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Dependence of Generation of Hippocampal CAI Slow Oscillations on Electrical Synapses

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Neuroscience Bulletin 2020年第1期36卷 39-48页

作者： Yuan Xu Feng-Yan Shen Yu-Zhang Liu Lidan WANG Ying-Wei wang Zhiru wang Institute and Key Laboratory of Brain Functional Genomics of The Chinese Ministry of Education Shanghai Key Laboratory of Brain Functional GenomicsSchool of Life SciencesEast China Normal UniversityShanghai 200062China Department of Anesthesiology Huashan HospitalFudan UniversityShanghai 200040China

Neuronal oscillations in the hippocampus are critical for many brain functions including learning and memory.The underlying mechanism of oscillation generation has been extensively investigated in terms of chemical synapses and ion channels.Recently,electrical synapses have also been indicated to play important roles,as reported in various brain areas in vivo and in brain slices.However,this issue remains to be further clarified,including in hippocampal networks.Here,using the completely isolated hippocampus,we investigated in vitro the effect of electrical synapses on slow CA1 oscillations(0.5 Hz-1.5 Hz)generated intrinsically by the hippocampus.We found that these oscillations were totally abolished by bath application of a general blocker of gap junctions(carbenoxolone)or a specific blocker of electrical synapses(mefloquine),as determined by whole-cell recordings in both CA1 pyramidal cells and fast-spiking cells.Our findings indicate that electrical synapses are required for the hippocampal generation of slow CA1 oscillations.

关键词： Electrical synapse Hippocampus Oscillation CA1 Mefloquine Carbenoxolone Introduction

Excitatory Crossmodal Input to a Widespread Population of Primary Sensory Cortical Neurons

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Neuroscience Bulletin 2022年第10期38卷 1139-1152页

作者： Yuan-Jie Xiao Lidan WANG Yu-Zhang Liu Jiayu Chen Haoyu Zhang Yan Gao Hua He Zheng Zhao Zhiru wang Institute and Key Laboratory of Brain Functional Genomics of the Chinese Ministry of Education Shanghai Key Laboratory of Brain Functional GenomicsSchool of Life SciencesEast China Normal UniversityShanghai200062China Department of Neurosurgery Third Affiliated Hospital of the Navy Military Medical UniversityShanghai200438China Department of Neuroscience University of PittsburghPittsburgh15260USA

Crossmodal information processing in sensory cortices has been reported in sparsely distributed neurons under normal conditions and can undergo experience-or activity-induced plasticity.Given the potential role in brain function as indicated by previous reports,crossmodal connectivity in the sensory cortex needs to be further explored.Using perforated whole-cell recording in anesthetized adult rats,we found that almost all neurons recorded in the primary somatosensory,auditory,and visual cortices exhibited significant membrane-potential responses to crossmodal stimulation,as recorded when brain activity states were pharmacologically down-regulated in light anesthesia.These crossmodal cortical responses were excitatory and subthreshold,and further seemed to be relayed primarily by the sensory thalamus,but not the sensory cortex,of the stimulated modality.Our experiments indicate a sensory cortical presence of widespread excitatory crossmodal inputs,which might play roles in brain functions involving crossmodal information processing or plasticity.

关键词： Crossmodal input Crossmodal response Crossmodal plasticity Sensory cortex Crossmodal task Sensory loss GABAergic transmission

Silicon waveguide-based single cavity Fano resonance temperature sensor

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Optoelectronics Letters 2023年第3期19卷 139-143页

作者： wang Shuai LU Wenda LAI Xiaohan wang Hong ZHU Lianqing LU lidan Key Laboratory of the Ministry of Education for Optoelectronic Measurement Technology and Instrument Beijing Information Science and Technology UniversityBeijing 100059China

A compact Fano resonant temperature sensor composed of a micro-ring resonator(MRR)coupled double-T-shaped waveguide is developed.The coupling gap and coefficient of the device are optimized by the finite difference time domain(FDTD)method.The maximum slope ratio(SR)of the MRR-coupled single-T-shaped waveguide is-2.13 d B/nm.The SR of the double-T-shaped waveguide is-49.69 d B/nm which is 23 times that of the single-T-shaped waveguide.The simulation results show that the temperature sensitivity of optical intensity decreases with increasing temperature in the range from 303.6 K to 343.8 K.The wavelength-temperature sensitivity of the double-T-shaped waveguide microring is 76.5 pm/K.After introducing the double-T-shaped waveguide structure,the device’s performance is greatly improved,and the double-T-shaped waveguide has a good application prospect as a temperature sensor.

关键词： waveguide Fano resonator

Reconfigurable logic circuit design for stateful Boolean logic computing

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Science China(Information Sciences) 2021年第8期64卷 260-261页

作者： Li LUO Zhekang DONG Xiaofang HU Lidan WANG Shukai DUAN College of Electronic and Information Engineering Southwest University Brain-inspired Computing & Intelligent Control of Chongqing Key Lab School of Electronics and Information Hangzhou Dianzi University College of Artificial Intelligence Southwest University

Dear editor,The conventional von Neumann computer system has the memory wall problem [1], which limits the computation speed and causes high energy and latency of the computing system. To realize computing systems able to process massive data and complex computing tasks with high efficiency,a key and viable approach is in-memory computing.Memristor-based stateful logic design is a promising candidate for realizing the in-memory logic computing [2].

关键词： Reconfigurable logic circuit design for stateful Boolean logic computing

Single silicon waveguide MRR based Fano resonance in the whole spectral bands

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Optoelectronics Letters 2022年第7期18卷 398-403页

作者： LU lidan wang Shuai ZENG Zhoumo DONG Mingli ZHU Lianqing School of Instrument Science and Opto Electronics Engineering Beijing Information Science and Technology UniversityBeijing 100016China Department of Precision Instrument Engineering Tianjin UniversityTianjin 300072China

To improve the integration of Fano devices,we design a T-shaped waveguide coupling micro-ring resonator(MRR)structure to achieve a single cavity with Fano resonance in the whole spectral bands.The mathematical relationship between the phase factor,the coupling coefficient of the bus waveguide,and the Fano resonance slope extinction ratio(ER)is established.The electron beam exposure process is used to obtain a device with an insertion loss of~3 dB.The maximum ER of the Fano lineshape exceeds 15 dB,and the slope ratio(SR)is 251.3 dB/nm.This design improves the compactness of the Fano resonant device.

关键词： waveguide Fano resonator

Bayesian random Fourier filters for Gaussian noises

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Science China(Information Sciences) 2018年第12期61卷 214-216页

作者： Shiyuan wang Wanli wang Shukai DUAN Lidan WANG Chi K.TSE College of Electronic and Information Engineering Southwest University Chongqing Key Laboratory of Nonlinear Circuits and Intelligent Information Processing Department of Electronic and Information Engineering Hong Kong Polytechnic University

Dear editor,Signal processing algorithms are generally used to identify an unknown system, and can be classified as batch algorithms and online learning algorithms(OLAs). Batch algorithms are applied to offline scenar... 详细信息

关键词： Bayesian random Fourier filters for Gaussian noises

GABAergic Interneurons are Required for Generation of Slow CA1 Oscillation in Rat Hippocampus

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Neuroscience Bulletin 2016年第4期32卷 363-373页

作者： Yuan Xu Lidan WANG Yu-zhang Liu Yan Yang Xiaolin Xue Zhiru wang Institute and Key Laboratory of Brain Functional Genomics of The Ministry of Education of China Shanghai Key Laboratory of Brain Functional GenomicsSchool of Life Sciences East China Normal University

Neuronal oscillations are fundamental to hip- pocampal function. It has been shown that GABAergic interneurons make an important contribution to hippocampal oscillations, but the underlying mechanism is not well understood. Here, using whole-cell recording in the complete hippocampal formation isolated from rats at postnatal days 14-18, we showed that GABAA receptormediated activity enhanced the generation of slow CA1 oscillations. In vitro, slow oscillations （0.5-1.5 Hz） were generated in CA1 neurons, and they consisted primarily of excitatory rather than inhibitory membrane-potential changes. These oscillations were greatly reduced by blocking GABAA receptor-mediated activity with bicuculline and were enhanced by increasing such activity with midazolam, suggesting that interneurons are required for oscillation generation. Consistently, CA1 fast-spiking interneurons were found to generate action potentials usually preceding those in CA1 pyramidal cells. These findings indicate a GABAA receptor-based mechanism for the generation of the slow CA1 oscillation in the hippocampus.

关键词： Hippocampus - Oscillation SynchronizationGABAergic interneuron GABAA receptor

Silicon-based Fano resonance devices based on photonic crystal nanobeams

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Optoelectronics Letters 2023年第12期19卷 727-731页

作者： wang Yihao LU Wenda LAI Xiaohan DONG Mingli LU lidan ZHU Lianqing Beijing Information Science and Technology University Beijing 100192China State Grid Zhejiang Electric Power Corporation Information&Telecommunication Branch Hangzhou 310007China

To address the driving power and density of wavelength-division-multiplexing(WDM)computing architectures,a Fano resonator based on a photonic crystal nanobeam is proposed.The Fano resonator comprises a T-shaped waveguide,introducing an additional phase shift in the continuous propagation mode,and a photonic crystal nanobeam with a discrete mode.The device has one resonance peak within wavelength ranging from 1500 nm to 1600 nm,with a maximum extinction ratio of 8.7 dB and a transmission spectrum slope of up to 11.30 dB/nm.The device has good reusability,extinction ratio,and spectral resolution.It is expected to provide essential photonic components for low-energy consumption and high-density photonic computing to meet the requirements of future convolutional neural network(CNN)acceleration computing.

关键词： resonator Fano waveguide

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从特写集《西伯利亚》看拉斯普京的历史意识

外国文学研究 2022年第4期44卷 55-67页

作者：王丽丹南开大学外国语学院

当代俄罗斯经典作家瓦·拉斯普京的创作具有鲜明的历史意识,西伯利亚对其历史意识的形成具有特殊的文化意义。作家晚年的特写集《西伯利亚,西伯利亚》多维呈现了其以自然哲学为基础的历史意识。作家力图凭借历史记忆凝聚民族精神,主张... 详细信息

当代俄罗斯经典作家瓦·拉斯普京的创作具有鲜明的历史意识,西伯利亚对其历史意识的形成具有特殊的文化意义。作家晚年的特写集《西伯利亚,西伯利亚》多维呈现了其以自然哲学为基础的历史意识。作家力图凭借历史记忆凝聚民族精神,主张以批判反思意识对待历史与现实。作家融唯物史观与神学自然哲学观为一体的历史观,表明其反对历史虚无主义的坚定立场。《西伯利亚》中的悲情历史叙事,揭示出拉斯普京作为创作主体所具有的历史意识和历史批判精神,彰显作家融历史记忆、现实反思与未来想象为一体的历史情结。

关键词：拉斯普京《西伯利亚西伯利亚》历史意识历史记忆历史主体性