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Therapeutic Effects of Different Animal Bile Powders on Lipid Metabolism Disorders and Their Composition Analysis

Chinese Journal of Integrative Medicine 2022年第10期28卷 918-923页

作者： CHEN Da-xin CHU Jian-feng lin shan ZHANG ling CHEN Hong-wei SUN Zhi-wei XU Jian-feng CAI Qiao-yan WANG Li-li PENG Jun Academy of Integrative Medicine Cardiovascular Research Institute Fuzhou(350122)China Fujian Key Laboratory of Integrative Medicine on Geriatric Fujian University of Traditional Chinese MedicineFuzhou(350122)China Chen Ke-ji Academic Thought Heritage Studio Fuzhou(350122)China Fujian Guizhentang Pharmaceutical Co. Ltd.HuianFujian Province(362142)China

Objective: To compare the therapeutic effect of different animal bile powders on lipid metabolism disorders induced by high-fat diet in rats, and analyze the bioactive components of each animal bile powder. Methods: Sixty Sprague-Dawley rats were randomly divided into 6 groups(n=10): normal diet control group, high-fat diet model group, high-fat diet groups orally treated with bear, pig, cow and chicken bile powders, respectively. Serum biochemical markers from the abdominal aorta in each group were analyzed. Changes in the body weight and liver weight were recorded. Pathohistological changes in the livers were examined. High performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry was used to determine the composition of bioactive components in each animal bile powder. Results: Treatment with different types of animal bile powders had different inhibitory effects on high-fat diet-induced increase of body weight and/or liver weight in rats, most notably in bear and pig bile powders(Pling, infiltration of inflammatory cells and formation of lipid vacuoles. Bioactive component analysis revealed that there were significant differences in the relative content of taurocholic acid, taurodeoxycholic acid and ursodeoxycholic acid among different types of animal bile. Interestingly, a unique component with molecular weight of 496.2738 Da, whose function has not yet been reported, was identified only in bear bile powder. Conclusions: Different animal bile powders had varying therapeutic effect against lipid metabolism disorders induced by high-fat diet, and bear bile powder demonstrated th

关键词： bile powders lipid metabolism active ingredient liver

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Functional Analysis of the Phosphoenolpyruvate Carboxylase on the Lipid Accumulation of Peanut(Arachis hypogaea L.) Seeds

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Journal of Integrative Agriculture 2013年第1期12卷 36-44页

作者： PAN Li-juan YANG Qing-li CHI Xiao-yuan CHEN Ming-na YANG Zhen CHEN Na WANG Tong WANG Mian HE Ya-nan YU shan-lin shandong Peanut Research Institute

Phosphoenolpyruvate carboxylase（PEPC;EC 4.***.1.31） catalyses phosphoenolpyruvate（PEP） to yield oxaloacetate,which is involved in protein *** kinase（PK;EC 2.***.1.40） catalyzes PEP to yield pyruvate,which is involved in fatty acid *** this study,five PEPC genes（AhPEPC1,AhPEPC2,AhPEPC3,AhPEPC4,and AhPEPC5） from peanut have been *** a quantitative real-time RT-PCR approach,the expression pattern of each gene was monitored during the seed development of four peanut varieties（E11,Hebeigaoyou,Naihan 1,and Huayu 26）.It was found that these five genes shared similar expression behaviors over the developmental stages of E11 with high expression levels at 30 and 40 d after pegging（DAP）;whereas these five genes showed irregular expression patterns during the seed development of *** Naihan 1 and Huayu 26,the expression levels of the five genes remained relatively high in the first *** PEPC activity was monitored during the seed development of four peanut varieties and seed oil content was also characterized during whole period of seed *** PEPC activity followed the oil accumulation pattern during the early stages of development but they showed a significantly negative correlation *** results suggested that PEPC may play an important role in lipid accumulation during the seed development of four peanut varieties tested.

关键词： peanut(Arachis hypogaea L.) phosphoenolpyruvate carboxylase PEPC activity lipid accumulation

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甘蓝型油菜漆酶基因家族成员表达模式及与茎秆抗折力的关联分析

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作物学报 2025年第1期51卷 134-148页

作者：徐林珊郜耿东王宇王家星杨吉招武亚瑞张宵寒常影李真谢雄泽龚德平王晶葛贤宏华中农业大学植物科学技术学院湖北武汉430070 襄阳市农业科学院湖北襄阳441057 荆州农业科学院湖北荆州434000

漆酶是一种含铜的多酚氧化酶家族,在植物中主要参与木质素合成以及抵御各种逆境胁迫。本研究对甘蓝型油菜漆酶基因(BnaLACs)家族成员进行鉴定,通过氨基酸数量、分子量、等电点、不稳定系数以及脂溶性系数等指标衡量其理化性质。后对其... 详细信息

漆酶是一种含铜的多酚氧化酶家族,在植物中主要参与木质素合成以及抵御各种逆境胁迫。本研究对甘蓝型油菜漆酶基因(BnaLACs)家族成员进行鉴定,通过氨基酸数量、分子量、等电点、不稳定系数以及脂溶性系数等指标衡量其理化性质。后对其染色体位置、进化关系、基因结构、组织部位表达模式等进行预测和分析。结果表明,甘蓝型油菜基因组共有53个BnaLACs家族成员,基本为碱性、稳定蛋白,大多数BnaLACs定位在液泡膜和细胞外。基因结构分析发现, BnaLACs结构较为保守。组织部位表达模式分析表明,除花药外, BnaLACs在各组织部位均有表达,其中在根、种子、角果皮和茎秆中表达量较高。分析茎秆中BnaLAC4s表达模式发现,BnaA05G0074200ZS与甘蓝型油菜抗倒性显著相关;单倍型分析表明,包含BnaA05G0074200ZS两种单倍型的品系间抗倒性、木质素含量均存在显著差异。研究结果将为进一步解析甘蓝型油菜漆酶基因家族功能及茎秆抗倒伏机制奠定基础。

关键词：甘蓝型油菜漆酶进化表达模式单倍型抗倒性

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我国长期照护保险制度的构建与财务平衡分析

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福建师范大学学报（哲学社会科学版） 2013年第1期 28-34页

作者：林姗姗福建师范大学经济学院福建福州350117

人口老化加剧、人口平均寿命提高和传统家庭结构改变,促使我国长期照护的需求逐年攀升。因此,建立我国长期照护保险制度已是当务之急。本文通过对我国长期照护保险制度完整构建,利用相关因素的架构进行长期照护保险基金财务平衡的测算,... 详细信息

人口老化加剧、人口平均寿命提高和传统家庭结构改变,促使我国长期照护的需求逐年攀升。因此,建立我国长期照护保险制度已是当务之急。本文通过对我国长期照护保险制度完整构建,利用相关因素的架构进行长期照护保险基金财务平衡的测算,以此评估我国实施长期照护保险的可行性与路径选择。

关键词：长期照护保险保险费率财务平衡

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Moxibustion improves experimental colitis in rats with Crohn's disease by regulating bile acid enterohepatic circulation and intestinal farnesoid X receptor

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Journal of Integrative Medicine 2023年第2期21卷 194-204页

作者： Jia-cheng Shen Qin Qi Dong Han Yuan Lu Rong Huang Yi Zhu lin-shan Zhang Xiu-di Qin Fang Zhang Huan-gan Wu Hui-rong Liu Key Laboratory of Acupuncture and Immunological Effects Shanghai University of Traditional Chinese MedicineShanghai 200030China shanghai Research Institute of Acupuncture and Meridian Shanghai 200030China

Objective:This study was conducted to explore the mechanism of intestinal inflammation and barrier repair in Crohn’s disease(CD)regulated by moxibustion through bile acid(BA)enterohepatic circulation and intestinal farnesoid X receptor(FXR).Methods:Sprague-Dawley rats were randomly divided into control group,CD model group,mild moxibustion group and herb-partitioned moxibustion *** model rats induced by 2,4,6-trinitrobenzene sulfonic acid were treated with mild moxibustion or herb-partitioned moxibustion at Tianshu(ST25)and Qihai(CV6).The changes in CD symptoms were rated according to the disease activity index score,the serum and colon tissues of rats were collected,and the pathological changes in colon tissues were observed via *** blot,immunohistochemistry(IHC)and immunofluorescence were used to evaluate the improvement of moxibustion on intestinal inflammation and mucosal barrier in CD by the BA-FXR ***:Mild moxibustion and herb-partitioned moxibustion improved the symptoms of CD,inhibited inflammation and repaired mucosal damage to the colon in CD ***,moxibustion could improve the abnormal expression of BA in the colon,liver and serum,downregulate the expression of interferon-γand upregulate the expression of FXR mRNA,and inhibit Toll-like receptor 4(TLR4)and myeloid differentiation factor 88(MyD88)*** IHC results showed that moxibustion could upregulate the expression of FXR and mucin2 and inhibit TLR4 *** blot showed that moxibustion inhibited the protein expression of TLR4 and MyD88 and upregulated the expression of *** image analysis showed that moxibustion increased the colocalization sites and intensity of FXR with TLR4 or nuclear factor-κB *** particular,herb-partitioned moxibustion has more advantages in improving BA and upregulating FXR and TLR4 in the ***:Mild moxibustion and herb-partitioned moxibustion can improve CD by regulating the enterohepatic

关键词： Crohn’s disease Moxibustion Bile acid Farnesoid X receptor Colitis Intestinal mucosal barrier

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江苏碳排放的数量测算及其影响因素——基于改进STIRPAT模型的计量检验

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南通大学学报（社会科学版） 2015年第4期31卷 9-16页

作者：林珊珊南通大学商学院江苏南通226019

文章从时间和行业两大维度测算了江苏碳排放的数量特征及其演进规律,在此基础上借助理论分析框架,运用改进的STIRPAT模型,基于江苏1990-2013年的时间序列数据对各变量间的关系进行了计量检验。实证结果显示:碳排放量与技术进步、经济增... 详细信息

文章从时间和行业两大维度测算了江苏碳排放的数量特征及其演进规律,在此基础上借助理论分析框架,运用改进的STIRPAT模型,基于江苏1990-2013年的时间序列数据对各变量间的关系进行了计量检验。实证结果显示:碳排放量与技术进步、经济增长及人口变动之间存在协整关系,技术进步对江苏碳排放的抑制作用不显著,而经济增长和人口变动在这方面的作用较显著。江苏应以技术进步为主要抓手,营造较好的产业平台与制度环境,以全方位推动低碳技术创新和应用。为了减少碳排放,江苏应该加大科技投入,促进低碳技术创新;应该改变能源结构,提高能源利用效率;应该借鉴先进经验,推进企业商业模式创新。

关键词：碳排放 STIRPAT模型技术进步经济增长

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Pharmacodynamic Mechanism of Kuanxiong Aerosol for Vasodilation and Improvement of Myocardial Ischemia

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Chinese Journal of Integrative Medicine 2022年第4期28卷 319-329页

作者： LU Yan YANG Mei-ling SHEN A-ling lin shan PENG Mei-zhong WANG Tian-yi LU Zhu-qing WANG Yi-lian PENG Jun CHU Jian-feng Academy of Integrative Medicine Fujian University of Traditional Chinese MedicineFuzhou350122China Chen Keji Academic Thought Inheritance Studio Fujian University of Traditional Chinese MedicineFuzhou350122China Fujian Key Laboratory of Integrative Medicine on Geriatrics Fujian University of Traditional Chinese MedicineFuzhou350122China Department of Acupuncture and Moxibustion Third People’s Hospital Affiliated to Fujian University of Traditional Chinese MedicineFuzhou350122China

Objective: To explore the effect of Kuanxiong Aerosol(KXA)on isoproterenol(ISO)-induced myocardial injury in rat ***: Totally 24 rats were radomly divided into control,ISO,KXA low-dose and high-dose groups according to the randomized block design method,and were administered by intragastric administration for 10 consecutive days,and on the 9th and 10th days,rats were injected with ISO for 2 consecutive days to construct an acute myocardial ischemia model to evaluate the improvement of myocardial ischemia by *** addition,the diastolic effect of KXA on rat thoracic aorta and its regulation of ion channels were tested by in vitro vascular tension *** influence of KXA on the expression of calcium-CaM-dependent protein kinase Ⅱ(CaMK Ⅱ)/extracellular regulated protein kinases(ERK)signaling pathway has also been ***: KXA significantly reduced the ISO-induced increase in ST-segment,interventricular septal thickness,cardiac mass index and cardiac tissue pathological changes in ***,the relaxation of isolated thoracic arterial rings that had been precontracted using norepinephrine(NE)or potassium chloride(KCl)was increased after KXA treatment in an endothelium-independent manner,and was attenuated by preincubation with verapamil,but not with tetraethylammonium chloride,4-aminopyridine,glibenclamide,or barium *** pretreatment attenuated vasoconstriction induced by CaCl_(2)in Ca^(2+)-free solutions containing K^(+) or *** addition,KXA pretreatment inhibited accumulation of Ca^(2+)in A7r5 cells mediated by KCl and NE and significantly decreased p-CaMK Ⅱ and p-ERK ***: KXA may inhibit influx and release of calcium and activate the CaMK Ⅱ/ERK signaling pathway to produce vasodilatory effects,thereby improving myocardial injury.

关键词： Kuanxiong Aerosol myocardial ischemia vasodilation Ca^(2+) CaMKⅡ/ERK pathway

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Genomic Evolution of Lung Cancer Metastasis:Current Status and Perspectives

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Cancer Communications 2021年第12期41卷 1252-1256页

作者： Wen-Fang Tang Rui Fu Yi Liang Jie-shan lin Zhen-Bin Qiu Yi-Long Wu Wen-Zhao Zhong Department of Cardiothoracic Surgery Zhongshan City People’s HospitalZhongshanGuangdong 528403P.R.China Guangdong Lung Cancer Institute Guangdong Provincial Key Laboratory of Translational Medicine in Lung CancerGuangdong Provincial People’s Hospital&Guangdong Academy of Medical SciencesGuangzhouGuangdong 510080P.R.China Department of Nephrology Blood Purification CenterZhongshan City People’s HospitalZhongshanGuangdong 528403P.R.China Southern Medical University GuangzhouGuangdong 510515P.R.China

INTRODUCTION Lung cancer is one of the cancers with the highest morbidity and mortality *** the two past decades,although the treatment of non-small cell lung cancer(NSCLC)has been revolutionized by the use of tyrosine kinase inhibitor(TKI)and immune treatments,metastatic disease remains largely incurable and presents a 5-year survival rate of approximately 10%[1].

关键词： Lung mortality lung

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台湾地区服务贸易国际竞争力研究

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国际贸易问题 2008年第11期311卷 80-84页

作者：林珊福建社会科学院亚太经济研究所 350001

利用显示性比较优势指数、贸易净出口和贸易竞争力指数,对台湾地区服务贸易的国际竞争力进行具体分析。根据台湾地区1997-2004年数据计算结果显示,台湾地区服务贸易竞争力在总体上处于劣势;各项服务贸易竞争力有所差异,但基本上除其他... 详细信息

利用显示性比较优势指数、贸易净出口和贸易竞争力指数,对台湾地区服务贸易的国际竞争力进行具体分析。根据台湾地区1997-2004年数据计算结果显示,台湾地区服务贸易竞争力在总体上处于劣势;各项服务贸易竞争力有所差异,但基本上除其他商业服务部门因三角贸易的巨额顺差形成带来了一定的国际竞争力外,其余10个服务贸易部门在国际贸易领域的竞争力大多数年份均处于比较劣势中。

关键词：台湾地区服务贸易国际竞争力

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福建自贸试验区贸易便利化措施及其评估

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亚太经济 2016年第6期 57-62页

作者：林涛林珊厦门理工学院经济与管理学院福建社科院亚太经济研究所

新常态下,如何构建安全稳定的开放型经济体系,进一步提升贸易便利化水平,提高贸易效率、降低贸易成本,建立符合国际新规则的贸易体制,已成为国家战略问题。福建自贸试验区设立1年多来,根据《中国(福建)自贸试验区总体方案》,遵循国际贸... 详细信息

新常态下,如何构建安全稳定的开放型经济体系,进一步提升贸易便利化水平,提高贸易效率、降低贸易成本,建立符合国际新规则的贸易体制,已成为国家战略问题。福建自贸试验区设立1年多来,根据《中国(福建)自贸试验区总体方案》,遵循国际贸易通行惯例和标准,陆续出台了贸易便利化新举措,经各方面评估成效显著。

关键词：贸易便利化措施评估福建自贸试验区

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