE;CAMCOG score (p = 0.015);and CAMCOG divided items score including orientation (p = 0.003), comprehension (p = 0.005), expression (p = 0.020), attention (p = 0.002), and abstraction (p = 0.008) as well as depression screening scores (P = 0.002). Using Receiver Operating Characteristic, CAMCOG had better sensitivity and MOMSSE had better specificity. Conclusion: Cognitive impairment was associated with poor glycemic control, and impairment in attention and abstraction, related to executive function, functions were found to be associated with poor glycemic control. These function

关键词： Diabetes Mellitus Cognition Depression Anxiety Hb A1c elders

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The Surface Reactivity of Pure and Monohydrogenated Nanocones Formed from Graphene Sheets

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Graphene 2015年第4期4卷 75-83页

作者： Ahlam A. el-Barbary Mohamed A. Kamel Khaled M. Eid Hayam O. taha Rasha A. Mohamed Mohammed A. Al-Khateeb Physics Department Faculty of Education Ain Shams University Cairo Egypt Physics Department Faculty of Science Jazan University Jazan KSA Bukairiayh for Science Qassim University Qassim KSA

A systematic computational study of surface reactivity for pure and mono-hydrogenated carbon nanocoes (CNCs) formed from graphene sheets as functions of disclination angle, cone size and hydrogenation sites has been investigated through density functional (DFT) calculations and at the B3LYP/3-21G level of theory. Five disclination angles (60°, 120°, 180°, 240° and 300°) are applied and at any disclination angle four structures with different sizes are studied. For comparison, pure and mono-hydrogenated boron nitride nanocones (BNNCs) with disclination angles 60°, 120°, 180°, 240° and 300° are also investigated. The hydrogenation is done on three different sites, HS1 (above the first neighbor atom of the apex atoms), HS2 (above one atom of the apex atoms) and HS3 (above one atom far from the apex atoms). Our calculations show that the highest surface reactivity for pure CNCs and BNNCs at disclination angles 60°, 180° and 300° is 23.50 Debye for B41N49H10 cone and at disclination angles 120° and 240° is 15.30 Debye for C94H14 cone. For mono-hydrogenated CNCs, the highest surface reactivity is 22.17 Debye for C90H10-HS3 cone at angle 300° and for mono-hydrogenated BNNCs the highest surface reactivity is 28.97 Debye for B41N49H10-HS1 cone when the hydrogen atom is adsorbed on boron atom at cone angle 240°.

关键词： Carbon Nanocones Boron Nitride Nanocones DFT Surface Reactivity Hydrogenation

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Biosynthesis of raw starch degradingβ-cyclodextrin glycosyltransferase by immobilized cells of Bacillus licheniformis using potato wastewater

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BIOCelL 2021年第6期45卷 1661-1672页

作者： YASSER S.MOSTAFA SAAD A.ALAMRI SULIMAN A.ALRUMMAN TAREK H.taha MOHAMED HASHEM MAHMOUD MOUSTAFA LAMIAA I.FAHMY Department of Biology College of ScienceKing Khalid UniversityAbha9004Saudi Arabia Prince Sultan Bin Abdulaziz Center for Environmental and Tourism Research and Studies King Khalid UniversityAbha9004Saudi Arabia Environmental Biotechnology Department Genetic Engineering and Biotechnology Research InstituteCity of Scientific Research&Technological ApplicationsNew Borg El-Arab City21934Egypt Department of Botany and Microbiology Faculty of ScienceAssiut UniversityAssiut71515Egypt Department of Botany and Microbiology Faculty of ScienceSouth Valley UniversityQena83523Egypt Department of Microbiology and Immunology Faculty of PharmacyOctober University for Modern Science and ArtGiza12451Egypta

The study was sought to enhance the synthesis of thermal stableβ-cyclodextrin glycosyltransferase(β-CGTase)using potato wastewater as a low-cost medium and assess the degree to which it is efficient for industrial production ofβ-cyclodextrin(β-CD)from raw potato *** bacteria producingβ-CGTase was isolated from Saudi Arabia and the promising strain was identified as Bacillus licheniformis using phylogenetic analysis of the 16S rRNA ***-encapsulated cultures exhibited twice-fold ofβ-CGTase production more than free *** electron microscopy(SEM)of polymeric capsules indicated the potential for a longer shelf-life,which promotes the restoration of activity in bacterial cells across semi-continuous fermentation ofβ-CGTase production for 252 *** optimal conditions forβ-CGTase synthesis using potato wastewater medium were at 36 h,pH of 8.0,and 50°C with 0.4%potato starch and 0.6%yeast extract as carbon and nitrogen sources,*** purified enzyme showed a specific activity of 63.90 U/mg with a molecular weight of∼84.6 kDa as determined by SDS-PAGE *** high enzyme activity was observed up to 60°C,and complete stability was achieved at 75°*** levels of activity and stability were shown at pH 8.0,and the pH range from 7.0–10.0,*** enzyme has an appreciable affinity for raw potato starch with a Km of 5.7×10−6 M and a Vmax of 87.71μmoL/mL/min.β-CD production was effective against 25 U/g of raw potato *** outcomes demonstrated its feasibility to develop a fermentation process by integrating the cost-effective production ofβ-CGTase having distinctive properties forβ-CD production with ecofriendly utilization of potato wastewater.

关键词： Potato wastewater Bacillus licheniformis β-CGTase 16S rDNA gene Semi-continuous fermentation β-cyclodextrin

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Assessment of Endometrial Carcinoma Markers and Hormone Receptors Profile before and after Bariatric Surgery: A Clinico-Pathological-Immunohistochemical Study

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Open Journal of Obstetrics and Gynecology 2019年第7期9卷 1019-1031页

作者： Walid Mohamed elnagar Samah Said elbasateeny Mai Mohamed Abdelwahab Mahmoud Abdou Yassin taha Abdelwahab Baiomy Maha Abdelhamid Fathy Amin Dalia Abdallah el-Shafei Department of Obstetrics and Gynecology Faculty of Medicine Zagazig University Zagazig Egypt Department of Pathology Faculty of Medicine (Rabigh Branch) King Abdul Aziz University Jeddah KSA Department of Pathology Faculty of Medicine Zagazig University Zagazig Egypt Department of General Surgery Faculty of Medicine Zagazig University Zagazig Egypt Department of Physiology Faculty of Medicine Zagazig University Zagazig Egypt Department of Community Environmental & Occupational Medicine Faculty of Medicine Zagazig University Zagazig Egypt

Background: Obesity is a major risk factor for endometrial carcinoma, and we aim to assess markers of carcinogenesis including PTEN and Ki-67 and hormone receptors profile including ER, PR and AR before and after bariatric surgery to find out its effects in reducing endometrial carcinoma risk in morbid obese females. Patients and methods: The study included 80 females with morbid obesity (BMI > 40 Kg/m2) who underwent bariatric surgery. All were sampled by Pipelle biopsy at baseline and 12 months after operation and examined histopathologically and immunohistochemically for Ki-67, PTEN, ER, PR and AR. Results: Sixty two out of 80 (62/80) females showed no pathological abnormalities;4 had polyps;7 had simple endometrial hyperplasia;4 had atypical endometrial hyperplasia and 3 had endometrial carcinoma. In total, 34 females underwent gastric bypass operation (42.5%) and 46 underwent a sleeve gastrectomy operation (57.5%). There was a statistically significant difference between baseline weight and BMI before and after surgery (p eline biopsies were glandular PTEN null, including 9/15 of the women with baseline endometrial abnormalities, of whom 5/15 regained glandular PTEN expression as their endometrial abnormalities resolved. There was a significant reduction in ER score after surgery (p ely (p = 0.193). AR H-scores were higher significantly in pre-operative biopsies than post-operative ones (p < 0.001). Conclusion: Females with morbid obesity have a higher risk of harboring endometrial abnormalities even if asymptomatic. However, the endometrial pathology and the high ER and PR expression can be normalized within one year without me

关键词： Bariatric Surgery Obesity Endometrial Cancer Hormone Receptors

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Adsorption of CO, CO2, NO and NO2on Boron Nitride Nanotubes: DFT Study

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Journal of Surface Engineered Materials and Advanced Technology 2015年第3期5卷 154-161页

作者： A. A. el-Barbary Kh. M. Eid M. A. Kamel H. O. taha G. H. Ismail Physics Department Faculty of Education Ain Shams University Cairo Egypt Physics Department Faculty of Science Jazan University Jazan KSA Bukairiayh for Science Qassim University Qassim KSA

The adsorption of CO, CO2, NO and CO2 gas molecules on different chiralities of single boron nitride nanotubes (BNNTs) is investigated, applying the density functional theory and using basis set 6 - 31 g (d,p). The energetic, electronic properties and surface reactivity have been discussed. We found that the best BNNT for adsorbing the CO, CO2, NO and NO2 gas molecules is (5,0) BNNT with adsorption energy of -0.27, -0.37 eV, -0.23 and -0.92 eV, respectively. Also, the electronic character of (5,0), (9,0), (5,5) and (6,6) BNNTs is found to be not affected by the adsorption of CO, CO2, NO and NO2 gas molecules. It is found that the dipole moments of zig-zag (5,0) and (9,0) BNNTs are always higher than the arm-chair (5,5) and (6,6) BNNTs. Also, it is noticed that the highest dipole moment is for (9,0) BNNT.

关键词： BN Nanotubes DFT Gas Sensors

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Adsorption of CO, CO2, NO and NO2on Carbon Boron Nitride Hetero Junction: DFT Study

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Journal of Surface Engineered Materials and Advanced Technology 2015年第4期5卷 169-176页

The adsorption of CO, CO2, NO and CO2 gas molecules on different diameters and chiralities of carbon nanotube-boron nitride nanotube (CNT-BNNT) heterojunctions is investigated, applying the density functional theory and using basis set 6 - 31 g (d,p). The energetic, electronic properties and surface reactivity have been discussed. We found that the best CNT-BNNT heterojunctions for adsorbing the CO, NO, CO2 and NO2 gas molecules is (5,0) CNT-BNNT heterojunction through forming C-N bonds with adsorption energy of -0.26, -0.41 eV, -0.33 and -0.63 eV, respectively. Also, the adsorption of CO, NO, CO2 and NO2 gas molecules on (5,5) and (6,6) CNT-BNNT heterojunctions does not affect the electronic character of the CNT-BNNT heterojunctions, however the adsorption of NO and NO2 gas molecules on (5,0) and (9,0)CNT-BNNT heterojunctions in case of forming C-B bonds increases the band gaps to 1.21 eV and 1.52 eV, respectively. In addition, it is reported that the values of dipole moment for armchair (5,5) and (6,6) CNT-BNNT heterojunctions are not affected by gas adsorption. Also, for the zig-zag (5,0) and (9,0) CNT-BNNT heterojunctions, the values of dipole moment increase through forming C-N bonds and decrease through forming C-B bonds. In addition, it is reported that the highest dipole moment is obtained for (9,0) CNT-BNNT heterojunctions. Therefore, the zig-zag CNT-BNNT heterojunctions can be selected as good candidate for gas sensors.

关键词： CNT-BNNT Heterojunctions DFT Gas Sensors

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Development of bis-thiobarbiturates as successful urease inhibitors and their molecular modeling studies

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Chinese Chemical Letters 2016年第5期27卷 693-697页

作者： Fazal Rahim Muhammad Ali Shifa Ullah Umer Rashid Hayat Ullah Muhammad taha Muhammad Tariq Javed Wajid Rehman Aftab Ahmad Khan Obaid Ur Rahman Abid Muhammad Bilal Department of Chemistry Hazara University Department of Chemistry COMSATS Institute of Information Technology Department of Biochemistry and Biotechnology The Islamia University of Bahawalpur Atta-ur-Rahman Institute for Natural Product Discovery Universiti Teknologi MARA (UiTM)Puncak Alam Campus Faculty of Applied Science UiTM Department of Environmental Science COMSATS Institute of Information Technology

Bis-thiobarbiturate derivatives 1-15 have been synthesized, characterized by 1HNMR and el-MS and screened for urease inhibition. All compounds showed various degree of urease inhibitory activity with iC50 values ranging 7.45 ± 0.12 - 74.24 ± 0.81 μmol/L while the standard thiourea behaved normally （ICso = 21.10 ±0.12）. Compounds I （IC50= 7.45 ± 0.12 ]μmol/L）, 9 （IC50 =18,17 ± 1.03 bmol/L） and 13 （IC50= 8.61 ± 0.45 bmol/L） showed excellent urease inhibitory activity in the series. Molecular modeling studies were performed to understand the binding site with the bimetallic nickel center of the enzyme. Structure-activity relationship has also been established for these compounds. This study identified bis- thiobarbiturate as a novel class of urease inhibitors.

关键词： Thiobarbituric acid Synthesis Urease inhibition Molecular docking studies

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New 3D Aware Formulation of MoM-GEC Method for Studying Planar Structures with Vertical Sources

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Journal of electromagnetic Analysis and Applications 2016年第4期8卷 79-94页

作者： Oueslati Basma Ben Salah taha Larbi Chiraz Aguili Taoufik Communication System Laboratory Sys’Com National Engineering School of Tunis University Tunis El Manar Tunis Tunisia

This paper proposes a generalization of the MoM-GEC method [1] needed for studying planar structures excited with a source located at perpendicular plan relative to circuit plan. A general formulation is detailed to allow modeling excitation of a planar structure with one or more sources located in plans other than the circuit plan. The numerical approach elaborated is based on the definition of new admittance operators and rotational transformations describing the transition from one plan to another. To validate this approach, we consider the case of a single source located in the perpendicular plan to the circuit.

关键词： Admittance Operator MoM-GEC 3D Discontinuities Vertical Source

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