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World Journal of Clinical Cases 2023年第17期11卷 4065-4071页

作者： Ji-Ping Xie lin-lin chen Wen Lv Wu Li Hui Fang Guang Zhu Department of Gynecology Tongde Hospital of Zhejiang ProvinceHangzhou 310012Zhejiang ProvinceChina Department of Medical Ultrasonics Tongde Hospital of Zhejiang ProvinceHangzhou 310012Zhejiang ProvinceChina

BACKGROUND Cesarean scar pregnancy(CSP)is rare but may result in uterine rupture during pregnancy or massive hemorrhage during abortion procedures.Awareness of this condition is increasing,and most patients with CSP are now diagnosed early and can be managed safely.However,some atypical patients are misdiagnosed,and their surgical risks are underestimated,increasing the risk of fatal hemorrhage.CASE SUMMARY A 27-year-old Asian woman visited our institution because of abnormal pregnancy,and she was diagnosed with a hydatidiform mole through transvaginal ultrasound(TVS).Under hysteroscopy,a large amount of placental tissue was found in the scar of the lower uterine segment,and a sudden massive hemorrhage occurred during the removal process.The bilateral internal iliac arteries were temporarily blocked under laparoscopy,and scar resection and repair were rapidly performed.She was discharged in good condition 5 d after the operation.CONCLUSION Although TVS is widely used in the diagnosis of CSP,delays in the diagnosis of atypical CSP remain.Surgical treatment following internal iliac artery temporary occlusion may be an appropriate management method for unanticipated massive hemorrhage during CSP surgery.

关键词： Internal iliac artery temporary occlusion Cesarean scar pregnancy Uterine artery embolization Misdiagnosis Hysteroscopy Laparoscopy Case report

N-hydroxyphthalimide anchored on hexagonal boron nitride as a metal-free heterogeneous catalyst for deep oxidative desulfurization

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Petroleum Science 2022年第3期19卷 1382-1389页

作者： lin-Jie Lu Pei-Wen Wu Jing He Ming-Qing Hua Yan-Hong Chao Ning Yang lin-lin chen Wei Jiang Lei Fan Hong-Bing Ji Wen-Shuai Zhu School of Chemistry and Chemical Engineering Institute for Energy ResearchJiangsu UniversityZhenjiangJiangsu212013PR China School of Pharmacy Jiangsu UniversityZhenjiangJiangsu212013PR China Yangzhou University YangzhouJiangsu225002PR China Fine Chemical Industry Research Institute School of ChemistrySun Yat-sen UniversityGuangzhouGuangdong510275PR China

A metal-free N-hydroxyphthalimide/hexagonal boron nitride(NHPI/h-BN)catalytic system was developed for deep oxidative desulfurization(ODS)of fuel oils.Detailed experiments find that the heterogenization process of loading NHPI on h-BN not only benefits to the dispersion and utilization of NHPI,but also can significantly promote the catalytic performance.By employing NHPI/h-BN as the catalyst,azodiisobutyronitrile(AIBN)as the metal-free initiator,a 95%conversion of dibenzothiophene(DBT)can be acquired under the reaction conditions of 120°C and atmospheric pressure with molecular oxygen(O_(2))as oxidant.Moreover,the heterogenization is convenient for the regeneration of the catalyst with>94%DBT conversion after being recycled seven times.Characterizations illustrate that the promoted catalytic activity along with the regenerability originate from the interactions between NHPI and h-BN.The catalytic mechanism study shows that molecular oxygen is readily activated by the NHPI/h-BN to form a superoxide radical(O_(2)^(·-)),which oxidize DBT to DBTO2 for desulfurization.

关键词： N-hydroxyphthalimide Hexagonal boron nitride Oxidative desulfurization Heterogeneous catalysis

Biocompatibility of polyetheretherketone for the treatment of orbital bone defects

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International Journal of Ophthalmology(English edition) 2020年第5期13卷 725-730页

作者： Rui-Dong Gu Fan Xiao lin Wang Kai-Jian Sun lin-lin chen Department of Ophthalmology the Fourth People’s Hospital of ShenyangShenyang 110031Liaoning ProvinceChina

AIM: To investigate the biocompatibility and therapeutic effects of polyetheretherketone(PEEK) on recovery of a rabbit orbital defect.METHODS: Totally 16 New Zealand rabbits were used to establish an orbital bone defect model and then randomly divided into two groups. PEEK was implanted in the experimental group. The control group was blank, and no substance was implanted. The model rabbits were sacrificed at 4 and 8 wk, and examined by general observations, histology, electron microscopy, Western blotting, and realtime polymerase chain reaction.RESULTS: No infection or rejection occurred after PEEK implantation, and biocompatibility was good. The relative expression of vascular endothelial growth factor(VEGF) protein in the experimental group was significantly higher than that in the control group postoperatively(P<0.05). Bone defect repair in the experimental group was significantly better than that in the control group in the same period and some osteogenesis was observed.CONCLUSION: PEEK has good biocompatibility and efficacy for the treatment of orbital bone defects in a rabbit model.

关键词： polyetheretherketone histocompatibility orbital defect orbital burst fracture three-dimensional printing rabbit

Therapeutic effects of four strains of probiotics on experimental colitis in mice

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World Journal of Gastroenterology 2009年第3期15卷 321-327页

作者： lin-lin chen Xue-Hong Wang Yi Cui Guang-Hui Lian Jie Zhang Chun-Hui Ouyang Fang-Gen Lu Department of Gastroenterology The Second Xiangya Hospital of Central South University Changsha 410011 Hunan Province China Department of Gastroenterology Zhongshan City People's Hospital Zhongshan 528400 Guangdong Province China

AIM:To investigate the therapeutic effects of four strains of probiotics(E.feacalis,L.acidophilus,C.butyricum and B.adolescentis) on dextran sulphate sodium(DSS)-induced experimental colitis in Balb/c mice.METHODS:Eighty Balb/c mice were randomly divided into 8 groups.Weight-loss,fecal character,fecal occult blood and hematochezia were recorded daily.Disease activity index(DAI) scores were also evaluated everyday.Length of colon was measured and histological scores were evaluated on the 13th day.Myeloperoxidase(MPO) activity was detected.Interleukin-1(IL-1) and IL-4 expression was detected by ELISA and RT-PCR.RESULTS:The four strains of probiotics relieved the inflammatory condition of DSS-induced experimental colitis in mice.Weight loss was slowed down in all probiotics-treated mice.Even weight gain was observed by the end of probiotics treatment.The DAI and histological scores of probiotics-treated mice were lower than those of mice in the control group(1.9 ± 0.2 vs 8.6 ± 0.4,P < 0.05 for E.faecalis).The length of colon of probiotics-treated mice was longer than that of mice in the control group(10.3 ± 0.34 vs 8.65 ± 0.77,P < 0.05 for E.faecalis).The four strains of probiotics decreased the MP activity and the IL-1 expression,but increased the IL-4 expression.E.faecalis had a better effect on DSS-induced experimental colitis in mice than the other three strains.CONCLUSION:The four strains of probiotics have beneficial effects on experimental colitis in mice.E.faecalis has a better effect on DSS-induced experimental colitis in mice than the other three strains.Supplement of probiotics provides a new therapy for UC.

关键词：大肠炎白介素-1 白介素-4 前生命期

Lactobacillus species shift in distal esophagus of high-fat-diet-fed rats

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World Journal of Gastroenterology 2011年第26期17卷 3151-3157页

作者： Xin Zhao Xiao-Wei Liu Ning Xie Xue-Hong Wang Yi Cui Jun-Wen Yang lin-lin chen Fang-Gen Lu Department of Gastroenterol-ogy The Second Xiangya Hospital of Central South UniversityChangsha 410011 Hunan Province China Department of Gastroenterology Xiangya Hospi-tal of Central South University Changsha 410008 Hunan Prov-ince China

AIM:To analyze the microbiota shift in the distal esophagus of Sprague-Dawley rats fed a high-fat diet.METHODS:Twenty Sprague-Dawley rats were divided into high-fat diet and normal control groups of 10 rats each.The composition of microbiota in the mucosa from the distal esophagus was analyzed based on selective culture.A variety of Lactobacillus species were identified by molecular biological techniques.Bacterial DNA from Lactobacillus colonies was extracted,and 16S rDNA was amplified by PCR using bacterial universal primers.The amplified 16S rDNA products were separated by denaturing gradient gel electrophoresis(DGGE).Every single band was purified from the gel and sent to be sequenced.RESULTS:Based on mucosal bacterial culturing in the distal esophagus,Staphylococcus aureus was absent,and total anaerobes and Lactobacillus species were decreased significantly in the high-fat diet group compared with the normal control group(P < 0.01).Detailed DGGE analysis on the composition of Lactobacillus species in the distal esophagus revealed that Lactobacillus crispatus,Lactobacillus gasseri(L.gasseri) and Lactobacillus reuteri(L.reuteri) comprised the Lactobacillus species in the high-fat diet group,while the composition of Lactobacillus species in the normal control group consisted of L.gasseri,Lactobacillus jensenii and L.reuteri.CONCLUSION:High-fat diet led to a mucosal microflora shift in the distal esophagus in rats,especially the composition of Lactobacillus species.

关键词：乳酸菌种 SD大鼠高脂肪食管饮食远端变性梯度凝胶电泳金黄色葡萄球菌

High incidences and similar patterns of Wolbachia infection in fig wasp communities from three different continents

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Insect Science 2010年第2期17卷 101-111页

作者： lin-lin chen James M. Cook Hui Xiao Hao-Yuan Hu Li-Ming Niu Da-Wei Huang Key Laboratory of Zoological Systematics and Evolution Institute of Zoology Chinese Academy of Sciences Beijing China Graduate University of Chinese Academy of Sciences Beijing China School of Biological Sciences University of Reading Reading UK College of Plant Protection Shandong Agricultural University Tai'an Shandong Province China

Wolbachia are endosymbiotic bacteria that infect numerous arthropod species. Previous studies in Panama and Australia revealed that the majority of fig wasp species harbor Wolbachia infections, but that similar patterns of incidence have evolved inde- pendently with different wasp species and Wolbachia strains on the two continents. We found Wolbachia infections in 25/47 species （53%） of fig wasp associated with 25 species of Chinese figs. Phylogenetic analyses of Wotbachia wsp sequences indicated that very similar strains are not obviously found in either closely related or ecologically linked fig wasps species. The extremely high prevalence of Wolbachia in fig wasps （over 50% of species infected） is not constrained by geographical origin and is a recurrent theme of fig wasp/Wolbachia interactions.

关键词： fig wasps horizontal transmission Wolbachia wsp

Study on possible synergistic anticancer cachexia effects of the main active compounds of Radix Sophorae flavescentis

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Traditional Medicine Research 2021年第4期6卷 46-61页

作者： Hong Zhang lin-lin chen Meng-Yi Chi Xi-Peng Sun Quan-Jun Yang Li-Li Wan cheng Guo Department of Pharmacy Shanghai Jiao Tong University Affiliated Shanghai Sixth People’s HospitalShanghai 200233China School of Medicine Shanghai Jiao Tong UniversityShanghai 200240China School of Pharmacy Shanghai University of Traditional Chinese MedicineShanghai 201203China

Background:Cancer cachexia is a complex disease secondary to cancer,and no specific therapy for it has been found.The Chinese herb Kushen(Radix Sophorae flavescentis)is the dried root of Sophora flavescens Aiton,which has been widely applied in treating digestive and urinary inflammatory diseases.Matrine,one of the main components of Radix Sophorae flavescentis,can alleviate cancer cachexia.Methods:Compounds from Radix Sophorae flavescentis were screened using the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform.The targets related to cancer cachexia were queried from the Therapeutic Target Database(http://***),DisGeNET database(http://***),and Search Tool for Interacting Chemicals database,related literature,and constructed cancer cachexia-protein network.Cancer cachexia-protein network was merged with compound-protein networks respectively using Cytoscape software as well as network topology data and key targets counting.Pathway enrichment analysis was conducted via the Database for Functional Annotation Bioinformatics Microarray Analysis.Protein crystal structures and compound structures were queried from RCSB and PubChem databases,respectively.Molecular docking was conducted using Discovery Studio software.Results:The anticancer cachexia compounds of Radix Sophorae flavescentis were screened as oxymatrine,matrine,and kurarinol,and targets such as BIRC2,TNF and STAT3 were found.The mechanisms of oxymatrine,matrine,and kurarinol have the characteristics of synergy and complementarity.Kurarinol has a mechanism similar to that of matrine,which includes the FoxO signaling pathway,insulin resistance and mTOR signaling pathway.TNF signaling pathway is a common signaling pathway of kurarinol,oxymatrine and matrine.Adipocytokine signaling pathway is the other common pathway of kurarinol and oxymatrine except for the TNF signaling pathway.Kurarinol can be successfully docked with CYCS,GPX2,BIRC7,etc.,and kushenol C can be successfully docked with IKBKB and PIK3CD.Conclusion:Kurarinol,mat

关键词： Radix Sophorae flavescentisn Cancer cachexia Kurarinol Matrine Oxymatrine TNF signaling pathway

Efficacy profiles for different concentrations of Lactobacillus acidophilus in experimental colitis

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World Journal of Gastroenterology 2013年第32期19卷 5347-5356页

作者： lin-lin chen Yi-You Zou Fang-Gen Lu Fu-Jun Li Guang-Hui Lian Department of Gastroenterology Xiangya Hospital of Central South University Department of Gastroenterology Second Xiangya Hospital of Central South University

AIM:To determine the efficacy profiles of different concentrations of Lactobacillus acidophilus(L.acidophilus)for treating colitis using an experimental murine model.METHODS:Colitis was established in 64 BALB/c mice by adding 5%dextran sodium sulfate(DSS)to the drinking water and allowing ad libitum access for 7 d.The mice were then randomly divided into the following control and experimental model groups(n=8 each;day 0):untreated model control;negative-treatment model control(administered gavage of 1 mL/10 g normal saline);experimental-treatment models C4-C8(administered gavage of 104,105,106,107,or 108CFU/10 g L.acidophilus,respectively);positive-treatment model control(administration of the anti-inflammatory agent prednisone acetate at 45 g/10 g).Eight mice given regular water(no DSS)and no subsequent treatments served as the normal control group.Body weight,fecal traits,and presence of fecal occult blood were assessed daily.All animals were sacrificed on post-treatment day7 to measure colonic length,perform histological scoring,and quantify the major bacteria in the proximal and distal colon.Intergroup differences were determined by one-way ANOVA and post-hoc Student-Newman-Keuls comparison.RESULTS:All treatments(L.acidophilus and prednisone acetate)protected against colitis-induced weight loss(PC4>C5>C7>C8>C6;P0.05).The C6 group also had the lowest disease activity index scores among the model groups.The bacterial profiles in the proximal colon were similar between all of the experimental-treatment model groups(all P>0.05).In contrast,the bacterial profile in the distal colon of the C6 group showed the distinctive features(P<0.05 vs all other experimental-treatment model groups)of Lactobacillus sp.and Bifidobacterium sp.being the most abundan

关键词： Lactobacillus acidophilus Bifidobacterium Colonic flora Therapeutic dose Experimental colitis Efficacy profile

Emerging role of lncRNAs as mechanical signaling molecules in mechanotransduction and their association with Hippo-YAP signaling:a review

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第4期25卷 280-292页

作者： Siyi lin Xinyu HE Ying WANG Yu chen Aifu lin College of Medicine Zhejiang UniversityHangzhou 310058China College of Life Sciences Zhejiang UniversityHangzhou 310058China Cancer Center Zhejiang UniversityHangzhou 310058China Key Laboratory for Cell and Gene Engineering of Zhejiang Province Hangzhou 310058China International School of Medicine International Institutes of Medicinethe Fourth Affiliated Hospital of Zhejiang University School of MedicineYiwu 322000China Key Laboratory of Cancer Prevention and Intervention China National Ministry of EducationHangzhou 310058China Future Health Laboratory Innovation Center of Yangtze River DeltaZhejiang UniversityJiaxing 314100China

Cells within tissues are subject to various mechanical forces,including hydrostatic pressure,shear stress,compression,and tension.These mechanical stimuli can be converted into biochemical signals through mechanoreceptors or cytoskeleton-dependent response processes,shaping the microenvironment and maintaining cellular physiological balance.Several studies have demonstrated the roles of Yes-associated protein(YAP)and its homolog transcriptional coactivator with PDZ-binding motif(TAZ)as mechanotransducers,exerting dynamic influence on cellular phenotypes including differentiation and disease pathogenesis.This regulatory function entails the involvement of the cytoskeleton,nucleoskeleton,integrin,focal adhesions(FAs),and the integration of multiple signaling pathways,including extracellular signal-regulated kinase(ERK),wingless/integrated(WNT),and Hippo signaling.Furthermore,emerging evidence substantiates the implication of long non-coding RNAs(lncRNAs)as mechanosensitive molecules in cellular mechanotransduction.In this review,we discuss the mechanisms through which YAP/TAZ and lncRNAs serve as effectors in responding to mechanical stimuli.Additionally,we summarize and elaborate on the crucial signal molecules involved in mechanotransduction.

关键词： YAP/TAZ Long non-coding RNA(lncRNA) Mechanotransduction F-actin

Distribution of per-and polyfluoroalkyl substances in blood,serum,and urine of patients with liver cancer and associations with liver function biomarkers

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Journal of Environmental Sciences 2024年第5期139卷 418-427页

作者： Cao Dai lin Peng Yanjie Li Zhendong Li Da chen Fei Wang Nan lin Department of Hepatobiliary Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China School of Environment Guangdong Key Laboratory of Environmental Pollution and HealthJinan UniversityGuangzhou 510632China State Key Laboratory of Environmental and Biological Analysis Department of ChemistryHong Kong Baptist UniversityHong Kong 999077China South China Institute of Environmental Sciences MEEGuangzhou 510655China

Studies have shown that per-and polyfluoroalkyl substances(PFASs)may be hepatotoxic in animals or humans.However,data on clinical epidemiology are very limited.In this study,21PFASs were determined in patients with liver diseases,with the highest median concentrations detected in the serum sample(26.7 ng/mL),followed by blood(10.7 ng/mL)and urine(5.02 ng/mL).Higher total PFAS concentrations were found in hepatocellular carcinoma(HCC)patients compared to non-HCC patients,with significant discrepancies in serum and blood samples.Besides,significant correlations were also found among PFAS concentrations and age,gender,body mass index(BMI),and liver function biomarkers levels.For example,PFAS concentrations are significantly higher in males than in females;Several serum PFASs concentrations increase with age and BMI,while the serum perfluorohexane sulfonic acid(PFHxS)concentrations are negatively correlated with age.In addition,multiple regression models adjusted for age,gender and BMI found that increased serum perfluorobutane sulfonic acid(PFBS),perfluoroheptane sulfonic acid(PFHpS)and perfluorohexylphosphonic acid(PFHxPA)conentrations are correlated with elevated alkaline phosphatase(ALP),aspartate aminotransferase(AST),and alpha-fetoprotein(AFP)(plinical hepatotoxicity of PFAS.

关键词： Per-and polyfluoroalkyl substances(PFASs) Liver cancer Serum Blood Urine Liver function biomarkers