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利用屏蔽栅极功率MOSFET技术降低传导和开关损耗

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今日电子 2011年第4期 38-39页

作者： Mike Speed Joe Yedinak hl lin 飞兆半导体公司

监管机构与终端客户对DC/DC电源效率的要求越来越高。新的设计要求更低的导通阻抗,同时不能影响非钳位电感性开关（UIS）能力或者不增加开关损耗。屏蔽栅极MOSFET可为30～200V范围的DC/DC电源设计人员提供相关解决方案。现在,通过提高... 详细信息

监管机构与终端客户对DC/DC电源效率的要求越来越高。新的设计要求更低的导通阻抗,同时不能影响非钳位电感性开关（UIS）能力或者不增加开关损耗。屏蔽栅极MOSFET可为30～200V范围的DC/DC电源设计人员提供相关解决方案。现在,通过提高开关性能,导通阻抗Rds（on）已能降低50%及以上,从而提高效率,为更高频率工作创造条件。本文讨论了屏蔽栅极MOSFET在中等电压MOSFET（40～300V）应用中的优势。

关键词：功率MOSFET 开关损耗栅极屏蔽 DC/DC电源 Rds(on) 传导技术

Progress of Lyman-alpha-based beam emission spectroscopy(Ly BES)diagnostic on the hl-2A tokamak

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Plasma Science and Technology 2024年第3期26卷 118-125页

作者：周艺轩余羿许敏柯锐聂林徐皓赵光义刘灏袁子豪肖晨雨李继全肖池阶 the hl-2A Team Southwestern Institute of Physics Chengdu 610041People's Republic of China Sino-French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082People's Republic of China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871People's Republic of China

An edge Lyman-alpha-based beam emission spectroscopy(LyBES)diagnostic,using a heating NBI(neutral beam injection)system,is currently under development on the hl-2A *** 20-channel edge LyBES,which is intended to measure the density fluctuation in plasma edge(from R=1960 mm to R=2026 mm)with an improved spatial resolution of 3.3 mm,is a complement to the existing conventional beam emission spectroscopy(BES)*** this article,we introduce the progress of LyBES diagnostic,including the collection optics,the monochromator,and the detector *** reflectance of the collection mirrors is measured to be~82%at 122 nm,and the aberration geometrical radius of the collection optics is tested to be~150μm in the aimed *** linear dispersion of the LyBES monochromator is designed to be~0.09 nm mm^(-1).The bandwidth of the detector system with the 5×10^(7)V A^(-1)preamplifier gain is measured to be~280 kHz,and the peak-to-peak noise of the detector system is tested to be~16 *** finalized design,components development and testing of the LyBES diagnostic have been completed at present,and an overall performance of the LyBES diagnostic is to be confirmed in the next hl-2A campaign.

关键词： density fluctuation Ly BES BES vacuum ultraviolet

Visual function and morphological changes in the macular area of patients with type 2 diabetes mellitus after intensive insulin therapy

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Chinese Medical Journal 2014年第4期127卷 658-661页

作者： ChenZG Zhang JY Lu CJ lin SS ChertJW Zhong hl Tian B Wei WB Department of Ophthalmology Ruian People&#39 s Hospital RuianZhejiang 325200 China Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical UniversityBeijing Key Laboratory of Ophthalmology and Visual Science Beijing 100730 China

Background Intensive insulin therapy has been found to lessen the progress of diabetic retinopathy （DR） to some extent,while it has also been implicated to be responsible for decrease of *** investigated visual function and morphological changes in the macular area in short-term follow-up of patients with type 2 diabetes mellitus after intensive insulin *** This was a prospective clinical study of nonproliferative DR patients （102 eyes,120 patients） undergoing intensive insulin *** Contrast Glare Tester （Takagi CGT-1000） was used to examine contrast sensitivity （CS） and Heidelberg Retina Tomograph （HRT） Ⅱ and Stratus Model 3000 OCT were used to observe the changes of morphology in the macular ***-up times were pre-intensive therapy,3 and 6 months post-intensive *** CS at low and middle frequencies was higher at 3 and 6 months post-therapy compared with pre-therapy （P 〈0.05）.Significant differences in CS at low frequency were found between 6 and 3 months post-therapy （P 〈0.05）.Macular edema index was lower in the first,second,and third rings of the macular area after intensive therapy compared with pre-therapy （P 〈0.05）.Compared with 3 months post-therapy,the macular edema index was lower in the first,second,and third rings of the macular area at 6 months post-therapy （P 〉0.05）.No significant differences in the thickness of the first,second,and third rings of the macular area were detected between 3 and 6 months post-therapy and pre-therapy （P〉0.05）.Conclusion CS and macular edema indexes were significantly improved in nonproliferative diabetic retinopathy patients after intensive insulin therapy,but thickness of the macular area was unchanged.

关键词： intensive insulin therapy diabetic retinopathy contrast sensitivity Heidelberg Retina Tomograph Ⅱ optical coherence tomography

Bioinspired Self-assembly Nanochaperone Inhibits Tau-Derived PHF6 Peptide Aggregation in Alzheimer’s Disease

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Chinese Journal of Polymer Science 2022年第9期40卷 1062-1070页

作者： lin Zhu Ming-Qing Zhang Hao-Ren Jing Xi-Peng Zhang lin-lin Xu Ru-Jiang Ma Fan Huang lin-Qi Shi State Key Laboratory of Medicinal Chemical Biology Key Laboratory of Functional Polymer Materials of Ministry of EducationCollege of ChemistryNankai UniversityTianjin 300071China Key Laboratory of Radiopharmacokinetics for Innovative Drugs Chinese Academy of Medical Sciencesand Institute of Radiation MedicineChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin300192China Nankai University School ofMedicine Nankai UniversityTianjinChina Department of Colorectal SurgeryTianjin Union Medical CenterTianjin 300074 China Department of Colorectal Surgery Tianjin Union Medical CenterTianjin 300121China

After repeated frustrations with amyloid beta(Aβ)-targeted clinical trials for Alzheimer’s disease(AD)in recent years,the therapeutic focus of AD has gradually shifted from Aβto tau *** misfolding and aggregation of tau protein into neurofibrillary tangles(NFTs)cause neuron death and synaptic dysfunction,and the deposition of NFTs is more closely related to the severity of AD than Aβ***,it has great potential to target tau protein aggregation for AD *** hexapeptide VQIVYK(known as PHF6)in tau protein has been found to play a dominant role for tau aggregation and was widely used as a model to design tau protein aggregation ***,inspired by natural heat shock protein(HSPs),we fabricated a self-assembly nanochaperone based on mixed-shell polymeric micelle(MSPM)as a novel tau-targeted AD *** tunable phase-separated microdomains on the surface,the nanochaperone could effectively bind with PHF6 aggregates,inhibit PHF6 aggregation,block neuronal internalization of PHF6 species,thus significantly alleviating PHF6 mediated ***,the as-prepared nanochaperone could work with proteinase to facilitate the degradation of PHF6 *** bioinspired nanochaperone demonstrated a new way to target tau protein and provided a promising strategy for AD treatment.

关键词： Alzheimer’s disease Tau protein PHF6 Nanochaperone Inhibition

影响湖相沉积岩中有机碳分布的主要因素——以三水盆地为例

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沉积学报 2001年第1期19卷 113-116页

作者：刘春莲杨建林 Hans-JoachimRhl Annette Schmid Rhl 中山大学地球科学系广州510275 InstitutfürGeologieundPalontologie

湖相沉积中的有机质含量随有机质堆积条件变化而发生波动。本文以三水盆地下第三系土布心组二段地层为例 ,对其作高分辨率岩芯取样并结合地球化学方法 ,分析生物学因素对有机碳分布的影响。在较干燥的气候条件下 ,水生浮游生物是有机质... 详细信息

湖相沉积中的有机质含量随有机质堆积条件变化而发生波动。本文以三水盆地下第三系土布心组二段地层为例 ,对其作高分辨率岩芯取样并结合地球化学方法 ,分析生物学因素对有机碳分布的影响。在较干燥的气候条件下 ,水生浮游生物是有机质的主要来源 ,由于此时湖泊与海洋沟通 ,出现半咸水环境 ,硫酸盐还原作用显著 ,不利于有机质保存。所取岩芯段的中上部即是这种情况 ,以低TOC和高SRI值为特征。而当气候湿润时 ,植物繁荣 ,湖水淡化 ,陆源有机质丰富。缺氧条件下的有机质降解主要是效率极低的发酵作用。有利于有机质保存。这种情形出现于岩芯段的下部。

关键词：有机碳地球化学三水盆地湖相沉积岩硫酸盐

New bipartition model of neutral particle transport in the hl-2A divertor region

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核聚变与等离子体物理 2005年第2期25卷 139-145页

作者： DENGBai-quan YANJian-cheng PENGLi-lin SouthwesternInstituteofPhysics Chengdu610041

A new bipartition neutral transport model has been developed for simulation of the hydrogenic neutral particle transport in the vicinity of hl-2A divertor target *** numerical calculation results on the basis of this model are fairly consistent with the results obtained with the "multi-generation method". One possible application of this model is to provide a source term originating from neutral transport calculation for any other edge plasma transport code, for instance, B-2 code, which has been used to simulate edge plasma transport of the hl-2A divertor configuration. Especially it can be utilized to quickly classify the plasma in divertor region as high or low recycling regime.

关键词：中性粒子传输氢原子 hl-2A托卡马克计算机仿真

Effect of perioperative branched chain amino acids supplementationin liver cancer patients undergoing surgical intervention: Asystematic review

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World Journal of Gastrointestinal Surgery 2023年第11期15卷 2596-2618页

作者： Kwan Yi Yap HongHui Chi Sherryl Ng Doris hl Ng Vishal G Shelat Yong Loo lin School of Medicine National University of SingaporeSingapore 117597Singapore Department of Gastroenterology and Hepatology Tan Tock Seng HospitalSingapore 308433Singapore Lee Kong Chian School of Medicine Nanyang Technological UniversitySingapore 636921Singapore Department of General Surgery Tan Tock Seng HospitalSingapore 308433Singapore

performed independently by authors(Yap KY,Chi H,Ng S)identified 50 studies for full-text ***,12 prospective RCTs and 4 non-randomised studies(1 non-randomised trial and 3 observational studies)were included.A detailed PRISMA diagram is shown in Figure *** studies included were assessed for risk of bias,with a summary of the assessment shown in Figure 2 and Table 1 for trials and non-interventional studies,*** PRISMA checklist is appended in Supplementary Figure 1.

关键词： Branched-chain amino acid Liver cancer Liver surgery Nutritional supplement Perioperative supplementation

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胃癌雌激素受体的研究

世界华人消化杂志 2000年第5期8卷 560-561页

作者：秦环龙林擎天上海市第六人民医院外科上海市200233

自20世纪60年代发现雌激素受体以来,学者们开展了对各种不同器官肿瘤受体的研究,并形成了激素作用机制的3种模式(二步模式、核模式和平衡模式).目前已在众多的肿瘤中发现了性激素受体,如孕酮激素(PR)、雌激素(ER)和雄激素(AR).这些肿瘤... 详细信息

自20世纪60年代发现雌激素受体以来,学者们开展了对各种不同器官肿瘤受体的研究,并形成了激素作用机制的3种模式(二步模式、核模式和平衡模式).目前已在众多的肿瘤中发现了性激素受体,如孕酮激素(PR)、雌激素(ER)和雄激素(AR).这些肿瘤包括激素依赖性器官和非依赖性器官的肿瘤.经复习文献,发现对胃癌性激素受体的研究起步较晚,自20世纪70年代发现胃癌与乳腺癌具有相同的流行病学特点以后,逐渐有作者报告性激素可以影响胃癌肿瘤的生长,但具体机制尚不清楚.本文就胃癌与雌激素受体的关系综述如下,以明确胃癌是否为激素依赖性以及内分泌治疗的可行性.

关键词：胃肿瘤雌激素受体分子生物学流行病学

Magnetic and electro-catalytic properties of a copper complex with 2-(pyridylmethyl)amino-N,N-bis(2-methylene-4,6-difluorophenol)

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Chinese Chemical Letters 2017年第7期28卷 1424-1428页

作者： Dong Li Chen-Neng lin Shu-Zhong Zhan Chun-lin Ni College of Chemistry & Chemical Engineering South China University of Technology College of Materials and Energy Institute of Biomaterial South China Agricultural University

A new material for both magnetic coupling and electrocatalytic hydrogen generation based on a copper complex,[（hl）CuCl-CuCl（hl）]HCl 1 is prepared by the reaction of 2-（pyridylmethyl）amino-N,N-bis（2-methylene-4,6-difluorophenol）（H2L） and CuCl2·*** solid,complex 1 is built from two copper units（[（hl）CuCl]）,and exhibits an antiferromagnetic exchange interaction between copper（Ⅱ） ions（J=-160cm^-1）.In liquid,1 can electrocatalyze hydrogen generation both from acetic acid with a turnover frequency（TOF） of 16.3 moles of hydrogen per mole of catalyst per hour at an overpotential（OP）of 941.6 mV（in DMF）,and a neutral buffer with a TOF of 1415.6 moles of hydrogen per mole of catalyst per hour at an OP of 787.6 mV.

关键词： Copper complex Molecular structure Magnetic properties Electrocatalyst Proton or water reduction Hydrogen generation